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Matti Narkia

Retinol-induced Intestinal Tumorigenesis in Min/+ Mice and Importance of Vitamin D Stat... - 1 views

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    "Retinol-induced Intestinal Tumorigenesis in Min/+ Mice and Importance of Vitamin D Status.
    Hetland RB, Alexander J, Berg JP, Svendsen C, Paulsen JE.
    Anticancer Res. 2009 Nov;29(11):4353-60.
    PMID: 20032378

    The effects of life-long dietary exposure, starting in utero, to high retinol, low vitamin D, or high retinol in combination with low vitamin D on intestinal tumorigenesis in Min/+ mice were investigated. In males, high retinol alone significantly increased the number (2.6-fold) and size (1.3-fold) of small intestinal tumours; in females no significant increase in tumour number or size was seen. In both genders, low vitamin D intake alone did not affect intestinal tumorigenesis. In males, intake of the combined high retinol/low vitamin D diet did not further increase the effects caused by high retinol alone. In females, however, the high retinol/low vitamin D-induced increase in tumour number (3.1-fold) and tumour size (1.5-fold) exceeded that of high retinol alone. In conclusion, a high dietary intake of retinol stimulated intestinal tumorigenesis in Min/+ mice. Furthermore, the results indicate a combined effect of high retinol and low vitamin D on tumorigenesis in females"
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