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What causes autism? Exploring the environmental contribution : Current Opinion in Pedia... - 0 views

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    Purpose of review: Autism is a biologically based disorder of brain development. Genetic factors - mutations, deletions, and copy number variants - are clearly implicated in causation of autism. However, they account for only a small fraction of cases, and do not easily explain key clinical and epidemiological features. This suggests that early environmental exposures also contribute. This review explores this hypothesis. Recent findings: Indirect evidence for an environmental contribution to autism comes from studies demonstrating the sensitivity of the developing brain to external exposures such as lead, ethyl alcohol and methyl mercury. But the most powerful proof-of-concept evidence derives from studies specifically linking autism to exposures in early pregnancy - thalidomide, misoprostol, and valproic acid; maternal rubella infection; and the organophosphate insecticide, chlorpyrifos. There is no credible evidence that vaccines cause autism. Summary: Expanded research is needed into environmental causation of autism. Children today are surrounded by thousands of synthetic chemicals. Two hundred of them are neurotoxic in adult humans, and 1000 more in laboratory models. Yet fewer than 20% of high-volume chemicals have been tested for neurodevelopmental toxicity. I propose a targeted discovery strategy focused on suspect chemicals, which combines expanded toxicological screening, neurobiological research and prospective epidemiological studies.
Skeptical Debunker

Paper prevails over electronic documents - 0 views

  • "Despite the fact that the legal admissibility of scanned paper documents has been established for nearly 20 years and is nailed down in legislation and standards around the world, there is still this suspicion among users that they may need to produce the original paper copy at some stage," Mancini said. The survey also found that many documents are "born digital," then printed out to be signed and later scanned into document systems.
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    Office employees are loath to give up the vast amount of paper stored in their filing cabinets, much to the chagrin of companies that sell scanners and electronic document management systems. A recent survey by AIIM, an industry association representing vendors of such products, found that 62% of important documents are still archived in paper form. Even when documents are sent off to be scanned for archiving, 25% are photocopied beforehand "just in case," the survey found.
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    And no wonder. We know that "quality" paper will last for hundreds of years through a wide variety of conditions. Even "cheap" and/or abused paper can still be marginally useful (or have information from it recovered with extreme means). Generally NOT so with electronic media. Remember NASA's sad loss of terabytes of space data stored on tape? And then there is the real (as little as 2 years) verses the touted (20 to 100 years) lifetime of optical disks of various sorts. From http://www.archives.gov/records-mgmt/initiatives/temp-opmedia-faq.html - CD/DVD experiential life expectancy is 2 to 5 years even though published life expectancies are often cited as 10 years, 25 years, or longer. However, a variety of factors discussed in the sources cited in FAQ 15, below, may result in a much shorter life span for CDs/DVDs. Life expectancies are statistically based; any specific medium may experience a critical failure before its life expectancy is reached. Additionally, the quality of your storage environment may increase or decrease the life expectancy of the media. We recommend testing your media at least every two years to assure your records are still readable.
Skeptical Debunker

Unintended Consequences: Twelve Years under the DMCA | Electronic Frontier Foundation - 1 views

  • The DMCA Chills Free Expression and Scientific Research. Experience with section 1201 demonstrates that it is being used to stifle free speech and scientific research. The lawsuit against 2600 magazine, threats against Princeton Professor Edward Felten's team of researchers, and prosecution of Russian programmer Dmitry Sklyarov have chilled the legitimate activities of journalists, publishers, scientists, students, programmers, and members of the public. The DMCA Jeopardizes Fair Use. By banning all acts of circumvention, and all technologies and tools that can be used for circumvention, the DMCA grants to copyright owners the power to unilaterally eliminate the public's fair use rights. Already, the movie industry's use of encryption on DVDs has curtailed consumers' ability to make legitimate, personal-use copies of movies they have purchased. The DMCA Impedes Competition and Innovation. Rather than focusing on pirates, some have wielded the DMCA to hinder legitimate competitors. For example, the DMCA has been used to block aftermarket competition in laser printer toner cartridges, garage door openers, and computer maintenance services. Similarly, Apple has used the DMCA to tie its iPhone and iPod devices to Apple's own software and services. The DMCA Interferes with Computer Intrusion Laws. Further, the DMCA has been misused as a general-purpose prohibition on computer network access, a task for which it was not designed and to which it is ill-suited. For example, a disgruntled employer used the DMCA against a former contractor for simply connecting to the company's computer system through a virtual private network ("VPN").
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    Since they were enacted in 1998, the "anti-circumvention" provisions of the Digital Millennium Copyright Act ("DMCA"), codified in section 1201 of the Copyright Act, have not been used as Congress envisioned. Congress meant to stop copyright infringers from defeating anti-piracy protections added to copyrighted works and to ban the "black box" devices intended for that purpose.1 In practice, the anti-circumvention provisions have been used to stifle a wide array of legitimate activities, rather than to stop copyright infringement. As a result, the DMCA has developed into a serious threat to several important public policy priorities:
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