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The World Mosquito Program (WMP), a nonprofit that pioneered this technique, had run small pilot studies in Australia that suggested it could work. Utarini, who co-leads WMP Yogyakarta, has now shown conclusively that it does.

Carried around the world aboard slave ships, Aedes aegypti has thrived. It is now arguably the most effective human-hunter on the planet, its senses acutely attuned to the carbon dioxide in our breath, the warmth of our bodies, and the odors of our skin.

Wolbachia was first discovered in 1924, in a different species of mosquito. At first, it seemed so unremarkable that scientists ignored it for decades. But starting in the 1980s, they realized that it has an extraordinary knack for spreading. It passes down mainly from insect mothers to their children, and it uses many tricks to ensure that infected individuals are better at reproducing than uninfected ones. To date, it exists in at least 40 percent of all insect species, making it one of the most successful microbes on the planet.

The team divided a large portion of the city into 24 zones and released Wolbachia-infected mosquitoes in half of them. Almost 10,000 volunteers helped distribute egg-filled containers to local backyards. Within a year, about 95 percent of the Aedes mosquitoes in the 12 release zones harbored Wolbachia.

The team found that just 2.3 percent of feverish people who lived in the Wolbachia release zones had dengue, compared with 9.4 percent in the control areas. Wolbachia also seemed to work against all four dengue serotypes, and reduced the number of dengue hospitalizations by 86 percent.

Even then, these already remarkable numbers are likely to be underestimates. The mosquitoes moved around, carrying Wolbachia into the 12 control zones where no mosquitoes were released. And people also move: They might live in a Wolbachia release zone but be bitten and infected with dengue elsewhere. Both of these factors would have worked against the trial, weakening its results

The Wolbachia method does have a few limitations. The bacterium takes months to establish itself, so it can’t be “deployed to contain an outbreak today,” Vazquez-Prokopec told me. As the Yogyakarta trial showed, it works only when Wolbachia reaches a prevalence of at least 80 percent, which requires a lot of work and strong community support

The method has other benefits too. It is self-amplifying and self-perpetuating: If enough Wolbachia-infected mosquitoes are released initially, the bacterium should naturally come to dominate the local population, and stay that way. Unlike insecticides, Wolbachia isn’t toxic, it doesn’t kill beneficial insects (or even mosquitoes), and it doesn’t need to be reapplied, which makes it very cost-effective.

An analysis by Brady’s team showed that it actually saves money by preventing infections

Wolbachia also seems to work against the other diseases that Aedes aegypti carries, including Zika and yellow fever. It could transform this mosquito from one of the most dangerous species to humans into just another biting nuisance.

Long before scientists were studying the properties of neurons, artists had devised a series of techniques to deceive the brain into thinking that a flat canvas was three-dimensional or that a series of brushstrokes was indeed a still life.

Visual illusions are defined by the dissociation between the physical reality and the subjective perception of an object or event.

Brightness, color, shading, eye movement and other factors can have powerful effects on what we “see.”

Recreating these and other features without LCDM’s titular ingredient, Spergel showed, requires the finest of theoretical needle threading. “We haven’t disproven the existence of all these [modified-gravity theories],” he says. “But any alternative theory has to jump through these hoops.”

Złosnik and Skordis believe they’ve done just that—although in a way that might surprise MOND skeptics and fans alike. They managed to construct a theory of gravity that contains an ingredient that acts exactly like an invisible form of matter on cosmic scales, blurring the line between the dark matter and MOND paradigms.

Their theory, dubbed RelMOND, adds to the equations of general relativity an omnipresent field that behaves differently in different arenas. On the grandest scales, where the universe noticeably stretches as it expands, the field acts like invisible matter. In this mode, which Złosnik calls “dark dust,” the field could have shaped the visible universe just as dark matter would

RelMOND “cannot do worse than LCDM,” says Złosnik, who notes that it very closely mimics that theory for the universe as a whole.

But if we zoom in on a galaxy, where the fabric of space holds rather still, the field acts in a way that’s true to its MOND roots: It entwines itself with the standard gravitational field, beefing it up just enough to hold a galaxy together without extra matter

(The researchers aren’t yet sure how the field acts for larger clusters of galaxies, a perennial MOND sore spot. They suggest that this intermediate scale might be a good place to look for observational clues that could set the theory apart.)

Despite this mathematical achievement by Złosnik and Skordis, dark matter remains the simpler theory. Constructing the new field takes four new moving mathematical parts, while LCDM handles dark matter with just one. Hooper likens the situation to a detective debating whether a person at a murder scene is the murderer or has been framed by the CIA. Even if the available evidence matches both theories, one requires less of a leap.

I don’t know if that sounds too complicated. But the point is, it’s not just giving up domination. It’s giving up this sense of separateness in favor of a sense of kinship. And those people who do often wonder how they failed to see how much continuity there is in the more-than-human world with the human world.

to go from terror into being and into that sense that the experiment is sacred, not this one outcome of the experiment, is to immediately transform the way that you think even about very fundamental social and economic and cultural things. If the experiment is sacred, how can we possibly justify our food systems, for instance?

when I first went to the Smokies and hiked up into the old growth in the Southern Appalachians, it was like somebody threw a switch. There was some odd filter that had just been removed, and the world sounded different and smelled different.

richard powersYeah. In human exceptionalism, we may be completely aware of evolutionary continuity. We may understand that we have a literal kinship with the rest of creation, that all life on Earth employs the same genetic code, that there is a very small core of core genes and core proteins that is shared across all the kingdoms and phyla of life. But conceptually, we still have this demented idea that somehow consciousness creates a sanctity and a separation that almost nullifies the continuous elements of evolution and biology that we’ve come to understand.

if we want to begin this process of rehabilitation and transformation of consciousness that we are going to need in order to become part of the living Earth, it is going to be other kinds of minds that give us that clarity and strength and diversity and alternative way of thinking that could free us from this stranglehold of thought that looks only to the maximizing return on investment in very leverageable ways.

richard powersIt amazed me to get to the end of the first draft of “Bewilderment” and to realize how much Buddhism was in the book, from the simplest things.

I think there is nothing more science inflected than being out in the living world and the more-than-human world and trying to understand what’s happening.

And of course, we can combine this with what we were talking about earlier with death. If we see all of evolution as somehow leading up to us, all of human, cultural evolution leading up to neoliberalism and here we are just busily trying to accumulate and make meaning for ourselves, death becomes the enemy.

And you’re making the point in different ways throughout the book that it is the minds we think of as unusual, that we would diagnose as having some kind of problem or dysfunction that are, in some cases, are the only ones responding to the moment in the most common sense way it deserves. It is almost everybody else’s brain that has been broken.

it isn’t surprising. If you think of the characteristics of this dominant culture that we’ve been talking about — the fixation on control, the fixation on mastery, the fixation on management and accumulation and the resistance of decay — it isn’t surprising that that culture is also threatened by difference and divergence. It seeks out old, stable hierarchies — clear hierarchies — of control, and anything that’s not quite exploitable or leverageable in the way that the normal is terrifying and threatening.

And the more I looked for it, the more it pervaded the book.

ezra kleinI’ve heard you say that it has changed the way you measure a good day. Can you tell me about that?richard powersThat’s true.I suppose when I was still enthralled to commodity-mediated individualist market-driven human exceptionalism — we need a single word for this

And since moving to the Smokies and since publishing “The Overstory,” my days have been entirely inverted. I wake up, I go to the window, and I look outside. Or I step out onto the deck — if I haven’t been sleeping on the deck, which I try to do as much as I can in the course of the year — and see what’s in the air, gauge the temperature and the humidity and the wind and see what season it is and ask myself, you know, what’s happening out there now at 1,700 feet or 4,000 feet or 5,000 feet.

let me talk specifically about the work of a scientist who has herself just recently published a book. It’s Dr. Suzanne Simard, and the book is “Finding the Mother Tree.” Simard has been instrumental in a revolution in our way of thinking about what’s happening underground at the root level in a forest.

it was a moving moment for me, as an easterner, to stand up there and to say, this is what an eastern forest looks like. This is what a healthy, fully-functioning forest looks like. And I’m 56 years old, and I’d never seen it.

the other topics of that culture tend to circle back around these sorts of trends, human fascinations, ways of magnifying our throw weight and our ability and removing the last constraints to our desires and, in particular, to eliminate the single greatest enemy of meaning in the culture of the technological sublime that is, itself, such a strong instance of the culture of human separatism and commodity-mediated individualist capitalism— that is to say, the removal of death.

Why is it that we have known about the crisis of species extinction for at least half a century and longer? And I mean the lay public, not just scientists. But why has this been general knowledge for a long time without public will demanding some kind of action or change

And when you make kinship beyond yourself, your sense of meaning gravitates outwards into that reciprocal relationship, into that interdependence. And you know, it’s a little bit like scales falling off your eyes. When you do turn that corner, all of the sources of anxiety that are so present and so deeply internalized become much more identifiable. And my own sense of hope and fear gets a much larger frame of reference to operate in.

I think, for most of my life, until I did kind of wake up to forests and to trees, I shared — without really understanding this as a kind of concession or a kind of subscription — I did share this cultural consensus that meaning is a private thing that we do for ourselves and by ourselves and that our kind of general sense of the discoveries of the 19th and 20th century have left us feeling a bit unsponsored and adrift beyond the accident of human existence.

The largest single influence on any human being’s mode of thought is other human beings. So if you are surrounded by lots of terrified but wishful-thinking people who want to believe that somehow the cavalry is going to come at the last minute and that we don’t really have to look inwards and change our belief in where meaning comes from, that we will somehow be able to get over the finish line with all our stuff and that we’ll avert this disaster, as we have other kinds of disasters in the past.

I think what was happening to me at that time, as I was turning outward and starting to take the non-human world seriously, is my sense of meaning was shifting from something that was entirely about me and authored by me outward into this more collaborative, reciprocal, interdependent, exterior place that involved not just me but all of these other ways of being that I could make kinship with.

And I think I was right along with that sense that somehow we are a thing apart. We can make purpose and make meaning completely arbitrarily. It consists mostly of trying to be more in yourself, of accumulating in one form or another.

I can’t really be out for more than two or three miles before my head just fills with associations and ideas and scenes and character sketches. And I usually have to rush back home to keep it all in my head long enough to get it down on paper.

for my journey, the way to characterize this transition is from being fascinated with technologies of mastery and control and what they’re doing to us as human beings, how they’re changing what the capacities and affordances of humanity are and how we narrate ourselves, to being fascinated with technologies and sciences of interdependence and cooperation, of those sciences that increase our sense of kinship and being one of many, many neighbors.

And that’s an almost impossible persuasion to rouse yourself from if you don’t have allies. And I think the one hopeful thing about the present is the number of people trying to challenge that consensual understanding and break away into a new way of looking at human standing is growing.

And when you do subscribe to a culture like that and you are confronted with the reality of your own mortality, as I was when I was living in Stanford, that sense of stockpiling personal meaning starts to feel a little bit pointless.

And I just head out. I head out based on what the day has to offer. And to have that come first has really changed not only how I write, but what I’ve been writing. And I think it really shows in “Bewilderment.” It’s a totally different kind of book from my previous 12.

the marvelous thing about the work, which continues to get more sophisticated and continues to turn up newer and newer astonishments, is that there was odd kind of reciprocal interdependence and cooperation across the species barrier, that Douglas firs and birches were actually involved in these sharing back and forth of essential nutrients. And that’s a whole new way of looking at forest.

she began to see that the forests were actually wired up in very complex and identifiable ways and that there was an enormous system of resource sharing going on underground, that trees were sharing not only sugars and the hydrocarbons necessary for survival, but also secondary metabolites. And these were being passed back and forth, both symbiotically between the trees and the fungi, but also across the network to other trees so that there were actually trees in wired up, fungally-connected forests where large, dominant, healthy trees were subsidizing, as it were, trees that were injured or not in favorable positions or damaged in some way or just failing to thrive.

so when I was still pretty much a card-carrying member of that culture, I had this sense that to become a better person and to get ahead and to really make more of myself, I had to be as productive as possible. And that meant waking up every morning and getting 1,000 words that I was proud of. And it’s interesting that I would even settle on a quantitative target. That’s very typical for that kind of mindset that I’m talking about — 1,000 words and then you’re free, and then you can do what you want with the day.

there will be a threshold, as there have been for these other great social transformations that we’ve witnessed in the last couple of decades where somehow it goes from an outsider position to absolutely mainstream and common sense.

I am persuaded by those scholars who have showed the degree to which the concept of nature is itself an artificial construction that’s born of cultures of human separatism. I believe that everything that life does is part of the living enterprise, and that includes the construction of cities. And there is no question at all the warning that you just gave about nostalgia creating a false binary between the built world and the true natural world is itself a form of cultural isolation.

Religion is a technology to discipline, to discipline certain parts of the human impulse. A lot of the book revolves around the decoded neurofeedback machine, which is a very real literalization of a technology, of changing the way we think

one of the things I think that we have to take seriously is that we have created technologies to supercharge some parts of our natural impulse, the capitalism I think should be understood as a technology to supercharge the growth impulse, and it creates some wonders out of that and some horrors out of that.

richard powersSure. I base my machine on existing technology. Decoded neurofeedback is a kind of nascent field of exploration. You can read about it; it’s been publishing results for a decade. I first came across it in 2013. It involves using fMRI to record the brain activity of a human being who is learning a process, interacting with an object or engaged in a certain emotional state. That neural activity is recorded and stored as a data structure. A second subsequent human being is then also scanned in real time and fed kinds of feedback based on their own internal neural activity as determined by a kind of software analysis of their fMRI data structures.

And they are queued little by little to approximate, to learn how to approximate, the recorded states of the original subject. When I first read about this, I did get a little bit of a revelation. I did feel my skin pucker and think, if pushed far enough, this would be something like a telepathy conduit. It would be a first big step in answering that age-old question of what does it feel like to be something other than we are

in the book I simply take that basic concept and extend it, juke it up a little bit, blur the line between what the reader might think is possible right now and what they might wonder about, and maybe even introduce possibilities for this empathetic transference

ezra kleinOne thing I loved about the role this played in the book is that it’s highlighting its inverse. So a reader might look at this and say, wow, wouldn’t that be cool if we had a machine that could in real time change how we think and change our neural pathways and change our mental state in a particular direction? But of course, all of society is that machine,

Robin and Theo are in an airport. And you’ve got TVs everywhere playing the news which is to say playing a constant loop of outrage, and disaster, and calamity. And Robbie, who’s going through these neural feedback sessions during this period, turns to his dad and says, “Dad, you know how the training’s rewiring my brain? This is what is rewiring everybody else.”

ezra kleinI think Marshall McLuhan knew it all. I really do. Not exactly what it would look like, but his view and Postman’s view that we are creating a digital global nervous system is a way they put it, it was exactly right. A nervous system, it was such the exact right metaphor.

the great insight of McLuhan, to me, what now gets called the medium is the message is this idea that the way media acts upon us is not in the content it delivers. The point of Twitter is not the link that you click or even the tweet that you read; it is that the nature and structure of the Twitter system itself begins to act on your system, and you become more like it.If you watch a lot of TV, you become more like TV. If you watch a lot of Twitter, you become more like Twitter, Facebook more like Facebook. Your identities become more important to you — that the content is distraction from the medium, and the medium changes you

it is happening to all of us in ways that at least we are not engaging in intentionally, not at that level of how do we want to be transformed.

richard powersI believe that the digital neural system is now so comprehensive that the idea that you could escape it somewhere, certainly not in the Smokies, even more remotely, I think, becomes more and more laughable. Yeah, and to build on this idea of the medium being the message, not the way in which we become more like the forms and affordances of the medium is that we begin to expect that those affordances, the method in which those media are used, the physiological dependencies and castes of behavior and thought that are required to operate them and interact with them are actual — that they’re real somehow, and that we just take them into human nature and say no, this is what we’ve always wanted and we’ve simply been able to become more like our true selves.

Well, the warpage in our sense of time, the warpage in our sense of place, are profound. The ways in which digital feedback and the affordances of social media and all the rest have changed our expectations with regard to what we need to concentrate on, what we need to learn for ourselves, are changing profoundly.

If you look far enough back, you can find Socrates expressing great anxiety and suspicion about the ways in which writing is going to transform the human brain and human expectation. He was worried that somehow it was going to ruin our memories. Well, it did up to a point — nothing like the way the digital technologies have ruined our memories.

my tradition is Jewish, the Sabbath is a technology, is a technology to create a different relationship between the human being, and time, and growth, and productive society than you would have without the Sabbath which is framed in terms of godliness but is also a way of creating separation from the other impulses of the weak.

Governments are a technology, monogamy is a technology, a religiously driven technology, but now one that is culturally driven. And these things do good and they do bad. I’m not making an argument for any one of them in particular. But the idea that we would need to invent something wholly new to come up with a way to change the way human beings act is ridiculous

My view of the story of this era is that capitalism was one of many forces, and it has become, in many societies, functionally the only one that it was in relationship with religion, it was in relationship with more rooted communities.

it has become not just an economic system but a belief system, and it’s a little bit untrammeled. I’m not an anti-capitalist person, but I believe it needs countervailing forces. And my basic view is that it doesn’t have them anymore.

the book does introduce this kind of fable, this kind of thought experiment about the way the affordances that a new and slightly stronger technology of empathy might deflect. First of all, the story of a little boy and then the story of his father who’s scrambling to be a responsible single parent. And then, beyond that, the community of people who hear about this boy and become fascinated with him as a narrative, which again ripples outward through these digital technologies in ways that can’t be controlled or whose consequences can be foreseen.

I’ve talked about it before is something I’ve said is that I think a push against, functionally, materialism and want is an important weight in our society that we need. And when people say it is the way we’ll deal with climate change in the three to five year time frame, I become much more skeptical because to the point of things like the technology you have in the book with neural feedback, I do think one of the questions you have to ask is, socially and culturally, how do you move people’s minds so you can then move their politics?

You’re going to need something, it seems to me, outside of politics, that changes humans’ sense of themselves more fundamentally. And that takes a minute at the scale of billions.

richard powersWell, you are correct. And I don’t think it’s giving away any great reveal in the book to say that a reader who gets far enough into the story probably has this moment of recursive awareness where they, he or she comes to understand that what Robin is doing in this gradual training on the cast of mind of some other person is precisely what they’re doing in the act of reading the novel “Bewilderment” — by living this act of active empathy for these two characters, they are undergoing their own kind of neurofeedback.

The more we understand about the complexities of living systems, of organisms and the evolution of organisms, the more capable it is to feel a kind of spiritual awe. And that certainly makes it easier to have reverence for the experiment beyond me and beyond my species. I don’t think those are incommensurable or incompatible ways of knowing the world. In fact, I think to invoke one last time that Buddhist precept of interbeing, I think there is a kind of interbeing between the desire, the true selfless desire to understand the world out there through presence, care, measurement, attention, reproduction of experiment and the desire to have a spiritual affinity and shared fate with the world out there. They’re really the same project.

richard powersWell, sure. If we turn back to the new forestry again and researchers like Suzanne Simard who were showing the literal interconnectivity across species boundaries and the cooperation of resource sharing between different species in a forest, that is rigorous science, rigorous reproducible science. And it does participate in that central principle of practice, or collection of practices, which always requires the renunciation of personal wish and ego and prior belief in favor of empirical reproduction.

I’ve begun to see people beginning to build out of the humbling sciences a worldview that seems quite spiritual. And as you’re somebody who seems to me to have done that and it has changed your life, would you reflect on that a bit?

So much of the book is about the possibility of life beyond Earth. Tell me a bit about the role that’s playing. Why did you make the possibility of alien life in the way it might look and feel and evolve and act so central in a book about protecting and cherishing life here?

richard powersI’m glad that we’re slipping this in at the end because yes this framing of the book around this question of are we alone or does the universe want life it’s really important. Theo, Robin’s father, is an astrobiologist.

Imagine that everything happens just right so that every square inch of this place is colonized by new forms of experiments, new kinds of life. And the father trying to entertain his son with the story of this remarkable place in the sun just stopping him and saying, Dad, come on, that’s asking too much. Get real, that’s science fiction. That’s the vision that I had when I finished the book, an absolutely limitless sense of just how lucky we’ve had it here.

one thing I kept thinking about that didn’t make it into the final book but exists as a kind of parallel story in my own head is the father and son on some very distant planet in some very distant star, many light years from here, playing that same game. And the father saying, OK, now imagine a world that’s just the right size, and it has plate tectonics, and it has water, and it has a nearby moon to stabilize its rotation, and it has incredible security and safety from asteroids because of other large planets in the solar system.

they make this journey across the universe through all kinds of incubators, all kinds of petri dishes for life and the possibilities of life. And rather than answer the question — so where is everybody? — it keeps deferring the question, it keeps making that question more subtle and stranger

For the purposes of the book, Robin, who desperately believes in the sanctity of life beyond himself, begs his father for these nighttime, bedtime stories, and Theo gives him easy travel to other planets. Father and son going to a new planet based on the kinds of planets that Theo’s science is turning up and asking this question, what would life look like if it was able to get started here?

I don’t think these tools will ever render learning foreign languages completely obsolete. Real conversation in the flowing nuances of casual speech cannot be rendered by a program, at least not in a way that would convey full humanity.

even if it may fail at genuine, nuanced conversation — for now, at least — technology is eliminating most of the need to learn foreign languages for more utilitarian purposes.

The old-school language textbook scenarios, of people reserving hotel rooms or ordering meals in the language of the country they are visiting — “Greetings. Please bring me a glass of lemonade and a sandwich!” — will now be obsolete

to actively enjoy piecing together how other languages work is an individual quirk, not a human universal

Obsessive language learners have come to call themselves the polyglot community over the past couple of decades, and I am one of them, to an extent. As such, I know well how hard it can be to recognize that most human beings are numb to this peculiar desire.

Most human beings are interested much less in how they are saying things, and which language they are saying them in, than in what they are saying.

Learning to express this what — beyond the very basics — in another language is hard. It can be especially hard for us Anglophones, as speaking English works at least decently in so many places

To polyglots, foreign languages are Mount Everests daring us to climb them — a metaphor used by Hofstadter in his article. But to most people, they are just a barrier to get to the other side of.

After all, despite the sincere and admirable efforts of foreign language teachers nationwide, fewer than one in 100 American students become proficient in a language they learned in school.

Because I love trying to learn languages and am endlessly fascinated by their varieties and complexities, I am working hard to wrap my head around this new reality. With an iPhone handy and an appropriate app downloaded, foreign languages will no longer present most people with the barrier or challenge they once did

Learning to genuinely speak a new language will hardly be unknown. It will continue to beckon, for instance, for those actually relocating to a new country. And it will persist with people who want to engage with literature or media in the original language, as well as those of us who find pleasure in mastering these new codes just because they are “there.”

In other words, it will likely become an artisanal pursuit, of interest to a much smaller but more committed set of enthusiasts. And weird as that is, it is in its way a kind of progress.

Discokeryx xiezhi was an early relative of today’s giraffes, but more like a cousin and not a direct ancestor.

“To the best of our knowledge, D. xiezhi exhibits the most optimized head-butting adaptation in vertebrate evolution,” the researchers write in the paper.

The discovery of Discokeryx xiezhi suggests this fighting style and competition for mates may be a contributing factor in their long-neck evolution.

“In reality, it was likely a combination of natural selection ... for a particular dietary preference and sexual selection in that lineage that drove the evolution of modern giraffe necks and limbs,” Advait Jukar, a paleobiologist at Yale University who was not involved in the study tells Scientific American’s Rachel Nuwer.

Haunting von Neumann’s thought experiment is the specter of a construct that, in its very internal perfection, lacks the element that would account for itself as a construct. “If someone succeeded in creating a formal system of axioms that was free of all internal paradoxes and contradictions,” another of von Neumann’s interlocutors, the logician Kurt Gödel, explains, “it would always be incomplete, because it would contain truths and statements that — while being undeniably true — could never be proven within the laws of that system.”

its deeper (and, for me, more compelling) theme: the relation between reason and madness.

Almost all the scientists populating the book are mad, their desire “to understand, to grasp the core of things” invariably wedded to “an uncontrollable mania”; even their scrupulously observed reason, their mode of logic elevated to religion, is framed as a form of madness. Von Neumann’s response to the detonation of the Trinity bomb, the world’s first nuclear explosion, is “so utterly rational that it bordered on the psychopathic,” his second wife, Klara Dan, muses

fanaticism, in the 1930s, “was the norm … even among us mathematicians.”

Pondering Gödel’s own descent into mania, the physicist Eugene Wigner claims that “paranoia is logic run amok.” If you’ve convinced yourself that there’s a reason for everything, “it’s a small step to begin to see hidden machinations and agents operating to manipulate the most common, everyday occurrences.”

the game theory-derived system of mutually assured destruction he devises in its wake is “perfectly rational insanity,” according to its co-founder Oskar Morgenstern.

Labatut has Morgenstern end his MAD deliberations by pointing out that humans are not perfect poker players. They are irrational, a fact that, while instigating “the ungovernable chaos that we see all around us,” is also the “mercy” that saves us, “a strange angel that protects us from the mad dreams of reason.”

But does von Neumann really deserve the title “Father of Computers,” granted him here by his first wife, Mariette Kovesi? Doesn’t Ada Lovelace have a prior claim as their mother? Feynman’s description of the Trinity bomb as “a little Frankenstein monster” should remind us that it was Mary Shelley, not von Neumann and his coterie, who first grasped the monumental stakes of modeling the total code of life, its own instructions for self-replication, and that it was Rosalind Franklin — working alongside, not under, Maurice Wilkins — who first carried out this modeling.

he at least grants his women broader, more incisive wisdom. Ehrenfest’s lover Nelly Posthumus Meyjes delivers a persuasive lecture on the Pythagorean myth of the irrational, suggesting that while scientists would never accept the fact that “nature cannot be cognized as a whole,” artists, by contrast, “had already fully embraced it.”

it lacks practical application. If humans found something on another planet that seemed to be alive, how much time would we have to sit around and wait for it to evolve?

The only life we know is life on Earth. Some scientists call this the n=1 problem, where n is the number of examples from which we can generalize.

He measures the complexity of an object—say, a molecule—by calculating the number of steps necessary to put the object’s smallest building blocks together in that certain way. His lab has found, for example, when testing a wide range of molecules, that those with an “assembly number” above 15 were exclusively the products of life. Life makes some simpler molecules, too, but only life seems to make molecules that are so complex.

What we really want is more than a definition of life. We want to know what life, fundamentally, is. For that kind of understanding, scientists turn to theories. A theory is a scientific fundamental. It not only answers questions, but frames them, opening new lines of inquiry. It explains our observations and yields predictions for future experiments to test.

Consider the difference between defining gravity as “the force that makes an apple fall to the ground” and explaining it, as Newton did, as the universal attraction between all particles in the universe, proportional to the product of their masses and so on. A definition tells us what we already know; a theory changes how we understand things.

the potential rewards of unlocking a theory of life have captivated a clutch of researchers from a diverse set of disciplines. “There are certain things in life that seem very hard to explain,” Sara Imari Walker, a physicist at Arizona State University who has been at the vanguard of this work, told me. “If you scratch under the surface, I think there is some structure that suggests formalization and mathematical laws.”

Walker doesn’t think about life as a biologist—or an astrobiologist—does. When she talks about signs of life, she doesn’t talk about carbon, or water, or RNA, or phosphine. She reaches for different examples: a cup, a cellphone, a chair. These objects are not alive, of course, but they’re clearly products of life. In Walker’s view, this is because of their complexity. Life brings complexity into the universe, she says, in its own being and in its products, because it has memory: in DNA, in repeating molecular reactions, in the instructions for making a chair.

Cronin studies the origin of life, also a major interest of Walker’s, and it turned out that, when expressed in math, their ideas were essentially the same. They had both zeroed in on complexity as a hallmark of life. Cronin is devising a way to systematize and measure complexity, which he calls Assembly Theory.

who knows how strange life on another world might be? What if life as we know it is the wrong life to be looking for?

Walker’s whole notion is that it’s not only theoretically possible but genuinely achievable to identify something smaller—much smaller—that still nonetheless simply must be the result of life. The model would, in a sense, function like biosignatures as an indication of life that could be searched for. But it would drastically improve and expand the targets.

Walker would use the theory to predict what life on a given planet might look like. It would require knowing a lot about the planet—information we might have about Venus, but not yet about a distant exoplanet—but, crucially, would not depend at all on how life on Earth works, what life on Earth might do with those materials.

Without the ability to divorce the search for alien life from the example of life we know, Walker thinks, a search is almost pointless. “Any small fluctuations in simple chemistry can actually drive you down really radically different evolutionary pathways,” she told me. “I can’t imagine [life] inventing the same biochemistry on two worlds.”

Walker’s approach is grounded in the work of, among others, the philosopher of science Carol Cleland, who wrote The Quest for a Universal Theory of Life.

she warns that any theory of life, just like a definition, cannot be constrained by the one example of life we currently know. “It’s a mistake to start theorizing on the basis of a single example, even if you’re trying hard not to be Earth-centric. Because you’re going to be Earth-centric,” Cleland told me. In other words, until we find other examples of life, we won’t have enough data from which to devise a theory. Abstracting away from Earthliness isn’t a way to be agnostic, Cleland argues. It’s a way to be too abstract.

Cleland calls for a more flexible search guided by what she calls “tentative criteria.” Such a search would have a sense of what we’re looking for, but also be open to anomalies that challenge our preconceptions, detections that aren’t life as we expected but aren’t familiar not-life either—neither a flower nor a rock

it speaks to the hope that exploration and discovery might truly expand our understanding of the cosmos and our own world.

The astrobiologist Kimberley Warren-Rhodes studies life on Earth that lives at the borders of known habitability, such as in Chile’s Atacama Desert. The point of her experiments is to better understand how life might persist—and how it might be found—on Mars. “Biology follows some rules,” she told me. The more of those rules you observe, the better sense you have of where to look on other worlds.

In this light, the most immediate concern in our search for extraterrestrial life might be less that we only know about life on Earth, and more that we don’t even know that much about life on Earth in the first place. “I would say we understand about 5 percent,” Warren-Rhodes estimates of our cumulative knowledge. N=1 is a problem, and we might be at more like n=.05.

I reach for the theory of gravity as a familiar parallel. Someone might ask, “Okay, so in terms of gravity, where are we in terms of our understanding of life? Like, Newton?” Further back, further back, I say. Walker compares us to pre-Copernican astronomers, reliant on epicycles, little orbits within orbits, to make sense of the motion we observe in the sky. Cleland has put it in terms of chemistry, in which case we’re alchemists, not even true chemists yet

We understand so little, and we think we’re ready to find other life?

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This can be extremely time-consuming: In an interview with this magazine last year, an OnlyFans creator said she spends six hours a day just sexting with subscribers. But these relationships are important to cultivate. In a blog post on its website, OnlyFans encourages creators to cater to their “superfans,” who pay for custom content and will “give more if they feel they’re getting something special.”

But all of them take advantage of the same raw materials: the endless reproducibility of digital images; the widespread global availability of cheap English-speaking labor; and the world’s unquenchable desire for companionship.

The key to this business model is the ready availability of cheap English-speaking labor around the globe. Job postings for OnlyFans chatters are widespread on freelance sites like Upwork, many offering as little as $3 an hour. Agency heads told me they’ve hired workers from Eastern Europe, Africa and all across Southeast Asia. “At the end of the day, it is a geo-arbitrage business,”

This phenomenon is part of a broader boom in homespun online businesses that connect cheap developing-world labor with American consumers, allowing the proprietor to step back and reap the profits

During his stint as a chatter, Andre has become intimately familiar with the quirks and desires of the subscribers. Over time, he’s learned something of a sex-work cliché: More than sexual gratification, he said, many of the guys just want someone to talk to

The word for ‘philosophy’ in Korean is 철학, pronounced ch’ŏrhak. It literally means the ‘study of wisdom’ or, perhaps better, ‘how to become wise’, which reflects its more dynamic and proactive implications

At night, in the darkness of the cave, he drank water from a perfectly useful ‘bowl’. But when he could see properly, he found that there was no ‘bowl’ at all, only a disgusting human skull.

Our lives and minds are affected by others (and their actions), as others (and their minds) are affected by our actions. This is particularly true in the Korean application of Confucian and Buddhist ideas.

Wŏnhyo understood that how we think about things shapes their very existence – and in turn our own existence, which is constructed according to our thoughts.

In the Korean tradition of philosophy, human beings are social beings, therefore knowing how to interact with others is an essential part of living a good life – indeed, living well with others is our real contribution to human life

he realised that there isn’t a difference between the ‘bowl’ and the skull: the only difference lies with us and our perceptions. We interpret our lives through a continual stream of thoughts, and so we become what we think, or rather how we think

As our daily lives are shaped by our thoughts, so our experience of this reality is good or bad – depending on our thoughts – which make things ‘appear’ good or bad because, in ‘reality’, things in and of themselves are devoid of their own independent nature

We can take from Wŏnhyo the idea that, if you change the patterns that have become engrained in how you think, you will begin to live differently. To do this, you need to change your mental habits, which is why meditation and mindful awareness can help. And this needs to be practised every day

Wŏnhyo’s most important work is titled Awaken your Mind and Practice (in Korean, Palsim suhaeng-jang). It is an explicit call to younger adherents to put Buddhist ideas into practice, and an indirect warning not to get lost in contemplation or in the study of text

While Wŏnhyo had emphasised the mind and the need to ‘practise’ Buddhism, a later Korean monk, Chinul (1158-1210), spearheaded Sŏn, the meditational tradition in Korea that espoused the idea of ‘sudden enlightenment’ that alerts the mind, accompanied by ‘gradual cultivation’

we still need to practise meditation, for if not we can easily fall into our old ways even if our minds have been awakened

his greatest contribution to Sŏn is Secrets on Cultivating the Mind (Susim kyŏl). This text outlines in detail his teachings on sudden awakening followed by the need for gradual cultivation

hinul’s approach recognises the mind as the ‘essence’ of one’s Buddha nature (contained in the mind, which is inherently good), while continual practice and cultivation aids in refining its ‘function’ – this is the origin of the ‘essence-function’ concept that has since become central to Korean philosophy.

These ideas also influenced the reformed view of Confucianism that became linked with the mind and other metaphysical ideas, finally becoming known as Neo-Confucianism.

During the Chosŏn dynasty (1392-1910), the longest lasting in East Asian history, Neo-Confucianism became integrated into society at all levels through rituals for marriage, funerals and ancestors

Neo-Confucianism recognises that we as individuals exist through plural relationships with responsibilities to others (as a child, brother/sister, lover, husband/wife, parent, teacher/student and so on), an idea nicely captured in 2000 by the French philosopher Jean-Luc Nancy when he described our ‘being’ as ‘singular plural’

Corrupt interpretations of Confucianism by heteronormative men have historically championed these ideas in terms of vertical relationships rather than as a reciprocal set of benevolent social interactions, meaning that women have suffered greatly as a result.

Setting aside these sexist and self-serving interpretations, Confucianism emphasises that society works as an interconnected set of complementary reciprocal relationships that should be beneficial to all parties within a social system

Confucian relationships have the potential to offer us an example of effective citizenship, similar to that outlined by Cicero, where the good of the republic or state is at the centre of being a good citizen

There is a general consensus in Korean philosophy that we have an innate sociability and therefore should have a sense of duty to each other and to practise virtue.

The main virtue of Confucianism is the idea of ‘humanity’, coming from the Chinese character 仁, often left untranslated and written as ren and pronounced in Korean as in.

It is a combination of the character for a human being and the number two. In other words, it signifies what (inter)connects two people, or rather how they should interact in a humane or benevolent manner to each other. This character therefore highlights the link between people while emphasising that the most basic thing that makes us ‘human’ is our interaction with others.

Neo-Confucianism adopted a turn towards a more mind-centred view in the writings of the Korean scholar Yi Hwang, known by his pen name T’oegye (1501-70), who appears on the 1,000-won note. He greatly influenced Neo-Confucianism in Japan through his formidable text, Ten Diagrams on Sage Learning (Sŏnghak sipto), composed in 1568, which was one of the most-reproduced texts of the entire Chosŏn dynasty and represents the synthesis of Neo-Confucian thought in Korea

with commentaries that elucidate the moral principles of Confucianism, related to the cardinal relationships and education. It also embodies T’oegye’s own development of moral psychology through his focus on the mind, and illuminates the importance of teaching and the practice of self-cultivation.

He writes that we ourselves can transform the unrestrained mind and its desires, and achieve sagehood, if we take the arduous, gradual path of self-cultivation centred on the mind.

Confucians had generally accepted the Mencian idea that human nature was embodied in the unaroused state of the mind, before it was shaped by its environment. The mind in its unaroused state was taken to be theoretically good. However, this inborn tendency for goodness is always in danger of being reduced to passivity, unless you cultivate yourself as a person of ‘humanity’ (in the Confucian sense mentioned above).

You should constantly try to activate your humanity to allow the unhampered operation of the original mind to manifest itself through socially responsible and moral character in action

Humanity is the realisation of what I describe as our ‘optimum level of perfection’ that exists in an inherent stage of potentiality due our innate good nature

This, in a sense, is like the Buddha nature of the Buddhists, which suggests we are already enlightened and just need to recover our innate mental state. Both philosophies are hopeful: humans are born good with the potential to correct their own flaws and failures

this could hardly contrast any more greatly with the Christian doctrine of original sin

The seventh diagram in T’oegye’s text is entitled ‘The Diagram of the Explanation of Humanity’ (Insŏl-to). Here he warns how one’s good inborn nature may become impaired, hampering the operation of the original mind and negatively impacting our character in action. Humanity embodies the gradual realisation of our optimum level of perfection that already exists in our mind but that depends on how we think about things and how we relate that to others in a social context

For T’oegye, the key to maintaining our capacity to remain level-headed, and to control our impulses and emotions, was kyŏng. This term is often translated as ‘seriousness’, occasionally ‘mindfulness’, and it identifies the serious need for constant effort to control one’s mind in order to go about one’s life in a healthy manner

For T’oegye, mindfulness is as serious as meditation is for the Buddhists. In fact, the Neo-Confucians had their own meditational practice of ‘quiet-sitting’ (chŏngjwa), which focused on recovering the calm and not agitated ‘original mind’, before putting our daily plans into action

These diagrams reinforce this need for a daily practice of Confucian mindfulness, because practice leads to the ‘good habit’ of creating (and maintaining) routines. There is no short-cut provided, no weekend intro to this practice: it is life-long, and that is what makes it transformative, leading us to become better versions of who were in the beginning. This is consolation of Korean philosophy.

Seeing the world as it is can steer us away from making unnecessary mistakes, while highlighting what is good and how to maintain that good while also reducing anxiety from an agitated mind and harmful desires. This is why Korean philosophy can provide us with consolation; it recognises the bad, but prioritises the good, providing several moral pathways that are referred to in the East Asian traditions (Confucianism, Buddhism and Daoism) as modes of ‘self-cultivation’

As social beings, we penetrate the consciousness of others, and so humans are linked externally through conduct but also internally through thought. Humanity is a unifying approach that holds the potential to solve human problems, internally and externally, as well as help people realise the perfection that is innately theirs