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One way alcohol may lead to cancer is because the body metabolizes it into acetaldehyde, which causes changes and mutations in DNA, Dr. Gapstur said. The formation of acetaldehyde starts when alcohol comes in contact with bacteria in the mouth, which may explain the link between alcohol and cancers of the throat, voice box and esophagus

. In 2009, the researchers reported in the Journal of the American Medical Association that taking high doses of vitamin B12 along with folic acid (technically vitamin B9) was associated with greater risk of cancer and all-cause mortality.

There are legitimate and important uses for B-vitamin supplements, but the emerging evidence suggests we’re best to treat them more like pharmaceuticals than like panaceas to be shoveled into us in pursuit of energy, metabolic fortitude, “cardioprotection,” “bone wellness,” or whatever way in which we’d like to be better.

The research team is quick to note that the doses of B vitamins in question are enormous. The U.S. Recommended Dietary Allowance for B6 is 1.7 milligrams per day, and for B12 it’s 2.4 micrograms. The high-risk group in the study was taking around 20 times these amounts.That could seem nonsensical, except that these are the doses for sale at healthy-seeming places like Whole Foods and GNC. Many sellers offer daily 100-milligram B6 pills. B12 is available in doses of 5,000 micrograms.

Lung-cancer risk among men who took 20 milligrams of B6 daily for years was twice that of men who didn’t. Among people who smoke, the effect appeared to be synergistic, with B6 usage increasing risk threefold. The risk was even worse among smokers taking B12. Using more than 55 micrograms daily appeared to almost quadruple lung-cancer risk.

The current law gives consumers no reason to expect that risks will be listed on the labels of these products, or that health claims are accurate. A product like a high-dose B6 and B12 supplement hits shelves, and only decades later do researchers begin to understand the long-term health effects, who might benefit from taking it, and who might be harmed.  

Much of your brain’s activity happens outside your awareness. In every moment, your brain must figure out your body’s needs for the next moment and execute a plan to fill those needs in advance.

The budget for your body tracks resources

Each action that spends resources, such as standing up, running, and learning, is like a withdrawal from your account. Actions that replenish your resources, such as eating and sleeping, are like deposits.

Every thought you have, every feeling of happiness or anger or awe you experience, every kindness you extend and every insult you bear or sling is part of your brain’s calculations as it anticipates and budgets your metabolic needs.

This view of the brain has many implications for understanding human beings. So often, for example, we conceive of ourselves in mental terms, separate from the physical

There is no such thing as a purely mental cause, because every mental experience has roots in the physical budgeting of your body

When an unpleasant thought pops into your head, like “I can’t take this craziness anymore,” ask yourself body-budgeting questions. “Did I get enough sleep last night? Am I dehydrated? Should I take a walk? Call a friend? Because I could use a deposit or two in my body budget.”

I’m suggesting that it’s possible to acknowledge what your brain is actually doing and take some comfort from it. Your brain is not for thinking. Everything that it conjures, from thoughts to emotions to dreams, is in the service of body budgeting. This perspective, adopted judiciously, can be a source of resilience in challenging times.

“These results undermine the universality of scale-free networks and reveal that real-world networks exhibit a rich structural diversity that will likely require new ideas and mechanisms to explain,” wrote the study’s authors, Anna Broido and Aaron Clauset of the University of Colorado at Boulder.

Network scientists agree, by and large, that the paper’s analysis is statistically sound. But when it comes to interpreting its findings, the paper seems to be functioning like a Rorschach test, in which both proponents and critics of the scale-free paradigm see what they already believed to be true. Much of the discussion has played out in vigorous Twitter debates.

The scale-free paradigm in networks emerged at a historical moment when power laws had taken on an outsize role in statistical physics. In the 1960s and 1970s, they had played a key part in universal laws that underlie phase transitions in a wide range of physical systems, a finding that earned Kenneth Wilson the 1982 Nobel Prize in physics. Soon after, power laws formed the core of two other paradigms that swept across the statistical-physics world: fractals, and a theory about organization in nature called self-organized criticality.

From the beginning, though, the scale-free paradigm also attracted pushback. Critics pointed out that preferential attachment is far from the only mechanism that can give rise to power laws, and that networks with the same power law can have very different topologies. Some network scientists and domain experts cast doubt on the scale-freeness of specific networks such as power grids, metabolic networks, and the physical internet.

If you were to observe 1,000 falling objects instead of just a rock and a feather, Clauset says, a clear picture would emerge of how both gravity and air resistance work. But his and Broido’s analysis of nearly 1,000 networks has yielded no similar clarity. “It is reasonable to believe a fundamental phenomenon would require less customized detective work” than Barabási is calling for, Clauset wrote on Twitter.

Other animals that experienced mass die-offs include sea lions, tufted puffins, and baleen whales. But none of them compared to the murres in scale.

The murres likely starved to death because the Blob caused more competition for fewer small prey. The warming increased the metabolism of predatory fish like salmon, cod, and halibut -- meaning they were eating more than usual. These fish eat the same small fish as the murres, and there simply wasn't enough to go around.

During the 2015 breeding season, three colonies didn't produce a single chick. That number went up to 12 colonies in the 2016 season -- and in reality it could be even higher, since researchers only monitor a quarter of all colonies.

It's especially rare to see a patch of warm ocean water over such a large area, but scientists say global climate change is making these phenomena more common. From 1982 to 2016, there was an 82% rise in the number of heat wave days on the global ocean surface, according to a 2018 study. That's because heat waves are increasing in both frequency and duration, with the highest level of maritime heat wave activity occurring in the North Atlantic

this distinction between mental and physical is not meaningful. Anxiety does not cause stomach aches; rather, feelings of anxiety and stomach aches are both ways that human brains make sense of physical discomfort

There is no such thing as a purely mental cause, because every mental experience has roots in the physical budgeting of your body. This is one reason physical actions like taking a deep breath, or getting more sleep, can be surprisingly helpful in addressing problems we traditionally view as psychological.

Your burden may feel lighter if you understand your discomfort as something physical. When an unpleasant thought pops into your head, like “I can’t take this craziness anymore,” ask yourself body-budgeting questions. “Did I get enough sleep last night? Am I dehydrated? Should I take a walk? Call a friend? Because I could use a deposit or two in my body budget.”

I’m not saying you can snap your fingers and dissolve deep misery, or sweep away depression with a change of perspective. I’m suggesting that it’s possible to acknowledge what your brain is actually doing and take some comfort from it

Your brain is not for thinking. Everything that it conjures, from thoughts to emotions to dreams, is in the service of body budgeting. This perspective, adopted judiciously, can be a source of resilience in challenging times.

I think people are enervated not just by the Sisyphean pointlessness of their individual labors but also by the fact that they’re working in and for a society in which, increasingly, they have zero faith or investment. The future their elders are preparing to bequeath to them is one that reflects the fondest hopes of the same ignorant bigots a lot of them fled their hometowns to escape.

It turns out that millions of people never actually needed to waste days of their lives sitting in traffic or pantomime “work” under managerial scrutiny eight hours a day

We learned that nurses, cashiers, truckers and delivery people (who’ve always been too busy to brag about it) actually ran the world and the rest of us were mostly useless supernumeraries. The brutal hierarchies of work shifted, for the first time in recent memory, in favor of labor, and the outraged whines of former social Darwinists were a pleasure to savor.

Of course, everyone is still busy — worse than busy, exhausted, too wiped at the end of the day to do more than stress-eat, binge-watch and doomscroll — but no one’s calling it anything other than what it is anymore: an endless, frantic hamster wheel for survival.

The pandemic was the bomb cyclone of our discontents

American conservatism, which is demographically terminal and knows it, is acting like a moribund billionaire adding sadistic codicils to his will.

An increasingly popular retirement plan is figuring civilization will collapse before you have to worry about it

Midcentury science fiction writers assumed that the increased productivity brought on by mechanization would give workers an oppressive amount of leisure time, that our greatest threats would be boredom and ennui. But these authors’ prodigious imaginations were hobbled by their humanity and rationality; they’d forgotten that the world is ordered not by reason or decency but by rapacious avarice.

In the past few decades, capitalism has exponentially increased the creation of wealth for the already incredibly wealthy at the negligible expense of the well-being, dignity and happiness of most of humanity, plus the nominal cost of a mass extinction and the destruction of the biosphere — like cutting out the inefficient business of digestion and metabolism by pouring a fine bottle of wine directly into the toilet, thereby eliminating the middleman of you.

Everyone knows how productive you can be when you’re avoiding something. We are currently experiencing the civilizational equivalent of that anxiety you feel when you have something due the next day that you haven’t even started thinking about and yet still you sit there, helplessly watching whole seasons of mediocre TV or compulsively clicking through quintillions of memes even as your brain screams at you — the same way we scream at our politicians about guns and abortion and climate change — to do something.

Enough with the busywork already. We’ve been “productive” enough — produced way too much, in fact. And there is too much that urgently needs to be done: a republic to salvage, a civilization to reimagine and its infrastructure to reinvent, innumerable species to save, a world to restore and millions who are impoverished, imprisoned, illiterate, sick or starving. All while we waste our time at work.

“It makes sense to recognize that these skills provide a tool kit for moving into the future in a way that I’m not entirely sure we always recognize.”

it lacks practical application. If humans found something on another planet that seemed to be alive, how much time would we have to sit around and wait for it to evolve?

The only life we know is life on Earth. Some scientists call this the n=1 problem, where n is the number of examples from which we can generalize.

Cronin studies the origin of life, also a major interest of Walker’s, and it turned out that, when expressed in math, their ideas were essentially the same. They had both zeroed in on complexity as a hallmark of life. Cronin is devising a way to systematize and measure complexity, which he calls Assembly Theory.

What we really want is more than a definition of life. We want to know what life, fundamentally, is. For that kind of understanding, scientists turn to theories. A theory is a scientific fundamental. It not only answers questions, but frames them, opening new lines of inquiry. It explains our observations and yields predictions for future experiments to test.

Consider the difference between defining gravity as “the force that makes an apple fall to the ground” and explaining it, as Newton did, as the universal attraction between all particles in the universe, proportional to the product of their masses and so on. A definition tells us what we already know; a theory changes how we understand things.

the potential rewards of unlocking a theory of life have captivated a clutch of researchers from a diverse set of disciplines. “There are certain things in life that seem very hard to explain,” Sara Imari Walker, a physicist at Arizona State University who has been at the vanguard of this work, told me. “If you scratch under the surface, I think there is some structure that suggests formalization and mathematical laws.”

Walker doesn’t think about life as a biologist—or an astrobiologist—does. When she talks about signs of life, she doesn’t talk about carbon, or water, or RNA, or phosphine. She reaches for different examples: a cup, a cellphone, a chair. These objects are not alive, of course, but they’re clearly products of life. In Walker’s view, this is because of their complexity. Life brings complexity into the universe, she says, in its own being and in its products, because it has memory: in DNA, in repeating molecular reactions, in the instructions for making a chair.

He measures the complexity of an object—say, a molecule—by calculating the number of steps necessary to put the object’s smallest building blocks together in that certain way. His lab has found, for example, when testing a wide range of molecules, that those with an “assembly number” above 15 were exclusively the products of life. Life makes some simpler molecules, too, but only life seems to make molecules that are so complex.

I reach for the theory of gravity as a familiar parallel. Someone might ask, “Okay, so in terms of gravity, where are we in terms of our understanding of life? Like, Newton?” Further back, further back, I say. Walker compares us to pre-Copernican astronomers, reliant on epicycles, little orbits within orbits, to make sense of the motion we observe in the sky. Cleland has put it in terms of chemistry, in which case we’re alchemists, not even true chemists yet

Walker’s whole notion is that it’s not only theoretically possible but genuinely achievable to identify something smaller—much smaller—that still nonetheless simply must be the result of life. The model would, in a sense, function like biosignatures as an indication of life that could be searched for. But it would drastically improve and expand the targets.

Walker would use the theory to predict what life on a given planet might look like. It would require knowing a lot about the planet—information we might have about Venus, but not yet about a distant exoplanet—but, crucially, would not depend at all on how life on Earth works, what life on Earth might do with those materials.

Without the ability to divorce the search for alien life from the example of life we know, Walker thinks, a search is almost pointless. “Any small fluctuations in simple chemistry can actually drive you down really radically different evolutionary pathways,” she told me. “I can’t imagine [life] inventing the same biochemistry on two worlds.”

Walker’s approach is grounded in the work of, among others, the philosopher of science Carol Cleland, who wrote The Quest for a Universal Theory of Life.

she warns that any theory of life, just like a definition, cannot be constrained by the one example of life we currently know. “It’s a mistake to start theorizing on the basis of a single example, even if you’re trying hard not to be Earth-centric. Because you’re going to be Earth-centric,” Cleland told me. In other words, until we find other examples of life, we won’t have enough data from which to devise a theory. Abstracting away from Earthliness isn’t a way to be agnostic, Cleland argues. It’s a way to be too abstract.

Cleland calls for a more flexible search guided by what she calls “tentative criteria.” Such a search would have a sense of what we’re looking for, but also be open to anomalies that challenge our preconceptions, detections that aren’t life as we expected but aren’t familiar not-life either—neither a flower nor a rock

it speaks to the hope that exploration and discovery might truly expand our understanding of the cosmos and our own world.

The astrobiologist Kimberley Warren-Rhodes studies life on Earth that lives at the borders of known habitability, such as in Chile’s Atacama Desert. The point of her experiments is to better understand how life might persist—and how it might be found—on Mars. “Biology follows some rules,” she told me. The more of those rules you observe, the better sense you have of where to look on other worlds.

In this light, the most immediate concern in our search for extraterrestrial life might be less that we only know about life on Earth, and more that we don’t even know that much about life on Earth in the first place. “I would say we understand about 5 percent,” Warren-Rhodes estimates of our cumulative knowledge. N=1 is a problem, and we might be at more like n=.05.

who knows how strange life on another world might be? What if life as we know it is the wrong life to be looking for?

We understand so little, and we think we’re ready to find other life?

Functional Medicine isn't a protected title and a medical qualification isn't a prerequisite to practice. The result is an unregulated and disparate field, with medical doctors, nutritionists, naturopaths and homeopaths among the many practitioners.

Some other chronic illnesses the field claims to treat include heart disease, type 2 diabetes, irritable bowel syndrome, ulcerative colitis, depression, anxiety and arthritis

ll kinds of different reasons, some might have gluten issues, gut issues, others might have a deficiency causing neurological issues, MS is a symptom."

"There are components of Functional Medicine that absolutely lack an evidence base and there are practitioners of what they call Functional Medicine, they charge people for intravenous nutritional injections, they exaggerate claims, and that is professionally inappropriate, unethical and it lacks evidence.

On Dr Mark Hyman's view of MS he says, "there are a lot of terms put together there, all of which individually make a lot of sense, but put together in that way they do not.

"What does FM actually mean? It means nothing. It's a gift-gallop of words thrown together. It's criticised by advocates of evidence-based medicine because it's giving a veneer of scientific legitimacy to ideas that are considered pseudoscientific. For example, it'll take alternative medicine modalities like homeopathy and then call them 'bio-infusions' or something similar, rebranding it as something that works.

"It's a redundant name, real medicine is functional."

Next month the third annual Lifestyle and Functional Medical conference will take place in Salthill, Galway on November 3. Last year's event was attended by more than 500 people and featured a keynote address by honorary consultant cardiologist Dr Aseem Malhotra, author of bestselling The Pioppi Diet (which was named one of the top five worst celebrity diets to avoid in 2018 by the British Dietetic Foundation).

Dr David Robert Grimes is physicist and visiting fellow of Oxford and QUB. His research into cancer focuses on modelling tumour metabolism and radiation interactions. For Dr Grimes, the lack of definition, or "double-speak" as he puts it, in FM is troubling.

As well as the cost of appointments, FM practitioners commonly charge extra for tests. An omega finger prick test is around €100. A vitamin D test can cost upwards of €60, full thyroid panel more than €150 and a gut function test €400. Prices vary between practitioners.

"If I, as a GP, engaged in some of these behaviours I would be struck off." Specifically? "If I was recommending treatments that lacked an evidence base, or if I was promoting diagnostic tests which are expensive and lack an evidence base.

GPs engage every year in ongoing continuous professional development, I spend my evenings and my weekends outside of working hours attending educational events, small-group learning, large-group learning, engaging in research. This is an accusation that was levelled at the profession 30 years ago and then it was correct, but the profession has caught up…

"Obviously promoting wellness and healthy diet is very welcome but going beyond that and stating that certain aspects of 'functional medicine' can lead to reduced inflammation or prevent cancer, we have to be very careful about those claims.

Often the outcome of such tests are seemingly 'benign' prescriptions of vitamins or cleanses. However, dietitian Orla Walsh stresses that even these can have potentially harmful effects, especially on "vulnerable" patients, if not prescribed judiciously.

FM has five basic principles. 1. We are all genetically and biochemically unique so it treats the individual, not the disease. 2. It's science-based. 3. The body is intelligent and has the capacity for self-regulation. 4. The body has the ability to heal and prevent nearly all the diseases of ageing. 5. Health is not just the absence of disease, but a state of immense vitality.

She began her Functional Medicine career while training as a medical doctor and now travels the world working with high-profile clients. Dr McHale charges €425 for an initial consultation and €175 for follow-up appointments. Straightforward lab tests are €250 to €750, for complex cases testing fees can be up to €2,000.

"The term [Functional Medicine] tends to be bandied around quite a bit. Other things people say, such as 'functional nutritionist', can be misleading as a term. Many people are Functional Medicine practitioners but don't have any real medical background at all... I think regulation is always probably the best way forward."

"There's an awful lot to it in terms of biochemistry and physiology," she says. "You do need to have a very solid and well ingrained bio-chemistry background. A solely clinical background doesn't equip you with the knowledge to read a test.

"Evidence-base is the cornerstone of medicine and that has to be maintained. It becomes problematic in this area because you are looking at personalised medicine and that can be very difficult to evidence-base."

GP Christine Ritter travelled from England to attend the Galway conference last year with a view to integrating Functional Medicine into her practice.

"It was very motivating," she says. "Where it wasn't perhaps as strong was to find the evidence. The Functional Medicine people would say, 'we've done this study and this trial and we've used this supplement that was successful', but they can't show massive research data which might make it difficult to bring it into the mainstream.

"I also know the rigorous standard of trials we have in medicine they're not usually that great either, it's often driven by who's behind the trial and who's paying for it.

"Every approach that empowers patient to work on their destiny [is beneficial], but you'd have to be mindful that you're not missing any serious conditions."

Dr Hyman is working to grow the evidence-base for Functional Medicine worldwide. "The future is looking very bright," he says. "At the Cleveland Centre we're establishing a research base, building educational platforms, fellowships, residency programmes, rotations. We're advancing the field that's spreading across the world. We're seeing in China the development of a programme of Functional Medicine, South Africa, the UK, in London the Cleveland Clinic will hopefully have a Functional Medicine centre."

For Dr Mark Murphy regulation is a moot point as it can only apply once the field meets the standards of evidence-based medicine.

"Despite well intentioned calls for regulation, complementary and alternative medical therapies cannot be regulated," he says. "Only therapies that possess an evidence-base can enter our standard regulatory processes, including the Irish Medical Council, the Health Products Regulatory Authority and Irish advertising standards. In situations where complementary and alternative therapies develop an evidence base, they are no longer 'complementary and alternative', but in effect they become part of mainstream 'Medicine'.

l What are the principles?

"There's a huge variation between therapists, some are brilliant and some are okay, and some are ludicrous snake oil salesmen."

He is so concerned that patients' health and wealth are being put at risk by alternative therapies that earlier this year he joined Fine Gael TD Kate O'Connell and the Irish Cancer Society in introducing draft legislation earlier this year making it illegal to sell unproven treatments to cancer patients. Violators face jail and heavy fines.

Dr Grimes says criticism of variations in the standards of traditional medical research can be fair, however due to the weight of research it is ultimately self-correcting. He adds, "The reality is that good trials are transparent, independent and pre-registered.

"My involvement in shaping the Bill came from seeing first-hand the exploitation of patients and their families. Most patients undergoing treatment will take some alternative modalities in conjunction but a significant portion are talked out of their conventional medicine and seduced by false promises

Since the 1960s, advances in resuscitation had helped to revive thousands of people who might otherwise have died. About 10% or 20% of those people brought with them stories of near-death experiences in which they felt their souls or selves departing from their bodies

According to several international surveys and studies, one in 10 people claims to have had a near-death experience involving cardiac arrest, or a similar experience in circumstances where they may have come close to death. That’s roughly 800 million souls worldwide who may have dipped a toe in the afterlife.

In the 1970s, a small network of cardiologists, psychiatrists, medical sociologists and social psychologists in North America and Europe began investigating whether near-death experiences proved that dying is not the end of being, and that consciousness can exist independently of the brain. The field of near-death studies was born.

in 1975, an American medical student named Raymond Moody published a book called Life After Life.

Meanwhile, new technologies and techniques were helping doctors revive more and more people who, in earlier periods of history, would have almost certainly been permanently deceased.

“We are now at the point where we have both the tools and the means to scientifically answer the age-old question: What happens when we die?” wrote Sam Parnia, an accomplished resuscitation specialist and one of the world’s leading experts on near-death experiences, in 2006. Parnia himself was devising an international study to test whether patients could have conscious awareness even after they were found clinically dead.

Borjigin, together with several colleagues, took the first close look at the record of electrical activity in the brain of Patient One after she was taken off life support. What they discovered – in results reported for the first time last year – was almost entirely unexpected, and has the potential to rewrite our understanding of death.

“I believe what we found is only the tip of a vast iceberg,” Borjigin told me. “What’s still beneath the surface is a full account of how dying actually takes place. Because there’s something happening in there, in the brain, that makes no sense.”

Over the next 30 years, researchers collected thousands of case reports of people who had had near-death experiences

Moody was their most important spokesman; he eventually claimed to have had multiple past lives and built a “psychomanteum” in rural Alabama where people could attempt to summon the spirits of the dead by gazing into a dimly lit mirror.

near-death studies was already splitting into several schools of belief, whose tensions continue to this day. One influential camp was made up of spiritualists, some of them evangelical Christians, who were convinced that near-death experiences were genuine sojourns in the land of the dead and divine

It is no longer unheard of for people to be revived even six hours after being declared clinically dead. In 2011, Japanese doctors reported the case of a young woman who was found in a forest one morning after an overdose stopped her heart the previous night; using advanced technology to circulate blood and oxygen through her body, the doctors were able to revive her more than six hours later, and she was able to walk out of the hospital after three weeks of care

The second, and largest, faction of near-death researchers were the parapsychologists, those interested in phenomena that seemed to undermine the scientific orthodoxy that the mind could not exist independently of the brain. These researchers, who were by and large trained scientists following well established research methods, tended to believe that near-death experiences offered evidence that consciousness could persist after the death of the individua

Their aim was to find ways to test their theories of consciousness empirically, and to turn near-death studies into a legitimate scientific endeavour.

Finally, there emerged the smallest contingent of near-death researchers, who could be labelled the physicalists. These were scientists, many of whom studied the brain, who were committed to a strictly biological account of near-death experiences. Like dreams, the physicalists argued, near-death experiences might reveal psychological truths, but they did so through hallucinatory fictions that emerged from the workings of the body and the brain.

Between 1975, when Moody published Life After Life, and 1984, only 17 articles in the PubMed database of scientific publications mentioned near-death experiences. In the following decade, there were 62. In the most recent 10-year span, there were 221.

Today, there is a widespread sense throughout the community of near-death researchers that we are on the verge of great discoveries

“We really are in a crucial moment where we have to disentangle consciousness from responsiveness, and maybe question every state that we consider unconscious,”

“I think in 50 or 100 years time we will have discovered the entity that is consciousness,” he told me. “It will be taken for granted that it wasn’t produced by the brain, and it doesn’t die when you die.”

it is in large part because of a revolution in our ability to resuscitate people who have suffered cardiac arrest

In his book, Moody distilled the reports of 150 people who had had intense, life-altering experiences in the moments surrounding a cardiac arrest. Although the reports varied, he found that they often shared one or more common features or themes. The narrative arc of the most detailed of those reports – departing the body and travelling through a long tunnel, having an out-of-body experience, encountering spirits and a being of light, one’s whole life flashing before one’s eyes, and returning to the body from some outer limit – became so canonical that the art critic Robert Hughes could refer to it years later as “the familiar kitsch of near-death experience”.

Loss of oxygen to the brain and other organs generally follows within seconds or minutes, although the complete cessation of activity in the heart and brain – which is often called “flatlining” or, in the case of the latter, “brain death” – may not occur for many minutes or even hours.

That began to change in 1960, when the combination of mouth-to-mouth ventilation, chest compressions and external defibrillation known as cardiopulmonary resuscitation, or CPR, was formalised. Shortly thereafter, a massive campaign was launched to educate clinicians and the public on CPR’s basic techniques, and soon people were being revived in previously unthinkable, if still modest, numbers.

scientists learned that, even in its acute final stages, death is not a point, but a process. After cardiac arrest, blood and oxygen stop circulating through the body, cells begin to break down, and normal electrical activity in the brain gets disrupted. But the organs don’t fail irreversibly right away, and the brain doesn’t necessarily cease functioning altogether. There is often still the possibility of a return to life. In some cases, cell death can be stopped or significantly slowed, the heart can be restarted, and brain function can be restored. In other words, the process of death can be reversed.

In a medical setting, “clinical death” is said to occur at the moment the heart stops pumping blood, and the pulse stops. This is widely known as cardiac arrest

In 2019, a British woman named Audrey Schoeman who was caught in a snowstorm spent six hours in cardiac arrest before doctors brought her back to life with no evident brain damage.

That is a key tenet of the parapsychologists’ arguments: if there is consciousness without brain activity, then consciousness must dwell somewhere beyond the brain

Some of the parapsychologists speculate that it is a “non-local” force that pervades the universe, like electromagnetism. This force is received by the brain, but is not generated by it, the way a television receives a broadcast.

In order for this argument to hold, something else has to be true: near-death experiences have to happen during death, after the brain shuts down

To prove this, parapsychologists point to a number of rare but astounding cases known as “veridical” near-death experiences, in which patients seem to report details from the operating room that they might have known only if they had conscious awareness during the time that they were clinically dead.

At the very least, Parnia and his colleagues have written, such phenomena are “inexplicable through current neuroscientific models”. Unfortunately for the parapsychologists, however, none of the reports of post-death awareness holds up to strict scientific scrutiny. “There are many claims of this kind, but in my long decades of research into out-of-body and near-death experiences I never met any convincing evidence that this is true,”

In other cases, there’s not enough evidence to prove that the experiences reported by cardiac arrest survivors happened when their brains were shut down, as opposed to in the period before or after they supposedly “flatlined”. “So far, there is no sufficiently rigorous, convincing empirical evidence that people can observe their surroundings during a near-death experience,”

The parapsychologists tend to push back by arguing that even if each of the cases of veridical near-death experiences leaves room for scientific doubt, surely the accumulation of dozens of these reports must count for something. But that argument can be turned on its head: if there are so many genuine instances of consciousness surviving death, then why should it have so far proven impossible to catch one empirically?

The spiritualists and parapsychologists are right to insist that something deeply weird is happening to people when they die, but they are wrong to assume it is happening in the next life rather than this one. At least, that is the implication of what Jimo Borjigin found when she investigated the case of Patient One.

Given the levels of activity and connectivity in particular regions of her dying brain, Borjigin believes it’s likely that Patient One had a profound near-death experience with many of its major features: out-of-body sensations, visions of light, feelings of joy or serenity, and moral re-evaluations of one’s life. Of course,

“As she died, Patient One’s brain was functioning in a kind of hyperdrive,” Borjigin told me. For about two minutes after her oxygen was cut off, there was an intense synchronisation of her brain waves, a state associated with many cognitive functions, including heightened attention and memory. The synchronisation dampened for about 18 seconds, then intensified again for more than four minutes. It faded for a minute, then came back for a third time.

n those same periods of dying, different parts of Patient One’s brain were suddenly in close communication with each other. The most intense connections started immediately after her oxygen stopped, and lasted for nearly four minutes. There was another burst of connectivity more than five minutes and 20 seconds after she was taken off life support. In particular, areas of her brain associated with processing conscious experience – areas that are active when we move through the waking world, and when we have vivid dreams – were communicating with those involved in memory formation. So were parts of the brain associated with empathy. Even as she slipped irre

something that looked astonishingly like life was taking place over several minutes in Patient One’s brain.

Although a few earlier instances of brain waves had been reported in dying human brains, nothing as detailed and complex as what occurred in Patient One had ever been detected.

In the moments after Patient One was taken off oxygen, there was a surge of activity in her dying brain. Areas that had been nearly silent while she was on life support suddenly thrummed with high-frequency electrical signals called gamma waves. In particular, the parts of the brain that scientists consider a “hot zone” for consciousness became dramatically alive. In one section, the signals remained detectable for more than six minutes. In another, they were 11 to 12 times higher than they had been before Patient One’s ventilator was removed.

“The brain, contrary to everybody’s belief, is actually super active during cardiac arrest,” Borjigin said. Death may be far more alive than we ever thought possible.

“The brain is so resilient, the heart is so resilient, that it takes years of abuse to kill them,” she pointed out. “Why then, without oxygen, can a perfectly healthy person die within 30 minutes, irreversibly?”

Evidence is already emerging that even total brain death may someday be reversible. In 2019, scientists at Yale University harvested the brains of pigs that had been decapitated in a commercial slaughterhouse four hours earlier. Then they perfused the brains for six hours with a special cocktail of drugs and synthetic blood. Astoundingly, some of the cells in the brains began to show metabolic activity again, and some of the synapses even began firing.