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Matti Narkia

Low vitamin D tied to heart, stroke deaths: MedlinePlus - 0 views

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    "NEW YORK (Reuters Health) - Low vitamin D levels in the body may be deadly, according to a new study hinting that adults with lower, versus higher, blood levels of vitamin D may be more likely to die from heart disease or stroke.

    Vitamin D is an essential vitamin mostly obtained from direct sunlight exposure, but also found in foods and multivitamins.

    Dr. Annamari Kilkkinen, at the National Institute for Health and Welfare in Helsinki, Finland, and colleagues compared blood levels of vitamin D and deaths from heart disease or stroke over time in 2,817 men and 3,402 women in Finland."
Matti Narkia

Aggressive Vitamin D Treatment for Osteoporosis - 0 views

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    "May 19, 2008 (Orlando, Florida) - A new study shows that a proactive vitamin D treatment plan should be considered when caring for all osteoporosis patients, and that such treatment might help decrease the likelihood of developing vitamin D deficiency.

    Vitamin D deficiency is widespread among patients being treated for osteoporosis, and such deficiency should be treated aggressively, according to the findings presented here at the American Association of Clinical Endocrinologists 17th Annual Meeting and Clinical Congress."
Matti Narkia

Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elder... - 0 views

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    Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elderly men and women.
    Dawson-Hughes B, Harris SS, Dallal GE.
    Am J Clin Nutr. 1997 Jan;65(1):67-71.
    PMID: 8988915

    Plasma calcidiol and serum PTH concentrations were inversely related, with PTH rising slowly as calcidiol concentrations declined below 110 nmol/L (95 CI: 60, 168 nmol/L). More than 90% of the men and women had calcidiol concentrations below this value in the wintertime. The high prevalence of lower wintertime calcidiol values may increase risk of bone loss in elderly men and women.
Matti Narkia

Women With Breast Cancer Have Low Vitamin D Levels - 0 views

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    "ScienceDaily (Oct. 8, 2009) - Women with breast cancer should be given high doses of vitamin D because a majority of them are likely to have low levels of vitamin D, which could contribute to decreased bone mass and greater risk of fractures, according to scientists at the University of Rochester Medical Center."

    Scientists funded by the NCI analyzed vitamin D levels in each woman, and the average level was 27 nanograms per milliliter; more than two-thirds of the women had vitamin deficiency. Weekly supplementation with high doses of vitamin D -- 50,000 international units or more -- improved the levels, according to Peppone's study.

    The U.S. Institute of Medicine suggests that blood levels nearing 32 nanograms per milliliter are adequate.
Matti Narkia

Arch Intern Med -- Vitamin D as an Analgesic for Patients With Type 2 Diabetes and Neur... - 0 views

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    Vitamin D as an analgesic for patients with type 2 diabetes and neuropathic pain.
    Lee P, Chen R.
    Arch Intern Med. 2008 Apr 14;168(7):771-2.
    PMID: 18413561
Matti Narkia

1,25(OH)2 Vitamin D Inhibits Foam Cell Formation and Suppresses Macrophage Cholesterol ... - 0 views

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    1,25(OH)2 vitamin d inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus.
    Oh J, Weng S, Felton SK, Bhandare S, Riek A, Butler B, Proctor BM, Petty M, Chen Z, Schechtman KB, Bernal-Mizrachi L, Bernal-Mizrachi C.
    Circulation. 2009 Aug 25;120(8):687-98. Epub 2009 Aug 10.
    PMID: 19667238
    doi: 10.1161/CIRCULATIONAHA.109.856070

    Conclusion- These results identify reduced vitamin D receptor signaling as a potential mechanism underlying increased foam cell formation and accelerated cardiovascular disease in diabetic subjects.
Matti Narkia

Why Low Vitamin D Raises Heart Disease Risks In Diabetics - 0 views

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    ScienceDaily (Aug. 25, 2009) - Low levels of vitamin D are known to nearly double the risk of cardiovascular disease in patients with diabetes, and researchers at Washington University School of Medicine in St. Louis now think they know why.

    They have found that diabetics deficient in vitamin D can't process cholesterol normally, so it builds up in their blood vessels, increasing the risk of heart attack and stroke. The new research has identified a mechanism linking low vitamin D levels to heart disease risk and may lead to ways to fix the problem, simply by increasing levels of vitamin D.
Matti Narkia

Seniors With Insufficient Levels Of Vitamin D At Increased Risk Of Dying From Heart Dis... - 0 views

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    A new study by researchers at the University of Colorado Denver and Massachusetts General Hospital (MGH) shows vitamin D plays a vital role in reducing the risk of death associated with older age. The research, just published in the Journal of the American Geriatrics Society, evaluated the association between vitamin D levels in the blood and the death rates of those 65 and older. The study found that older adults with insufficient levels of vitamin D die from heart disease at greater rates that those with adequate levels of the vitamin.
Matti Narkia

Low vitamin D raises blood pressure in women: study | Health | Reuters - 0 views

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    WASHINGTON (Reuters) - Younger white women with vitamin D deficiencies are about three times more likely to have high blood pressure in middle age than those with normal vitamin levels, according to a study released on Thursday.

    The study, presented at a meeting of the American Heart Association in Chicago, adds younger women to a growing list of people including men who may develop high blood pressure at least in part because of low vitamin D.
Matti Narkia

Stress fractures in the Israeli defense forces from 1995 to 1996. - Clin Orthop Relat R... - 0 views

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    Stress fractures in the Israeli defense forces from 1995 to 1996.
    Givon U, Friedman E, Reiner A, Vered I, Finestone A, Shemer J.
    Clin Orthop Relat Res. 2000 Apr;(373):227-32.
    PMID: 10810481

    Serum levels of bone specific alkaline phosphatase and osteocalcin were elevated in patients with high grade stress fractures compared with control subjects with no symptoms: 37.6 versus 26.2 units/L, and 10.8 versus 8.8 ng/mL, respectively. Levels of 25-hydroxy vitamin D were lower in patients with high grade stress fractures (25.3 ng/mL) than in control subjects (29.8 ng/mL). This study revealed that several parameters can distinguish soldiers with high grade stress fractures, but their predictive value and precise pathogenetic role remain unclear.
Matti Narkia

Association between serum 25(OH)D concentrations and bone stress fractures in Finnish y... - 0 views

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    Association between serum 25(OH)D concentrations and bone stress fractures in Finnish young men.
    Ruohola JP, Laaksi I, Ylikomi T, Haataja R, Mattila VM, Sahi T, Tuohimaa P, Pihlajamäki H.
    J Bone Miner Res. 2006 Sep;21(9):1483-8.
    doi: 10.1359/jbmr.060607

    Conclusions: A lower level of serum 25(OH)D concentration may be a generally predisposing element for bone stress fractures. Considering the obvious need of additional vitamin D in prevention of stress fractures, the effects of vitamin D fortification of foods and supplementation will be subjects of interest for future research
    PMID: 16939407
Matti Narkia

Association of vitamin D deficiency with heart failure and sudden cardiac death in a la... - 0 views

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    Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography.
    Pilz S, März W, Wellnitz B, Seelhorst U, Fahrleitner-Pammer A, Dimai HP, Boehm BO, Dobnig H.
    J Clin Endocrinol Metab. 2008 Oct;93(10):3927-35. Epub 2008 Aug 5.
    PMID: 18682515
    doi:10.1210/jc.2008-0784

    Conclusions: Low levels of 25(OH)D and 1,25(OH)2D are associated with prevalent myocardial dysfunction, deaths due to heart failure and SCD. Interventional trials are warranted to elucidate whether vitamin D supplementation is useful for treatment and/or prevention of myocardial diseases.
Matti Narkia

Vitamin D Status and the Risk of Cardiovascular Disease Death -- Kilkkinen et al., 10.1... - 0 views

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    Vitamin D Status and the Risk of Cardiovascular Disease Death.
    Kilkkinen A, Knekt P, Aro A, Rissanen H, Marniemi J, Heliövaara M, Impivaara O, Reunanen A.
    Am J Epidemiol. 2009 Sep 17. [Epub ahead of print]
    PMID: 19762371
    doi:10.1093/aje/kwp227

    A low vitamin D level may be associated with higher risk of a fatal CVD event, particularly cerebrovascular death. These findings need to be replicated in other populations. To demonstrate a causal link between vitamin D and CVD, randomized controlled trials are required.
Matti Narkia

Association between serum 25-hydroxyvitamin D and depressive symptoms in Japanese: anal... - 0 views

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    Association between serum 25-hydroxyvitamin D and depressive symptoms in Japanese: analysis by survey season
    A Nanri, T Mizoue, Y Matsushita, K Poudel-Tandukar, M Sato, M Ohta, N Mishima
    European Journal of Clinical Nutrition (19 August 2009) doi:10.1038/ejcn.2009.96 Short Communication
Matti Narkia

Depression linked to low levels of vitamin D in the blood - foodconsumer.org - 0 views

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    Depression may be triggered by low vitamin D levels in the blood, according to a new study published in the Aug 19, 2009 issue of European Journal of Clinical Nutrition.

    The study led by Nanri A and colleagues from International Medical center of Japan in Shinjuku-ku, Tokyo, Japan found that in November, people with their serum levels of vitamin D falling in the highest quartile were 49 percent less likely to feel depressed.

    The study involved 527 municipal employees aged 21 to 67 who worked in two municipal offices in Japan. It was meant to examine the association between vitamin D deficiency and depression
Matti Narkia

New Research by D*action Member Dr. Cedric Garland Suggests Role Low Levels of Vitamin ... - 0 views

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    San Diego, CA (PRWEB) May 25, 2009 -- Coming on the heels of the publishing in the Annals of Epidemiology of a new study led by Dr. Cedric Garland, on the preventive measures of vitamin D, GrassrootsHealth D*action Project is calling on physicians, health clinics and groups throughout the country to recognize the need for determining vitamin D levels and to ensure the public have their blood levels of vitamin D tested.

    According to research from the newly published study by Cedric F. Garland, Dr. P.H., FACE, Department of Family and Preventive Medicine and Moores Cancer Center of the University of California, San Diego (UCSD), "It is projected that raising the minimum year-around serum 25(OH)D level to 40-60 ng/ml (100-150 nmol/L) would prevent approximately 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer each year, and three quarters of deaths from these diseases, in the US and Canada."
Matti Narkia

Vitamin D Status and Glucose Homeostasis in the 1958 British Birth Cohort - Diabetes Care - 0 views

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    Vitamin D status and glucose homeostasis in the 1958 British birth cohort: the role of obesity.
    Hyppönen E, Power C.
    Diabetes Care. 2006 Oct;29(10):2244-6.
    PMID: 17003300
    doi: 10.2337/dc06-0946

    CONCLUSIONS-Body size was a strong determinant for 25(OH)D, with concentrations being suboptimal in most obese participants. Randomized controlled trials [using dosages sufficient to improve 25(OH)D also for the obese] are required to determine whether clinically relevant improvements in glucose metabolism can be obtained by vitamin D supplementation.
Matti Narkia

Low Vitamin D Levels Predict Stroke in Patients Referred to Coronary Angiography -- Pil... - 0 views

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    Low vitamin d levels predict stroke in patients referred to coronary angiography.
    Pilz S, Dobnig H, Fischer JE, Wellnitz B, Seelhorst U, Boehm BO, März W.
    Stroke. 2008 Sep;39(9):2611-3. Epub 2008 Jul 17.
    PMID: 18635847
    doi: 10.1161/STROKEAHA.107.513655

    Conclusions- Low levels of 25(OH)D and 1,25(OH)2D are independently predictive for fatal strokes, suggesting that vitamin D supplementation is a promising approach in the prevention of strokes.
Matti Narkia

Independent Association of Low Serum 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Le... - 0 views

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    Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality.
    Dobnig H, Pilz S, Scharnagl H, Renner W, Seelhorst U, Wellnitz B, Kinkeldei J, Boehm BO, Weihrauch G, Maerz W.
    Arch Intern Med. 2008 Jun 23;168(12):1340-9.
    PMID: 18574092

    Conclusions Low 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels are independently associated with all-cause and cardiovascular mortality. A causal relationship has yet to be proved by intervention trials using vitamin D.
Matti Narkia

25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men: A Prospective Study, June... - 0 views

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    25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study.
    Giovannucci E, Liu Y, Hollis BW, Rimm EB.
    Arch Intern Med. 2008 Jun 9;168(11):1174-80.
    PMID: 18541825

    Conclusion Low levels of 25(OH)D are associated with higher risk of myocardial infarction in a graded manner, even after controlling for factors known to be associated with coronary artery disease.
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