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Matti Narkia

Vitamin D may curb diabetes - Pharmacy News - 0 views

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    A New Zealand study has found that South Asian women with insulin resistance improved markedly after taking vitamin D supplements

    Nutrition researcher Pamela von Hurst of the Institute of Food, Nutrition and Human Health at Albany, said while diet and exercise played a major part in the onset of type-2 diabetes, her findings reinforced the importance of vitamin D from the sun and supplements to prevent type-2 diabetes.

    Initial screening of 235 Auckland women from India, Pakistan and Sri Lanka aged 20 and older, revealed 47 per cent were insulin deficient and 84 per cent were vitamin D deficient. The 81 recruited for the study were split into two groups for a randomised controlled trial and given a vitamin D supplement or placebo. As well as an improvement in insulin resistance among those who took vitamin D for six months, Ms Von Hurst said post-menopausal women in the study also showed a reduced rate of bone breakdown.
Matti Narkia

Benefits of Vitamin D Supplementation - Journal of American Physicians and Surgeons Vol... - 1 views

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    Benefits of Vitamin D Supplementation
    Joel M. Kauffman, Ph.D.
    Journal of American Physicians and Surgeons
    Volume 14 Number 2 - Summer 2009

    Clinical trials show that vitamin D supplementation at higher
    levels than previously recommended is beneficial for many
    conditions. It decreases the frequency of falls and fractures, helps
    prevent cardiovascular disease, and reduces symptoms of colds or
    influenza. Benefits are also seen in diabetes mellitus, multiple
    sclerosis, Crohn disease, pain, depression, and possibly autism.
    Sunlight does not cause an overdose of vitamin D production,
    and toxicity from supplementation is rare. Dose recommendations
    are increasing, but appear to be lagging the favorable trial results. A
    number of common drugs deplete vitamin D levels, and others may
    limit its biosynthesis from sunlight.
    People with adequate levels from sun exposure will not benefit
    from supplementation. While dietary intake is helpful,
    supplementation is better able to raise serum 25-hydroxyvitamin D ,
    the major circulating metabolite, to the level now thought adequate,
    30-50 ng/mL.
    Where there is inadequate daily sun exposure, oral doses of
    1,000-2,000 IU/d are now considered routine, with much higher
    doses (up to 50,000 IU) for rapid repletion now considered safe.
Matti Narkia

Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sun... - 0 views

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    Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sunny country?
    Pignotti GA, Genaro PS, Pinheiro MM, Szejnfeld VL, Martini LA.
    Eur J Nutr. 2009 Nov 28. [Epub ahead of print]
    PMID: 19946776

    CONCLUSION: The dose given (400 IU/day) was not enough to achieve 25(OH)D concentration, considered optimal for bone health.
Matti Narkia

Vitamin D deficiency is associated with worse cognitive performance and lower bone dens... - 0 views

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    Vitamin D deficiency is associated with worse cognitive performance and lower bone density in older African Americans.
    Wilkins CH, Birge SJ, Sheline YI, Morris JC.
    J Natl Med Assoc. 2009 Apr;101(4):349-54.
    PMID: 19397226

    CONCLUSIONS: Vitamin D deficiency in older African Americans was associated with worse cognitive performance and lower BMD of the hip
Matti Narkia

Effects Of Vitamin D Deficiency Amplified By Shortage Of Estrogen - 0 views

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    "Researchers at Johns Hopkins are reporting what is believed to be the first conclusive evidence in men that the long-term ill effects of vitamin D deficiency are amplified by lower levels of the key sex hormone estrogen, but not testosterone.

    In a national study in 1010 men, to be presented Nov. 15 at the American Heart Association's (AHA) annual Scientific Sessions in Orlando, researchers say the new findings build on previous studies showing that deficiencies in vitamin D and low levels of estrogen, found naturally in differing amounts in men and women, were independent risk factors for hardened and narrowed arteries and weakened bones. Vitamin D is an essential part to keeping the body healthy, and can be obtained from fortified foods, such as milk and cereals, and by exposure to sunlight.
Matti Narkia

A phase 2 trial exploring the effects of high-dose (10,000 IU/day) vitamin D(3) in brea... - 0 views

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    A phase 2 trial exploring the effects of high-dose (10,000 IU/day) vitamin D(3) in breast cancer patients with bone metastases.
    Amir E, Simmons CE, Freedman OC, Dranitsaris G, Cole DE, Vieth R, Ooi WS, Clemons M.
    Cancer. 2009 Nov 13. [Epub ahead of print]
    PMID: 19918922
    DOI: 10.1002/cncr.24749

    METHODS:
    Patients with bone metastases treated with bisphosphonates were enrolled into this single-arm phase 2 study. Patients received 10,000 IU of vitamin D3 and 1000 mg of calcium supplementation each day for 4 months. The effect of this treatment on palliation, bone resorption markers, calcium metabolism, and toxicity were evaluated at baseline and monthly thereafter.


    CONCLUSIONS:
    Daily doses of 10,000 IU vitamin D3 for 4 months appear safe in patients without comorbid conditions causing hypersensitivity to vitamin D. Treatment reduced inappropriately elevated parathyroid hormone levels, presumably caused by long-term bisphosphonate use. There did not appear to be a significant palliative benefit nor any significant change in bone resorption. Cancer 2010. © 2009 American Cancer Society.
Matti Narkia

Coeliac bone loss link uncovered - BBC NEWS | Health - 0 views

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    "People with coeliac disease may be more susceptible to osteoporosis because their own immune system attacks their bone tissue, a study suggests.

    Osteoporosis is a known risk of coeliac disease and has been explained by a failure to absorb calcium or vitamin D. "
Matti Narkia

Serum 25-hydroxyvitamin D levels in vitamin D-insufficient hip fracture patients after ... - 0 views

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    Serum 25-hydroxyvitamin D levels in vitamin D-insufficient hip fracture patients after supplementation with ergocalciferol and cholecalciferol.
    Glendenning P, Chew GT, Seymour HM, Gillett MJ, Goldswain PR, Inderjeeth CA, Vasikaran SD, Taranto M, Musk AA, Fraser WD.
    Bone. 2009 Nov;45(5):870-5. Epub 2009 Jul 23.
    PMID: 19631774
    doi:10.1016/j.bone.2009.07.015

    Cholecalciferol supplementation resulted in a 31% greater increase in total HPLC-measured 25OHD (p=0.010) and 52% greater rise in RIA-measured 25OHD (p<0.001) of supplementation dose with than ergocalciferol equivalent an>0.05). In vitamin D-insufficient hip fracture patients, supplementation with cholecalciferol 1000 IU/day for three months was more effective in increasing serum 25OHD than an equivalent dose of ergocalciferol. However, the lack of difference in PTH lowering between calciferol treatments raises questions about the biological importance of this observation.
Matti Narkia

Vitamin D and vitamin D analogues for preventing fractures associated with involutional... - 0 views

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    Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis.
    Avenell A, Gillespie WJ, Gillespie LD, O'Connell D.
    Cochrane Database Syst Rev. 2009 Apr 15;(2):CD000227. Review.
    PMID: 19370554
    DOI: 10.1002/14651858.CD000227.pub3

    AUTHORS' CONCLUSIONS: Frail older people confined to institutions may sustain fewer hip fractures if given vitamin D with calcium. Vitamin D alone is unlikely to prevent fracture. Overall there is a small but significant increase in gastrointestinal symptoms and renal disease associated with vitamin D or its analogues. Calcitriol is associated with an increased incidence of hypercalcaemia.
Matti Narkia

Reducing fracture risk with calcium and vitamin D. - Wiley InterScience :: JO... - 0 views

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    Reducing fracture risk with calcium and vitamin D.
    Lips P, Bouillon R, van Schoor NM, Vanderschueren D, Verschueren S, Kuchuk N, Milisen K, Boonen S.
    Clin Endocrinol (Oxf). 2009 Sep 10. [Epub ahead of print]
    PMID: 19744099
    DOI: 10.1111/j.0300-0664.2009.03701.x
Matti Narkia

Manninen Nutraceuticals: Blast from the Past: D-vitamiini ja rasitusmurtumat - 0 views

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    Kovaa harjoittelevat urheilijat! Lukekaa tämä teksti! Kova harjoittelu voi aiheuttaa rasitusmurtumia alaraajan luihin ja D-vitamiinia nauttimalla voidaan rasitusmurtumien synty ehkäistä.

    Lääkäri Juha-Petri Ruoholan väitöskirjan mukaan liian vähäinen D-vitamiinin saanti voi altistaa rasitusmurtumien syntymiselle urheilijoille. Tutkimuksen mukaan murtumapotilailla oli selkeästi normaalia alhaisemmat D-vitamiinitasot.
Matti Narkia

Dairy and Bone Health -- Heaney 28 (1): 82S -- Journal of the American College of Nutri... - 0 views

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    Dairy and bone health.
    Heaney RP.
    J Am Coll Nutr. 2009 Feb;28 Suppl 1:82S-90S.
    PMID: 19571166
Matti Narkia

Long-term effects of giving nursing home residents bread fortified with 125 {micro}g (5... - 0 views

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    Long-term effects of giving nursing home residents bread fortified with 125 {micro}g (5000 IU) vitamin D3 per daily serving.
    Mocanu V, Stitt PA, Costan AR, Voroniuc O, Zbranca E, Luca V, Vieth R.
    Am J Clin Nutr. 2009 Feb 25. [Epub ahead of print]
    PMID: 19244376
Matti Narkia

Prevention of Nonvertebral Fractures With Oral Vitamin D and Dose Dependency: A Meta-an... - 0 views

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    Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials.
    Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck AE, Staehelin HB, Orav EJ, Thoma A, Kiel DP, Henschkowski J.
    Arch Intern Med. 2009 Mar 23;169(6):551-61.
    PMID: 19307517

    Conclusion Nonvertebral fracture prevention with vitamin D is dose dependent, and a higher dose should reduce fractures by at least 20% for individuals aged 65 years or older.
Matti Narkia

Long-term effects of giving nursing home residents bread fortified with 125 microg (500... - 0 views

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    Long-term effects of giving nursing home residents bread fortified with 125 microg (5000 IU) vitamin D(3) per daily serving.
    Mocanu V, Stitt PA, Costan AR, Voroniuc O, Zbranca E, Luca V, Vieth R.
    Am J Clin Nutr. 2009 Apr;89(4):1132-7. Epub 2009 Feb 25.
    PMID: 19244376
    doi:10.3945/ajcn.2008.26890
Matti Narkia

The same annual dose of 292 000 IU of vitamin D(3) (cholecalciferol) on either daily or... - 0 views

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    The same annual dose of 292 000 IU of vitamin D(3) (cholecalciferol) on either daily or four monthly basis for elderly women: 1-year comparative study of the effects on serum 25(OH)D(3) concentrations and renal function.
    Pekkarinen T, Välimäki VV, Aarum S, Turpeinen U, Hämäläinen E, Löyttyniemi E, Välimäki MJ.
    Clin Endocrinol (Oxf). 2009 May 25. [Epub ahead of print]
    PMID: 19486025
    DOI: 10.1111/j.1365-2265.2009.03637.x
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