TOK Friends

And studies have confirmed that people tend to undergo a kind of withdrawal: A study a few years ago from Swansea University found that people experienced the psychological symptoms of withdrawal when they stopped using (this went for all internet use, not just social media).

It triggers more sadness, less well-being

The more we use social media, the less happy we seem to be. One study a few years ago found that Facebook use was linked to both less moment-to-moment happiness and less life satisfaction—the more people used Facebook in a day, the more these two variables dropped off

In fact, another study found that social media use is linked to greater feelings of social isolation.

Comparing our lives with others is mentally unhealthy

One study looked at how we make comparisons to others posts, in “upward” or “downward” directions—that is, feeling that we’re either better or worse off than our friends.

It can lead to jealousy—and a vicious cycle

Studies have certainly shown that social media use triggers feelings of jealousy. The authors of one study, looking at jealousy and other negative feelings while using Facebook, wrote that “This magnitude of envy incidents taking place on FB alone is astounding, providing evidence that FB offers a breeding ground for invidious feelings."

We get caught in the delusion of thinking it will help

Part of the unhealthy cycle is that we keep coming back to social media, even though it doesn’t make us feel very good.

This is probably because of what’s known as a forecasting error: Like a drug, we think getting a fix will help, but it actually makes us feel worse, which comes down to an error in our ability to predict our own response.

More friends on social doesn’t mean you’re more social

A couple of years ago, a study found that more friends on social media doesn’t necessarily mean you have a better social life—there seems to be a cap on the number of friends a person’s brain can handle, and it takes actual social interaction (not virtual) to keep up these friendships

All of this is not to say that there’s no benefit to social media—obviously it keeps us connected across great distances, and helps us find people we’d lost touch with years ago

Learning how to make friends is a major part of growing up, and friendship requires a certain amount of risk-taking. This is true for making a new friend, but it’s also true for maintaining friendships. When there are problems that need to be faced—big ones or small ones—it takes courage to be honest about your feelings and then hear what the other person has to say

But when friendship is conducted online and through texts, kids are doing this in a context stripped of many of the most personal—and sometimes intimidating—aspects of communication

The other big danger that comes from kids communicating more indirectly is that it has gotten easier to be cruel. “Kids text all sorts of things that you would never in a million years contemplate saying to anyone’s face,”

“Girls are socialized more to compare themselves to other people, girls in particular, to develop their identities, so it makes them more vulnerable to the downside of all this.” She warns that a lack of solid self-esteem is often to blame. “We forget that relational aggression comes from insecurity and feeling awful about yourself, and wanting to put other people down so you feel better.”

. Teenage girls sort through hundreds of photos, agonizing over which ones to post online. Boys compete for attention by trying to out-gross one other, pushing the envelope as much as they can in the already disinhibited atmosphere online.

Another big change that has come with new technology and especially smart phones is that we are never really alone. Kids update their status, share what they’re watching, listening to, and reading, and have apps that let their friends know their specific location on a map at all times.

Offline, the gold standard advice for helping kids build healthy self-esteem is to get them involved in something that they’re interested in

The ‘urge’ to check one’s social media may be linked to both instant gratification (the need to experience fast, short term pleasure) and dopamine production (the chemical in the brain associated with reward and pleasure).

The popular concept of Fear of Missing Out (FOMO) refers to ‘a pervasive apprehension that others might be having rewarding experiences from which one is absent’ and is ‘characterised by the desire to stay continually connected with what others are doing’.

Data from qualitative studies has shown that using social media compulsively can damage sleeping patterns, having an adverse effect on young people’s performance in school

The University of Glasgow found that young people found it difficult to relax following night time social media use, reducing their brain’s ability to prepare for sleep. Sleep loss works in a vicious cycle of reinforcement with mental health; that is, that loss of sleep due to night time social media use can lead to poorer mental health, and poor mental health can lead to intense night time use and sleep loss

What is dangerous about this compulsive use is that, if gratification is not experienced, users may internalise beliefs that this is due to being ‘unpopular’, ‘unfunny’ etc. A lack of ‘likes’ on a status update may cause negative self-reflection, prompting continual ‘refreshing’ of the page in the hope of seeing that another person has ‘enjoyed’ the post, thus helping to achieve personal validation.

FOMO has been linked to intensive social media use and is associated with lower mood and life satisfaction.

Social media has been linked to poor self-esteem and self-image through the advent of image manipulation on photo sharing platforms. In particular, the notion of the ‘idealised body image’ has arguably been detrimental to self-esteem and image, especially that of young women. The 24/7 circulation of easily viewable manipulated images promotes and entrenches unrealistic expectations of how young people should look and behave.

The evidence suggests that social media use is strongly associated with anxiety, loneliness and depression

FOMO—fear of missing out—also plays a role

A 2018 British study tied social media use to decreased, disrupted, and delayed sleep, which is associated with depression, memory loss, and poor academic performance.

Social media use can affect users’ physical health even more directly. Researchers know the connection between the mind and the gut can turn anxiety and depression into nausea, headaches, muscle tension, and tremors.

The earlier teens start using social media, the greater impact the platforms have on mental health. This is especially true for females. While teen males tend to express aggression physically, females do so relationally by excluding others and sharing hurtful comments. Social media increases the opportunity for such harmful interactions.

In the past, teens read magazines that contained altered photos of models. Now, these images are one thumb-scroll away at any given time. Apps that provide the user with airbrushing, teeth whitening, and more filters are easy to find and easier to use. It’s not only celebrities who look perfect—it’s everyone.

In recent years, plastic surgeons have seen an uptick in requests from patients who want to look like their filtered Snapchat and Instagram photos.

A person experiences impostor syndrome when feeling chronic self-doubt and a sense of being exposed as ‘a fraud’ in terms of success and intellect. “Whether it’s another pretty vacation or someone’s bouquet of flowers, my mind went from ‘Why not me?’ to ‘I don’t deserve those things, and I don’t know why,’ and it made me feel awful.”

Sperling encourages people to conduct their own behavior experiments by rating their emotions on a scale of 0-10, with 10 being the most intensely one could experience an emotion, before and after using social media sites at the same time each day for a week.

There are many things that our colleagues in Korea did that allowed them to have a very effective initial response. Our public-private smorgasbord of clinical laboratories and testing, our regulatory environment for how new lab tests can be rolled out, the public health capacity [being] very weak in terms of ability to get the contact tracing done.

There were just many things that delayed us. That said, there was lots of great work in many communities. But I think as a nation, it wasn't a good performance.

The supply chain is very interdependent internationally. This was a really complex, systemwide assault.

The increase came even though the number of miles traveled by vehicle fell 13% from 2019.

Motorcyclist deaths rose 9% last year to 5,015, while bicyclist deaths were up 5% to 846. Pedestrian deaths remained steady at 6,205, and the number of people killed in passenger vehicles rose 5% to 23,395, according to NHTSA.

Deaths involving a large truck fell 2%, while traffic fatalities among people 65 and older fell 9%.

These trees have lived for thousands of years. They've survived dozens of wildfires already,"

The consequences of losing large numbers of giant sequoias could be felt for decades, forest managers said.

Redwood and sequoia forests are among the world's most efficient at removing and storing carbon dioxide in the atmosphere.

"I have a vain hope that once we get out on the ground the situation won't be as bad, but that's hope — that's not science," she said.

The newspaper said the extent of the damage to one of the world's most treasured trees is noteworthy because the sequoias themselves are incredibly well adapted to fire.

The old-growth trees — some of which are more than 2,000 years old and 250 feet (76 meters) tall — require fire to burst their pine cones and reproduce.

Brigham estimates that the park will need to burn around 30 times that number to get the forest back to a healthy state.

She says with all the Western wildfires in recent years, the wild grass and forage seeds have become expensive.

The region is parched from near the Canadian border clear to the edge of Nevada, with triple digit temps on the way making it worse.

Earlier this year, Oregon declared drought zones for eight counties, and six more have requested it since. Now the drought is rapidly expanding into usually cooler and wetter western Oregon, according to Ryan Andrews, a hydrologist for the state's Water Resources Department.

Jeff Marti, a drought expert for Washington's Department of Ecology, says it hasn't been this dry since the 1920s.

"It's the story of the irrigation haves and the have nots," he says. "Meaning those folks who get their water from rivers or storage, are probably going to be fine for their irrigation needs. But the dryland users and the folks that have cattle that depend on forage on the rangelands may be more challenged."

He says it's hard to lose animals and bloodlines that he's worked so hard to build up. He figures it could take him up to a decade to build his herd back up without going into debt.

Most ranchers say they don't have time to dwell on the trucked-off cattle or lost crops. They're busy applying for federal disaster aid. And they're also keeping an eye out for wildfires that are always top-of-mind in the dry, hot summer, but expected to be worse because of this year's terrible drought.

"We've seen stratospheric compensation levels. We see stock buybacks and dividend distribution. Yet, wages throughout our economy are essentially flat."

Bank executives, Warren says, "have a responsibility to execute on making their banks part of the solution to our economic and racial problems across this nation."

But even with a change in power in Congress, analysts warn banks are likely to face continued pressure from Democrats — and society — on key aspects of their operations, from whom they lend money to where they invest.

"Banks have no choice but to address these issues, because it impacts their communities, their customers and their employees,"

"You have to live in the real world, and the real world has these issues as part of the banks' businesses."

In the U.S., more than 100 million adults — about 1 in 3 — are obese.

Dropping even 5% of one's weight can bring health benefits, such as improved energy, blood pressure, blood sugar and cholesterol levels, but that amount often doesn't satisfy patients who are focused on weight loss

The drug carries a potential risk for a type of thyroid tumor, so it shouldn't be taken by people with a personal or family history of certain thyroid and endocrine tumors. Wegovy also has a risk of depression and pancreas inflammation.

Like other weight-loss drugs, it's to be used along with exercise, a healthy diet and other steps like keeping a food diary.

Wegovy builds on a trend in which makers of relatively new diabetes drugs test them to treat other conditions common in diabetics.

"The United States was one of the countries that supported the resolution to hold the special session," the WHO said Monday in response to an NPR inquiry. "That is not to say it has committed to support the treaty yet, as the process of moving forward was only confirmed today."

"The safety of the world's people cannot rely solely on the goodwill of governments."

A treaty would make countries more accountable to one another, he said.

The lack of sharing — of information, technology, resources and data — is the COVID-19 pandemic's defining characteristic, the WHO leader said.

"a monumental error for any country to think the danger has passed."

Tedros' remarks echoed the frustrations he raised last year, when he said the pandemic was presenting humanity with a test — one that we are failing.

"Are we unable to distinguish or identify the common enemy?"

The agency cites the results of a study in Germany and clinical trials in the U.K. and Spain as supporting the safety of vaccine interchangeability.

As of late May, 50.6% of Canada's population had received at least one vaccination shot — but only 4.6% of the population was fully vaccinated.

"Different vaccine products have been used to complete a vaccine series for influenza, hepatitis A, and others to complete a vaccine series for influenza, hepatitis A, and others."

"Basically, all vaccines work by showing people's immune systems something that looks like an invading virus but really isn't. If the real virus ever comes along, their immune systems will recognize it and be prepared to fight it off.

"Using two different vaccines is a bit like giving the immune system two pictures of the virus, maybe one face-on and one in profile."

"Individuals who have received one dose of the Pfizer-BioNTech or Moderna COVID-19 vaccine should receive a second dose of the same vaccine to complete the vaccination series," the spokesperson added.

Little kids were new casualties in our country’s ongoing struggle to define itself. Its endless argument over guns appeared to be a symptom of a national identity crisis between political polar opposites – two parties so ideologically opposed that even the needless deaths of tiny innocents couldn’t bridge the divide between them.

What sickened me most, though, wasn’t our government’s failure to prioritize people over partisanship. It was knowing that there were parents who took their kids to school and returned home eternally empty-handed.

Survivors of school shootings like me are now raising kids of their own, worrying they will suffer similar fates. Although the psychological effects of school shootings on parents may not yet be fully known or understood, research suggests that those with loved ones who have been exposed to “assaultive violence” have a higher risk of mental health disorders.

School shootings don’t just deprive children of their lives and innocence; they deprive parents of a sense of safety and security their parents and grandparents took for granted.

This reality is a painful part of our collective consciousness. We send our kids to school, hoping the horror of gun violence won’t happen there, but knowing no child or school is immune.

Both sides seem content to debate the second amendment and the founders’ intent until they run out of breath. But in the meantime, Congress must come together, in earnest, to find common ground and common-sense solutions to stop this bleeding. The consequences of inaction have become too high – and our kids are counting on them.

The incentive programs have become a bipartisan trend with governors from deep-red states like West Virginia or deep-blue states like California offering a range of inducements.

“It would be really great if we didn’t need any incentives at all. Hopefully, not dying is a great incentive,” the governor said according to the Deseret News.

According to the NFL, a panel of neuropsychologists that was formed recently to propose a new testing regime to the court includes two female and three Black doctors.

The NFL noted that the norms were developed in medicine “to stop bias in testing, not perpetrate it.”

The binary race norms, when they are used in the testing, assumes that Black patients start with worse cognitive function than whites and other non-Blacks.

The awards so far have averaged $516,000 for the 379 players with early-stage dementia and $715,000 for the 207 players with moderate dementia.

he settlement ended thousands of lawsuits that accused the NFL of long hiding what it knew about the link between concussions and traumatic brain injury.

The school district’s board president told the Lake Highlands Advocate that Smith’s speech had not been submitted or approved and that her actions were “unexpected and not supported”

“It kind of makes me sad that this is a universal issue,” she said. “This is one of those times where it’s getting a voice, and it hasn’t really had a voice that’s very big before.”

Globally, the numbers can be even worse, and the stakes often higher. “Say a person comes into the hospital in Sierra Leone with a fever and flulike symptoms,” DeRisi says. “After a few days, or a week, they die. What caused that illness? Most of the time, we never find out. Because if the cause isn’t something that we can culture and test for” — like hepatitis, or strep throat — “it basically just stays a mystery.”

It would be better, DeRisi says, to watch for rare cases of mystery illnesses in people, which often exist well before a pathogen gains traction and is able to spread.

Based on a retrospective analysis of blood samples, scientists now know that H.I.V. emerged nearly a dozen times over a century, starting in the 1920s, before it went global.

Zika was a relatively harmless illness before a single mutation, in 2013, gave the virus the ability to enter and damage brain cells.

The beauty of this approach” — running blood samples from people hospitalized all over the world through his system, known as IDseq — “is that it works even for things that we’ve never seen before, or things that we might think we’ve seen but which are actually something new.”

In this scenario, an undiscovered or completely new virus won’t trigger a match but will instead be flagged. (Even in those cases, the mystery pathogen will usually belong to a known virus family: coronaviruses, for instance, or filoviruses that cause hemorrhagic fevers like Ebola and Marburg.)

And because different types of bacteria require specific conditions in order to grow, you also need some idea of what you’re looking for in order to find it.

The same is true of genomic sequencing, which relies on “primers” designed to match different combinations of nucleotides (the building blocks of DNA and RNA).

Even looking at a slide under a microscope requires staining, which makes organisms easier to see — but the stains used to identify bacteria and parasites, for instance, aren’t the same.

The practice that DeRisi helped pioneer to skirt this problem is known as metagenomic sequencing

Unlike ordinary genomic sequencing, which tries to spell out the purified DNA of a single, known organism, metagenomic sequencing can be applied to a messy sample of just about anything — blood, mud, seawater, snot — which will often contain dozens or hundreds of different organisms, all unknown, and each with its own DNA. In order to read all the fragmented genetic material, metagenomic sequencing uses sophisticated software to stitch the pieces together by matching overlapping segments.

The assembled genomes are then compared against a vast database of all known genomic sequences — maintained by the government-run National Center for Biotechnology Information — making it possible for researchers to identify everything in the mix

Traditionally, the way that scientists have identified organisms in a sample is to culture them: Isolate a particular bacterium (or virus or parasite or fungus); grow it in a petri dish; and then examine the result under a microscope, or use genomic sequencing, to understand just what it is. But because less than 2 percent of bacteria — and even fewer viruses — can be grown in a lab, the process often reveals only a tiny fraction of what’s actually there. It’s a bit like planting 100 different kinds of seeds that you found in an old jar. One or two of those will germinate and produce a plant, but there’s no way to know what the rest might have grown into.

Such studies have revealed just how vast the microbial world is, and how little we know about it

“The selling point for researchers is: ‘Look, this technology lets you investigate what’s happening in your clinic, whether it’s kids with meningitis or something else,’” DeRisi said. “We’re not telling you what to do with it. But it’s also true that if we have enough people using this, spread out all around the world, then it does become a global network for detecting emerging pandemics

One study found more than 1,000 different kinds of viruses in a tiny amount of human stool; another found a million in a couple of pounds of marine sediment. And most were organisms that nobody had seen before.

After the Biohub opened in 2016, one of DeRisi’s goals was to turn metagenomics from a rarefied technology used by a handful of elite universities into something that researchers around the world could benefit from

metagenomics requires enormous amounts of computing power, putting it out of reach of all but the most well-funded research labs. The tool DeRisi created, IDseq, made it possible for researchers anywhere in the world to process samples through the use of a small, off-the-shelf sequencer, much like the one DeRisi had shown me in his lab, and then upload the results to the cloud for analysis.

he’s the first to make the process so accessible, even in countries where lab supplies and training are scarce. DeRisi and his team tested the chemicals used to prepare DNA for sequencing and determined that using as little as half the recommended amount often worked fine. They also 3-D print some of the labs’ tools and replacement parts, and offer ongoing training and tech support

The metagenomic analysis itself — normally the most expensive part of the process — is provided free.

But DeRisi’s main innovation has been in streamlining and simplifying the extraordinarily complex computational side of metagenomics

IDseq is also fast, capable of doing analyses in hours that would take other systems weeks.

“What IDseq really did was to marry wet-lab work — accumulating samples, processing them, running them through a sequencer — with the bioinformatic analysis,”

“Without that, what happens in a lot of places is that the researcher will be like, ‘OK, I collected the samples!’ But because they can’t analyze them, the samples end up in the freezer. The information just gets stuck there.”

Meningitis itself isn’t a disease, just a description meaning that the tissues around the brain and spinal cord have become inflamed. In the United States, bacterial infections can cause meningitis, as can enteroviruses, mumps and herpes simplex. But a high proportion of cases have, as doctors say, no known etiology: No one knows why the patient’s brain and spinal tissues are swelling.

When Saha and her team ran the mystery meningitis samples through IDseq, though, the result was surprising. Rather than revealing a bacterial cause, as expected, a third of the samples showed signs of the chikungunya virus — specifically, a neuroinvasive strain that was thought to be extremely rare. “At first we thought, It cannot be true!” Saha recalls. “But the moment Joe and I realized it was chikungunya, I went back and looked at the other 200 samples that we had collected around the same time. And we found the virus in some of those samples as well.”

Until recently, chikungunya was a comparatively rare disease, present mostly in parts of Central and East Africa. “Then it just exploded through the Caribbean and Africa and across Southeast Asia into India and Bangladesh,” DeRisi told me. In 2011, there were zero cases of chikungunya reported in Latin America. By 2014, there were a million.

Chikungunya is a mosquito-borne virus, but when DeRisi and Saha looked at the results from IDseq, they also saw something else: a primate tetraparvovirus. Primate tetraparvoviruses are almost unknown in humans, and have been found only in certain regions. Even now, DeRisi is careful to note, it’s not clear what effect the virus has on people. “Maybe it’s dangerous, maybe it isn’t,” DeRisi says. “But I’ll tell you what: It’s now on my radar.

it reveals a landscape of potentially dangerous viruses that we would otherwise never find out about. “What we’ve been missing is that there’s an entire universe of pathogens out there that are causing disease in humans,” Imam notes, “ones that we often don’t even know exist.”

“The plan was, Let’s let researchers around the world propose studies, and we’ll choose 10 of them to start,” DeRisi recalls. “We thought we’d get, like, a couple dozen proposals, and instead we got 350.”

Metagenomic sequencing is especially good at what scientists call “environmental sampling”: identifying, say, every type of bacteria present in the gut microbiome, or in a teaspoon of seawater.

“When you draw blood from someone who has a fever in Ghana, you really don’t know very much about what would normally be in their blood without fever — let alone about other kinds of contaminants in the environment. So how do you interpret the relevance of all the things you’re seeing?”

Such criticisms have led some to say that metagenomics simply isn’t suited to the infrastructure of developing countries. Along with the problem of contamination, many labs struggle to get the chemical reagents needed for sequencing, either because of the cost or because of shipping and customs holdups

we’re less likely to be caught off-guard. “With Ebola, there’s always an issue: Where’s the virus hiding before it breaks out?” DeRisi explains. “But also, once we start sampling people who are hospitalized more widely — meaning not just people in Northern California or Boston, but in Uganda, and Sierra Leone, and Indonesia — the chance of disastrous surprises will go down. We’ll start seeing what’s hidden.”

“In addition to capturing everyone’s shopping habits (from amazon.com) and their internet activity (as AWS is one of the most dominant web hosting services) … now they are also effectively becoming a global ISP with a flick of a switch, all without even having to lay a single foot of fiber”

Amazon is not the first company to look to create such a network. Apple has taken a similar approach with the company’s range of AirTag item trackers, which can connect to the internet through any compatible iPhone they come into contact with, not simply their owner’s.