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Matti Narkia

Sweat gland epithelial and myoepithelial cells are vitamin D targets. - Wiley InterScie... - 0 views

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2007 February study research in_vivo animal_study autoradiography skin Sweat gland epithelial glands myoepithelial cells vitamin_D targets VDR 1.25(OH)2D calcitriol nutrition

shared by Matti Narkia on 25 Nov 09 - No Cached
  • Matti Narkia on 25 Nov 09
     
    Sweat gland epithelial and myoepithelial cells are vitamin D targets. Koike N, Stumpf WE. Exp Dermatol. 2007 Feb;16(2):94-7. PMID: 17222221 DOI: 10.1111/j.1600-0625.2006.00513.x Nuclear receptor binding of 1,25(OH)2-vitamin D3 (vitamin D) in skin keratinocytes of epidermis, hair sheaths and sebaceous glands was discovered through receptor microscopic autoradiography. Extended experiments with 3H-1,25(OH)2-vitamin D3 and its analog 3H-oxacalcitriol (OCT) now demonstrate nuclear receptor binding in sweat gland epithelium of secretory coils and ducts as well as in myoepithelial cells, as studied in paws of nude mice after i.v. injection. The results suggest genomic regulation of cell proliferation and differentiation, as well as of secretory and excretory functions, indicating potential therapies for impaired secretion as in hypohidrosis of aged and diseased skin.
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