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“GMO will make Ghanaian farmers poor” and “Our Food Under Our Control!!!”

Monsanto is also part of the New Alliance for Food Security and Nutrition, a group of private corporations tasked by the G8 to invest in solutions to African hunger over the next decade.

Hating Monsanto is “a luxury when you’re surrounded by food 24/7,” writes one defender, who argues that spreading negative sentiment against the company actually “impedes global economic growth.” Even Britain’s Environmental Secretary, Owen Paterson, said organizations fighting the spread of GMOs are “absolutely wicked” and “cast a dark shadow over attempts to feed the world.”

But African farmers also have very legitimate concerns about Monsanto’s reputation for investigating, suing, and ruining farmers who try to save GM seeds.

ood Sovereignty Ghana warns against the “control of our resources by multinational corporations and other foreign entities,” and the “avaricious calculations behind the proposition that food is just another commodity or component for international agribusiness.”

they call for “collective control over our collective resources.”

ontroversial GM golden rice, which is supposed to pump up Vitamin A levels in regular rice to make it more nutritious, could well be a promising use of technology

However, golden rice is still mainly theoretical after a decade of research.

hunger is not caused by a food shortage but by “a lack of purchasing power and/or the inability of the rural poor to be self-sufficient.”

India is getting hotter as humans continue to pump carbon dioxide into the atmosphere. With these increases in heat, the report — produced by 1,250 international experts and approved by every major government in the world — said with high confidence that the risk of heat-related mortality would rise due to climate change and population increases, along with greater risk of drought-related water and food shortages.

“Attribution of events to climate change is still emerging as a science, but recent and numerous studies continue to speak to heat waves having strong links to warming climate,”

extreme heat events “have become as much as 10 times more likely due to the current cumulative effects of human-induced climate change.”

Mann said that as climate change threatens to worsen as more carbon is emitted into the atmosphere, heat events once considered extreme would become relatively common. He noted that India’s nearly unprecedented deadly heat wave is occurring at current global warming levels of just 1.5 degrees Fahrenheit — so heat waves occurring under the “business as usual” global warming scenario that sees average temperatures rise 7 to 9 degrees by the end of the century would be much, much worse

The impacts of climate change are widely expected to be more harmful in poor countries than in their fully developed counterparts.

The study, in other words, isn’t about how much see level rise happens this century, but whether this century’s emissions bank enough carbon for total ice melt down—or some less drastic version. “Our analysis really looks at a 2000 year envelope,” says Strauss.

Under the ice, Greenland and Antarctica are uncharted territories. In order to calculate the rate at which those massive ice sheets slough off, Levermann says he would need to know more about the texture of the underlying rock.

Students will be able to substitute a tech sequence and local test for one of the history exams, however the Regents did not present, design, or even describe what the tech alternative will look like. Although it will be implemented immediately, the Regents left all the details completely up to local initiative.

Under the proposal, students can substitute career-focused courses in subjects such as carpentry, advertising or hospitality management rather than one of two history Regents exams that are now required

In June 2010 the Regents eliminated 5th and 8th grade social studies, history, and geography assessments so teachers and schools could concentrate on preparing students for high-stakes Common Core standardized reading and math assessments.

Mace reports his middle school students have no idea which were the original thirteen colonies, where they were located, or who were the founders and settlers. The students in his honors class report that all they studied in elementary school was English and math. Morning was math; afternoon was ELA. He added, "Teachers were worried that this would happen, and it has."

Debate over the importance of teaching history and social studies is definitely not new. During World War I, many Americans worried that new immigrants did not understand and value the history and government of the United States so new high school classes and tests that developed into the current classes and tests were put in place.

Mace describes his students as the "common core kids, inundated with common core, but they do not know the history of the United States." The cardinal rule of public education in the 21st Century seems to be that which gets tested is important and that which does not is dropped.

"By making state social studies exams optional, we have come to a point where our nation's own history has been marginalized in the classroom and, with it, the means to understand ourselves and the world around us. America's heritage is being eliminated as a requirement for graduation.

I am biased. I am a historian, a former social studies teacher, and I help to prepare the next generation of social studies teachers.

But these decisions by the Regents are politically motivated, lower graduation standards, and are outright dangerous.

The city is under a lot of pressure to support the revised and lower academic standards because in the next few weeks it is required to present plans to the state for turning around as many as 250 schools that are labeled as "failing."

Merryl Tisch, Chancellor of the State Board of Regents, described the change as an effort to "back-fill opportunities for students with different interests, with different opportunities, with different choice."

The need to educate immigrants and to understand global issues like ISIS and Ebola remain pressing, but I guess not for New York State high school students. Right now, it looks like social studies advocates have lost the battle and we are finally witnessing the end of history.

Coulter’s deeper point is that for America to truly be America, it must stand apart

The core problem with embracing soccer is that in so doing, America would become more like the rest of the world.

America’s own league, Major League Soccer, draws as many fans to its stadiums as do the NHL and NBA.

I wrote an essay entitled “The End of American Exceptionalism,” which argued that on subjects where the United States has long been seen as different, attitudes in America increasingly resemble those in Europe. Soccer is one of the best examples yet.

“Soccer,” Markovits and Hellerman argue, “was perceived by both native-born Americans and immigrants as a non-American activity at a time in American history when nativism and nationalism emerged to create a distinctly American self-image … if one liked soccer, one was viewed as at least resisting—if not outright rejecting—integration into America.”

The average age of Americans who call baseball their favorite sport is 53. Among Americans who like football best, it’s 46. Among Americans who prefer soccer, by contrast, the average age is only 37.

Old-stock Americans, in other words, were elevating baseball, football, and basketball into symbols of America’s distinct identity. Immigrants realized that embracing those sports offered a way to claim that identity for themselves. Clinging to soccer, by contrast, was a declaration that you would not melt.

why is interest in soccer rising now? Partly, because the United States is yet again witnessing mass immigration from soccer-mad nations.

the key shift is that America’s sports culture is less nativist. More native-born Americans now accept that a game invented overseas can become authentically American, and that the immigrants who love it can become authentically American too. Fewer believe that to have merit, something must be invented in the United States.

why didn’t soccer gain a foothold in the U.S. in the decades between the Civil War and World War I, when it was gaining dominance in Europe? Precisely because it was gaining dominance in Europe. The arbiters of taste in late 19th and early 20th century America wanted its national pastimes to be exceptional.

Americans over the age of 50 were 15 points more likely to say “our culture is superior” than were people over 50 in Germany, Spain, Britain, and France

Americans under 30, by contrast, were actually less likely to say “our culture is superior” than their counterparts in Germany, Spain, and Britain.

Americans today are less likely to insist that America’s way of doing things is always best. In 2002, 60 percent of Americans told the Pew Research Center that, “our culture is superior to others.” By 2011, it was down to 49 percent.

the third major pro-soccer constituency is liberals. They’re willing to embrace a European sport for the same reason they’re willing to embrace a European-style health care system: because they see no inherent value in America being an exception to the global rule

When the real-estate website Estately created a seven part index to determine a state’s love of soccer, it found that Washington State, Maryland, the District of Columbia, New York, and New Jersey—all bright blue—loved soccer best, while Alabama, Arkansas, North Dakota, Mississippi and Montana—all bright red—liked it least.

the soccer coalition—immigrants, liberals and the young—looks a lot like the Obama coalition.

Sports-wise, therefore, Democrats constitute an alliance between soccer and basketball fans while Republicans disproportionately follow baseball, golf, and NASCAR. Football, by far America’s most popular sport, crosses the aisle.)

The willingness of growing numbers of Americans to embrace soccer bespeaks their willingness to imagine a different relationship with the world. Historically, conservative foreign policy has oscillated between isolationism and imperialism. America must either retreat from the world or master it. It cannot be one among equals, bound by the same rules as everyone else

Exceptionalists view sports the same way. Coulter likes football, baseball, and basketball because America either plays them by itself, or—when other countries play against us—we dominate them.

Embracing soccer, by contrast, means embracing America’s role as merely one nation among many, without special privileges. It’s no coincidence that young Americans, in addition to liking soccer, also like the United Nations. In 2013, Pew found that Americans under 30 were 24 points more favorable to the U.N. than Americans over 50.

Millennials were also 23 points more likely than the elderly to say America should take its allies’ opinion into account even if means compromising our desires.

In embracing soccer, Americans are learning to take something we neither invented nor control, and nonetheless make it our own. It’s a skill we’re going to need in the years to come.

Smith had a particular example in mind when he talked about market integration between continents: Europe and America.

Kevin O’Rourke and Jeffrey Williamson argued in a 2002 paper that globalisation only really began in the nineteenth century when a sudden drop in transport costs allowed the prices of commodities in Europe and Asia to converge

But there is one important market that Mssrs O’Rourke and Williamson ignore in their analysis: that for silver. As European currencies were generally based on the value of silver, any change in its value would have had big effects on the European price level.

The impact of what historians have called the resulting “price revolution” dramatically changed the face of Europe. Historians attribute everything from the dominance of the Spanish Empire in Europe to the sudden increase in witch hunts around the sixteenth century to the destabilising effects of inflation on European society. And if it were not for the sudden increase of silver imports from Europe to China and India during this period, European inflation would have been much worse than it was. Price rises only stopped in about 1650 when the price of silver coinage in Europe fell to such a low level that it was no longer profitable to import it from the Americas.

The German historical economist, Andre Gunder Frank, has argued that the start of globalisation can be traced back to the growth of trade and market integration between the Sumer and Indus civilisations of the third millennium BC. Trade links between China and Europe first grew during the Hellenistic Age, with further increases in global market convergence occuring when transport costs dropped in the sixteenth century and more rapidly in the modern era of globalisation, which Mssrs O’Rourke and Williamson describe as after 1750.

it is clear that globalisation is not simply a process that started in the last two decades or even the last two centuries. It has a history that stretches thousands of years, starting with Smith’s primitive hunter-gatherers trading with the next village, and eventually developing into the globally interconnected societies of today. Whether you think globalisation is a “good thing” or not, it appears to be an essential element of the economic history of mankind.

A statement from the White House press secretary said the president “reassured the leaders that America remains committed to the trans-Atlantic alliance and to robust efforts to protect the environment.”

The president’s speech was his boldest and most sweeping assertion of an “America first” foreign policy doctrine since he assumed office four months ago.

“At what point does America get demeaned? At what point do they start laughing at us as a country?” Mr. Trump said. “We don’t want other leaders and other countries laughing at us anymore. And they won’t be.”

said the decision would ultimately harm the economy by ceding the jobs of the future in clean energy and technology to overseas competitors.

In his remarks, Mr. Trump listed sectors of the United States economy that would lose revenue and jobs if the country remained part of the accord, citing a study — vigorously disputed by environmental groups — asserting that the agreement would cost 2.7 million jobs by 2025.

“Even in the absence of American leadership; even as this administration joins a small handful of nations that reject the future; I’m confident that our states, cities, and businesses will step up and do even more to lead the way, and help protect for future generations the one planet we’ve got,” Mr. Obama said.

In recent days, Mr. Trump withstood withering criticism from European counterparts who accused him of shirking America’s role as a global leader and America’s responsibility as history’s largest emitter of planet-warming greenhouse gasses.

shortsightedness about the planet and a reckless willingness to shatter longstanding diplomatic relationships.

“It undermines America’s standing in the world and threatens to damage humanity’s ability to solve the climate crisis in time.”

they’re also used as talking points by politicians who are working to make it more difficult for the EPA and other federal agencies to use science in their regulatory decision-making, under the guise of basing policy on “sound science.” Science’s virtues are being wielded against it.

What distinguishes the two calls for transparency is intent: Whereas the “open science” movement aims to make science more reliable, reproducible and robust, proponents of “sound science” have historically worked to amplify uncertainty, create doubt and undermine scientific discoveries that threaten their interests.

“Our criticisms are founded in a confidence in science,” said Steven Goodman, co-director of the Meta-Research Innovation Center at Stanford and a proponent of open science. “That’s a fundamental difference — we’re critiquing science to make it better. Others are critiquing it to devalue the approach itself.”

alls to base public policy on “sound science” seem unassailable if you don’t know the term’s history. The phrase was adopted by the tobacco industry in the 1990s to counteract mounting evidence linking secondhand smoke to cancer.

The sound science tactic exploits a fundamental feature of the scientific process: Science does not produce absolute certainty. Contrary to how it’s sometimes represented to the public, science is not a magic wand that turns everything it touches to truth. Instead, it’s a process of uncertainty reduction, much like a game of 20 Questions.

Any given study can rarely answer more than one question at a time, and each study usually raises a bunch of new questions in the process of answering old ones. “Science is a process rather than an answer,” said psychologist Alison Ledgerwood of the University of California, Davis. Every answer is provisional and subject to change in the face of new evidence. It’s not entirely correct to say that “this study proves this fact,” Ledgerwood said. “We should be talking instead about how science increases or decreases our confidence in something.”

While insisting that they merely wanted to ensure that public policy was based on sound science, tobacco companies defined the term in a way that ensured that no science could ever be sound enough. The only sound science was certain science, which is an impossible standard to achieve.

“Doubt is our product,” wrote one employee of the Brown & Williamson tobacco company in a 1969 internal memo. The note went on to say that doubt “is the best means of competing with the ‘body of fact’” and “establishing a controversy.” These strategies for undermining inconvenient science were so effective that they’ve served as a sort of playbook for industry interests ever since

Doubt merchants aren’t pushing for knowledge, they’re practicing what Proctor has dubbed “agnogenesis” — the intentional manufacture of ignorance. This ignorance isn’t simply the absence of knowing something; it’s a lack of comprehension deliberately created by agents who don’t want you to know,

In the hands of doubt-makers, transparency becomes a rhetorical move. “It’s really difficult as a scientist or policy maker to make a stand against transparency and openness, because well, who would be against it?

But at the same time, “you can couch everything in the language of transparency and it becomes a powerful weapon.” For instance, when the EPA was preparing to set new limits on particulate pollution in the 1990s, industry groups pushed back against the research and demanded access to primary data (including records that researchers had promised participants would remain confidential) and a reanalysis of the evidence. Their calls succeeded and a new analysis was performed. The reanalysis essentially confirmed the original conclusions, but the process of conducting it delayed the implementation of regulations and cost researchers time and money.

Delay is a time-tested strategy. “Gridlock is the greatest friend a global warming skeptic has,” said Marc Morano, a prominent critic of global warming research

which has received funding from the oil and gas industry. “We’re the negative force. We’re just trying to stop stuff.”

these ploys are getting a fresh boost from Congress. The Data Quality Act (also known as the Information Quality Act) was reportedly written by an industry lobbyist and quietly passed as part of an appropriations bill in 2000. The rule mandates that federal agencies ensure the “quality, objectivity, utility, and integrity of information” that they disseminate, though it does little to define what these terms mean. The law also provides a mechanism for citizens and groups to challenge information that they deem inaccurate, including science that they disagree with. “It was passed in this very quiet way with no explicit debate about it — that should tell you a lot about the real goals,” Levy said.

in the 20 months following its implementation, the act was repeatedly used by industry groups to push back against proposed regulations and bog down the decision-making process. Instead of deploying transparency as a fundamental principle that applies to all science, these interests have used transparency as a weapon to attack very particular findings that they would like to eradicate.

Now Congress is considering another way to legislate how science is used. The Honest Act, a bill sponsored by Rep. Lamar Smith of Texas,3The bill has been passed by the House but still awaits a vote in the Senate. is another example of what Levy calls a “Trojan horse” law that uses the language of transparency as a cover to achieve other political goals. Smith’s legislation would severely limit the kind of evidence the EPA could use for decision-making. Only studies whose raw data and computer codes were publicly available would be allowed for consideration.

It might seem like an easy task to sort good science from bad, but in reality it’s not so simple. “There’s a misplaced idea that we can definitively distinguish the good from the not-good science, but it’s all a matter of degree,” said Brian Nosek, executive director of the Center for Open Science. “There is no perfect study.” Requiring regulators to wait until they have (nonexistent) perfect evidence is essentially “a way of saying, ‘We don’t want to use evidence for our decision-making,’

ost scientific controversies aren’t about science at all, and once the sides are drawn, more data is unlikely to bring opponents into agreement.

objective knowledge is not enough to resolve environmental controversies. “While these controversies may appear on the surface to rest on disputed questions of fact, beneath often reside differing positions of value; values that can give shape to differing understandings of what ‘the facts’ are.” What’s needed in these cases isn’t more or better science, but mechanisms to bring those hidden values to the forefront of the discussion so that they can be debated transparently. “As long as we continue down this unabashedly naive road about what science is, and what it is capable of doing, we will continue to fail to reach any sort of meaningful consensus on these matters,”

The dispute over tobacco was never about the science of cigarettes’ link to cancer. It was about whether companies have the right to sell dangerous products and, if so, what obligations they have to the consumers who purchased them.

Similarly, the debate over climate change isn’t about whether our planet is heating, but about how much responsibility each country and person bears for stopping it

While researching her book “Merchants of Doubt,” science historian Naomi Oreskes found that some of the same people who were defending the tobacco industry as scientific experts were also receiving industry money to deny the role of human activity in global warming. What these issues had in common, she realized, was that they all involved the need for government action. “None of this is about the science. All of this is a political debate about the role of government,”

These controversies are really about values, not scientific facts, and acknowledging that would allow us to have more truthful and productive debates. What would that look like in practice? Instead of cherry-picking evidence to support a particular view (and insisting that the science points to a desired action), the various sides could lay out the values they are using to assess the evidence.

For instance, in Europe, many decisions are guided by the precautionary principle — a system that values caution in the face of uncertainty and says that when the risks are unclear, it should be up to industries to show that their products and processes are not harmful, rather than requiring the government to prove that they are harmful before they can be regulated. By contrast, U.S. agencies tend to wait for strong evidence of harm before issuing regulations

the difference between them comes down to priorities: Is it better to exercise caution at the risk of burdening companies and perhaps the economy, or is it more important to avoid potential economic downsides even if it means that sometimes a harmful product or industrial process goes unregulated?

But science can’t tell us how risky is too risky to allow products like cigarettes or potentially harmful pesticides to be sold — those are value judgements that only humans can make.

Worse still, the practice also impacts the ocean’s ability to absorb atmospheric carbon: if the water is already saturated from sources down below, it will be unable to absorb human-caused emissions from above, hamstringing one of our best assets in the fight against climate change.

Technological innovations such as green power generation and battery storage are vital for reducing global greenhouse gas emissions. But we still need to reduce atmospheric carbon, and so far technology has not been able to do that affordably and at scale.

And that's not just bikes, sales of golf equipment climbed 10%, in January camper sales were up almost 40% compared to January 2020, and boats are doing even better.

"Anytime you see a dramatic societal shift, like we have going on right now, a certain portion of that does stick,"

A society shift toward outdoor recreation presents sweeping opportunity for a company like Garmin International, in Olathe, Kan. It specializes in navigation and fitness devises.

For Garmin, locking in those new customers is partly a matter of rolling out new activity-specific devices, like the line of Descent dive computers it launched last year.

"It'll make you feel good. It really does. Little time spent outside will make you feel amazing,"

"The United States was one of the countries that supported the resolution to hold the special session," the WHO said Monday in response to an NPR inquiry. "That is not to say it has committed to support the treaty yet, as the process of moving forward was only confirmed today."

"The safety of the world's people cannot rely solely on the goodwill of governments."

A treaty would make countries more accountable to one another, he said.

The lack of sharing — of information, technology, resources and data — is the COVID-19 pandemic's defining characteristic, the WHO leader said.

"a monumental error for any country to think the danger has passed."

Tedros' remarks echoed the frustrations he raised last year, when he said the pandemic was presenting humanity with a test — one that we are failing.

"Are we unable to distinguish or identify the common enemy?"

Globally, the numbers can be even worse, and the stakes often higher. “Say a person comes into the hospital in Sierra Leone with a fever and flulike symptoms,” DeRisi says. “After a few days, or a week, they die. What caused that illness? Most of the time, we never find out. Because if the cause isn’t something that we can culture and test for” — like hepatitis, or strep throat — “it basically just stays a mystery.”

It would be better, DeRisi says, to watch for rare cases of mystery illnesses in people, which often exist well before a pathogen gains traction and is able to spread.

Based on a retrospective analysis of blood samples, scientists now know that H.I.V. emerged nearly a dozen times over a century, starting in the 1920s, before it went global.

Zika was a relatively harmless illness before a single mutation, in 2013, gave the virus the ability to enter and damage brain cells.

The beauty of this approach” — running blood samples from people hospitalized all over the world through his system, known as IDseq — “is that it works even for things that we’ve never seen before, or things that we might think we’ve seen but which are actually something new.”

In this scenario, an undiscovered or completely new virus won’t trigger a match but will instead be flagged. (Even in those cases, the mystery pathogen will usually belong to a known virus family: coronaviruses, for instance, or filoviruses that cause hemorrhagic fevers like Ebola and Marburg.)

And because different types of bacteria require specific conditions in order to grow, you also need some idea of what you’re looking for in order to find it.

The same is true of genomic sequencing, which relies on “primers” designed to match different combinations of nucleotides (the building blocks of DNA and RNA).

Even looking at a slide under a microscope requires staining, which makes organisms easier to see — but the stains used to identify bacteria and parasites, for instance, aren’t the same.

The practice that DeRisi helped pioneer to skirt this problem is known as metagenomic sequencing

Unlike ordinary genomic sequencing, which tries to spell out the purified DNA of a single, known organism, metagenomic sequencing can be applied to a messy sample of just about anything — blood, mud, seawater, snot — which will often contain dozens or hundreds of different organisms, all unknown, and each with its own DNA. In order to read all the fragmented genetic material, metagenomic sequencing uses sophisticated software to stitch the pieces together by matching overlapping segments.

The assembled genomes are then compared against a vast database of all known genomic sequences — maintained by the government-run National Center for Biotechnology Information — making it possible for researchers to identify everything in the mix

Traditionally, the way that scientists have identified organisms in a sample is to culture them: Isolate a particular bacterium (or virus or parasite or fungus); grow it in a petri dish; and then examine the result under a microscope, or use genomic sequencing, to understand just what it is. But because less than 2 percent of bacteria — and even fewer viruses — can be grown in a lab, the process often reveals only a tiny fraction of what’s actually there. It’s a bit like planting 100 different kinds of seeds that you found in an old jar. One or two of those will germinate and produce a plant, but there’s no way to know what the rest might have grown into.

Such studies have revealed just how vast the microbial world is, and how little we know about it

“The selling point for researchers is: ‘Look, this technology lets you investigate what’s happening in your clinic, whether it’s kids with meningitis or something else,’” DeRisi said. “We’re not telling you what to do with it. But it’s also true that if we have enough people using this, spread out all around the world, then it does become a global network for detecting emerging pandemics

One study found more than 1,000 different kinds of viruses in a tiny amount of human stool; another found a million in a couple of pounds of marine sediment. And most were organisms that nobody had seen before.

After the Biohub opened in 2016, one of DeRisi’s goals was to turn metagenomics from a rarefied technology used by a handful of elite universities into something that researchers around the world could benefit from

metagenomics requires enormous amounts of computing power, putting it out of reach of all but the most well-funded research labs. The tool DeRisi created, IDseq, made it possible for researchers anywhere in the world to process samples through the use of a small, off-the-shelf sequencer, much like the one DeRisi had shown me in his lab, and then upload the results to the cloud for analysis.

he’s the first to make the process so accessible, even in countries where lab supplies and training are scarce. DeRisi and his team tested the chemicals used to prepare DNA for sequencing and determined that using as little as half the recommended amount often worked fine. They also 3-D print some of the labs’ tools and replacement parts, and offer ongoing training and tech support

The metagenomic analysis itself — normally the most expensive part of the process — is provided free.

But DeRisi’s main innovation has been in streamlining and simplifying the extraordinarily complex computational side of metagenomics

IDseq is also fast, capable of doing analyses in hours that would take other systems weeks.

“What IDseq really did was to marry wet-lab work — accumulating samples, processing them, running them through a sequencer — with the bioinformatic analysis,”

“Without that, what happens in a lot of places is that the researcher will be like, ‘OK, I collected the samples!’ But because they can’t analyze them, the samples end up in the freezer. The information just gets stuck there.”

Meningitis itself isn’t a disease, just a description meaning that the tissues around the brain and spinal cord have become inflamed. In the United States, bacterial infections can cause meningitis, as can enteroviruses, mumps and herpes simplex. But a high proportion of cases have, as doctors say, no known etiology: No one knows why the patient’s brain and spinal tissues are swelling.

When Saha and her team ran the mystery meningitis samples through IDseq, though, the result was surprising. Rather than revealing a bacterial cause, as expected, a third of the samples showed signs of the chikungunya virus — specifically, a neuroinvasive strain that was thought to be extremely rare. “At first we thought, It cannot be true!” Saha recalls. “But the moment Joe and I realized it was chikungunya, I went back and looked at the other 200 samples that we had collected around the same time. And we found the virus in some of those samples as well.”

Until recently, chikungunya was a comparatively rare disease, present mostly in parts of Central and East Africa. “Then it just exploded through the Caribbean and Africa and across Southeast Asia into India and Bangladesh,” DeRisi told me. In 2011, there were zero cases of chikungunya reported in Latin America. By 2014, there were a million.

Chikungunya is a mosquito-borne virus, but when DeRisi and Saha looked at the results from IDseq, they also saw something else: a primate tetraparvovirus. Primate tetraparvoviruses are almost unknown in humans, and have been found only in certain regions. Even now, DeRisi is careful to note, it’s not clear what effect the virus has on people. “Maybe it’s dangerous, maybe it isn’t,” DeRisi says. “But I’ll tell you what: It’s now on my radar.

it reveals a landscape of potentially dangerous viruses that we would otherwise never find out about. “What we’ve been missing is that there’s an entire universe of pathogens out there that are causing disease in humans,” Imam notes, “ones that we often don’t even know exist.”

“The plan was, Let’s let researchers around the world propose studies, and we’ll choose 10 of them to start,” DeRisi recalls. “We thought we’d get, like, a couple dozen proposals, and instead we got 350.”

Metagenomic sequencing is especially good at what scientists call “environmental sampling”: identifying, say, every type of bacteria present in the gut microbiome, or in a teaspoon of seawater.

“When you draw blood from someone who has a fever in Ghana, you really don’t know very much about what would normally be in their blood without fever — let alone about other kinds of contaminants in the environment. So how do you interpret the relevance of all the things you’re seeing?”

Such criticisms have led some to say that metagenomics simply isn’t suited to the infrastructure of developing countries. Along with the problem of contamination, many labs struggle to get the chemical reagents needed for sequencing, either because of the cost or because of shipping and customs holdups

we’re less likely to be caught off-guard. “With Ebola, there’s always an issue: Where’s the virus hiding before it breaks out?” DeRisi explains. “But also, once we start sampling people who are hospitalized more widely — meaning not just people in Northern California or Boston, but in Uganda, and Sierra Leone, and Indonesia — the chance of disastrous surprises will go down. We’ll start seeing what’s hidden.”

He writes with disarming composure about the factors that have led to the disintegration of empires and the abandonment of cities and about the mechanism that, in his view, makes it nearly certain that all states that rise will one day fall

societal collapse and its associated terms — “fragility” and “resilience,” “risk” and “sustainability” — have become the objects of extensive scholarly inquiry and infrastructure.

Princeton has a research program in Global Systemic Risk, Cambridge a Center for the Study of Existential Risk

even Tainter, for all his caution and reserve, was willing to allow that contemporary society has built-in vulnerabilities that could allow things to go very badly indeed — probably not right now, maybe not for a few decades still, but possibly sooner. In fact, he worried, it could begin before the year was over.

Plato, in “The Republic,” compared cities to animals and plants, subject to growth and senescence like any living thing. The metaphor would hold: In the early 20th century, the German historian Oswald Spengler proposed that all cultures have souls, vital essences that begin falling into decay the moment they adopt the trappings of civilization.

that theory, which became the heart of “The Collapse of Complex Societies.” Tainter’s argument rests on two proposals. The first is that human societies develop complexity, i.e. specialized roles and the institutional structures that coordinate them, in order to solve problems

All history since then has been “characterized by a seemingly inexorable trend toward higher levels of complexity, specialization and sociopolitical control.”

Eventually, societies we would recognize as similar to our own would emerge, “large, heterogeneous, internally differentiated, class structured, controlled societies in which the resources that sustain life are not equally available to all.”

Something more than the threat of violence would be necessary to hold them together, a delicate balance of symbolic and material benefits that Tainter calls “legitimacy,” the maintenance of which would itself require ever more complex structures, which would become ever less flexible, and more vulnerable, the more they piled up.

Social complexity, he argues, is inevitably subject to diminishing marginal returns. It costs more and more, in other words, while producing smaller and smaller profits.

Take Rome, which, in Tainter's telling, was able to win significant wealth by sacking its neighbors but was thereafter required to maintain an ever larger and more expensive military just to keep the imperial machine from stalling — until it couldn’t anymore.

This is how it goes. As the benefits of ever-increasing complexity — the loot shipped home by the Roman armies or the gentler agricultural symbiosis of the San Juan Basin — begin to dwindle, Tainter writes, societies “become vulnerable to collapse.”

haven’t countless societies weathered military defeats, invasions, even occupations and lengthy civil wars, or rebuilt themselves after earthquakes, floods and famines?

Only complexity, Tainter argues, provides an explanation that applies in every instance of collapse.

Complexity builds and builds, usually incrementally, without anyone noticing how brittle it has all become. Then some little push arrives, and the society begins to fracture.

A disaster — even a severe one like a deadly pandemic, mass social unrest or a rapidly changing climate — can, in Tainter’s view, never be enough by itself to cause collapse

The only precedent Tainter could think of, in which pandemic coincided with mass social unrest, was the Black Death of the 14th century. That crisis reduced the population of Europe by as much as 60 percent.

Whether any existing society is close to collapsing depends on where it falls on the curve of diminishing returns.

The United States hardly feels like a confident empire on the rise these days. But how far along are we?

Scholars of collapse tend to fall into two loose camps. The first, dominated by Tainter, looks for grand narratives and one-size-fits-all explanations

The second is more interested in the particulars of the societies they study

Patricia McAnany, who teaches at the University of North Carolina at Chapel Hill, has questioned the usefulness of the very concept of collapse — she was an editor of a 2010 volume titled “Questioning Collapse” — but admits to being “very, very worried” about the lack, in the United States, of the “nimbleness” that crises require of governments.

We’re too vested and tied to places.” Without the possibility of dispersal, or of real structural change to more equitably distribute resources, “at some point the whole thing blows. It has to.”

In Turchin’s case the key is the loss of “social resilience,” a society’s ability to cooperate and act collectively for common goals. By that measure, Turchin judges that the United States was collapsing well before Covid-19 hit. For the last 40 years, he argues, the population has been growing poorer and more unhealthy as elites accumulate more and more wealth and institutional legitimacy founders. “The United States is basically eating itself from the inside out,

Inequality and “popular immiseration” have left the country extremely vulnerable to external shocks like the pandemic, and to internal triggers like the killings of George Floyd

Societies evolve complexity, he argues, precisely to meet such challenges.

Eric H. Cline, who teaches at the George Washington University, argued in “1177 B.C.: The Year Civilization Collapsed” that Late Bronze Age societies across Europe and western Asia crumbled under a concatenation of stresses, including natural disasters — earthquakes and drought — famine, political strife, mass migration and the closure of trade routes. On their own, none of those factors would have been capable of causing such widespread disintegration, but together they formed a “perfect storm” capable of toppling multiple societies all at once.

Collapse “really is a matter of when,” he told me, “and I’m concerned that this may be the time.”

In “The Collapse of Complex Societies,” Tainter makes a point that echoes the concern that Patricia McAnany raised. “The world today is full,” Tainter writes. Complex societies occupy every inhabitable region of the planet. There is no escaping. This also means, he writes, that collapse, “if and when it comes again, will this time be global.” Our fates are interlinked. “No longer can any individual nation collapse. World civilization will disintegrate as a whole.”

If it happens, he says, it would be “the worst catastrophe in history.”

The quest for efficiency, he wrote recently, has brought on unprecedented levels of complexity: “an elaborate global system of production, shipping, manufacturing and retailing” in which goods are manufactured in one part of the world to meet immediate demands in another, and delivered only when they’re needed. The system’s speed is dizzying, but so are its vulnerabilities.

A more comprehensive failure of fragile supply chains could mean that fuel, food and other essentials would no longer flow to cities. “There would be billions of deaths within a very short period,” Tainter says.

If we sink “into a severe recession or a depression,” Tainter says, “then it will probably cascade. It will simply reinforce itself.”

Tainter tells me, he has seen “a definite uptick” in calls from journalists: The study of societal collapse suddenly no longer seems like a purely academic pursuit

Turchin is keenly aware of the essential instability of even the sturdiest-seeming systems. “Very severe events, while not terribly likely, are quite possible,” he says. When he emigrated from the U.S.S.R. in 1977, he adds, no one imagined the country would splinter into its constituent parts. “But it did.”

He writes of visions of “bloated bureaucracies” becoming the basis of “entire political careers.” Arms races, he observes, presented a “classic example” of spiraling complexity that provides “no tangible benefit for much of the population” and “usually no competitive advantage” either.

It is hard not to read the book through the lens of the last 40 years of American history, as a prediction of how the country might deteriorate if resources continued to be slashed from nearly every sector but the military, prisons and police.

The more a population is squeezed, Tainter warns, the larger the share that “must be allocated to legitimization or coercion.

And so it was: As U.S. military spending skyrocketed — to, by some estimates, a total of more than $1 trillion today from $138 billion in 1980 — the government would try both tactics, ingratiating itself with the wealthy by cutting taxes while dismantling public-assistance programs and incarcerating the poor in ever-greater numbers.

“As resources committed to benefits decline,” Tainter wrote in 1988, “resources committed to control must increase.”

The overall picture drawn by Tainter’s work is a tragic one. It is our very creativity, our extraordinary ability as a species to organize ourselves to solve problems collectively, that leads us into a trap from which there is no escaping

Complexity is “insidious,” in Tainter’s words. “It grows by small steps, each of which seems reasonable at the time.” And then the world starts to fall apart, and you wonder how you got there.

Perhaps collapse is not, actually, a thing. Perhaps, as an idea, it was a product of its time, a Cold War hangover that has outlived its usefulness, or an academic ripple effect of climate-change anxiety, or a feedback loop produced by some combination of the two

if you pay attention to people’s lived experience, and not just to the abstractions imposed by a highly fragmented archaeological record, a different kind of picture emerges.

Tainter’s understanding of societies as problem-solving entities can obscure as much as it reveals

Plantation slavery arose in order to solve a problem faced by the white landowning class: The production of agricultural commodities like sugar and cotton requires a great deal of backbreaking labor. That problem, however, has nothing to do with the problems of the people they enslaved. Which of them counts as “society”?

Since the beginning of the pandemic, the total net worth of America’s billionaires, all 686 of them, has jumped by close to a trillion dollars.

If societies are not in fact unitary, problem-solving entities but heaving contradictions and sites of constant struggle, then their existence is not an all-or-nothing game.

Collapse appears not as an ending, but a reality that some have already suffered — in the hold of a slave ship, say, or on a long, forced march from their ancestral lands to reservations faraway — and survived.

The current pandemic has already given many of us a taste of what happens when a society fails to meet the challenges that face it, when the factions that rule over it tend solely to their own problems

the real danger comes from imagining that we can keep living the way we always have, and that the past is any more stable than the present.

If you close your eyes and open them again, the periodic disintegrations that punctuate our history — all those crumbling ruins — begin to fade, and something else comes into focus: wiliness, stubbornness and, perhaps the strongest and most essential human trait, adaptability.

When one system fails, we build another. We struggle to do things differently, and we push on. As always, we have no other choice.

Striking the right balance between markets and government is the central issue in policy debates over economic developmen

What is the role of governments in promoting economic growth?

What can governments do to seize the opportunities of globalization, while minimizing its downsides?

we have to recognize that the tension between markets and government is not new. In fact, it has been the central issue in the evolution of political economy over the last 200 years.

There have been three distinct phases in this evolution.

Phase One: The rise of the market

The “rise of the market” began in the late 18th century, shaped by the writings of Adam Smith and David Ricardo. The “invisible hand” of the market guided supply and demand toward equilibrium and efficiency.

This phase came to an end in the 1930s, when the concept of self-correcting markets collapsed under the weight of the Great Depression.

Falling prices, instead of bringing demand and supply into equilibrium,

Phase Two: The rise of government

markets were inherently unstable. Left on their own, they may not always self-correct

Government intervention was necessary to boost aggregate demand during periods of high unemployment.

The 1940s also saw the advent of the welfare state.

The welfare state was enabled through redistributive taxation and government regulation.

Phase Three: The return of the market

This phase began with growing disenchantment with government’s ability to deliver and was driven forward mainly by U.S.-based economists

The stagflation of the 1970s — persistently high inflation and unemployment — called into question the ability of governments to fine-tune the economy. Meanwhile, the welfare state began to impose an unsustainable fiscal burden,

Friedrich Hayek and Milton Friedman led the charge against “Big Government.” They argued eloquently how an overreaching government dulled the fundamental human instincts that power the capitalist system:

In the 1980s, U.S. President Ronald Reagan and UK Prime Minister Margaret Thatcher reduced taxes, deregulated industries, privatized state-owned enterprises, curbed union power, and scaled back welfare programs. The global economy boomed.

Phase Four: Balancing markets and governments

The financial crisis has revealed significant imperfections in market mechanisms: information asymmetry, moral hazard, systemic risks and behavioral or nonrational motivators of choice.

In a more globalized and complex economy, governments have fewer levers to pull

It has also revealed the inherent limitations of governmen

Neither market fundamentalism nor central planning has worked.

Yet one thing is certain: The choice is not between big government and small government. It is about creating effective government. What matters is what governments do, not how big they are.