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Matti Narkia

Decreased bioavailability of vitamin D in obesity -- Wortsman et al. 72 (3): 690 -- Ame... - 0 views

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    Decreased bioavailability of vitamin D in obesity.
    Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF.
    Am J Clin Nutr. 2000 Sep;72(3):690-3. Erratum in: Am J Clin Nutr. 2003 May;77(5):1342.
    PMID: 10966885

    Conclusions: Obesity-associated vitamin D insufficiency is likely due to the decreased bioavailability of vitamin D3 from cutaneous and dietary sources because of its deposition in body fat compartments.
Matti Narkia

Vitamin D and prevention of breast cancer: pooled analysis. - ScienceDirect - The Journ... - 0 views

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    Vitamin D and prevention of breast cancer: pooled analysis.
    Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, Newmark H, Holick MF, Garland FC.
    J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):708-11.
    PMID: 17368188

    CONCLUSIONS: Intake of 2000 IU/day of Vitamin D(3), and, when possible, very moderate exposure to sunlight, could raise serum 25(OH)D to 52 ng/ml, a level associated with reduction by 50% in incidence of breast cancer, according to observational studies.
Matti Narkia

The Role of Vitamin D in Cancer Prevention -- Garland et al. 96 (2): 252 -- American Jo... - 0 views

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    The role of vitamin D in cancer prevention.
    Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF.
    Am J Public Health. 2006 Feb;96(2):252-61. Epub 2005 Dec 27. Review.
    PMID: 16380576
    DOI: 10.2105/AJPH.2004.045260

    Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased risk of deficiency. A PubMed database search yielded 63 observational studies of vitamin D status in relation to cancer risk, including 30 of colon, 13 of breast, 26 of prostate, and 7 of ovarian cancer, and several that assessed the association of vitamin D receptor genotype with cancer risk.

    The majority of studies found a protective relationship between sufficient vitamin D status and lower risk of cancer. The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects.
Matti Narkia

The Role of Vitamin D in Cancer Prevention -- Garland et al. 96 (2): 252 -- American Jo... - 0 views

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    The role of vitamin D in cancer prevention.
    Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF.
    Am J Public Health. 2006 Feb;96(2):252-61. Epub 2005 Dec 27. Review.
    PMID: 16380576
    DOI: 10.2105/AJPH.2004.045260

    Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased risk of deficiency. A PubMed database search yielded 63 observational studies of vitamin D status in relation to cancer risk, including 30 of colon, 13 of breast, 26 of prostate, and 7 of ovarian cancer, and several that assessed the association of vitamin D receptor genotype with cancer risk.

    The majority of studies found a protective relationship between sufficient vitamin D status and lower risk of cancer. The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects
Matti Narkia

Estimates of optimal vitamin D status. - Osteoporos Int. 2005 Jul;16(7):713-6. - Spring... - 0 views

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    Estimates of optimal vitamin D status.
    Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R.
    Osteoporos Int. 2005 Jul;16(7):713-6. Epub 2005 Mar 18.
    PMID: 15776217
Matti Narkia

Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy m... - 0 views

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    Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men.
    Barger-Lux MJ, Heaney RP, Dowell S, Chen TC, Holick MF.
    Osteoporos Int. 1998;8(3):222-30.
    PMID: 9797906
Matti Narkia

Epidemic influenza and vitamin D. - Epidemiol Infect. 2006 Dec;134(6):1129-40. (full t... - 0 views

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    Epidemic influenza and vitamin D.
    Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, Garland CF, Giovannucci E.
    Epidemiol Infect. 2006 Dec;134(6):1129-40. Epub 2006 Sep 7. Review.
    PMID: 16959053
Matti Narkia

Prevalence of Vitamin D Inadequacy among Postmenopausal North American Women Receiving ... - 0 views

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    Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy.
    Holick MF, Siris ES, Binkley N, Beard MK, Khan A, Katzer JT, Petruschke RA, Chen E, de Papp AE.
    J Clin Endocrinol Metab. 2005 Jun;90(6):3215-24. Epub 2005 Mar 29.
    PMID: 15797954
    doi:10.1210/jc.2004-2364

    Conclusions: More than half of North American women receiving therapy to treat or prevent osteoporosis have vitamin D inadequacy, underscoring the need for improved physician and public education regarding optimization of vitamin D status in this population.
Matti Narkia

Chronic Sunscreen Use Decreases Circulating Concentrations of 25-Hydroxyvitamin D: A Pr... - 0 views

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    Matsuoka, L. Y., Wortsman, J., Hanifan, N. & Holick, M. F. (1988)
    Chronic sunscreen use decreases circulating concentrations of 25-hydroxyvitamin D: a preliminary study.
    Arch. Dermatol. 124:1802-1804
Matti Narkia

Regulation of cutaneous previtamin D3 photosynthesis in man: skin pigment is not an ess... - 0 views

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    Holick, M. F., MacLaughlin, J. A. & Doppelt, S. H. (1981)
    Factors that influence the cutaneous photosynthesis of previtamin D3. Science 211:590-593

    When human skin was exposed to simulated solar ultraviolet radiation, epidermal 7-dehydrocholesterol was converted to previtamin D3. During prolonged exposure to simulated solar ultraviolet radiation, the synthesis of previtamin D3 reached a plateau at about 10 to 15 percent of the original 7-dehydrocholesterol content, and previtamin D3 was photoisomerized to two biologically inert isomers, lumisterol3 and tachysterol3. Increases either in skin melanin concentration or in latitude necessitated increases in the exposure time to simulated solar ultraviolet radiation required to maximize the formation, but not the total content, of previtamin D3. In order of importance, the significant determinants limiting the cutaneous production of previtamin D3 are (i) photochemical regulation, (ii) pigmentation, and (iii) latitude.
Matti Narkia

An evaluation of the relative contributions of exposure to sunlight and of diet to the ... - 0 views

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    An evaluation of the relative contributions of exposure to sunlight and of diet to the circulating concentrations of 25-hydroxyvitamin D in an elderly nursing home population in Boston.
    Webb AR, Pilbeam C, Hanafin N, Holick MF.
    Am J Clin Nutr. 1990 Jun;51(6):1075-81.
    PMID: 2349922
Matti Narkia

Aging decreases the capacity of human skin to produce vitamin D3. - Journal of Clinical... - 0 views

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    Aging decreases the capacity of human skin to produce vitamin D3.
    MacLaughlin J, Holick MF.
    J Clin Invest. 1985 Oct;76(4):1536-8.
    PMID: 2997282
    doi:10.1172/JCI112134

    An evaluation of surgically obtained skin (age range, 8-92 yr) revealed that there is an age-dependent decrease in the epidermal concentrations of provitamin D3 (7-dehydrocholesterol). To ascertain that aging indeed decreased the capacity of human skin to produce vitamin D3, some of the skin samples were exposed to ultraviolet radiation and the content of previtamin D3 was determined in the epidermis and dermis. The epidermis in the young and older subjects was the major site for the formation of previtamin D3, accounting for greater than 80% of the total previtamin D3 that was produced in the skin. A comparison of the amount of previtamin D3 produced in the skin from the 8- and 18-yr-old subjects with the amount produced in the skin from the 77- and 82-yr-old subjects revealed that aging can decrease by greater than twofold the capacity of the skin to produce previtamin D3. Recognition of this difference may be extremely important for the elderly, who infrequently expose a small area of skin to sunlight and who depend on this exposure for their vitamin D nutritional needs.
Matti Narkia

Vitamin D deficiency: a worldwide problem with health consequences -- Holick and Chen 8... - 0 views

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    Vitamin D deficiency: a worldwide problem with health consequences.
    Holick MF, Chen TC.
    Am J Clin Nutr. 2008 Apr;87(4):1080S-6S. Review.
    PMID: 18400738

    A reevaluation needs to take place of what the adequate intakes of vitamin D should be for children and adults. The literature over the past decade suggests that the Institute of Medicine recommendations in 1997 (83) are inadequate, and some experts including us suggest that both children and adults should take ≥800-1000 IU vitamin D/d from dietary and supplemental sources (4, 9, 77) when sunlight is unable to provide it. This recommendation, however, has not yet been embraced either by official government or pediatric organizations in the United States, Canada, or Europe for either children or adults.
Matti Narkia

Evolution and function of vitamin D. [Recent Results Cancer Res. 2003] - PubMed Result - 0 views

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    Evolution and function of vitamin D.
    Holick MF.
    Recent Results Cancer Res. 2003;164:3-28. Review.
    PMID: 12899511
Matti Narkia

Vitamin D Status: Measurement, Interpretation, and Clinical Application - 0 views

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    Vitamin D status: measurement, interpretation, and clinical application.
    Holick MF.
    Ann Epidemiol. 2009 Feb;19(2):73-8. Epub 2008 Mar 10. Review.
    PMID: 18329892

    Conclusion

    The only way to determine whether a person is vitamin D deficient or sufficient is to measure their circulating level of 25(OH)D. There are a variety of assays used to measure 25(OH)D. The radioimmunoassays and competitive protein binding assays for 25(OH)D are useful in detecting vitamin D deficiency and sufficiency. However, these assays are fraught with technical difficulties, especially if they are not run routinely (Fig. 4) (33). Several reference laboratories have now switched to LC-MS ,which measures both 25(OH)D2 and 25(OH)D3 quantitatively. The total 25(OH)D, i.e., 25(OH)D2 plus 25(OH)D3, is what physicians need to be aware of for their patients. A level >30 ng/mL is
Matti Narkia

Factors that Influence the Cutaneous Synthesis and Dietary Sources of Vitamin D - 0 views

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    Factors that influence the cutaneous synthesis and dietary sources of vitamin D.
    Chen TC, Chimeh F, Lu Z, Mathieu J, Person KS, Zhang A, Kohn N, Martinello S, Berkowitz R, Holick MF.
    Arch Biochem Biophys. 2007 Apr 15;460(2):213-7. Epub 2007 Jan 8.
    PMID: 17254541
    doi: 10.1016/j.abb.2006.12.017

    Vitamin D is rare in food. Among the vitamin D-rich food, oily fish are considered to be one of the best sources. Therefore, we analyzed the vitamin D content in several commonly consumed oily and non-oily fish. The data showed that farmed salmon had a mean content of vitamin D that was ~25% of the mean content found in wild caught salmon from Alaska, and that vitamin D2 was found in farmed salmon, but not in wild caught salmon. The results provide useful global guidelines for obtaining sufficient vitamin D3 by cutaneous synthesis and from dietary intake to prevent vitamin D deficiency and its health consequences.ensuing illness, especially, bone fractures in the elderly.
Matti Narkia

Vitamin D and skin physiology: a D-lightful story - JBMR Online - Journal of Bone and M... - 0 views

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    Vitamin D and skin physiology: a D-lightful story.
    Holick MF, Chen TC, Lu Z, Sauter E.
    J Bone Miner Res. 2007 Dec;22 Suppl 2:V28-33.
    PMID: 18290718
    doi: 10.1359/jbmr.07s211

    Very few foods naturally contain vitamin D, and those that do have a very variable vitamin D content. Recently it was observed that wild caught salmon had between 75% and 90% more vitamin D(3) compared with farmed salmon. The associations regarding increased risk of common deadly cancers, autoimmune diseases, infectious diseases, and cardiovascular disease with living at higher latitudes and being prone to vitamin D deficiency should alert all health care professionals about the importance of vitamin D for overall health and well being.

    Humans have depended on sunlight for their vitamin D requirement. The impact of season, time of day, and latitude on vitamin D synthesis is well documented.(2,3) We now report that altitude also has a dramatic influence on vitamin D3 production and that living at altitudes above 3500 m permits previtamin D3 production at a time when very little is produced at latitudes below 3400 m. It was surprising that, at 27° N in Agra (169 M), little previtamin D3 production was observed. However, there was significant air pollution that caused a haze over the city. It is likely the ozone and other UVB-absorbing pollutants in the air prevented the solar UVB photons from reaching the earth's surface to produce previtamin D3.
Matti Narkia

Vitamin D2 Is as Effective as Vitamin D3 in Maintaining Circulating Concentrations of 2... - 0 views

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    Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D.
    Holick MF, Biancuzzo RM, Chen TC, Klein EK, Young A, Bibuld D, Reitz R, Salameh W, Ameri A, Tannenbaum AD.
    J Clin Endocrinol Metab. 2008 Mar;93(3):677-81. Epub 2007 Dec 18.
    PMID: 18089691

    Conclusion: A 1000 IU dose of vitamin D2 daily was as effective as 1000 IU vitamin D3 in maintaining serum 25-hydroxyvitamin D levels and did not negatively influence serum 25-hydroxyvitamin D3 levels. Therefore, vitamin D2 is equally as effective as vitamin D3 in maintaining 25-hydroxyvitamin D status.
Matti Narkia

Sunlight and Vitamin D: both good for cardiovascular health. - 0 views

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    Sunlight and vitamin D: both good for cardiovascular health.
    Holick MF.
    J Gen Intern Med. 2002 Sep;17(9):733-5.
    PMID: 12220371
    doi: 10.1046/j.1525-1497.2002.20731.x.
Matti Narkia

Aging decreases the capacity of human skin to produce vitamin D3. - J Clin Invest. 198... - 0 views

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    Aging decreases the capacity of human skin to produce vitamin D3.
    MacLaughlin J, Holick MF.
    J Clin Invest. 1985 Oct;76(4):1536-8.
    PMID: 2997282
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