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“I feel like a shadow of my former self. I am not living right now, I am simply existing.”Nicholson-McKellar is far from alone.

“Doctors and scientists wouldn’t necessarily use [brain fog] as a diagnosis as it doesn’t exactly tell you what the problem is and what could be causing that,” says Zandi.

Zandi says there could be many causes of brain fog in Covid survivors, from inflammation in the body to a lack of oxygen to the brain – the latter is a particular concern for those who spent time on ventilators.

terms similar to “brain fog” have previously been used in connection with extreme tiredness, low mood and conditions such as post-traumatic stress disorder (PTSD) – the latter of which is thought to affect about a quarter of Covid survivors who were in intensive care.

The aim of the new work, he says, is to explore whether even those without neurological symptoms show markers of neurological damage, and to what extent any processes are ongoing.

“I’m just existing in this haze-like frame of mind in which I’m constantly on autopilot,” she says.

“What we don’t know is how long it will go on for,” says Zandi. “But we have seen patients who get better and are functioning.”

A quarter of children in primary school are bullied on the playground, causing significant physiological, psychological and social challenges

resilience is developed through social, cultural, mental and physical factors. All facets become important when supporting the growth and development of a child.

The earlier the child experiences stress without supportive platforms in place, the more likely that this stress will compromise the cognitive platforms on which the mental constructs of resilience are developed.

This experience of early adversity can result as a trauma in the brain, thus compromising the ability for the child to use the executive skills that support the development of cognitive resilience.

Understanding the risks and/or impact that early trauma and adversity can have on a developing brain can facilitate the intervention of techniques and a modification in environment that a child may need to transform maladaptive ways of coping to a more adaptive, resilience-supporting response

Research indicates school-based mental health, resilience and social and emotional learning initiatives, in Australia and internationally, can significantly improve the health, wellbeing and psychosocial skills of children – particularly for those who may have experienced early adversity.

The key achievement of middle age, according to Jaques, is to move beyond youthful idealism to what he called "contemplative pessimism" and "constructive resignation." He argued midlife was when we reach maturity by overcoming our denial of death and human destructiveness.Carl Jung presented a different view. He argued midlife was a time when previously suppressed aspects of the psyche might become integrated. Men could recover their unconscious feminine side, or anima, previously submerged during their youth, and women come alive to their hidden opposite, the animus.

Arguably there is no distinct midlife crisis, just crises that occur during midlife but might equally have occurred before or after.

But there may be something to it that's even more basic and biological. Chimpanzees and orangutans aren't known to suffer from existential dread, empty nest syndrome or job stress. And still, they show the same midlife dip in well-being as their human cousins.One study found chimps in their late 20s and orangutans in the mid-30s showed the lowest mood, the least pleasure in social activities, and the poorest capacity to achieve their goals. The researchers speculated this pattern might reflect age-related changes in brain structures associated with well-being that are similar between primate species.

Consider personality change, for example. One longitudinal study that followed thousands of Americans from age 41 to 50 found they became less neurotic and self-conscious with age. These personality changes were unrelated to the adults' experience of life adversity: resilience, not crisis, was the norm.

Another study that followed a sample of women from age 43 to 52 showed they tended to become less dependent and self-critical, and more confident, responsible and decisive, as they aged. These changes were unrelated to the women's menopausal status or empty nest experiences.

Even the self-reported midlife crises may have a silver lining. One study showed the more crises people reported, the more empathetic they were towards others. It is perhaps unsurprising older adults choose middle adulthood as the phase of life they most prefe

Some estimated that the CDC had reported more than 20% of COVID-19 cases as of March 15, but others predicted that the agency had identified just 5% of cases. Some predicted that the US could see 1 million deaths by the end of 2020, while others predicted that the death toll would be in the thousands.

The New York Times recently used CDC data to model how the how the virus could spread if no actions were taken to stop transmission in the US. The models show that between 160 million and 214 million people could be infected and as many as 200,000 to 1.7 million people could die.

Even if all patients were able to receive treatment at hospitals, however, the researchers predicted that about 1.2 million people in the US could die.

But since this particular coronavirus hasn't been seen before in humans, scientists aren't certain whether it will behave the same way. Plus, it's spreading in places with high temperatures, like Australia.

A second outbreak could also arise after people resume normal activity. The US asked citizens to avoid international travel starting March 19, but opening its borders again could fuel the virus' spread. The same goes for allowing citizens to return to work or use mass transit.

"United States is no longer trustworthy. It's 50% less less trustworthy than it was when we first started a survey back in 2016," said McPhillips.

The US also came in at number 15 in citizenship, quality of life and best place to visit. It ranked 17th in greenest countries, 18th in most transparent countries, and 26th in best places to travel alone -- another safety issue.

Irrational stockpiling can also lead to price gouging, says Steven Taylor, a professor and clinical psychologist at the University of British Columbia, and the author of The Psychology of Pandemics. “If the price of a roll of toilet paper is tripled, that’s seen as a scarcer commodity to acquire, which can lead to anxiety,” he says.

Panic buying, Taylor says, is fuelled by anxiety, and a willingness to go to lengths to quell those fears: like queueing for hours or buying way more than you need. We’ve seen this before throughout history. Back in 1962 during the Cuban missile crisis, when nuclear war seemed imminent, American families filled their basements with enough canned goods and bottled water to survive an atomic blast.

“But for many people, hand-washing seems to be too ordinary. This is a dramatic event, therefore a dramatic response is required, so that leads to people throwing money at things in hopes of protecting themselves.”

“Panic is a subjective, emotional state, and mostly what we can observe is the behaviour,” says Oppenheim. “Maybe someone reads articles or a couple of tweets about supply chain disruptions in China and mask shortages in Hong Kong, and then makes a very reasoned decision to stock up on masks just in case. All we can infer from the purchasing is the timing, so it could look panicky even if it's well thought through.”

“We know that kids seek validation via the Like button. We know that it can negatively affect kids’ and teenagers’ self-esteem,” said Jim Steyer, chief executive of the nonprofit Common Sense Media. “The public is finally waking up to how many of these tactics can be manipulative.”

Instagram, the photo-sharing site owned by Facebook, also began hiding some Likes and other metrics this year as part of an experiment intended to make users feel happier about the time they spend on the platform.

This could create “a less pressurized environment where people feel comfortable expressing themselves,” Mr. Mosseri said at the time.

Experts like Paul Ehrlich argue that the population of the world has long since surpassed optimal levels, though critics counter that consumption is as important as population levels.

one-third of all people – almost 4 billion – will be African.

By that year, there will be more Nigerians than Americans.

The level of education in a society – of women in particular – is one of the most important predictors for the number of children families have.

In the pre-modern era, fertility rates of 4.5 to 7 children per woman were common. At that time, high mortality rates of young people kept population growth low.

If birthrates have fallen so far, why is the population still rising fast?

People are living longer

which means that one child in 13 die before their fifth birthday.

This compares with six for every 1,000 in Europe and northern America and four for every 1,000 in Australia and New Zealand.

A consequence of falling child mortality but continuing high fertility is a “youth bulge” – a high population of young people.

But ageing populations can be a cause for celebration. It means development has taken place.

What next?

Family planning organisations are learning that to survive political shifts and budget cuts, they need to diversify their sources of funding. This means seeing family planning as not just a public health concern but also about development and a clear return on investment.

Last week alone, though, 1.6 million people newly applied for unemployment benefits. That’s the equivalent of 2,300 Carrier plants

Somehow, for years, the four tragic deaths in Benghazi consumed the agenda of six GOP-controlled congressional committees and the programming of the most-watched cable news channel. But today, a deadly shock magnified by government ineptitude that has led to 46,000 times as many lives lost “is what it is.”

the coronavirus death toll is about 46,000 Benghazis

According to congressional investigators, Navarro negotiated a contract that resulted in the government overpaying for ventilators by $500 million. (The contract was canceled Monday.) He also championed a $765 million federal loan to Eastman Kodak to transform it into a drugmaker. (The loan has since unraveled and is the subject of a securities investigation.)

So how many taxpayer dollars was Navarro involved in wasting through these two deals alone? Measured in units that should be familiar to consumers of right-wing news, it’s roughly two Solyndras.

The debt increase under Trump during a single term is on track to surpass that under Obama across two terms.

For each Hillary Clinton private email scandal (one), there are at least eight senior Trump officials who have reportedly used private email to conduct official business

For every Obama-era incident involving supposed retaliation against political opponents, there are literally dozens of instances of Trump trying to use the power of his office to punish perceived enemie

Because of its large population, India alone accounted for an estimated 22% -- or 4.1 million -- of the global deaths. The U.S. and Russia were the next highest with 1.1 million each, followed by Mexico, Brazil and Indonesia.

In the end, the scientists estimated there was an excess of 120 deaths for every 100,000 people around the world. The study found 21 countries had estimated mortality rates higher than 300 per 100,000, led by Bolivia and Bulgaria

Places with the lowest estimated excess mortality rate were Iceland, Australia, Singapore and New Zealand.

Mask-wearing, physical distancing and other public health measures led to a decline in other communicable diseases, which reduced mortality in some countries

the prevalence of obesity and older age in a population were two of the biggest determinants of excess mortality, Murray said. 

“When inequality increases, people with high incomes don’t benefit much from their gains – many rich people are focused on those who have even more than they do, and they never feel they have enough,”

“But people who earn little really suffer from falling further behind – they feel excluded and frustrated by not being able to keep up even with people who receive average incomes.”

examined survey data of life satisfaction levels, where people rate their life satisfaction on a scale of one to 10, and linked it to Gini coefficient numbers – a measure of inequality – from 1981 to 2020.

In 1981, as the UK was gripped by a recession, life satisfaction stood at 7.7. But during the economic boom of the 1980s, inequality grew, and the research shows that the happiness figure dropped to 7.4 by 1999.

However, as measures to reduce inequality began to take effect, happiness slowly returned so that by 2018, life satisfaction stood at 7.8.

Any country that moved from the lowest quarter of countries in terms of inequality to the highest quarter saw a decrease in life satisfaction of about 0.4 on the 10-point scale, he found.

India’s life satisfaction declined from 6.7 in 1990 to 5.8 in 2006 as inequality rose. By 2012 it was still lower than in 1990, despite the country’s prolonged economic boom.

The US and Australia also both saw pronounced falls in life satisfaction, but those countries where inequality had fallen were generally happier, such as Poland, Peru, Mexico and Ukraine, before the Russian invasion.

“In some of the previous research, you see people saying ‘inequality isn’t that big a deal, so all efforts to address inequality are misguided because inequality is beneficial’.

“I think that’s misguided – inequality is generally damaging to people’s life satisfaction so we should pay attention to efforts to mitigate it,

"Go ask him what he means by 'I now know what I need to do,'" she instructed Bremmer. "If it's a matter of him picking up an automatic rifle or something, we have to intervene."

As he clarified to Bremmer, love is what he had just realised he had to do. "Love is the most important thing," he told the baffled research assistant. "Nothing matters without

When de Wit recounted this story to me nearly two years after the fact, she still could hardly believe it. "Isn't that amazing?" she said. "It's what everyone says about this damn drug, that it makes people feel love. To think that a drug could change somebody's beliefs and thoughts without any expectations – it's mind-boggling."

Over the past few years, I've been investigating the scientific research and medical potential of MDMA for a book called "I Feel Love: MDMA and the Quest for Connection in a Fractured World". I learnt how this once-vilified drug is now remerging as a therapeutic agent – a role it previously played in the 1970s and 1980s, prior to its criminalisation

He attended the notorious "Unite the Right" rally in Charlottesville and quickly rose up the ranks of his organisation, first becoming the coordinator for Illinois and then the entire Midwest. He travelled to Europe and around the US to meet other white nationalist groups, with the ultimate goal of taking the movement mainstream

some researchers have begun to wonder if it could be an effective tool for pushing people who are already somehow primed to reconsider their ideology toward a new way of seeing things

While MDMA cannot fix societal-level drivers of prejudice and disconnection, on an individual basis it can make a difference. In certain cases, the drug may even be able to help people see through the fog of discrimination and fear that divides so many of us.

in December 2021 I paid Brendan a visit

What I didn't expect was how ordinary the 31-year-old who answered the door would appear to be: blue plaid button-up shirt, neatly cropped hair, and a friendly smile.

Brendan grew up in an affluent Chicago suburb in an Irish Catholic family. He leaned liberal in high school but got sucked into white nationalism at the University of Illinois Urbana-Champaign, where he joined a fraternity mostly composed of conservative Republican men, began reading antisemitic conspiracy books, and fell down a rabbit hole of racist, sexist content online. Brendan was further emboldened by the populist rhetoric of Donald Trump during his presidential campaign. "His speech talking about Mexicans being rapists, the fixation on the border wall and deporting everyone, the Muslim ban – I didn't really get white nationalism until Trump started running for president," Brendan said.

If this comes to pass, MDMA – and other psychedelics-assisted therapy – could transform the field of mental health through widespread clinical use in the US and beyond, for addressing trauma and possibly other conditions as well, including substance use disorders, depression and eating disorders.

A group of anti-fascist activists published identifying information about him and more than 100 other people in Identity Evropa. He was immediately fired from his job and ostracised by his siblings and friends outside white nationalism.

When Brendan saw a Facebook ad in early 2020 for some sort of drug trial at the University of Chicago, he decided to apply just to have something to do and to earn a little money

At the time, Brendan was "still in the denial stage" following his identity becoming public, he said. He was racked with regret – not over his bigoted views, which he still held, but over the missteps that had landed him in this predicament.

About 30 minutes after taking the pill, he started to feel peculiar. "Wait a second – why am I doing this? Why am I thinking this way?" he began to wonder. "Why did I ever think it was okay to jeopardise relationships with just about everyone in my life?"

Just then, Bremmer came to collect Brendan to start the experiment. Brendan slid into an MRI, and Bremmer started tickling his forearm with a brush and asked him to rate how pleasant it felt. "I noticed it was making me happier – the experience of the touch," Brendan recalled. "I started progressively rating it higher and higher." As he relished in the pleasurable feeling, a single, powerful word popped into his mind: connection.

It suddenly seemed so obvious: connections with other people were all that mattered. "This is stuff you can't really put into words, but it was so profound," Brendan said. "I conceived of my relationships with other people not as distinct boundaries with distinct entities, but more as we-are-all-on

I realised I'd been fixated on stuff that doesn't really matter, and is just so messed up, and that I'd been totally missing the point. I hadn't been soaking up the joy that life has to offer."

Brendan hired a diversity, equity, and inclusion consultant to advise him, enrolled in therapy, began meditating, and started working his way through a list of educational books. S still regularly communicates with Brendan and, for his part, thinks that Brendan is serious in his efforts to change

"I think he is trying to better himself and work on himself, and I do think that experience with MDMA had an impact on him. It's been a touchstone for growth, and over time, I think, the reflection on that experience has had a greater impact on him than necessarily the experience itself."

Brendan is still struggling, though, to make the connections with others that he craves. When I visited him, he'd just spent Thanksgiving alone

He also has not completely abandoned his bigoted ideology, and is not sure that will ever be possible. "There are moments when I have racist or antisemitic thoughts, definitely," he said. "But now I can recognise that those kinds of thought patterns are harming me more than anyone else."

it's not without precedent. In the 1980s, for example, an acquaintance of early MDMA-assisted therapy practitioner Requa Greer administered the drug to a pilot who had grown up in a racist home and had inherited those views. The pilot had always accepted his bigoted way of thinking as being a normal, accurate reflection of the way things were. MDMA, however, "gave him a clear vision that unexamined racism was both wrong and mean," Greer says

Encouraging stories of seemingly spontaneous change appear to be exceptions to the norm, however, and from a neurological point of view, this makes sense

Research shows that oxytocin – one of the key hormones that MDMA triggers neurons to release – drives a "tend and defend" response across the animal kingdom. The same oxytocin that causes a mother bear to nurture her newborn, for example, also fuels her rage when she perceives a threat to her cub. In people, oxytocin likewise strengthens caregiving tendencies toward liked members of a person's in-group and strangers perceived to belong to the same group, but it increases hostility toward individuals from disliked groups

In a 2010 study published in Science, for example, men who inhaled oxytocin were three times more likely to donate money to members of their team in an economic game, as well as more likely to harshly punish competing players for not donating enough. (Read more: "The surprising downsides of empathy.")

According to research published this week in Nature by Johns Hopkins University neuroscientist Gül Dölen, MDMA and other psychedelics – including psilocybin, LSD, ketamine and ibogaine – work therapeutically by reopening a critical period in the brain. Critical periods are finite windows of impressionability that typically occur in childhood, when our brains are more malleable and primed to learn new things

Dölen and her colleagues' findings likewise indicate that, without the proper set and setting, MDMA and other psychedelics probably do not reopen critical periods, which means they will not have a spontaneous, revelatory effect for ridding someone of bigoted beliefs.

In the West, plenty of members of right-wing authoritarian political movements, including neo-Nazi groups, also have track records of taking MDMA and other psychedelics

This suggests, researchers write, that psychedelics are nonspecific, "politically pluripotent" amplifiers of whatever is going on in somebody's head, with no particular directional leaning "on the axes of conservatism-liberalism or authoritarianism-egalitarianism."

That said, a growing body of scientific evidence indicates that the human capacity for compassion, kindness, empathy, gratitude, altruism, fairness, trust, and cooperation are core features of our natures

As Emory University primatologist Frans de Waal wrote, "Empathy is the one weapon in the human repertoire that can rid us of the curse of xenophobia."

Ginsberg also envisions using the drug in workshops aimed at eliminating racism, or as a means of bringing people together from opposite sides of shared cultural histories to help heal intergenerational trauma. "I think all psychedelics have a role to play, but I think MDMA has a particularly key role because you're both expanded and present, heart-open and really able to listen in a new way," Ginsberg says. "That's something really powerful."

"If you give MDMA to hard-core haters on each side of an issue, I don't think it'll do a lot of good,"

if you start with open-minded people on both sides, then I think it can work. You can improve communications and build empathy between groups, and help people be more capable of analysing the world from a more balanced perspective rather than from fear-based, anxiety-based distrust."

In 2021, Ginsberg and Doblin were coauthors on a study investigating the possibility of using ayahuasca – a plant-based psychedelic – in group contexts to bridge divides between Palestinians and Israelis, with positive findings

"I kind of have a fantasy that maybe as we get more reacquainted with psychedelics, there could be group-based experiences that build community resiliency and are intentionally oriented toward breaking down barriers between people, having people see things from other perspectives and detribalising our society,

"But that's not going to happen on its own. It would have to be intentional, and – if it happens – it would probably take multiple generations."

Based on his experience with extremism, Brendan agreed with expert takes that no drug, on its own, will spontaneously change the minds of white supremacists or end political conflict in the US

he does think that, with the right framing and mindset, MDMA could be useful for people who are already at least somewhat open to reconsidering their ideologies, just as it was for him. "It helped me see things in a different way that no amount of therapy or antiracist literature ever would have done," he said. "I really think it was a breakthrough experience."

But one piece of advice almost no one is giving? Be lucky. Pediatrician Neil Stone says that there’s no “secret” for staying Covid-19 free because there’s just too much luck involved.

As for me, I have some data that can, to an extent, quantify and explain my own good luck in avoiding Covid so far. I’m participating in a study on immunity which allowed me to learn that my blood still carries loads of antibodies induced by my vaccine and December booster shot, and no signs of any prior infection. Not everyone’s antibodies wane at the same rate, and in some people, the antibodies don’t wane much at all. (At some point it should become routine to collect this information to help people decide whether to get additional booster shots.)

My high level of vaccine antibodies probably explains my success more than my behavior. I make some effort to avoid Covid, but have been far from perfect. And I’ve been potentially exposed at least twice: Once last December, when someone at a small holiday gathering I’d attended developed symptoms the next day, and more recently, when I shared a large indoor space with two people who later tested positive. But according to my lab work, I’ve never had even a silent infection.

It’s possible I was protected by my high antibodies, or that some quirk of air flow meant I never breathed in enough virus to get sick. Or perhaps I benefited from a different form of luck. There’s another facet to immunity called the innate immune system, which acts as a first line of defense and sometimes knocks out a virus or other pathogen before it replicates enough to elicit the production of antibodies. Good innate immunity might help explain something many of us have experienced — not getting a cold or flu even when sleeping in the same bed with the sick person through the whole illness.

Stress, diet, general health and even sunlight might all affect innate immunity. So could other factors. There’s so much we still don’t know about the immune system. And that’s one reason we talk about “luck.”

understanding how the luck works could help other people avoid Covid, whether for the first time or for the second or third time. Taking a closer look at what passed for luck helped researchers like Gary Taubes discover that public health had obesity all wrong, and the standard high carb/low fat diets were causing people to gain weight.

The Lancet and the University College London Institute for Global Health Commission called climate change the biggest threat to global health—and mental health in particular—of the 21st century (The Lancet, Vol. 373, No. 9676, 2009).

Humans have evolved to adjust to some environmental stressors, researchers have found, through allostasis, the system by which the body responds to stress.

The greater the stressors and the longer we are exposed to them, the more likely our response systems are to fail—and those stress responses may remain elevated for the rest of our lives (Crews, D. E., et al., Annals of Human Biology , Vol. 46, No. 1, 2019)

In 2017, for example, APA and ecoAmerica defined “eco-anxiety” as “a chronic fear of environmental doom” (APA and ecoAmerica, 2017).

It’s not just those directly affected by a disaster who suffer. Often, simply knowing that others are in the path of disaster can trigger anxiety or depression, says Amy Lykins, PhD, an American clinical psychologist and researcher working in Australia and in South Pacific islands such as Fiji

It is normal for people to be worried about environmental issues—it isn’t a disorder to be stressed by stressors. “We certainly don’t want to pathologize someone’s reasonable distress about climate and environmental threats,” Doherty says. “But we also don’t want to minimize issues that are causing significant impairment to a person’s life.”

According to the February 2020 APA poll, 4 in 10 people have not changed their behavior in light of climate change, but 7 in 10 say they wish they could do more, while 5 in 10 say they don’t know where to begin

Other research bears this out: Even when people are concerned about climate change and the environment, they may feel paralyzed or useless when it comes to taking action (Landry, N., et al., Journal of Environmental Psychology , Vol. 55, 2018).