How the Brain Deletes Old Memories | Science | AAAS - 0 views
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Although the precise role of neurogenesis in memory is still controversial, more than a decade of research has demonstrated that boosting neurogenesis with exercise and antidepressants such as Prozac can increase rodents' ability to learn new information about places and events. A few years ago, however, neuroscientist Paul Frankland of the Hospital for Sick Children in Toronto, Canada, noticed that some of the animals in his experiment actually did worse on certain memory tasks when their neuron birth rates had been ramped up. In particular, they performed poorly on tests that required them to retain details about past events.
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It is difficult to completely eliminate the birth of new neurons in infant mice, but by genetically engineering dividing neural stem cells to self-destruct the team was able to achieve about a 50% reduction of neurogenesis in the animals, Frankland says. With less neurogenesis, the young rodents acted more like adult mice in the experiment. They froze when first placed in the box for roughly a week, rather than just 1 day, after receiving the foot shocks.