Skip to main content

Home/ Vitamin D/ Group items tagged clinical_trial PTH

Rss Feed Group items tagged

Matti Narkia

Evidence for alteration of the vitamin D-endocrine system in obese subjects. - Journal ... - 0 views

  •  
    Evidence for alteration of the vitamin D-endocrine system in obese subjects.
    Bell NH, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S.
    J Clin Invest. 1985 Jul;76(1):370-3.
    PMID: 2991340

    The results provide evidence that alteration of the vitamin D-endocrine system in obese subjects is characterized by secondary hyperparathyroidism which is associated with enhanced renal tubular reabsorption of calcium and increased circulating 1,25(OH)2D. The reduction of serum 25-OHD in them is attributed to feedback inhibition of hepatic synthesis of the precursor by the increased serum 1,25(OH)2D.
Matti Narkia

A phase 2 trial exploring the effects of high-dose (10,000 IU/day) vitamin D(3) in brea... - 0 views

  •  
    A phase 2 trial exploring the effects of high-dose (10,000 IU/day) vitamin D(3) in breast cancer patients with bone metastases.
    Amir E, Simmons CE, Freedman OC, Dranitsaris G, Cole DE, Vieth R, Ooi WS, Clemons M.
    Cancer. 2009 Nov 13. [Epub ahead of print]
    PMID: 19918922
    DOI: 10.1002/cncr.24749

    METHODS:
    Patients with bone metastases treated with bisphosphonates were enrolled into this single-arm phase 2 study. Patients received 10,000 IU of vitamin D3 and 1000 mg of calcium supplementation each day for 4 months. The effect of this treatment on palliation, bone resorption markers, calcium metabolism, and toxicity were evaluated at baseline and monthly thereafter.


    CONCLUSIONS:
    Daily doses of 10,000 IU vitamin D3 for 4 months appear safe in patients without comorbid conditions causing hypersensitivity to vitamin D. Treatment reduced inappropriately elevated parathyroid hormone levels, presumably caused by long-term bisphosphonate use. There did not appear to be a significant palliative benefit nor any significant change in bone resorption. Cancer 2010. © 2009 American Cancer Society.
Matti Narkia

Serum 25-hydroxyvitamin D levels in vitamin D-insufficient hip fracture patients after ... - 0 views

  •  
    Serum 25-hydroxyvitamin D levels in vitamin D-insufficient hip fracture patients after supplementation with ergocalciferol and cholecalciferol.
    Glendenning P, Chew GT, Seymour HM, Gillett MJ, Goldswain PR, Inderjeeth CA, Vasikaran SD, Taranto M, Musk AA, Fraser WD.
    Bone. 2009 Nov;45(5):870-5. Epub 2009 Jul 23.
    PMID: 19631774
    doi:10.1016/j.bone.2009.07.015

    Cholecalciferol supplementation resulted in a 31% greater increase in total HPLC-measured 25OHD (p=0.010) and 52% greater rise in RIA-measured 25OHD (p<0.001) of supplementation dose with than ergocalciferol equivalent an>0.05). In vitamin D-insufficient hip fracture patients, supplementation with cholecalciferol 1000 IU/day for three months was more effective in increasing serum 25OHD than an equivalent dose of ergocalciferol. However, the lack of difference in PTH lowering between calciferol treatments raises questions about the biological importance of this observation.
Matti Narkia

Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (... - 0 views

  •  
    Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients.
    Vieth R, Kimball S, Hu A, Walfish PG.
    Nutr J. 2004 Jul 19;3:8.
    PMID: 15260882
    doi:10.1186/1475-2891-3-8

    CONCLUSION: The highest AI for vitamin D brought summertime 25(OH)D to >40 nmol/L, lowered PTH, and its use was associated with improved wellbeing. The 100 mcg/day dose produced greater responses. Since it was ethically necessary to provide a meaningful dose of vitamin D to these insufficient patients, we cannot rule out a placebo wellbeing response, particularly for those on the lower dose. This work confirms the safety and efficacy of both 15 and 100 mcg/day vitamin D3 in patients who needed additional vitamin D.
Matti Narkia

An evaluation of the relative contributions of exposure to sunlight and of diet to the ... - 0 views

  •  
    An evaluation of the relative contributions of exposure to sunlight and of diet to the circulating concentrations of 25-hydroxyvitamin D in an elderly nursing home population in Boston.
    Webb AR, Pilbeam C, Hanafin N, Holick MF.
    Am J Clin Nutr. 1990 Jun;51(6):1075-81.
    PMID: 2349922
Matti Narkia

A positive dose-response effect of vitamin D supplementation on site-specific bone mine... - 0 views

  •  
    A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: a double-blinded randomized placebo-controlled 1-year intervention.
    Viljakainen HT, Natri AM, Kärkkäinen M, Huttunen MM, Palssa A, Jakobsen J, Cashman KD, Mølgaard C, Lamberg-Allardt C.
    J Bone Miner Res. 2006 Jun;21(6):836-44.
    PMID: 16753014
    doi: 10.1359/jbmr.060302

    We conclude that the current vitamin D recommendation for adolescent girls, at least in the northern latitudes, is too low to ensure sufficient vitamin D status during winter. Intake of vitamin D at rates of 10-15 μg/day aids to maintain stable S-25(OH)D concentrations during winter. Vitamin D induced BMC augmentation by decreasing bone resorption, but not affecting bone formation, which was reflected by the biochemical markers of bone turnover. Optimizing bone mineral gain in adolescence is crucial to the prevention of osteoporosis later in life. Increasing vitamin D intake to 10-15 μg/day aids in attaining this goal.
Matti Narkia

Wintertime vitamin D supplementation inhibits seasonal variation of calcitropic hormone... - 0 views

  •  
    Wintertime vitamin D supplementation inhibits seasonal variation of calcitropic hormones and maintains bone turnover in healthy men.
    Viljakainen HT, Väisänen M, Kemi V, Rikkonen T, Kröger H, Laitinen EK, Rita H, Lamberg-Allardt C.
    J Bone Miner Res. 2009 Feb;24(2):346-52.
    PMID: 18847321
Matti Narkia

Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascu... - 0 views

  •  
    Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers.
    Zittermann A, Frisch S, Berthold HK, Götting C, Kuhn J, Kleesiek K, Stehle P, Koertke H, Koerfer R.
    Am J Clin Nutr. 2009 May;89(5):1321-7. Epub 2009 Mar 25.
    PMID: 19321573
Matti Narkia

Clinical Responses to a Mega-dose of Vitamin D3 in Infants and Toddlers With Vitamin D ... - 0 views

  •  
    Clinical Responses to a Mega-dose of Vitamin D3 in Infants and Toddlers With Vitamin D Deficiency Rickets.
    Soliman AT, El-Dabbagh M, Adel A, Ali MA, Aziz Bedair EM, Elalaily RK.
    J Trop Pediatr. 2009 Jun 8. [Epub ahead of print]
    PMID: 19506025
    doi:10.1093/tropej/fmp040

    Conclusion: An IM injection of a mega dose of cholecalciferol is a safe and effective therapy for treatment of VDD rickets in infants and toddlers with normalization of all the biochemical parameters and healing of radiological manifestations. Measurement of serum 25(OH)D level is highly recommended in all short children with a clear need for a general vitamin D supplementation for all infants and young children in Qatar.
Matti Narkia

Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalcif... - 0 views

  •  
    Conclusions: Healthy men seem to use 3000-5000 IU cholecalciferol/d, apparently meeting > 80% of their winter cholecalciferol need with cutaneously synthesized accumulations from solar sources during the preceding summer months. Current recommended vitamin D inputs are inadequate to maintain serum 25-hydroxycholecalciferol concentration in the absence of substantial cutaneous production of vitamin D.

    Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol.
    Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ.
    Am J Clin Nutr. 2003 Jan;77(1):204-10. Erratum in: Am J Clin Nutr. 2003 Nov;78(5):1047.
    PMID: 12499343
Matti Narkia

Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. - ... - 0 views

  •  
    Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D.
    Heaney RP, Dowell MS, Hale CA, Bendich A.
    J Am Coll Nutr. 2003 Apr;22(2):142-6.
    PMID: 12672710
Matti Narkia

The same annual dose of 292 000 IU of vitamin D(3) (cholecalciferol) on either daily or... - 0 views

  •  
    The same annual dose of 292 000 IU of vitamin D(3) (cholecalciferol) on either daily or four monthly basis for elderly women: 1-year comparative study of the effects on serum 25(OH)D(3) concentrations and renal function.
    Pekkarinen T, Välimäki VV, Aarum S, Turpeinen U, Hämäläinen E, Löyttyniemi E, Välimäki MJ.
    Clin Endocrinol (Oxf). 2009 May 25. [Epub ahead of print]
    PMID: 19486025
    DOI: 10.1111/j.1365-2265.2009.03637.x
1 - 12 of 12
Showing 20 items per page