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Matti Narkia

Arch Intern Med -- Vitamin D as an Analgesic for Patients With Type 2 Diabetes and Neur... - 0 views

    Vitamin D as an analgesic for patients with type 2 diabetes and neuropathic pain.
    Lee P, Chen R.
    Arch Intern Med. 2008 Apr 14;168(7):771-2.
    PMID: 18413561
Matti Narkia

1,25(OH)2 Vitamin D Inhibits Foam Cell Formation and Suppresses Macrophage Cholesterol ... - 0 views

    1,25(OH)2 vitamin d inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus.
    Oh J, Weng S, Felton SK, Bhandare S, Riek A, Butler B, Proctor BM, Petty M, Chen Z, Schechtman KB, Bernal-Mizrachi L, Bernal-Mizrachi C.
    Circulation. 2009 Aug 25;120(8):687-98. Epub 2009 Aug 10.
    PMID: 19667238
    doi: 10.1161/CIRCULATIONAHA.109.856070

    Conclusion- These results identify reduced vitamin D receptor signaling as a potential mechanism underlying increased foam cell formation and accelerated cardiovascular disease in diabetic subjects.
Matti Narkia

Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness amo... - 0 views

    Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients.
    Targher G, Bertolini L, Padovani R, Zenari L, Scala L, Cigolini M, Arcaro G.
    Clin Endocrinol (Oxf). 2006 Nov;65(5):593-7.
    PMID: 17054459
    DOI: 10.1111/j.1365-2265.2006.02633.x

    CONCLUSIONS: Hypovitaminosis D is highly prevalent in type 2 diabetic adults and is strongly and independently associated with increased carotid IMT. Further investigation into whether vitamin D may play a role in the prevention of atherosclerosis appears to be warranted.

    In conclusion, our results show that type 2 diabetic adults have significant reductions in serum 25(OH)D concentrations (vs matched controls) that predict preclinical atherosclerosis, independent of classical risk factors, renal function tests, inflammatory markers, use of medications and presence of the metabolic syndrome. These findings suggest the need for ongoing evaluation of the possible protective role of vitamin D3 supplementation in the development of atherosclerosis.
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