Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis.\nSmolders J, Thewissen M, Peelen E, Menheere P, Cohen Tervaert JW, Damoiseaux J, Hupperts R.\nPLoS One. 2009 Aug 13;4(8):e6635.\nPMID: 19675671
Association study on two vitamin D receptor gene polymorphisms and vitamin D metabolites in multiple sclerosis.
Smolders J, Damoiseaux J, Menheere P, Tervaert JW, Hupperts R.
Ann N Y Acad Sci. 2009 Sep;1173:515-20.
PMID: 19758194
DOI: 10.1111/j.1749-6632.2009.04656.x
Discussion: We found no association of the Apal and Taql VDR gene SNPs with MS or with vitamin D metabolism in our population. Further research should assess the complex interaction between vitamin D, the VDR, and susceptibility to MS.
Vitamin D treatment in multiple sclerosis.
Myhr KM.
J Neurol Sci. 2009 Jun 22. [Epub ahead of print]
PMID: 19549608
doi:10.1016/j.jns.2009.05.002
Epidemiological evidence combined with clinical and laboratory analyses, and experimental animal models, suggest a possible influence of vitamin D on MS susceptibility as well as clinical disease activity.
Supplement with vitamin D may reduce the risk of developing MS. An intervention may also reduce the risk of conversion from a first clinical event suggestive of MS to clinical definite MS, as well as reduce the relapse rate among patients with relapsing remitting MS. More studies are, however, needed to determine optimal dose and serum level for vitamin D, as well as target populations and optimal timing for intervention.
Explaining multiple sclerosis prevalence by ultraviolet exposure: a geospatial analysis.
Beretich B, Beretich T.
Mult Scler. 2009 Aug;15(8):891-8.
PMID: 19667017
DOI: 10.1177/1352458509105579
Conclusion
This analysis suggests a strong association between UV radiation and MS distribution, and an increase in risk for MS in those areas with a low UVI.
Higher levels of 25-hydroxyvitamin D are associated with a lower incidence of multiple sclerosis only in women.
Kragt J, van Amerongen B, Killestein J, Dijkstra C, Uitdehaag B, Polman Ch, Lips P.
Mult Scler. 2009 Jan;15(1):9-15. Epub 2008 Aug 13.
PMID: 18701572
DOI: 10.1177/1352458508095920
CONCLUSIONS: Our data suggest that higher circulating levels of 25(OH)D are associated with a lower incidence of MS and MS-related disability in women. This may imply clues to the pathogenesis of the sex difference in risk and to the nature of the environmental factors involved in MS.
Vitamin D may suppress infections which lead to development of Multiple Sclerosis
Steven R Brenner, None (16 August 2007)
J Neurol Neurosurg Psychiatry 2008
I read the article with reference to the inverse relationship between multiple sclerosis clinical activity and deficiency of vitamin D by Soilu-Hannienen (1) with interest, and was considering what mechanism could be in play to cause such a relationship.
25-hydroxylated metabolites of vitamin D act as intracellular regulators of the synthesis and action of defensin (2) molecules against bacterial antigens, defensin being an endogenously synthesized antimicrobial substance (2).
Human cathelicidin antimicrobial peptide gene is a target of vitamin D receptor and is strongly up-regulated by 1,25-dihydroxyvitamin D3, indicating vitamin D receptor and the 1,25-dihydroxyvitaminD3 regulate primate innate immunity (3)
A longitudinal study of serum 25-hydroxyvitamin D and intact parathyroid hormone levels indicate the importance of vitamin D and calcium homeostasis regulation in multiple sclerosis.
Soilu-Hänninen M, Laaksonen M, Laitinen I, Erälinna JP, Lilius EM, Mononen I.
J Neurol Neurosurg Psychiatry. 2008 Feb;79(2):152-7. Epub 2007 Jun 19.
PMID: 17578859
doi:10.1136/jnnp.2006.105320
Conclusions: The endocrine circuitry regulating serum calcium may be altered in MS. There is an inverse relationship between serum vitamin D level and MS clinical activity. The role of vitamin D in MS must be explored further.
25-Hydroxyvitamin D levels in serum at the onset of multiple sclerosis.
Soilu-Hänninen M, Airas L, Mononen I, Heikkilä A, Viljanen M, Hänninen A.
Mult Scler. 2005 Jun;11(3):266-71.
PMID: 15957505
DOI: 10.1191/1352458505ms1157oa
This is a very long newsletter. I will answer questions about oil versus water-soluble Vitamin D, depression, mental clarity, malignant melanoma, Crohn's disease, an imagist poet, multiple sclerosis, sun-exposure, high-intensity red light and collagen repair in the skin, non-alcoholic fatty liver disease, influenza, the 1918 influenza pandemic, statins, the new Food and Nutrition Board, thyroid disease, chronic fatigue syndrome, athletes, the upcoming 14th Vitamin D Workshop, prostate cancer, the wrong blood test, pregnancy, autism, Alzheimer's disease, soap and sebum, asthma, sleep, the co-factors vitamin D needs to work (all contained in spinach), and-my favorite-UVC light and Vitamin D
NaturalNews) Researchers from Oxford University and the University of British Columbia have discovered that Vitamin D deficiency affects a section of the human genome already linked with multiple sclerosis (MS) risk, adding further weight to theories that this vitamin deficiency might play a role in development of the disease.
"Here we show that the main environmental risk candidate -- vitamin D -- and the main gene region are directly linked and interact," said co-author George Ebers.
High prevalence of vitamin D inadequacy and implications for health.\nHolick MF.\nMayo Clin Proc. 2006 Mar;81(3):353-73. Review.\nPMID: 16529140 \ndoi: 10.4065/81.3.353\n
Grant WB, Holick MF.
Benefits and requirements of vitamin D for optimal health: a review.
Altern Med Rev. 2005 Jun;10(2):94-111. Review.
PMID: 15989379
itamin D and autoimmunity: new aetiological and therapeutic considerations.
Arnson Y, Amital H, Shoenfeld Y.
Ann Rheum Dis. 2007 Sep;66(9):1137-42. Epub 2007 Jun 8. Review.
PMID: 17557889
doi:10.1136/ard.2007.069831
Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis.
Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A.
JAMA. 2006 Dec 20;296(23):2832-8.
PMID: 17179460