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search could be – and was – personalised, because Google’s algorithms could figure out what each user was most likely to be interested in, and therefore what kinds of information would be most relevant for her or him. So, imperceptibly, but inexorably over time, we have come to live in what Eli Pariser christened a “filter bubble”.

Before the internet, our problem with information was its scarcity. Now our problem is unmanageable abundance. So now the scarce resources are attention and time, over which a vicious war has broken out between traditional media and the internet-based upstarts.

YouTube has a billion users, half of whom access it via mobile devices. The average time spent on the site is 40 minutes. Facebook now claims to have 1.65 billion monthly active users, who spend on average 50 minutes a day on its services. So if Google is an 800lb gorilla, Facebook is a megaton King Kong.

Competition for attention and time is a zero-sum game that traditional media are losing. In desperation, they are trying both to appease Facebook and to harness its hold on people’s attention

In doing so, they have entered into a truly Faustian bargain. Because while publishers can without difficulty ship their stuff to Instant Articles, they cannot control which ones Facebook users actually get to see. This is because users’ news feeds are determined by Facebook’s machine-learning algorithms that try to guess what each user would like to see (and what might dispose them to click on an advertisement).

when you ask – as Professor George Brock memorably did – whether Mark Zuckerberg and his satraps understand that they have acquired editorial responsibilities, they look blank. Facebook is not a publisher, they explain, merely a “platform”. And, besides, no humans are involved in curating users’ news feeds: it’s all done by algorithms and is therefore neutral. In other words: nothing to see here; move on.

Any algorithm that has to make choices has criteria that are specified by its designers. And those criteria are expressions of human values. Engineers may think they are “neutral”, but long experience has shown us they are babes in the woods of politics, economics and ideology.

Normal accidents, like these, occur because two or more independent failures happen and interact in unpredictable ways. After studying calamities such as the Three Mile Island meltdown, explosions at chemical plants, and ships colliding in the open sea, Perrow observed that safety mechanisms put in place to make the systems safer in fact frequently trigger the final failure.

That solution won’t work for financial markets. We need currency hedges, futures markets, and derivatives to keep our economic systems functioning. But we also have to realize tweaking the current system will not fix the problem. Most of the supposedly strong cures implemented by legislators to date, such as prohibiting bank holding companies from proprietary trading, are inadequate as well.

how do we make our markets less danger prone? A good place to start would be to reduce the excessive trading volumes that lie at the root of accidents like the Flash Freeze, Flash Cash, and Goldman debacle. There is no valid reason for high frequency trading to make up more than 50 percent of all stock trades, and there is no pressing need for some $4 trillion in daily foreign currency transactions. A Tobin tax on transactions, first suggested by Noble laureate James Tobin in 1972, of as little as 0.1 percent, would significantly reduce these volumes. Smaller transaction volumes would reduce the size of accidents and possibly their frequency.

But tinkering with the current system and looking for easy ways out, as we are now, is bound to fail. We’re in danger of letting normal accidents in the financial system become all too normal.

This is one key feature of the faith-based presidency: open dialogue, based on facts, is not seen as something of inherent value. It may, in fact, create doubt, which undercuts faith. It could result in a loss of confidence in the decision-maker and, just as important, by the decision-maker.

has spent a lot of time trying to size up the president. ''Most successful people are good at identifying, very early, their strengths and weaknesses, at knowing themselves,'' he told me not long ago. ''For most of us average Joes, that meant we've relied on strengths but had to work on our weakness -- to lift them to adequacy -- otherwise they might bring us down. I don't think the president really had to do that, because he always had someone there -- his family or friends -- to bail him out. I don't think, on balance, that has served him well for the moment he's in now as president. He never seems to have worked on his weaknesses.''

Details vary, but here's the gist of what I understand took place. George W., drunk at a party, crudely insulted a friend of his mother's. George senior and Barbara blew up. Words were exchanged along the lines of something having to be done. George senior, then the vice president, dialed up his friend, Billy Graham, who came to the compound and spent several days with George W. in probing exchanges and walks on the beach. George W. was soon born again. He stopped drinking, attended Bible study and wrestled with issues of fervent faith. A man who was lost was saved.

Rubenstein described that time to a convention of pension managers in Los Angeles last year, recalling that Malek approached him and said: ''There is a guy who would like to be on the board. He's kind of down on his luck a bit. Needs a job. . . . Needs some board positions.'' Though Rubenstein didn't think George W. Bush, then in his mid-40's, ''added much value,'' he put him on the Caterair board. ''Came to all the meetings,'' Rubenstein told the conventioneers. ''Told a lot of jokes. Not that many clean ones. And after a while I kind of said to him, after about three years: 'You know, I'm not sure this is really for you. Maybe you should do something else. Because I don't think you're adding that much value to the board. You don't know that much about the company.' He said: 'Well, I think I'm getting out of this business anyway. And I don't really like it that much. So I'm probably going to resign from the board.' And I said thanks. Didn't think I'd ever see him again.''

challenges -- from either Powell or his opposite number as the top official in domestic policy, Paul O'Neill -- were trials that Bush had less and less patience for as the months passed. He made that clear to his top lieutenants. Gradually, Bush lost what Richard Perle, who would later head a largely private-sector group under Bush called the Defense Policy Board Advisory Committee, had described as his open posture during foreign-policy tutorials prior to the 2000 campaign. (''He had the confidence to ask questions that revealed he didn't know very much,'' Perle said.) By midyear 2001, a stand-and-deliver rhythm was established. Meetings, large and small, started to take on a scripted quality.

That a deep Christian faith illuminated the personal journey of George W. Bush is common knowledge. But faith has also shaped his presidency in profound, nonreligious ways. The president has demanded unquestioning faith from his followers, his staff, his senior aides and his kindred in the Republican Party. Once he makes a decision -- often swiftly, based on a creed or moral position -- he expects complete faith in its rightness.

A cluster of particularly vivid qualities was shaping George W. Bush's White House through the summer of 2001: a disdain for contemplation or deliberation, an embrace of decisiveness, a retreat from empiricism, a sometimes bullying impatience with doubters and even friendly questioners.

By summer's end that first year, Vice President Dick Cheney had stopped talking in meetings he attended with Bush. They would talk privately, or at their weekly lunch. The president was spending a lot of time outside the White House, often at the ranch, in the presence of only the most trustworthy confidants.

''When I was first with Bush in Austin, what I saw was a self-help Methodist, very open, seeking,'' Wallis says now. ''What I started to see at this point was the man that would emerge over the next year -- a messianic American Calvinist. He doesn't want to hear from anyone who doubts him.''

, I had a meeting with a senior adviser to Bush. He expressed the White House's displeasure, and then he told me something that at the time I didn't fully comprehend -- but which I now believe gets to the very heart of the Bush presidency.

The aide said that guys like me were ''in what we call the reality-based community,'' which he defined as people who ''believe that solutions emerge from your judicious study of discernible reality.'' I nodded and murmured something about enlightenment principles and empiricism. He cut me off. ''That's not the way the world really works anymore,'' he continued. ''We're an empire now, and when we act, we create our own reality. And while you're studying that reality -- judiciously, as you will -- we'll act again, creating other new realities, which you can study too, and that's how things will sort out. We're history's actors . . . and you, all of you, will be left to just study what we do.''

''If you operate in a certain way -- by saying this is how I want to justify what I've already decided to do, and I don't care how you pull it off -- you guarantee that you'll get faulty, one-sided information,'' Paul O'Neill, who was asked to resign his post of treasury secretary in December 2002, said when we had dinner a few weeks ago. ''You don't have to issue an edict, or twist arms, or be overt.''

George W. Bush and his team have constructed a high-performance electoral engine. The soul of this new machine is the support of millions of likely voters, who judge his worth based on intangibles -- character, certainty, fortitude and godliness -- rather than on what he says or does.

In the study, the NOAA researchers argue that long-standing problems with the way temperatures are measured have masked years of sea surface warming. Once those problems are corrected for, “this hiatus or slowdown simply vanishes,” said lead study author Thomas Karl, director of NOAA's National Climatic Data Center in Asheville, N.C.

Although researchers have long known that sea surface temperatures measured by autonomous buoys run cooler than temperatures measured by ships, they have failed to account for this as they expanded their use of buoy readings over the last two decades, the study authors argued.

“The buckets, when you pull them up, tend to evaporate their water, and if they're canvas there's even more evaporation,” Karl said. “By the time people stick a thermistor in the bucket to measure temperature, it's already slightly cool.”

“If you start a short-time series on an anomalous value, you tend to get an anomalous trend,” Karl said.

A growing number of climate scientists have argued that this phenomenon, as well as other hiatus effects, are evidence of a poorly understood pattern of wind, ocean current and temperature variations that have far-reaching effects on global climate. They say the oceans have absorbed heat energy from the sun, causing Arctic ice to melt and sea levels to rise.

“One way to think about it is that global warming continued, but the oceans just juggled a bit of heat around and made the surface seem cooler for a while,” said Joshua Willis, another climate scientist at JPL.

“All of those factors are real,” Karl said. “If those factors had not occurred, the warming rate would have been even greater. … If anything we may still be underestimating the trend.” 

We are not blank slates. All humans seem to share similar sets of biases. There is such a thing as universal human nature. The trick is to understand the universals and how tightly or loosely they tie us down.

We are players in a game we don’t understand. Most of our own thinking is below awareness. Fifty years ago, people may have assumed we are captains of our own ships, but, in fact, our behavior is often aroused by context in ways we can’t see. Our biases frequently cause us to want the wrong things. Our perceptions and memories are slippery, especially about our own mental states. Our free will is bounded. We have much less control over ourselves than we thought.

They also figured out ways to navigate around our shortcomings. Kahneman champions the idea of “adversarial collaboration” — when studying something, work with people you disagree with. Tversky had a wise maxim: “Let us take what the terrain gives.” Don’t overreach. Understand what your circumstances are offer

prefer print when reading both for pleasure and for school or work.

But the real nail in the coffin for one-size-fits-all electronic reading is concentration. Over 92 percent of those I surveyed said they concentrate best when reading a hard copy. The explanation is hardly rocket science. When a digital device has an Internet connection, it’s hard to resist the temptation to jump ship: I’ll just respond to that text I heard come in, check the headlines, order those boots that are on sale.

Readers are human. If you dangle distractions in front of us (or if we know they are just a click or swipe away), it’s hard not to take the bait.

no seller can offer more than 5 percent off the cover price of new books. That means a book costs more or less the same wherever you buy it in France, even online. The Lang law was designed to make sure France continues to have lots of different books, publishers and booksellers.

Readers say they trust books far more than any other medium, including newspapers and TV.

Six of the world’s 10 biggest book-selling countries — Germany, Japan, France, Italy, Spain and South Korea — have versions of fixed book prices.

What underlies France’s book laws isn’t just an economic position — it’s also a worldview. Quite simply, the French treat books as special. Some 70 percent of French people said they read at least one book last year; the average among French readers was 15 books.

In Britain, which abandoned its own fixed-price system in the 1990s, there are fewer than 1,000 independent bookstores left. A third closed in the past nine years, as supermarkets and Amazon discounted some books by more than 50 percent.

The French government classifies books as an “essential good,” along with electricity, bread and water.

None of this is taken for granted. People here have thought for centuries about what makes a book industry vibrant, and are watching developments in Britain and America as cautionary tales. “We don’t sell potatoes,” says Mr. Moni. “There are also ideas in books. That’s what’s dangerous. Because the day that you have a large seller that sells 80 percent of books, he’s the one who will decide what’s published, or what won’t be published.

“When your computer dies, you throw it away,” says Mr. Montagne of the publishers’ association. “But you’ll remember a book 20 years later. You’ve deeply entered into a story that’s not your own. It’s forged who you are. You’ll only see later how much it has affected you. You don’t keep all books, but it’s not a market like others. The contents of a bookcase can define who you are.”

But these latest shifts challenge key infection control assumptions that go back a century, putting a lot of what went wrong last year in context

They may also signal one of the most important advancements in public health during this pandemic.

If the importance of aerosol transmission had been accepted early, we would have been told from the beginning that it was much safer outdoors, where these small particles disperse more easily, as long as you avoid close, prolonged contact with others.

We would have tried to make sure indoor spaces were well ventilated, with air filtered as necessary.

Instead of blanket rules on gatherings, we would have targeted conditions that can produce superspreading events: people in poorly ventilated indoor spaces, especially if engaged over time in activities that increase aerosol production, like shouting and singing

We would have started using masks more quickly, and we would have paid more attention to their fit, too. And we would have been less obsessed with cleaning surfaces.

The implications of this were illustrated when I visited New York City in late April — my first trip there in more than a year.

A giant digital billboard greeted me at Times Square, with the message “Protecting yourself and others from Covid-19. Guidance from the World Health Organization.”

That billboard neglected the clearest epidemiological pattern of this pandemic: The vast majority of transmission has been indoors, sometimes beyond a range of three or even six feet. The superspreading events that play a major role in driving the pandemic occur overwhelmingly, if not exclusively, indoors.

The billboard had not a word about ventilation, nothing about opening windows or moving activities outdoors, where transmission has been rare and usually only during prolonged and close contact. (Ireland recently reported 0.1 percent of Covid-19 cases were traced to outdoor transmission.)

Mary-Louise McLaws, an epidemiologist at the University of New South Wales in Sydney, Australia, and a member of the W.H.O. committees that craft infection prevention and control guidance, wanted all this examined but knew the stakes made it harder to overcome the resistance. She told The Times last year, “If we started revisiting airflow, we would have to be prepared to change a lot of what we do.” She said it was a very good idea, but she added, “It will cause an enormous shudder through the infection control society.”

In contrast, if the aerosols had been considered a major form of transmission, in addition to distancing and masks, advice would have centered on ventilation and airflow, as well as time spent indoors. Small particles can accumulate in enclosed spaces, since they can remain suspended in the air and travel along air currents. This means that indoors, three or even six feet, while helpful, is not completely protective, especially over time.

To see this misunderstanding in action, look at what’s still happening throughout the world. In India, where hospitals have run out of supplemental oxygen and people are dying in the streets, money is being spent on fleets of drones to spray anti-coronavirus disinfectant in outdoor spaces. Parks, beaches and outdoor areas keep getting closed around the world. This year and last, organizers canceled outdoor events for the National Cherry Blossom Festival in Washington, D.C. Cambodian customs officials advised spraying disinfectant outside vehicles imported from India. The examples are many.

Meanwhile, many countries allowed their indoor workplaces to open but with inadequate aerosol protections. There was no attention to ventilation, installing air filters as necessary or even opening windows when possible, more to having people just distancing three or six feet, sometimes not requiring masks beyond that distance, or spending money on hard plastic barriers, which may be useless at best

clear evidence doesn’t easily overturn tradition or overcome entrenched feelings and egos. John Snow, often credited as the first scientific epidemiologist, showed that a contaminated well was responsible for a 1854 London cholera epidemic by removing the suspected pump’s handle and documenting how the cases plummeted afterward. Many other scientists and officials wouldn’t believe him for 12 years, when the link to a water source showed up again and became harder to deny.

Along the way to modern public health shaped largely by the fight over germs, a theory of transmission promoted by the influential public health figure Charles Chapin took hold

Dr. Chapin asserted in the early 1900s that respiratory diseases were most likely spread at close range by people touching bodily fluids or ejecting respiratory droplets, and did not allow for the possibility that such close-range infection could occur by inhaling small floating particles others emitted

He was also concerned that belief in airborne transmission, which he associated with miasma theories, would make people feel helpless and drop their guard against contact transmission. This was a mistake that would haunt infection control for the next century and more.

It was in this context in early 2020 that the W.H.O. and the C.D.C. asserted that SARS-CoV-2 was transmitted primarily via these heavier, short-range droplets, and provided guidance accordingly

Amid the growing evidence, in July, hundreds of scientists signed an open letter urging the public health agencies, especially the W.H.O., to address airborne transmission of the coronavirus.

Last October, the C.D.C. published updated guidance acknowledging airborne transmission, but as a secondary route under some circumstances, until it acknowledged airborne transmission as crucial on Friday. And the W.H.O. kept inching forward in its public statements, most recently a week ago.

Linsey Marr, a professor of engineering at Virginia Tech who made important contributions to our understanding of airborne virus transmission before the pandemic, pointed to two key scientific errors — rooted in a lot of history — that explain the resistance, and also opened a fascinating sociological window into how science can get it wrong and why.

Dr. Marr said that if you inhale a particle from the air, it’s an aerosol.

biomechanically, she said, nasal transmission faces obstacles, since nostrils point downward and the physics of particles that large makes it difficult for them to move up the nose. And in lab measurements, people emit far more of the easier-to-inhale aerosols than the droplets, she said, and even the smallest particles can be virus laden, sometimes more so than the larger ones, seemingly because of how and where they are produced in the respiratory tract.

Second, she said, proximity is conducive to transmission of aerosols as well because aerosols are more concentrated near the person emitting them. In a twist of history, modern scientists have been acting like those who equated stinky air with disease, by equating close contact, a measure of distance, only with the larger droplets, a mechanism of transmission, without examination.

Since aerosols also infect at close range, measures to prevent droplet transmission — masks and distancing — can help dampen transmission for airborne diseases as well. However, this oversight led medical people to circularly assume that if such measures worked at all, droplets must have played a big role in their transmission.

Another dynamic we’ve seen is something that is not unheard-of in the history of science: setting a higher standard of proof for theories that challenge conventional wisdom than for those that support it.

Another key problem is that, understandably, we find it harder to walk things back. It is easier to keep adding exceptions and justifications to a belief than to admit that a challenger has a better explanation.

The ancients believed that all celestial objects revolved around the earth in circular orbits. When it became clear that the observed behavior of the celestial objects did not fit this assumption, those astronomers produced ever-more-complex charts by adding epicycles — intersecting arcs and circles — to fit the heavens to their beliefs.

In a contemporary example of this attitude, the initial public health report on the Mount Vernon choir case said that it may have been caused by people “sitting close to one another, sharing snacks and stacking chairs at the end of the practice,” even though almost 90 percent of the people there developed symptoms of Covid-19

So much of what we have done throughout the pandemic — the excessive hygiene theater and the failure to integrate ventilation and filters into our basic advice — has greatly hampered our response.

Some of it, like the way we underused or even shut down outdoor space, isn’t that different from the 19th-century Londoners who flushed the source of their foul air into the Thames and made the cholera epidemic worse.

Righting this ship cannot be a quiet process — updating a web page here, saying the right thing there. The proclamations that we now know are wrong were so persistent and so loud for so long.

the progress we’ve made might lead to an overhaul in our understanding of many other transmissible respiratory diseases that take a terrible toll around the world each year and could easily cause other pandemics.

So big proclamations require probably even bigger proclamations to correct, or the information void, unnecessary fears and misinformation will persist, damaging the W.H.O. now and in the future.

I’ve seen our paper used in India to try to reason through aerosol transmission and the necessary mitigations. I’ve heard of people in India closing their windows after hearing that the virus is airborne, likely because they were not being told how to respond

The W.H.O. needs to address these fears and concerns, treating it as a matter of profound change, so other public health agencies and governments, as well as ordinary people, can better adjust.

It needs to begin a campaign proportional to the importance of all this, announcing, “We’ve learned more, and here’s what’s changed, and here’s how we can make sure everyone understands how important this is.” That’s what credible leadership looks like. Otherwise, if a web page is updated in the forest without the requisite fanfare, how will it matter?

Globally, the numbers can be even worse, and the stakes often higher. “Say a person comes into the hospital in Sierra Leone with a fever and flulike symptoms,” DeRisi says. “After a few days, or a week, they die. What caused that illness? Most of the time, we never find out. Because if the cause isn’t something that we can culture and test for” — like hepatitis, or strep throat — “it basically just stays a mystery.”

It would be better, DeRisi says, to watch for rare cases of mystery illnesses in people, which often exist well before a pathogen gains traction and is able to spread.

Based on a retrospective analysis of blood samples, scientists now know that H.I.V. emerged nearly a dozen times over a century, starting in the 1920s, before it went global.

Zika was a relatively harmless illness before a single mutation, in 2013, gave the virus the ability to enter and damage brain cells.

The beauty of this approach” — running blood samples from people hospitalized all over the world through his system, known as IDseq — “is that it works even for things that we’ve never seen before, or things that we might think we’ve seen but which are actually something new.”

In this scenario, an undiscovered or completely new virus won’t trigger a match but will instead be flagged. (Even in those cases, the mystery pathogen will usually belong to a known virus family: coronaviruses, for instance, or filoviruses that cause hemorrhagic fevers like Ebola and Marburg.)

And because different types of bacteria require specific conditions in order to grow, you also need some idea of what you’re looking for in order to find it.

The same is true of genomic sequencing, which relies on “primers” designed to match different combinations of nucleotides (the building blocks of DNA and RNA).

Even looking at a slide under a microscope requires staining, which makes organisms easier to see — but the stains used to identify bacteria and parasites, for instance, aren’t the same.

The practice that DeRisi helped pioneer to skirt this problem is known as metagenomic sequencing

Unlike ordinary genomic sequencing, which tries to spell out the purified DNA of a single, known organism, metagenomic sequencing can be applied to a messy sample of just about anything — blood, mud, seawater, snot — which will often contain dozens or hundreds of different organisms, all unknown, and each with its own DNA. In order to read all the fragmented genetic material, metagenomic sequencing uses sophisticated software to stitch the pieces together by matching overlapping segments.

The assembled genomes are then compared against a vast database of all known genomic sequences — maintained by the government-run National Center for Biotechnology Information — making it possible for researchers to identify everything in the mix

Traditionally, the way that scientists have identified organisms in a sample is to culture them: Isolate a particular bacterium (or virus or parasite or fungus); grow it in a petri dish; and then examine the result under a microscope, or use genomic sequencing, to understand just what it is. But because less than 2 percent of bacteria — and even fewer viruses — can be grown in a lab, the process often reveals only a tiny fraction of what’s actually there. It’s a bit like planting 100 different kinds of seeds that you found in an old jar. One or two of those will germinate and produce a plant, but there’s no way to know what the rest might have grown into.

Such studies have revealed just how vast the microbial world is, and how little we know about it

“The selling point for researchers is: ‘Look, this technology lets you investigate what’s happening in your clinic, whether it’s kids with meningitis or something else,’” DeRisi said. “We’re not telling you what to do with it. But it’s also true that if we have enough people using this, spread out all around the world, then it does become a global network for detecting emerging pandemics

One study found more than 1,000 different kinds of viruses in a tiny amount of human stool; another found a million in a couple of pounds of marine sediment. And most were organisms that nobody had seen before.

After the Biohub opened in 2016, one of DeRisi’s goals was to turn metagenomics from a rarefied technology used by a handful of elite universities into something that researchers around the world could benefit from

metagenomics requires enormous amounts of computing power, putting it out of reach of all but the most well-funded research labs. The tool DeRisi created, IDseq, made it possible for researchers anywhere in the world to process samples through the use of a small, off-the-shelf sequencer, much like the one DeRisi had shown me in his lab, and then upload the results to the cloud for analysis.

he’s the first to make the process so accessible, even in countries where lab supplies and training are scarce. DeRisi and his team tested the chemicals used to prepare DNA for sequencing and determined that using as little as half the recommended amount often worked fine. They also 3-D print some of the labs’ tools and replacement parts, and offer ongoing training and tech support

The metagenomic analysis itself — normally the most expensive part of the process — is provided free.

But DeRisi’s main innovation has been in streamlining and simplifying the extraordinarily complex computational side of metagenomics

IDseq is also fast, capable of doing analyses in hours that would take other systems weeks.

“What IDseq really did was to marry wet-lab work — accumulating samples, processing them, running them through a sequencer — with the bioinformatic analysis,”

“Without that, what happens in a lot of places is that the researcher will be like, ‘OK, I collected the samples!’ But because they can’t analyze them, the samples end up in the freezer. The information just gets stuck there.”

Meningitis itself isn’t a disease, just a description meaning that the tissues around the brain and spinal cord have become inflamed. In the United States, bacterial infections can cause meningitis, as can enteroviruses, mumps and herpes simplex. But a high proportion of cases have, as doctors say, no known etiology: No one knows why the patient’s brain and spinal tissues are swelling.

When Saha and her team ran the mystery meningitis samples through IDseq, though, the result was surprising. Rather than revealing a bacterial cause, as expected, a third of the samples showed signs of the chikungunya virus — specifically, a neuroinvasive strain that was thought to be extremely rare. “At first we thought, It cannot be true!” Saha recalls. “But the moment Joe and I realized it was chikungunya, I went back and looked at the other 200 samples that we had collected around the same time. And we found the virus in some of those samples as well.”

Until recently, chikungunya was a comparatively rare disease, present mostly in parts of Central and East Africa. “Then it just exploded through the Caribbean and Africa and across Southeast Asia into India and Bangladesh,” DeRisi told me. In 2011, there were zero cases of chikungunya reported in Latin America. By 2014, there were a million.

Chikungunya is a mosquito-borne virus, but when DeRisi and Saha looked at the results from IDseq, they also saw something else: a primate tetraparvovirus. Primate tetraparvoviruses are almost unknown in humans, and have been found only in certain regions. Even now, DeRisi is careful to note, it’s not clear what effect the virus has on people. “Maybe it’s dangerous, maybe it isn’t,” DeRisi says. “But I’ll tell you what: It’s now on my radar.

it reveals a landscape of potentially dangerous viruses that we would otherwise never find out about. “What we’ve been missing is that there’s an entire universe of pathogens out there that are causing disease in humans,” Imam notes, “ones that we often don’t even know exist.”

“The plan was, Let’s let researchers around the world propose studies, and we’ll choose 10 of them to start,” DeRisi recalls. “We thought we’d get, like, a couple dozen proposals, and instead we got 350.”

Metagenomic sequencing is especially good at what scientists call “environmental sampling”: identifying, say, every type of bacteria present in the gut microbiome, or in a teaspoon of seawater.

“When you draw blood from someone who has a fever in Ghana, you really don’t know very much about what would normally be in their blood without fever — let alone about other kinds of contaminants in the environment. So how do you interpret the relevance of all the things you’re seeing?”

Such criticisms have led some to say that metagenomics simply isn’t suited to the infrastructure of developing countries. Along with the problem of contamination, many labs struggle to get the chemical reagents needed for sequencing, either because of the cost or because of shipping and customs holdups

we’re less likely to be caught off-guard. “With Ebola, there’s always an issue: Where’s the virus hiding before it breaks out?” DeRisi explains. “But also, once we start sampling people who are hospitalized more widely — meaning not just people in Northern California or Boston, but in Uganda, and Sierra Leone, and Indonesia — the chance of disastrous surprises will go down. We’ll start seeing what’s hidden.”

scientists have been monitoring the dwindling population of right whales in the North Atlantic.

the animals’ lengths have declined by roughly 7 percent since 1981

“We saw 5 and even 10-year-old whales that were about the size of 2-year-old whales,” Dr. Stewart said. In one case, an 11-year-old whale was the same size as a 1½-year-old whale.

Entanglement in fishing gear is an ever-present threat for the mammals and one of the primary drivers of their decline.

Whales who don’t drown or starve right away will often drag gear for several years.

“What we think is going on here is that dragging these big trailing heaps of gear is creating all this extra drag, which takes energy to pull around, and that’s energy that they would probably otherwise be devoting to growth,

​Smaller right whales are less resilient to climate change as they do not have the nutritional buffer they need to adapt during lean food years,”

the species can hardly afford declines in its birthrate.

“this population has recovered from very small numbers before, so it’s not completely grim.

“If we all were to demand these management changes of our elected officials the situation would change dramatically.”

The World Mosquito Program (WMP), a nonprofit that pioneered this technique, had run small pilot studies in Australia that suggested it could work. Utarini, who co-leads WMP Yogyakarta, has now shown conclusively that it does.

The team divided a large portion of the city into 24 zones and released Wolbachia-infected mosquitoes in half of them. Almost 10,000 volunteers helped distribute egg-filled containers to local backyards. Within a year, about 95 percent of the Aedes mosquitoes in the 12 release zones harbored Wolbachia.

Wolbachia was first discovered in 1924, in a different species of mosquito. At first, it seemed so unremarkable that scientists ignored it for decades. But starting in the 1980s, they realized that it has an extraordinary knack for spreading. It passes down mainly from insect mothers to their children, and it uses many tricks to ensure that infected individuals are better at reproducing than uninfected ones. To date, it exists in at least 40 percent of all insect species, making it one of the most successful microbes on the planet.

Carried around the world aboard slave ships, Aedes aegypti has thrived. It is now arguably the most effective human-hunter on the planet, its senses acutely attuned to the carbon dioxide in our breath, the warmth of our bodies, and the odors of our skin.

The team found that just 2.3 percent of feverish people who lived in the Wolbachia release zones had dengue, compared with 9.4 percent in the control areas. Wolbachia also seemed to work against all four dengue serotypes, and reduced the number of dengue hospitalizations by 86 percent.

Even then, these already remarkable numbers are likely to be underestimates. The mosquitoes moved around, carrying Wolbachia into the 12 control zones where no mosquitoes were released. And people also move: They might live in a Wolbachia release zone but be bitten and infected with dengue elsewhere. Both of these factors would have worked against the trial, weakening its results

The Wolbachia method does have a few limitations. The bacterium takes months to establish itself, so it can’t be “deployed to contain an outbreak today,” Vazquez-Prokopec told me. As the Yogyakarta trial showed, it works only when Wolbachia reaches a prevalence of at least 80 percent, which requires a lot of work and strong community support

The method has other benefits too. It is self-amplifying and self-perpetuating: If enough Wolbachia-infected mosquitoes are released initially, the bacterium should naturally come to dominate the local population, and stay that way. Unlike insecticides, Wolbachia isn’t toxic, it doesn’t kill beneficial insects (or even mosquitoes), and it doesn’t need to be reapplied, which makes it very cost-effective.

An analysis by Brady’s team showed that it actually saves money by preventing infections

Wolbachia also seems to work against the other diseases that Aedes aegypti carries, including Zika and yellow fever. It could transform this mosquito from one of the most dangerous species to humans into just another biting nuisance.

on these points — and for all of its virtues, buzz, spinoffs and a Pulitzer Prize — the 1619 Project has failed.

That doesn’t mean that the project seeks to erase the Declaration of Independence from history. But it does mean that it seeks to dethrone the Fourth of July by treating American history as a story of Black struggle against white supremacy — of which the Declaration is, for all of its high-flown rhetoric, supposed to be merely a part.

he deleted assertions went to the core of the project’s most controversial goal, “to reframe American history by considering what it would mean to regard 1619 as our nation’s birth year.”

She then challenged me to find any instance in which the project stated that “using 1776 as our country’s birth date is wrong,” that it “should not be taught to schoolchildren,” and that the only one “that should be taught” was 1619. “Good luck unearthing any of us arguing that,” she added.

I emailed her to ask if she could point to any instances before this controversy in which she had acknowledged that her claims about 1619 as “our true founding” had been merely metaphorical. Her answer was that the idea of treating the 1619 date metaphorically should have been so obvious that it went without saying.

“1619. It is not a year that most Americans know as a notable date in our country’s history. Those who do are at most a tiny fraction of those who can tell you that 1776 is the year of our nation’s birth. What if, however, we were to tell you that this fact, which is taught in our schools and unanimously celebrated every Fourth of July, is wrong, and that the country’s true birth date, the moment that its defining contradictions first came into the world, was in late August of 1619?”

Here is an excerpt from the introductory essay to the project by The New York Times Magazine’s editor, Jake Silverstein, as it appeared in print in August 2019 (italics added):

In his introduction, Silverstein argues that America’s “defining contradictions” were born in August 1619, when a ship carrying 20 to 30 enslaved Africans from what is present-day Angola arrived in Point Comfort, in the English colony of Virginia. And the title page of Hannah-Jones’s essay for the project insists that “our founding ideals of liberty and equality were false when they were written.”

What was surprising was that in 1776 a politically formidable “defining contradiction” — “that all men are created equal” — came into existence through the Declaration of Independence. As Abraham Lincoln wrote in 1859, that foundational document would forever serve as a “rebuke and stumbling block to the very harbingers of reappearing tyranny and oppression.”

As for the notion that the Declaration’s principles were “false” in 1776, ideals aren’t false merely because they are unrealized, much less because many of the men who championed them, and the nation they created, hypocritically failed to live up to them.

These two flaws led to a third, conceptual, error. “Out of slavery — and the anti-Black racism it required — grew nearly everything that has truly made America exceptional,” writes Silverstein.

Nearly everything? What about, say, the ideas contained by the First Amendment? Or the spirit of openness that brought millions of immigrants through places like Ellis Island? Or the enlightened worldview of the Marshall Plan and the Berlin airlift? Or the spirit of scientific genius and discovery exemplified by the polio vaccine and the moon landing?

On the opposite side of the moral ledger, to what extent does anti-Black racism figure in American disgraces such as the brutalization of Native Americans, the Chinese Exclusion Act or the internment of Japanese-Americans in World War II?

The world is complex. So are people and their motives. The job of journalism is to take account of that complexity, not simplify it out of existence through the adoption of some ideological orthodoxy.

This mistake goes far to explain the 1619 Project’s subsequent scholarly and journalistic entanglements. It should have been enough to make strong yet nuanced claims about the role of slavery and racism in American history. Instead, it issued categorical and totalizing assertions that are difficult to defend on close examination.

It should have been enough for the project to serve as curator for a range of erudite and interesting voices, with ample room for contrary takes. Instead, virtually every writer in the project seems to sing from the same song sheet, alienating other potential supporters of the project and polarizing national debate.

James McPherson, the Pulitzer Prize-winning author of “Battle Cry of Freedom” and a past president of the American Historical Association. He was withering: “Almost from the outset,” McPherson told the World Socialist Web Site, “I was disturbed by what seemed like a very unbalanced, one-sided account, which lacked context and perspective.”

In particular, McPherson objected to Hannah-Jones’s suggestion that the struggle against slavery and racism and for civil rights and democracy was, if not exclusively then mostly, a Black one. As she wrote in her essay: “The truth is that as much democracy as this nation has today, it has been borne on the backs of Black resistance.”

McPherson demurs: “From the Quakers in the 18th century, on through the abolitionists in the antebellum, to the Radical Republicans in the Civil War and Reconstruction, to the N.A.A.C.P., which was an interracial organization founded in 1909, down through the civil rights movements of the 1950s and 1960s, there have been a lot of whites who have fought against slavery and racial discrimination, and against racism,” he said. “And that’s what’s missing from this perspective.”

Wilentz’s catalog of the project’s mistakes is extensive. Hannah-Jones’s essay claimed that by 1776 Britain was “deeply conflicted” over its role in slavery. But despite the landmark Somerset v. Stewart court ruling in 1772, which held that slavery was not supported by English common law, it remained deeply embedded in the practices of the British Empire. The essay claimed that, among Londoners, “there were growing calls to abolish the slave trade” by 1776. But the movement to abolish the British slave trade only began about a decade later — inspired, in part, Wilentz notes, by American antislavery agitation that had started in the 1760s and 1770s.

ie M. Harris, an expert on pre-Civil War African-American life and slavery. “On Aug. 19 of last year,” Harris wrote, “I listened in stunned silence as Nikole Hannah-Jones … repeated an idea that I had vigorously argued against with her fact checker: that the patriots fought the American Revolution in large part to preserve slavery in North America.”

The larger problem is that The Times’s editors, however much background reading they might have done, are not in a position to adjudicate historical disputes. That should have been an additional reason for the 1619 Project to seek input from, and include contributions by, an intellectually diverse range of scholarly voices. Yet not only does the project choose a side, it also brooks no doubt.

“It is finally time to tell our story truthfully,” the magazine declares on its 1619 cover page. Finally? Truthfully? Is The Times suggesting that distinguished historians, like the ones who have seriously disputed aspects of the project, had previously been telling half-truths or falsehoods?

unlike other dates, 1776 uniquely marries letter and spirit, politics and principle: The declaration that something new is born, combined with the expression of an ideal that — because we continue to believe in it even as we struggle to live up to it — binds us to the date.

On the other, the 1619 Project has become, partly by its design and partly because of avoidable mistakes, a focal point of the kind of intense national debate that columnists are supposed to cover, and that is being widely written about outside The Times. To avoid writing about it on account of the first scruple is to be derelict in our responsibility toward the second.

None of that is true. This week, Facebook rushed to deny a report in Gizmodo that said the team in charge of its “trending” news list routinely suppressed conservative points of view. Last month, Gizmodo also reported that Facebook employees asked Mark Zuckerberg, the social network’s chief executive, if the company had a responsibility to “help prevent President Trump in 2017.” Facebook denied it would ever try to manipulate elections.

Even if you believe that Facebook isn’t monkeying with the trending list or actively trying to swing the vote, the reports serve as timely reminders of the ever-increasing potential dangers of Facebook’s hold on the news.

The question isn’t whether Facebook has outsize power to shape the world — of course it does, and of course you should worry about that power. If it wanted to, Facebook could try to sway elections, favor certain policies, or just make you feel a certain way about the world, as it once proved it could do in an experiment devised to measure how emotions spread online.

There is no evidence Facebook is doing anything so alarming now. The danger is nevertheless real. The biggest worry is that Facebook doesn’t seem to recognize its own power, and doesn’t think of itself as a news organization with a well-developed sense of institutional ethics and responsibility, or even a potential for bias. Neither does its audience, which might believe that Facebook is immune to bias because it is run by computers.

That myth should die. It’s true that beyond the Trending box, most of the stories Facebook presents to you are selected by its algorithms, but those algorithms are as infused with bias as any other human editorial decision.

“With Facebook, humans are never not involved. Humans are in every step of the process — in terms of what we’re clicking on, who’s shifting the algorithms behind the scenes, what kind of user testing is being done, and the initial training data provided by humans.”Everything you see on Facebook is therefore the product of these people’s expertise and considered judgment, as well as their conscious and unconscious biases apart from possible malfeasance or potential corruption. It’s often hard to know which, because Facebook’s editorial sensibilities are secret. So are its personalities: Most of the engineers, designers and others who decide what people see on Facebook will remain forever unknown to its audience.

Facebook also has an unmistakable corporate ethos and point of view. The company is staffed mostly by wealthy coastal Americans who tend to support Democrats, and it is wholly controlled by a young billionaire who has expressed policy preferences that many people find objectionable.

You could argue that none of this is unusual. Many large media outlets are powerful, somewhat opaque, operated for profit, and controlled by wealthy people who aren’t shy about their policy agendas — Bloomberg News, The Washington Post, Fox News and The New York Times, to name a few.But there are some reasons to be even more wary of Facebook’s bias. One is institutional. Many mainstream outlets have a rigorous set of rules and norms about what’s acceptable and what’s not in the news business.

Those algorithms could have profound implications for society. For instance, one persistent worry about algorithmic-selected news is that it might reinforce people’s previously held points of view. If News Feed shows news that we’re each likely to Like, it could trap us into echo chambers and contribute to rising political polarization. In a study last year, Facebook’s scientists asserted the echo chamber effect was muted.

are Facebook’s engineering decisions subject to ethical review? Nobody knows.

The other reason to be wary of Facebook’s bias has to do with sheer size. Ms. Caplan notes that when studying bias in traditional media, scholars try to make comparisons across different news outlets. To determine if The Times is ignoring a certain story unfairly, look at competitors like The Washington Post and The Wall Street Journal. If those outlets are covering a story and The Times isn’t, there could be something amiss about the Times’s news judgment.Such comparative studies are nearly impossible for Facebook. Facebook is personalized, in that what you see on your News Feed is different from what I see on mine, so the only entity in a position to look for systemic bias across all of Facebook is Facebook itself. Even if you could determine the spread of stories across all of Facebook’s readers, what would you compare it to?

He said more than 200 people were receiving treatment at the Bhayangkara police hospital and several others in Mamuju alone. Another 630 were injured in Majene.

The quake set off landslides in three locations and blocked a main road connecting Mamuju to Majene. Power and phone lines were down in many areas.

A governor office building was almost flattened by the quake and a shopping mall was reduced to a crumpled hulk.

Two ships headed to the devastated areas from the nearby cities of Makassar and Balikpapan with rescuers and equipment, including excavators.

The pope was praying for “the repose of the deceased, the healing of the injured and the consolation of all who grieve.” Francis also offered encouragement to those continuing search and rescue effects, and he invoked “the divine blessings of strength and hope.”

Indonesia, home to more than 260 million people, is frequently hit by earthquakes, volcanic eruptions and tsunamis because of its location on the “Ring of Fire,” an arc of volcanoes and fault lines in the Pacific Basin.

I’d non-defensively ask them, ‘Do you know how Google works?’ ‘What do you think my news feed looks like? Do you know why yours looks that way?’”

I would expect the following to happen.’ I

cognitive dissonance.

is to acknowledge that some conspiracies do exist — Watergate, the Catholic Church’s sexual abuse scandals, the billionaire Jeffrey Epstein’s network of underage sexual abuse.

And if people better understood the mechanisms and the economics, maybe then you can talk about the content.”

Witnesses come forward, then victims. And journalists circle like sharks to get the story. I try to get them to think about concrete things and logistical details, including the bureaucracy that’s required to maintain these vast alleged plots.”

“Sometimes it’s about turning the ‘do your research’ paradigm back on them,” he said. “I never appeal to authorities like the government or mainstream media, but I subtly imply that what they’re saying doesn’t match the historical record, which works better than outright dismissing them.”

Unfortunately, social platforms are often the worst forum for talking about these thorny issues. In many cases, a face-to-face conversation is a better place to voice your concerns.

They can also allow participants to pick up on subtle facial and body language expressions — or tone of voice — that may dissolve tensions.

“There it is. Biden’s wearing a wire.” It’s actually just a crease in his shirt. And a popular meme among teens was the claim that Wayfair is shipping children in industrial-grade cabinets.

The main gist of QAnon is that elite satanic pedophiles are everywhere and they’re coming to get your kids. More specifically, pedophiles are everywhere among liberals, celebrities, and the media.

“Q is the best thing that has ever happened to me.” There are now 87 QAnon supporters who have run for Congress, and the first will be elected this November. “I think it’s something worth listening to and paying attention to.” And Trump refuses to push back against QAnon because QAnon loves Trump.

One of the major reasons QAnon is on the rise right now is because when the world is scary and uncertain, we are drawn to magical thinking.

In this way, blockchain resembles another buzzword, “the cloud.” While detractors argued that the cloud was just “someone else’s computer,”