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Matti Narkia

The Bioavailability of Vitamin D from Fortified Cheeses and Supplements Is Equivalent i... - 0 views

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    The bioavailability of vitamin D from fortified cheeses and supplements is equivalent in adults.
    Wagner D, Sidhom G, Whiting SJ, Rousseau D, Vieth R.
    J Nutr. 2008 Jul;138(7):1365-71.
    PMID: 18567762

    Compared with baseline, serum parathyroid hormone decreased with both fortification (P = 0.003) and supplementation (P = 0.012). These data demonstrate that vitamin D is equally bioavailable from fortified hard cheeses and supplements, making cheese suitable for vitamin D fortification.
Matti Narkia

Bread Fortified with Cholecalciferol Increases the Serum 25-Hydroxyvitamin D Concentrat... - 0 views

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    Bread fortified with cholecalciferol increases the serum 25-hydroxyvitamin D concentration in women as effectively as a cholecalciferol supplement.
    Natri AM, Salo P, Vikstedt T, Palssa A, Huttunen M, Kärkkäinen MU, Salovaara H, Piironen V, Jakobsen J, Lamberg-Allardt CJ.
    J Nutr. 2006 Jan;136(1):123-7.
    PMID: 16365070

    Both fortified breads increased serum 25-hydroxyvitamin D concentration as effectively as the cholecalciferol supplement. Supplementation or fortification did not affect serum intact parathyroid hormone concentration or urinary calcium excretion. In conclusion, fortified bread is a safe and feasible way to improve vitamin D nutrition.
Matti Narkia

A randomised comparison of increase in serum 25-hydroxyvitamin D concentratio... - 0 views

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    A randomised comparison of increase in serum 25-hydroxyvitamin D concentration after 4 weeks of daily oral intake of 10 microg cholecalciferol from multivitamin tablets or fish oil capsules in healthy young adults.
    Holvik K, Madar AA, Meyer HE, Lofthus CM, Stene LC.
    Br J Nutr. 2007 Sep;98(3):620-5. Epub 2007 Apr 24.
    PMID: 17456248

    We conclude that fish oil capsules and multivitamin tablets containing 10 microg cholecalciferol administered over a 4-week period produced a similar mean increase in s-25(OH)D concentration.
Matti Narkia

The Effect of Vitamin D2 and Vitamin D3 on Intestinal Calcium Absorption in Nigerian Ch... - 0 views

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    The effect of vitamin D2 and vitamin D3 on intestinal calcium absorption in Nigerian children with rickets.
    Thacher TD, Obadofin MO, O'Brien KO, Abrams SA.
    J Clin Endocrinol Metab. 2009 Sep;94(9):3314-21. Epub 2009 Jun 30.
    PMID: 19567516

    Conclusions: Despite similar increases in 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D with vitamin D2 or vitamin D3, fractional calcium absorption did not increase, indicating that rickets in Nigerian children is not primarily due to vitamin D-deficient calcium malabsorption
Matti Narkia

Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sun... - 0 views

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    Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sunny country?
    Pignotti GA, Genaro PS, Pinheiro MM, Szejnfeld VL, Martini LA.
    Eur J Nutr. 2009 Nov 28. [Epub ahead of print]
    PMID: 19946776

    CONCLUSION: The dose given (400 IU/day) was not enough to achieve 25(OH)D concentration, considered optimal for bone health.
Matti Narkia

Plasma Vitamin D and 25OHD Responses of Young and Old Men to Supplementation with Vitam... - 0 views

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    Plasma vitamin D and 25OHD responses of young and old men to supplementation with vitamin D3.
    Harris SS, Dawson-Hughes B.
    J Am Coll Nutr. 2002 Aug;21(4):357-62.
    PMID: 12166534

    Conclusions: There appears to be no age-related impairment among men in the absorption or metabolism of 20 µg/day of vitamin D3 taken orally for at least eight weeks.
Matti Narkia

Serum 25-hydroxyvitamin D levels in vitamin D-insufficient hip fracture patients after ... - 0 views

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    Serum 25-hydroxyvitamin D levels in vitamin D-insufficient hip fracture patients after supplementation with ergocalciferol and cholecalciferol.
    Glendenning P, Chew GT, Seymour HM, Gillett MJ, Goldswain PR, Inderjeeth CA, Vasikaran SD, Taranto M, Musk AA, Fraser WD.
    Bone. 2009 Nov;45(5):870-5. Epub 2009 Jul 23.
    PMID: 19631774
    doi:10.1016/j.bone.2009.07.015

    Cholecalciferol supplementation resulted in a 31% greater increase in total HPLC-measured 25OHD (p=0.010) and 52% greater rise in RIA-measured 25OHD (p<0.001) of supplementation dose with than ergocalciferol equivalent an>0.05). In vitamin D-insufficient hip fracture patients, supplementation with cholecalciferol 1000 IU/day for three months was more effective in increasing serum 25OHD than an equivalent dose of ergocalciferol. However, the lack of difference in PTH lowering between calciferol treatments raises questions about the biological importance of this observation.
Matti Narkia

Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (... - 0 views

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    Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients.
    Vieth R, Kimball S, Hu A, Walfish PG.
    Nutr J. 2004 Jul 19;3:8.
    PMID: 15260882
    doi:10.1186/1475-2891-3-8

    CONCLUSION: The highest AI for vitamin D brought summertime 25(OH)D to >40 nmol/L, lowered PTH, and its use was associated with improved wellbeing. The 100 mcg/day dose produced greater responses. Since it was ethically necessary to provide a meaningful dose of vitamin D to these insufficient patients, we cannot rule out a placebo wellbeing response, particularly for those on the lower dose. This work confirms the safety and efficacy of both 15 and 100 mcg/day vitamin D3 in patients who needed additional vitamin D.
Matti Narkia

Chronic Sunscreen Use Decreases Circulating Concentrations of 25-Hydroxyvitamin D: A Pr... - 0 views

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    Matsuoka, L. Y., Wortsman, J., Hanifan, N. & Holick, M. F. (1988)
    Chronic sunscreen use decreases circulating concentrations of 25-hydroxyvitamin D: a preliminary study.
    Arch. Dermatol. 124:1802-1804
Matti Narkia

A positive dose-response effect of vitamin D supplementation on site-specific bone mine... - 0 views

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    A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: a double-blinded randomized placebo-controlled 1-year intervention.
    Viljakainen HT, Natri AM, Kärkkäinen M, Huttunen MM, Palssa A, Jakobsen J, Cashman KD, Mølgaard C, Lamberg-Allardt C.
    J Bone Miner Res. 2006 Jun;21(6):836-44.
    PMID: 16753014
    doi: 10.1359/jbmr.060302

    We conclude that the current vitamin D recommendation for adolescent girls, at least in the northern latitudes, is too low to ensure sufficient vitamin D status during winter. Intake of vitamin D at rates of 10-15 μg/day aids to maintain stable S-25(OH)D concentrations during winter. Vitamin D induced BMC augmentation by decreasing bone resorption, but not affecting bone formation, which was reflected by the biochemical markers of bone turnover. Optimizing bone mineral gain in adolescence is crucial to the prevention of osteoporosis later in life. Increasing vitamin D intake to 10-15 μg/day aids in attaining this goal.
Matti Narkia

Vitamin D2 Is as Effective as Vitamin D3 in Maintaining Circulating Concentrations of 2... - 0 views

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    Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D.
    Holick MF, Biancuzzo RM, Chen TC, Klein EK, Young A, Bibuld D, Reitz R, Salameh W, Ameri A, Tannenbaum AD.
    J Clin Endocrinol Metab. 2008 Mar;93(3):677-81. Epub 2007 Dec 18.
    PMID: 18089691

    Conclusion: A 1000 IU dose of vitamin D2 daily was as effective as 1000 IU vitamin D3 in maintaining serum 25-hydroxyvitamin D levels and did not negatively influence serum 25-hydroxyvitamin D3 levels. Therefore, vitamin D2 is equally as effective as vitamin D3 in maintaining 25-hydroxyvitamin D status.
Matti Narkia

Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does... - 0 views

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    Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2.
    Trang HM, Cole DE, Rubin LA, Pierratos A, Siu S, Vieth R.
    Am J Clin Nutr. 1998 Oct;68(4):854-8.
    PMID: 9771862

    Although the 1.7-times
    greater efficacy for vitamin D3 shown here may seem small, it is
    more than what others have shown for 25(OH)D increases when
    comparing 2-fold differences in vitamin D3 dose. The
    assumption that vitamins D2 and D3 have equal nutritional value
    is probably wrong and should be reconsidered.
Matti Narkia

Vitamin D2 Is Much Less Effective than Vitamin D3 in Humans -- Armas et al. 89 (11): 53... - 0 views

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    Vitamin D2 is much less effective than vitamin D3 in humans.
    Armas LA, Hollis BW, Heaney RP.
    J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91.
    PMID: 15531486

    Vitamin D2 potency is less than one third that of vitamin D3. Physicians resorting to use of vitamin D2 should be aware of its markedly lower potency and shorter duration of action relative to vitamin D3.
Matti Narkia

Supplementation with cholecalciferol does not improve glycaemic control in diabetic sub... - 0 views

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    Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels.
    Jorde R, Figenschau Y.
    Eur J Nutr. 2009 Apr 16. [Epub ahead of print]
    PMID: 19370371
    10.1007/s00394-009-0020-3

    Conclusions We were not able to demonstrate that vitamin D supplementation had a significant effect on glucose metabolism in subjects with type 2 diabetes but without vitamin D deficiency. Further studies are needed in larger groups of subjects with type 2 diabetes or impaired glucose tolerance, who also exhibit low serum 25-hydroxyvitamin D levels.
Matti Narkia

Comparison of Daily, Weekly, and Monthly Vitamin D3 in Ethanol Dosing Protocols for Two... - 0 views

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    Comparison of daily, weekly, and monthly vitamin D3 in ethanol dosing protocols for two months in elderly hip fracture patients.
    Ish-Shalom S, Segal E, Salganik T, Raz B, Bromberg IL, Vieth R.
    J Clin Endocrinol Metab. 2008 Sep;93(9):3430-5. Epub 2008 Jun 10.
    PMID: 18544622
    doi:10.1210/jc.2008-0241

    CONCLUSIONS: Supplementation with vitamin D can be achieved equally well with daily, weekly, or monthly dosing frequencies. Therefore, the choice of dose frequency can be based on whichever approach will optimize an individual's adherence with long-term vitamin D supplementation.
Matti Narkia

Estimation of the dietary requirement for vitamin D in free-living adults >=64 y of age... - 0 views

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    Estimation of the dietary requirement for vitamin D in free-living adults >=64 y of age.
    Cashman KD, Wallace JM, Horigan G, Hill TR, Barnes MS, Lucey AJ, Bonham MP, Taylor N, Duffy EM, Seamans K, Muldowney S, Fitzgerald AP, Flynn A, Strain JJ, Kiely M.
    Am J Clin Nutr. 2009 May;89(5):1366-74. Epub 2009 Mar 18.
    PMID: 19297462
    doi:10.3945/ajcn.2008.27334

    Conclusion: To ensure that the vitamin D requirement is met by the vast majority (>97.5%) of adults aged ≥64 y during winter, between 7.9 and 42.8 µg vitamin D/d is required, depending on summer sun exposure and the threshold of adequacy of 25(OH)D. .
Matti Narkia

Vitamin D intake to attain a desired serum 25-hydroxyvitamin D concentration -- Aloia e... - 0 views

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    Vitamin D intake to attain a desired serum 25-hydroxyvitamin D concentration.
    Aloia JF, Patel M, Dimaano R, Li-Ng M, Talwar SA, Mikhail M, Pollack S, Yeh JK.
    Am J Clin Nutr. 2008 Jun;87(6):1952-8.
    PMID: 18541590

    The mean daily dose was 86 microg (3440 IU). The use of computer simulations to obtain the most participants within the range of 75-220 nmol/L predicted an optimal daily dose of 115 microg/d (4600 IU). No hypercalcemia or hypercalciuria was observed. CONCLUSIONS: Determination of the intake required to attain serum 25(OH)D concentrations >75 nmol/L must consider the wide variability in the dose-response curve and basal 25(OH)D concentrations. Projection of the dose-response curves observed in this convenience sample onto the population of the third National Health and Nutrition Examination Survey suggests a dose of 95 microg/d (3800 IU) for those above a 25(OH)D threshold of 55 nmol/L and a dose of 125 microg/d (5000 IU) for those below that threshold.
Matti Narkia

A randomized controlled trial of vitamin D3 supplementation for the prevention of sympt... - 0 views

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    A randomized controlled trial of vitamin D3 supplementation for the prevention of symptomatic upper respiratory tract infections.
    Li-Ng M, Aloia JF, Pollack S, Cunha BA, Mikhail M, Yeh J, Berbari N.
    Epidemiol Infect. 2009 Mar 19:1-9. [Epub ahead of print]
    PMID: 19296870
Matti Narkia

High-dose oral vitamin D3 supplementation in the elderly. - [Osteoporos Int. 2009] - Pu... - 0 views

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    High-dose oral vitamin D3 supplementation in the elderly.
    Bacon CJ, Gamble GD, Horne AM, Scott MA, Reid IR.
    Osteoporos Int. 2009 Aug;20(8):1407-15. Epub 2008 Dec 20.
    PMID: 19101755

    Sixty-three elderly participants were randomized to three regimens of vitamin D supplementation: a 500,000-IU loading dose; the loading dose plus 50,000 IU/month; or 50,000 IU/month.

    CONCLUSIONS: Large loading doses of vitamin D(3) rapidly and safely normalize 25OHD levels in the frail elderly. Monthly dosing is similarly effective and safe, but takes 3-5 months for plateau 25OHD levels to be reached.
Matti Narkia

Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascu... - 0 views

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    Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers.
    Zittermann A, Frisch S, Berthold HK, Götting C, Kuhn J, Kleesiek K, Stehle P, Koertke H, Koerfer R.
    Am J Clin Nutr. 2009 May;89(5):1321-7. Epub 2009 Mar 25.
    PMID: 19321573
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