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Matti Narkia

Prospective study of serum 25(OH)-vitamin D concentration and risk of oesophageal and g... - 0 views

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    Prospective study of serum 25(OH)-vitamin D concentration and risk of oesophageal and gastric cancers.
    Chen W, Dawsey SM, Qiao YL, Mark SD, Dong ZW, Taylor PR, Zhao P, Abnet CC.
    Br J Cancer. 2007 Jul 2;97(1):123-8. Epub 2007 Jun 5.
    PMID: 17551495

    We prospectively examined the relation between pretrial serum vitamin D status and risk of oesophageal and gastric cancers among subjects who developed cancer over 5.25 years of follow-up, including 545 oesophageal squamous cell carcinomas (ESCC), 353 gastric cardia adenocarcinomas, 81 gastric noncardia adenocarcinomas, and an age- and sex-stratified random sample of 1105 subjects.

    We found no associations for gastric cardia or noncardia adenocarcinoma. Among subjects with low vitamin D status, higher serum 25(OH)D concentrations were associated with significantly increased risk of ESCC in men, but not in women. Further refinements of the analysis did not suggest any factors, which could explain this unexpected result.

    In conclusion, we found a direct association between higher serum 25(OH)D concentration and increased risk of ESCC in men but not women in a large population-based prospective cohort study from rural China. We found no association with risk of gastric cardia or noncardia adenocarcinoma in either sex. Greater than 50% of our cohort had an inadequate serum 25(OH)D concentration, yet higher concentrations were associated with increased risk of ESCC compared to lower concentrations.
Matti Narkia

Ecological studies of ultraviolet B, vitamin D and cancer since 2000. - Ann Epidemiol. ... - 1 views

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    Ecological studies of ultraviolet B, vitamin D and cancer since 2000.
    Grant WB, Mohr SB.
    Ann Epidemiol. 2009 Jul;19(7):446-54. Epub 2009 Mar 9. Review.
    PMID: 19269856

    CONCLUSION: These findings provide strong evidence that vitamin D status plays an important role in controlling the outcome of cancer. Support for the UVB-vitamin D-cancer theory is now scientifically strong enough to warrant use of vitamin D in cancer prevention, and as a component of treatment. More research studies would help to explore whether there are benefits beyond the substantial effects that have been observed.
Matti Narkia

Vitamin D for cancer prevention: global perspective. Garland CF et al. -Ann Epidemiol. ... - 2 views

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    Vitamin D for cancer prevention: global perspective.
    Garland CF, Gorham ED, Mohr SB, Garland FC.
    Ann Epidemiol. 2009 Jul;19(7):468-83. Review.
    PMID: 19523595
Matti Narkia

Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged... - 0 views

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    Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men.
    Lee DM, Tajar A, Ulubaev A, Pendleton N, O'Neill TW, O'Connor DB, Bartfai G, Boonen S, Bouillon R, Casanueva FF, Finn JD, Forti G, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean ME, Punab M, Silman AJ, Vanderschueren D, Wu FC; EMAS study group.
    J Neurol Neurosurg Psychiatry. 2009 Jul;80(7):722-9. Epub 2009 May 21.
    PMID: 19460797
    doi:10.1136/jnnp.2008.165720

    Conclusion: In this study, lower 25(OH)D levels were associated with poorer performance on the DSST. Further research is warranted to determine whether vitamin D sufficiency might have a role in preserving cognitive function in older adults.
Matti Narkia

Vitamin D for Cancer Prevention: Global Perspective - 0 views

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    Vitamin D for cancer prevention: global perspective.
    Garland CF, Gorham ED, Mohr SB, Garland FC.
    Ann Epidemiol. 2009 Jul;19(7):468-83. Review.
    PMID: 19523595

    RESULTS/CONCLUSIONS: It is projected that raising the minimum year-around serum 25(OH)D level to 40 to 60 ng/mL (100-150 nmol/L) would prevent approximately 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer each year, and three fourths of deaths from these diseases in the United States and Canada, based on observational studies combined with a randomized trial. Such intakes also are expected to reduce case-fatality rates of patients who have breast, colorectal, or prostate cancer by half. There are no unreasonable risks from intake of 2000 IU per day of vitamin D(3), or from a population serum 25(OH)D level of 40 to 60 ng/mL. The time has arrived for nationally coordinated action to substantially increase intake of vitamin D and calcium.
Matti Narkia

The Association of Solar Ultraviolet B (UVB) with Reducing Risk of Cancer: Multifactori... - 0 views

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    The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates.
    Grant WB, Garland CF.
    Anticancer Res. 2006 Jul-Aug;26(4A):2687-99.
    PMID: 16886679

    CONCLUSION: These results provide additional support for the hypothesis that solar UVB, through photosynthesis of vitamin D, is inversely-associated with cancer mortality rates, and that various other cancer risk-modifying factors do not detract from this link. It is thought that sun avoidance practices after 1980, along with improved cancer treatment, led to reduced associations in the latter period. The results regarding solar UVB should be studied further with additional observational and intervention studies of vitamin D indices and cancer incidence, mortality and survival rates.
Matti Narkia

Differences in vitamin D status between countries in young adults and the elderly - 0 views

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    Differences in vitamin D status between countries in young adults and the elderly.
    McKenna MJ.
    Am J Med. 1992 Jul;93(1):69-77.
    PMID: 1385673

    PURPOSE: To compare vitamin D status between countries in young adults and in the elderly. MATERIALS AND METHODS: Reports on vitamin D status (as assessed by serum 25-hydroxyvitamin D) from 1971 to 1990 were reviewed. Studies were grouped according to geographic regions: North America (including Canada and the United States); Scandinavia (including Denmark, Finland, Norway, and Sweden); and Central and Western Europe (including Belgium, France, Germany, Ireland, The Netherlands, Switzerland, and the United Kingdom). RESULTS: Vitamin D status varies with the season in young adults and in the elderly, and is lower during the winter in Europe than in both North America and Scandinavia. Oral vitamin D intake is lower in Europe than in both North America and Scandinavia. Hypovitaminosis D and related abnormalities in bone chemistry are most common in elderly residents in Europe but are reported in all elderly populations. CONCLUSIONS: The vitamin D status in young adults and the elderly varies widely with the country of residence. Adequate exposure to summer sunlight is the essential means to ample supply, but oral intake augmented by both fortification and supplementation is necessary to maintain baseline stores. All countries should adopt a fortification policy. It seems likely that the elderly would benefit additionally from a daily supplement of 10 micrograms of vitamin D.
Matti Narkia

Vitamin D and the epidemiology of prostate cancer. - Semin Dial. 2005 Jul-Aug;18(4):276... - 0 views

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    Vitamin D and the epidemiology of prostate cancer.
    Schwartz GG.
    Semin Dial. 2005 Jul-Aug;18(4):276-89. Review.
    PMID: 16076349
    DOI: 10.1111/j.1525-139X.2005.18403.x
Matti Narkia

Annals of Epidemiology - Volume 19, Issue 7, Pages 439-522 (July 2009) - 0 views

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    Articles about vitamin D and cancer
Matti Narkia

A seasonal variation of calcitropic hormones, bone turnover and bone mineral density in... - 0 views

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    A seasonal variation of calcitropic hormones, bone turnover and bone mineral density in early and mid-puberty girls - a cross-sectional study.
    Viljakainen HT, Palssa A, Kärkkäinen M, Jakobsen J, Cashman KD, Mølgaard C, Lamberg-Allardt C.
    Br J Nutr. 2006 Jul;96(1):124-30.
    PMID: 16870000

    Seasonal variation in S-25-OHD and bone remodelling markers accompanied by negative correlation between S-25-OHD and S-iPTH was seen in this cross-sectional study of adolescent girls. In addition, the seasonal rhythm contributed 7.0-7.6 % difference in the BMD of lumbar vertebrae and left femur in early puberty girls. This variation should be avoided since it could hamper peak bone mass attainment.
Matti Narkia

Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins -- Is... - 0 views

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    Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins.
    Islam T, Gauderman WJ, Cozen W, Mack TM.
    Neurology. 2007 Jul 24;69(4):381-8.
    PMID: 17646631

    Conclusion: Early sun avoidance seems to precede the diagnosis of multiple sclerosis (MS). This protective effect is independent of genetic susceptibility to MS.
Matti Narkia

Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic ... - 0 views

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    Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects.
    Tarcin O, Yavuz DG, Ozben B, Telli A, Velioglu Ogunc A, Yuksel M, Toprak A, Yazici D, Sancak S, Deyneli O, Akalin S.
    J Clin Endocrinol Metab. 2009 Jul 7. [Epub ahead of print]
    PMID: 19584181
    doi:10.1210/jc.2008-1212

    Conclusions: This study shows that 25(OH)D deficiency is associated with endothelial dysfunction and increased lipid peroxidation. Replacement of vitamin D has favorable effects on endothelial function. Vitamin D deficiency can be seen as an independent risk factor of atherosclerosis. Hypovitaminosis D associated endothelial dysfunction may predispose to higher cardiovascular disease in the winter.
Matti Narkia

A nested case control study of plasma 25-hydroxyvitamin D concentrations and risk of co... - 0 views

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    A nested case control study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancer.
    Wu K, Feskanich D, Fuchs CS, Willett WC, Hollis BW, Giovannucci EL.
    J Natl Cancer Inst. 2007 Jul 18;99(14):1120-9. Epub 2007 Jul 10.
    PMID: 17623801
Matti Narkia

Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 2... - 0 views

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    Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women.
    Peterson CA, Heffernan ME.
    J Inflamm (Lond). 2008 Jul 24;5:10.
    PMID: 18652680
    doi:10.1186/1476-9255-5-10

    Conclusion
    Serum 25(OH)D status is inversely related to TNF-α concentrations in healthy women, which may in part explain this vitamin's role in the prevention and treatment of inflammatory diseases. Results gleaned from this investigation also support the need to re-examine the biological basis for determining optimal vitamin D status.
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