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Matti Narkia

Measuring 25-hydroxyvitamin D in a clinical environment: challenges and needs -- Hollis... - 0 views

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    Measuring 25-hydroxyvitamin D in a clinical environment: challenges and needs.
    Hollis BW.
    Am J Clin Nutr. 2008 Aug;88(2):507S-510S. Review.
    PMID: 18689391

    In this article, I provide an overview of the techniques available for measuring 25(OH)D, compare these techniques with one another, and assess their clinical utility. I also briefly discuss the stability of 25(OH)D in biological media and present an overview of the Vitamin D External Quality Assessment Scheme.
Matti Narkia

The clinical importance of vitamin D (cholecalciferol): a paradigm shift with implicati... - 0 views

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    The clinical importance of vitamin D (cholecalciferol): a paradigm shift with implications for all healthcare providers.
    Vasquez A, Manso G, Cannell J.
    Altern Ther Health Med. 2004 Sep-Oct;10(5):28-36; quiz 37, 94. Review.
    PMID: 15478784
Matti Narkia

Clinical Guide to Sunscreens and Photoprotection - Google Books - 0 views

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    Designed with practicing dermatologists, dermatology trainees, physicians, and scientists interested in photoprotection in mind, this concise and highly illustrated guide provides the latest knowledge of photoprotection in dermatology and cosmetic science. Clinical Guide to Sunscreens and Photoprotectionalso addresses recent important international and domestic regulatory activity and requirements on the use of novel sun protective chemicals and proper labeling of products to ensure increased consumer awareness.This concisely written, problem-oriented text explores

    See chapter by Bischoff-Ferrari et al. from page 119 dealing with what dose is needed for 25(OH)D level of 80 nmol/l in 97% of population
Matti Narkia

Vitamin D Status: Measurement, Interpretation, and Clinical Application - 0 views

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    Vitamin D status: measurement, interpretation, and clinical application.
    Holick MF.
    Ann Epidemiol. 2009 Feb;19(2):73-8. Epub 2008 Mar 10. Review.
    PMID: 18329892

    Conclusion

    The only way to determine whether a person is vitamin D deficient or sufficient is to measure their circulating level of 25(OH)D. There are a variety of assays used to measure 25(OH)D. The radioimmunoassays and competitive protein binding assays for 25(OH)D are useful in detecting vitamin D deficiency and sufficiency. However, these assays are fraught with technical difficulties, especially if they are not run routinely (Fig. 4) (33). Several reference laboratories have now switched to LC-MS ,which measures both 25(OH)D2 and 25(OH)D3 quantitatively. The total 25(OH)D, i.e., 25(OH)D2 plus 25(OH)D3, is what physicians need to be aware of for their patients. A level >30 ng/mL is
Matti Narkia

Use of vitamin D in clinical practice. - Altern Med Rev. 2008 Mar - 0 views

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    Use of vitamin D in clinical practice.
    Cannell JJ, Hollis BW.
    Altern Med Rev. 2008 Mar;13(1):6-20.
    PMID: 18377099

    The recent discovery--from a meta-analysis of 18 randomized controlled trials--that supplemental cholecalciferol (vitamin D) significantly reduces all-cause mortality emphasizes the medical, ethical, and legal implications of promptly diagnosing and adequately treating vitamin D deficiency. Not only are such deficiencies common, and probably the rule, vitamin D deficiency is implicated in most of the diseases of civilization. Vitamin D's final metabolic product is a potent, pleiotropic, repair and maintenance, seco-steroid hormone that targets more than 200 human genes in a wide variety of tissues, meaning it has as many mechanisms of action as genes it targets. One of the most important genes vitamin D up-regulates is for cathelicidin, a naturally occurring broad-spectrum antibiotic. Natural vitamin D levels, those found in humans living in a sun-rich environment, are between 40-70 ng per ml, levels obtained by few modern humans. Assessing serum 25-hydroxy-vitamin D (25(OH)D) is the only way to make the diagnosis and to assure treatment is adequate and safe. Three treatment modalities exist for vitamin D deficiency: sunlight, artificial ultraviolet B (UVB) radiation, and vitamin D3 supplementation. Treatment of vitamin D deficiency in otherwise healthy patients with 2,000-7,000 IU vitamin D per day should be sufficient to maintain year-round 25(OH)D levels between 40-70 ng per mL. In those with serious illnesses associated with vitamin D deficiency, such as cancer, heart disease, multiple sclerosis, diabetes, autism, and a host of other illnesses, doses should be sufficient to maintain year-round 25(OH)D levels between 55 -70 ng per mL. Vitamin D-deficient patients with serious illness should not only be supplemented more aggressively than the well, they should have more frequent monitoring of serum 25(OH)D and serum calcium. Vitamin D should always be
Matti Narkia

Vitamin D, a Gene-Regulating Super-Nutrient - 0 views

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    Your cells use vitamin D to directly regulate your genes, making it one of the most powerful compounds in human health.
Matti Narkia

SI Units for Clinical Data - conversion factors - 0 views

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    The following table provides factors for converting conventional units to SI units for selected clinical data. Source: JAMA Author Instructions.
    Contains also conversion factors for circulating form of vitamin D, 25(OH)D (calcidiol).
Matti Narkia

A higher dose of vitamin d reduces the risk of falls in nursing home residents: a rando... - 0 views

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    Broe KE, Chen TC, Weinberg J, Bischoff-Ferrari HA, Holick MF, Kiel DP. \nA higher dose of vitamin d reduces the risk of falls in nursing home residents: a randomized, multiple-dose study.\nJ Am Geriatr Soc. 2007 Feb;55(2):234-9.\nPMID: 17302660 [PubMed -
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