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Matti Narkia

Meta-analysis of longitudinal studies: Serum vitamin D and prostate cancer risk - Scien... - 1 views

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    Meta-analysis of longitudinal studies: Serum vitamin D and prostate cancer risk.
    Yin L, Raum E, Haug U, Arndt V, Brenner H.
    Cancer Epidemiol. 2009 Dec;33(6):435-45. Epub 2009 Nov 25.
    PMID: 19939760
    doi:10.1016/j.canep.2009.10.014

    CONCLUSIONS: According to available evidence from longitudinal studies, serum 25(OH)D is not associated with PC incidence.
Matti Narkia

Ecological studies of ultraviolet B, vitamin D and cancer since 2000. - Ann Epidemiol. ... - 1 views

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    Ecological studies of ultraviolet B, vitamin D and cancer since 2000.
    Grant WB, Mohr SB.
    Ann Epidemiol. 2009 Jul;19(7):446-54. Epub 2009 Mar 9. Review.
    PMID: 19269856

    CONCLUSION: These findings provide strong evidence that vitamin D status plays an important role in controlling the outcome of cancer. Support for the UVB-vitamin D-cancer theory is now scientifically strong enough to warrant use of vitamin D in cancer prevention, and as a component of treatment. More research studies would help to explore whether there are benefits beyond the substantial effects that have been observed.
Matti Narkia

Vitamin D in pregnancy and lactation: maternal, fetal, and neonatal outcomes from human... - 0 views

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    Vitamin D in pregnancy and lactation: maternal, fetal, and neonatal outcomes from human and animal studies.
    Kovacs CS.
    Am J Clin Nutr. 2008 Aug;88(2):520S-528S. Review.
    PMID: 18689394

    Dosing recommendations for women during pregnancy and lactation might be best directed toward ensuring that the neonate is vitamin D-sufficient and that this sufficiency is maintained during infancy and beyond. A dose of vitamin D that provides 25(OH)D sufficiency in the mother during pregnancy should provide normal cord blood concentrations of 25(OH)D. Research has shown that during lactation, supplements administered directly to the infant can easily achieve vitamin D sufficiency; the mother needs much higher doses (100 µg or 4000 IU per day) to achieve adult-normal 25(OH)D concentrations in her exclusively breastfed infant. In addition, the relation (if any) of vitamin D insufficiency in the fetus or neonate to long-term nonskeletal outcomes such as type 1 diabetes and other chronic diseases needs to be investigated.
Matti Narkia

Diagnosis and treatment of vitamin D deficiency; Expert Opinion on Pharmacotherapy - 9(... - 0 views

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    Diagnosis and treatment of vitamin D deficiency.
    Cannell JJ, Hollis BW, Zasloff M, Heaney RP.
    Expert Opin Pharmacother. 2008 Jan;9(1):107-18.
    PMID: 18076342

    The recent discovery - in a randomised, controlled trial - that daily ingestion of 1100 IU of colecalciferol (vitamin D) over a 4-year period dramatically reduced the incidence of non-skin cancers makes it difficult to overstate the potential medical, social and economic implications of treating vitamin D deficiency. Not only are such deficiencies common, probably the rule, vitamin D deficiency stands implicated in a host of diseases other than cancer. The metabolic product of vitamin D is a potent, pleiotropic, repair and maintenance, secosteroid hormone that targets > 200 human genes in a wide variety of tissues, meaning it has as many mechanisms of action as genes it targets. A common misconception is that government agencies designed present intake recommendations to prevent or treat vitamin D deficiency. They did not. Instead, they are guidelines to prevent particular metabolic bone diseases. Official recommendations were never designed and are not effective in preventing or treating vitamin D deficiency and in no way limit the freedom of the physician - or responsibility - to do so. At this time, assessing serum 25-hydroxy-vitamin D is the only way to make the diagnosis and to assure that treatment is adequate and safe. The authors believe that treatment should be sufficient to maintain levels found in humans living naturally in a sun-rich environment, that is, > 40 ng/ml, year around. Three treatment modalities exist: sunlight, artificial ultraviolet B radiation or supplementation. All treatment modalities have their potential risks and benefits. Benefits of all treatment modalities outweigh potential risks and greatly outweigh the risk of no treatment. As a prolonged 'vitamin D winter', centred on the winter solstice, occurs at many temperate latitudes, ≤ 5000 IU (125 μg) of vitamin D/d
Matti Narkia

Vitamin D, Nutritional Deficiency, and the Medical Paradigm -- Heaney 88 (11): 5107 -- ... - 0 views

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    Vitamin D, nutritional deficiency, and the medical paradigm.
    Heaney RP.
    J Clin Endocrinol Metab. 2003 Nov;88(11):5107-8. Review. No abstract available.
    PMID: 14602734
Matti Narkia

Benefits of Vitamin D Supplementation - Journal of American Physicians and Surgeons Vol... - 1 views

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    Benefits of Vitamin D Supplementation
    Joel M. Kauffman, Ph.D.
    Journal of American Physicians and Surgeons
    Volume 14 Number 2 - Summer 2009

    Clinical trials show that vitamin D supplementation at higher
    levels than previously recommended is beneficial for many
    conditions. It decreases the frequency of falls and fractures, helps
    prevent cardiovascular disease, and reduces symptoms of colds or
    influenza. Benefits are also seen in diabetes mellitus, multiple
    sclerosis, Crohn disease, pain, depression, and possibly autism.
    Sunlight does not cause an overdose of vitamin D production,
    and toxicity from supplementation is rare. Dose recommendations
    are increasing, but appear to be lagging the favorable trial results. A
    number of common drugs deplete vitamin D levels, and others may
    limit its biosynthesis from sunlight.
    People with adequate levels from sun exposure will not benefit
    from supplementation. While dietary intake is helpful,
    supplementation is better able to raise serum 25-hydroxyvitamin D ,
    the major circulating metabolite, to the level now thought adequate,
    30-50 ng/mL.
    Where there is inadequate daily sun exposure, oral doses of
    1,000-2,000 IU/d are now considered routine, with much higher
    doses (up to 50,000 IU) for rapid repletion now considered safe.
Matti Narkia

Vitamin D for cancer prevention: global perspective. Garland CF et al. -Ann Epidemiol. ... - 2 views

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    Vitamin D for cancer prevention: global perspective.
    Garland CF, Gorham ED, Mohr SB, Garland FC.
    Ann Epidemiol. 2009 Jul;19(7):468-83. Review.
    PMID: 19523595
Matti Narkia

Benefit-risk assessment of vitamin D supplementation. - Osteoporos Int. 2009 Dec 3. - S... - 0 views

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    Benefit-risk assessment of vitamin D supplementation.
    Bischoff-Ferrari HA, Shao A, Dawson-Hughes B, Hathcock J, Giovannucci E, Willett WC.
    Osteoporos Int. 2009 Dec 3. [Epub ahead of print]
    PMID: 19957164

    Conclusion Our analysis suggests that mean serum 25(OH)D levels of about 75 to 110 nmol/l provide optimal benefits for all investigated endpoints without increasing health risks. These levels can be best obtained with oral doses in the range of 1,800 to 4,000 IU vitamin D per day; further work is needed, including subject and environment factors, to better define the doses that will achieve optimal blood levels in the large majority of the population.
Matti Narkia

How to Optimize Vitamin D Supplementation to Prevent Cancer, Based on Cellular Adaptati... - 0 views

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    How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology.
    Vieth R.
    Anticancer Res. 2009 Sep;29(9):3675-84. Review.
    PMID: 19667164
Matti Narkia

Athletic Performance and Vitamin D : Medicine & Science in Sports & Exercise - 0 views

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    Athletic performance and vitamin D.
    Cannell JJ, Hollis BW, Sorenson MB, Taft TN, Anderson JJ.
    Med Sci Sports Exerc. 2009 May;41(5):1102-10. Review.
    PMID: 19346976
    doi: 10.1249/MSS.0b013e3181930c2b

    Conclusions: Vitamin D may improve athletic performance in vitamin D-deficient athletes. Peak athletic performance may occur when 25(OH)D levels approach those obtained by natural, full-body, summer sun exposure, which is at least 50 ng·mL-1. Such 25(OH)D levels may also protect the athlete from several acute and chronic medical conditions.
Matti Narkia

A vitamin D nutritional cornucopia: new insights concerning the serum 25-hydroxyvitamin... - 0 views

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    A vitamin D nutritional cornucopia: new insights concerning the serum 25-hydroxyvitamin D status of the US population.
    Norman AW.
    Am J Clin Nutr. 2008 Dec;88(6):1455-6.
    PMID: 19064502
    doi:10.3945/ajcn.2008.27049

    In summary, the report of Looker et al should be required reading for all nutritionists, clinicians, and vitamin D aficionados who are decision makers with regard to 25(OH)D assays, vitamin D nutritional policy, and the care of patients with vitamin D-related diseases.
Matti Narkia

Vitamin D and mood disorders among women: an integrative review. - [J Midwifery Womens ... - 0 views

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    Vitamin D and mood disorders among women: an integrative review.
    Murphy PK, Wagner CL.
    J Midwifery Womens Health. 2008 Sep-Oct;53(5):440-6. Review.
    PMID: 18761297

    Four of six studies reviewed imparted significant results, with all four showing an association between low 25(OH)D levels and higher incidences of four mood disorders: premenstrual syndrome, seasonal affective disorder, non-specified mood disorder, and major depressive disorder. This review indicates a possible biochemical mechanism occurring between vitamin D and mood disorders affecting women, warranting further studies of these variables using rigorous methodologies.
Matti Narkia

Effects of vitamin D supplementation on strength, physical performance, and falls in ol... - 0 views

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    Effects of vitamin D supplementation on strength, physical performance, and falls in older persons: a systematic review.
    Latham NK, Anderson CS, Reid IR.
    J Am Geriatr Soc. 2003 Sep;51(9):1219-26. Review.
    PMID: 12919233
    DOI: 10.1046/j.1532-5415.2003.51405.

    Conclusion: Although there is insufficient evidence that vitamin D supplementation alone improves physical performance in older people, some data suggest a benefit from vitamin D combined with calcium supplementation, but this requires confirmation in large, well-designed trials.
Matti Narkia

Vitamin D and cognitive performance in adults: a systematic review. - Eur J Neurol. 200... - 0 views

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    Vitamin D and cognitive performance in adults: a systematic review.
    Annweiler C, Allali G, Allain P, Bridenbaugh S, Schott AM, Kressig RW, Beauchet O.
    Eur J Neurol. 2009 Oct;16(10):1083-9. Epub 2009 Jul 29.
    PMID: 19659751
    DOI: 10.1111/j.1468-1331.2009.02755.x

    This systematic review shows that the association between serum 25OHD concentrations and cognitive performance is not yet clearly established. The inconclusive results of the reviewed studies could be due to methodology, types of the cognitive tasks used and/or the cellular mechanisms of vitamin D.
Matti Narkia

Vitamin D-Related Changes in Physical Performance: A Systematic Review. - [J Nutr Healt... - 0 views

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    Vitamin D-Related Changes in Physical Performance: A Systematic Review.
    Annweiler C, Schott AM, Berrut G, Fantino B, Beauchet O.
    J Nutr Health Aging. 2009;13(10):893-898.
    PMID: 19924350

    Conclusions: The findings show that the association between vitamin D and physical performance remains controversial. Observational studies and clinical trials yielded divergent results, which highlights the complex and to date still poorly understood association between serum vitamin D concentration or vitamin D supplementation and physical performance.
Matti Narkia

Vitamin D and cardiovascular disease risk : Current Opinion in Clinical Nutrition & Met... - 0 views

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    Vitamin D and cardiovascular disease risk.
    Michos ED, Melamed ML.
    Curr Opin Clin Nutr Metab Care. 2008 Jan;11(1):7-12. Review.
    PMID: 18090651
    doi: 10.1097/MCO.0b013e3282f2f4dd

    Summary: Vitamin D deficiency is easy to screen for and easy to treat with supplementation. Further larger observational studies and randomized clinical trials are, however, needed to determine whether vitamin D supplementation could have any potential benefit in reducing future cardiovascular disease events and mortality risk.
Matti Narkia

Meta-analysis of vitamin D, calcium and the prevention of breast cancer. - [Breast Canc... - 0 views

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    Meta-analysis of vitamin D, calcium and the prevention of breast cancer.
    Chen P, Hu P, Xie D, Qin Y, Wang F, Wang H.
    Breast Cancer Res Treat. 2009 Oct 23. [Epub ahead of print]
    PMID: 19851861

    These results provide strong evidence that vitamin D and calcium have a chemopreventive effect against breast cancer.
Matti Narkia

African Americans, 25-hydroxyvitamin D, and osteoporosis: a paradox -- Aloia 88 (2): 54... - 0 views

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    African Americans, 25-hydroxyvitamin D, and osteoporosis: a paradox.
    Aloia JF.
    Am J Clin Nutr. 2008 Aug;88(2):545S-550S. Review.
    PMID: 18689399
Matti Narkia

Vitamin D for Cancer Prevention: Global Perspective - 0 views

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    Vitamin D for cancer prevention: global perspective.
    Garland CF, Gorham ED, Mohr SB, Garland FC.
    Ann Epidemiol. 2009 Jul;19(7):468-83. Review.
    PMID: 19523595

    RESULTS/CONCLUSIONS: It is projected that raising the minimum year-around serum 25(OH)D level to 40 to 60 ng/mL (100-150 nmol/L) would prevent approximately 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer each year, and three fourths of deaths from these diseases in the United States and Canada, based on observational studies combined with a randomized trial. Such intakes also are expected to reduce case-fatality rates of patients who have breast, colorectal, or prostate cancer by half. There are no unreasonable risks from intake of 2000 IU per day of vitamin D(3), or from a population serum 25(OH)D level of 40 to 60 ng/mL. The time has arrived for nationally coordinated action to substantially increase intake of vitamin D and calcium.
Matti Narkia

Vitamin D and prevention of breast cancer: pooled analysis. - ScienceDirect - The Journ... - 0 views

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    Vitamin D and prevention of breast cancer: pooled analysis.
    Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, Newmark H, Holick MF, Garland FC.
    J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):708-11.
    PMID: 17368188

    CONCLUSIONS: Intake of 2000 IU/day of Vitamin D(3), and, when possible, very moderate exposure to sunlight, could raise serum 25(OH)D to 52 ng/ml, a level associated with reduction by 50% in incidence of breast cancer, according to observational studies.
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