Skip to main content

Home/ TOK Friends/ Group items tagged effect

Rss Feed Group items tagged

oliviaodon

EFFECTIVE USE OF LANGUAGE - 0 views

  • To communicate effectively, it is not enough to have well organized ideas expressed in complete and coherent sentences and paragraphs. One must also think about the style, tone and clarity of his/her writing, and adapt these elements to the reading audience. Again, analyzing one's audience and purpose is the key to writing effectiveness. In order to choose the most effective language, the writer must consider the objective of the document, the context in which it is being written, and who will be reading it.
  • Effective language is: (1) concrete and specific, not vague and abstract; (2) concise, not verbose; (3) familiar, not obscure; (4) precise and clear, not inaccurate or ambiguous; (5) constructive, not destructive; and (6) appropriately formal.
  •  
    This article is informative and extremely helpful if you are preparing for an  essay or presentation!
Javier E

Clouds' Effect on Climate Change Is Last Bastion for Dissenters - NYTimes.com - 0 views

  • For decades, a small group of scientific dissenters has been trying to shoot holes in the prevailing science of climate change, offering one reason after another why the outlook simply must be wrong. Enlarge This Image Josh Haner/The New York Times A technician at a Department of Energy site in Oklahoma launching a weather balloon to help scientists analyze clouds. More Photos » Temperature Rising Enigma in the Sky This series focuses on the central arguments in the climate debate and examining the evidence for global warming and its consequences. More From the Series » if (typeof NYTDVideoManager != "undefined") { NYTDVideoManager.setAllowMultiPlayback(false); } function displayCompanionBanners(banners, tracking) { tmDisplayBanner(banners, "videoAdContent", 300, 250, null, tracking); } Multimedia Interactive Graphic Clouds and Climate Slide Show Understanding the Atmosphere Related Green Blog: Climate Change and the Body Politic (May 1, 2012) An Underground Fossil Forest Offers Clues on Climate Change (May 1, 2012) A blog about energy and the environment. Go to Blog » Readers’ Comments "There is always some possibility that the scientific consensus may be wrong and Dr. Lindzen may be right, or that both may be wrong. But the worst possible place to resolve such issues is the political arena." Alexander Flax, Potomac, MD Read Full Comment » Post a Comment » Over time, nearly every one of their arguments has been knocked down by accumulating evidence, and polls say 97 percent of working climate scientists now see global warming as a serious risk.
  • They acknowledge that the human release of greenhouse gases will cause the planet to warm. But they assert that clouds — which can either warm or cool the earth, depending on the type and location — will shift in such a way as to counter much of the expected temperature rise and preserve the equable climate on which civilization depends.
  • At gatherings of climate change skeptics on both sides of the Atlantic, Dr. Lindzen has been treated as a star. During a debate in Australia over carbon taxes, his work was cited repeatedly. When he appears at conferences of the Heartland Institute, the primary American organization pushing climate change skepticism, he is greeted by thunderous applause.
  • ...13 more annotations...
  • His idea has drawn withering criticism from other scientists, who cite errors in his papers and say proof is lacking. Enough evidence is already in hand, they say, to rule out the powerful cooling effect from clouds that would be needed to offset the increase of greenhouse gases.
  • “If you listen to the credible climate skeptics, they’ve really pushed all their chips onto clouds.”
  • Dr. Lindzen is “feeding upon an audience that wants to hear a certain message, and wants to hear it put forth by people with enough scientific reputation that it can be sustained for a while, even if it’s wrong science,” said Christopher S. Bretherton, an atmospheric researcher at the University of Washington. “I don’t think it’s intellectually honest at all.”
  • With climate policy nearly paralyzed in the United States, many other governments have also declined to take action, and worldwide emissions of greenhouse gases are soaring.
  • The most elaborate computer programs have agreed on a broad conclusion: clouds are not likely to change enough to offset the bulk of the human-caused warming. Some of the analyses predict that clouds could actually amplify the warming trend sharply through several mechanisms, including a reduction of some of the low clouds that reflect a lot of sunlight back to space. Other computer analyses foresee a largely neutral effect. The result is a big spread in forecasts of future temperature, one that scientists have not been able to narrow much in 30 years of effort.
  • The earth’s surface has already warmed about 1.4 degrees Fahrenheit since the Industrial Revolution, most of that in the last 40 years. Modest as it sounds, it is an average for the whole planet, representing an enormous addition of heat. An even larger amount is being absorbed by the oceans. The increase has caused some of the world’s land ice to melt and the oceans to rise.
  • Even in the low projection, many scientists say, the damage could be substantial. In the high projection, some polar regions could heat up by 20 or 25 degrees Fahrenheit — more than enough, over centuries or longer, to melt the Greenland ice sheet, raising sea level by a catastrophic 20 feet or more. Vast changes in  rainfall, heat waves and other weather patterns would most likely accompany such a large warming. “The big damages come if the climate sensitivity to greenhouse gases turns out to be high,” said Raymond T. Pierrehumbert, a climate scientist at the University of Chicago. “Then it’s not a bullet headed at us, but a thermonuclear warhead.”
  • But the problem of how clouds will behave in a future climate is not yet solved — making the unheralded field of cloud research one of the most important pursuits of modern science.
  • for more than a decade, Dr. Lindzen has said that when surface temperature increases, the columns of moist air rising in the tropics will rain out more of their moisture, leaving less available to be thrown off as ice, which forms the thin, high clouds known as cirrus. Just like greenhouse gases, these cirrus clouds act to reduce the cooling of the earth, and a decrease of them would counteract the increase of greenhouse gases. Dr. Lindzen calls his mechanism the iris effect, after the iris of the eye, which opens at night to let in more light. In this case, the earth’s “iris” of high clouds would be opening to let more heat escape.
  • Dr. Lindzen acknowledged that the 2009 paper contained “some stupid mistakes” in his handling of the satellite data. “It was just embarrassing,” he said in an interview. “The technical details of satellite measurements are really sort of grotesque.” Last year, he tried offering more evidence for his case, but after reviewers for a prestigious American journal criticized the paper, Dr. Lindzen published it in a little-known Korean journal. Dr. Lindzen blames groupthink among climate scientists for his publication difficulties, saying the majority is determined to suppress any dissenting views. They, in turn, contend that he routinely misrepresents the work of other researchers.
  • Ultimately, as the climate continues warming and more data accumulate, it will become obvious how clouds are reacting. But that could take decades, scientists say, and if the answer turns out to be that catastrophe looms, it would most likely be too late. By then, they say, the atmosphere would contain so much carbon dioxide as to make a substantial warming inevitable, and the gas would not return to a normal level for thousands of years.
  • In his Congressional appearances, speeches and popular writings, Dr. Lindzen offers little hint of how thin the published science supporting his position is. Instead, starting from his disputed iris mechanism, he makes what many of his colleagues see as an unwarranted leap of logic, professing near-certainty that climate change is not a problem society needs to worry about.
  • “Even if there were no political implications, it just seems deeply unprofessional and irresponsible to look at this and say, ‘We’re sure it’s not a problem,’ ” said Kerry A. Emanuel, another M.I.T. scientist. “It’s a special kind of risk, because it’s a risk to the collective civilization.”
charlottedonoho

How can we best assess the neuropsychological effects of violent video game play? | Pet... - 0 views

  • Every time a research paper about violent video games makes it into the news, it feels like we’re in a time loop. Any claims that the study makes about the potential positive or (usually) negative effects of playing games tend to get over-egged to the point of ridiculousness.
  • At best, the measures of aggression that are used in such work are unstandardised; at worst, the field has been shown to be riddled with basic methodological and analytical flaws. These problems are further compounded by entrenched ideologies and a reluctance from some researchers to even talk to their ‘adversaries’, let alone discuss the potential for adversarial collaborations
  • All of this means that we’re stuck at an impasse with violent video games research; it feels like we’re no more clued up on what the actual behavioural effects are now than, say, five or ten years ago.
  • ...4 more annotations...
  • In stage 1, they submit the introduction, methods, proposed analysis, and if necessary, pilot data. This manuscript then goes through the usual peer review process, and is assessed on criteria such as the soundness of the methods and analysis, and overall plausibility of the stated hypotheses.
  • Once researchers have passed through stage 1, they can then move on to data collection. In stage 2, they then submit the full manuscript – the introduction and agreed methods from stage 1, plus results and discussion sections. The results must include the outcome of the analyses agreed in stage 1, but the researchers are allowed to include additional analyses in a separate, ‘exploratory’ section (as long as they are justified).
  • Pre-registering scientific articles in this way helps to protect against a number of undesirable practices (such as p-hacking and HARKing) that can exaggerate statistical findings and make non-existent effects seem real. While this is a problem across psychology generally, it is a particularly extreme problem for violent video game research.
  • By outlining the intended methods and analysis protocols beforehand, Registered Reports protect against these problems, as the review process concentrates on the robustness of the proposed methods. And Registered Reports offer an additional advantage: because manuscripts are never accepted based on the outcome of the data analysis, the process is immune to researcher party lines. It doesn’t matter which research ‘camp’ you are in; your data – and just as importantly, your methods - will speak for themselves.
Javier E

These Studies Show How 'The Fox Effect' Pushed Congress, Country To The Right - 0 views

  • several studies showing how Fox broke into an untapped market for a single conservative news source after years of FCC regulations which required equal time for political debate (the so-called "fairness doctrine" ended in 1987 under President Reagan.)
  • Barlett also surfaced studies which show that that the Fox Effect changed not only Americans' media diet, but their political behavior as well — boosting turnout for the GOP and pushing both Republicans and Democrats rightward in Congress
  • A 2007 study in the Quarterly Journal of Economics found that the arrival of Fox had a "significant effect" on the presidential elections from 1996 to 2000: Republican candidates gained 0.4 to 0.7 percentage points in towns that broadcast the channel. (The research also credited Fox with GOP gains in the Senate.)
  • ...5 more annotations...
  • Meanwhile, a 2014 study by The National Bureau of Economic Research found that the likelihood of voting Republican increased by 0.9 points among viewers who watched "four additional minutes per week."
  • research that shows the Fox Effect caused congressmen in both parties to "increase their support for Republican policies."
  • during the Clinton years, members of Congress became "less supportive of President Clinton in districts where Fox News begins broadcasting than similar representatives in similar districts where Fox News was not broadcast."
  • These days, the misinformation peddled by Fox may actually lull conservative viewers and voters into a false sense of security.
  • "wishful thinking" may have hurt Republicans' efforts to take the White House in 2012. "It may be that some Republican Fox viewers became complacent and didn’t work as hard as they might if they had been more aware of how badly Romney was doing in the final days of the campaign," he wrote.
grayton downing

Tuning the Brain | The Scientist Magazine® - 0 views

  • first neurosurgeries took place about 7,000 years ago in South America with the boring of holes into hapless patients’ skulls, a process known as trephination. Practitioners of the day believed the source of neurologic and psychiatric disease to be evil spirits inhabiting the brain, and the way to treat such disorders, they reasoned, was to make holes in the skull and let the evil spirits escape. The procedure was surprisingly common, with as many as 1 percent of skulls at some archaeological sites having these holes.
  • disorders is a consequence of pathological activity within a specific brain circuit. In Parkinson’s disease and dystonia, neurons in the motor circuits misfire, causing aberrant movements of the limbs and torso. Malfunction in circuits that regulate mood can lead to depression.
  • observing patients’ behavioral changes following the stimulation or inhibition of specific neural circuits, DBS is helping to explain what goes wrong in the brain to cause symptoms
  • ...1 more annotation...
  • addition to neuroimaging techniques that can reveal regional brain activity, brain lesioning can also help shed light on the most important targets for a particular disorder. In brain lesioning, misfiring neurons or their connections are destroyed, most commonly using a heating probe inserted in the brain. Once the first patients are treated, data on effectiveness and side effects, in combination with continued neuroimaging, can help further focus the targets. Lesioning is an alternative to DBS in certain specific cases and can be effective, but it is irreversible, and any untoward effects can be permanent. Because the dose of DBS at the same site can be adjusted down if adverse effects emerge, it is considered to be a potentially safer alternative.
Javier E

Underselling the Vaccine - The New York Times - 0 views

  • Of the 32,000 people who received the Moderna or Pfizer vaccine in a research trial, do you want to guess how many contracted a severe Covid case? One.
  • If anything, the 95 percent number understates the effectiveness, because it counts anyone who came down with a mild case of Covid-19 as a failure. But turning Covid into a typical flu — as the vaccines evidently did for most of the remaining 5 percent — is actually a success.
  • Although no rigorous study has yet analyzed whether vaccinated people can spread the virus, it would be surprising if they did. “If there is an example of a vaccine in widespread clinical use that has this selective effect — prevents disease but not infection — I can’t think of one!” Dr. Paul Sax of Harvard has written
  • ...10 more annotations...
  • “Please be assured that YOU ARE SAFE after vaccine from what matters — disease and spreading.”
  • The risks for vaccinated people are still not zero, because almost nothing in the real world is zero risk. A tiny percentage of people may have allergic reactions
  • the evidence so far suggests that the vaccines are akin to a cure.
  • The Moderna and Pfizer vaccines — the only two approved in the U.S. — are among the best vaccines ever created, with effectiveness rates of about 95 percent after two doses.
  • That’s on par with the vaccines for chickenpox and measles.
  • The Moderna and Pfizer vaccines are “essentially 100 percent effective against serious disease,” Dr. Paul Offit, the director of the Vaccine Education Center at Children’s Hospital of Philadelphia, said. “It’s ridiculously encouraging.”
  • “It’s going to save your life — that’s where the emphasis has to be right now,”
  • “We’re underselling the vaccine,”
  • Right now, public discussion of the vaccines is full of warnings about their limitations: They’re not 100 percent effective. Even vaccinated people may be able to spread the virus. And people shouldn’t change their behavior once they get their shots.
  • These warnings have a basis in truth, just as it’s true that masks are imperfect.
katedriscoll

Metacontrol and body ownership: divergent thinking increases the virtual hand illusion ... - 0 views

  • The virtual hand illusion (VHI) paradigm demonstrates that people tend to perceive agency and bodily ownership for a virtual hand that moves in synchrony with their own movements. Given that this kind of effect can be taken to reflect self–other integration (i.e., the integration of some external, novel event into the representation of oneself), and given that self–other integration has been previously shown to be affected by metacontrol states (biases of information processing towards persistence/selectivity or flexibility/integration), we tested whether the VHI varies in size depending on the metacontrol bias. Persistence and flexibility biases were induced by having participants carry out a convergent thinking (Remote Associates) task or divergent-thinking (Alternate Uses) task, respectively, while experiencing a virtual hand moving synchronously or asynchronously with their real hand. Synchrony-induced agency and ownership effects were more pronounced in the context of divergent thinking than in the context of convergent thinking, suggesting that a metacontrol bias towards flexibility promotes self–other integration.
  • As in previous studies, participants were more likely to experience subjective agency and ownership for a virtual hand if it moved in synchrony with their own, real hand. As predicted, the size of this effect was significantly moderated by the type of creativity task in the context of which the illusion was induced.
  • It is important to keep in mind the fact that our present findings were obtained in a paradigm that strongly interleaved what we considered the task prime (i.e., the particular creativity task) and the induction of the VHI—the process we aimed to prime. The practical reason to do so was to increase the probability that the metacontrol state that the creativity tasks were hypothesized to induce or establish would be sufficiently close in time to the synchrony manipulation to have an impact on the thereby induced changes in self-perception. However, this implies that we are unable to disentangle the effects of the task prime proper and the effects of possible interactions between this task prime and the synchrony manipulation. There are indeed reasons to assume that such interactions are not unlikely to have occurred
  • ...2 more annotations...
  • and that they would make perfect theoretical sense. The observation that the VHI was affected by the type of creativity task and performance in the creativity tasks was affected by the synchrony manipulation suggests some degree of overlap between the ways that engaging in particular creativity tasks and experiencing particular degrees of synchrony are able to bias perceived ownership and agency. In terms of our theoretical framework, this implies that engaging in divergent thinking biases metacontrol towards flexibility in similar ways as experiencing synchrony between one’s own movements and those of a virtual effector does, while engaging in convergent thinking biases metacontrol towards persistence as experiencing asynchrony does. What the present findings demonstrate is that both kinds of manipulation together bias the VHI in the predicted direction, but they do not allow to statistically or numerically separate and estimate the contribution that each of the two confounded manipulations might have made. Accordingly, the present findings should not be taken to provide conclusive evidence that priming tasks alone are able to change self-perception without being supported (and perhaps even enabled) by the experience of synchrony
  • between proprioceptive and visual action feedback.
  •  
    This article relates to the ownership module. It talks about an experiment with VHI that is very interesting.
tongoscar

Did Trump Propose Cuts to Federal Pay Raises, Citing 'Serious Economic Conditions'? - 0 views

  • It was. In the message, Trump stated that federal law “authorizes me to implement alternative plans for pay adjustments for civilian Federal employees covered by the General Schedule and certain other pay systems if, because of ‘national emergency or serious economic conditions affecting the general welfare,’ I view the increases that would otherwise take effect as inappropriate.”
  • Congress approved a 3.1% raise for federal workers, which went into effect in 2020. It was the largest pay increase in a decade. Legislation introduced for 2021 calls for for a 3.5% increase.
  • It’s not unusual for presidents to make efforts to prevent full pay raises for federal workers from going into effect, Kauffman said. What is unusual is that Trump is using the economy to justify cuts even as he has been outspoken about the strength of the economy. One day after his message to Congress, Trump tweeted, “BEST USA ECONOMY IN HISTORY!”
  • ...2 more annotations...
  • “If the economy is doing so well, then why can’t we afford to provide a pay raise to the federal workers, a third of whom are veterans, who ensure our democracy is working every day and ensure services are delivered,” Kauffman said. “Currently federal employees make about 4% less today than they did at the start of the decade, counting for inflation.”
  • But “every single president except maybe the first year [the law was in effect] under [George H.W. Bush], they have used national security reasons or national economic concerns to prevent the full raise from taking effect,” Kauffman said.
Javier E

The Perks of Taking the High Road - The Atlantic - 0 views

  • hat is the point of arguing with someone who disagrees with you? Presumably, you would like them to change their mind. But that’s easier said than done
  • Research shows that changing minds, especially changing beliefs that are tied strongly to people’s identity, is extremely difficult
  • this personal attachment to beliefs encourages “competitive personal contests rather than collaborative searches for the truth.”
  • ...29 more annotations...
  • The way that people tend to argue today, particularly online, makes things worse.
  • You wouldn’t blame anyone involved for feeling as if they’re under fire, and no one is likely to change their mind when they’re being attacked.
  • odds are that neither camp is having any effect on the other; on the contrary, the attacks make opponents dig in deeper.
  • If you want a chance at changing minds, you need a new strategy: Stop using your values as a weapon, and start offering them as a gift.
  • hilosophers and social scientists have long pondered the question of why people hold different beliefs and values
  • One of the most compelling explanations comes from Moral Foundations Theory, which has been popularized by Jonathan Haidt, a social psychologist at NYU. This theory proposes that humans share a common set of “intuitive ethics,” on top of which we build different narratives and institutions—and therefore beliefs—that vary by culture, community, and even person.
  • Extensive survey-based research has revealed that almost everyone shares at least two common values: Harming others without cause is bad, and fairness is good. Other moral values are less widely shared
  • political conservatives tend to value loyalty to a group, respect for authority, and purity—typically in a bodily sense, in terms of sexuality—more than liberals do.
  • Sometimes conflict arises because one group holds a moral foundation that the other simply doesn’t feel strongly about
  • even when two groups agree on a moral foundation, they can radically disagree on how it should be expressed
  • When people fail to live up to your moral values (or your expression of them), it is easy to conclude that they are immoral people.
  • Further, if you are deeply attached to your values, this difference can feel like a threat to your identity, leading you to lash out, which won’t convince anyone who disagrees with you.
  • research shows that if you insult someone in a disagreement, the odds are that they will harden their position against yours, a phenomenon called the boomerang effect.
  • so it is with our values. If we want any chance at persuasion, we must offer them happily. A weapon is an ugly thing, designed to frighten and coerce
  • effective missionaries present their beliefs as a gift. And sharing a gift is a joyful act, even if not everyone wants it.
  • he solution to this problem requires a change in the way we see and present our own values
  • A gift is something we believe to be good for the recipient, who, we hope, may accept it voluntarily, and do so with gratitude. That requires that we present it with love, not insults and hatred.
  • 1. Don’t “other” others.
  • Go out of your way to welcome those who disagree with you as valued voices, worthy of respect and attention. There is no “them,” only “us.”
  • 2. Don’t take rejection personally.
  • just as you are not your car or your house, you are not your beliefs. Unless someone says, “I hate you because of your views,” a repudiation is personal only if you make it so
  • 3. Listen more.
  • when it comes to changing someone’s mind, listening is more powerful than talking. They conducted experiments that compared polarizing arguments with a nonjudgmental exchange of views accompanied by deep listening. The former had no effect on viewpoints, whereas the latter reliably lowered exclusionary opinions.
  • when possible, listening and asking sensitive questions almost always has a more beneficial effect than talking.
  • howing others that you can be generous with them regardless of their values can help weaken their belief attachment, and thus make them more likely to consider your point of view
  • for your values to truly be a gift, you must weaken your own belief attachment first
  • we should all promise to ourselves, “I will cultivate openness, non-discrimination, and non-attachment to views in order to transform violence, fanaticism, and dogmatism in myself and in the world.”
  • if I truly have the good of the world at heart, then I must not fall prey to the conceit of perfect knowledge, and must be willing to entertain new and better ways to serve my ultimate goal: creating a happier world
  • generosity and openness have a bigger chance of making the world better in the long run.
Javier E

I Thought I Was Saving Trans Kids. Now I'm Blowing the Whistle. - 0 views

  • Soon after my arrival at the Transgender Center, I was struck by the lack of formal protocols for treatment. The center’s physician co-directors were essentially the sole authority.
  • At first, the patient population was tipped toward what used to be the “traditional” instance of a child with gender dysphoria: a boy, often quite young, who wanted to present as—who wanted to be—a girl. 
  • Until 2015 or so, a very small number of these boys comprised the population of pediatric gender dysphoria cases. Then, across the Western world, there began to be a dramatic increase in a new population: Teenage girls, many with no previous history of gender distress, suddenly declared they were transgender and demanded immediate treatment with testosterone. 
  • ...27 more annotations...
  • The girls who came to us had many comorbidities: depression, anxiety, ADHD, eating disorders, obesity. Many were diagnosed with autism, or had autism-like symptoms. A report last year on a British pediatric transgender center found that about one-third of the patients referred there were on the autism spectrum.
  • This concerned me, but didn’t feel I was in the position to sound some kind of alarm back then. There was a team of about eight of us, and only one other person brought up the kinds of questions I had. Anyone who raised doubts ran the risk of being called a transphobe. 
  • I certainly saw this at the center. One of my jobs was to do intake for new patients and their families. When I started there were probably 10 such calls a month. When I left there were 50, and about 70 percent of the new patients were girls. Sometimes clusters of girls arrived from the same high school. 
  • There are no reliable studies showing this. Indeed, the experiences of many of the center’s patients prove how false these assertions are. 
  • The doctors privately recognized these false self-diagnoses as a manifestation of social contagion. They even acknowledged that suicide has an element of social contagion. But when I said the clusters of girls streaming into our service looked as if their gender issues might be a manifestation of social contagion, the doctors said gender identity reflected something innate.
  • To begin transitioning, the girls needed a letter of support from a therapist—usually one we recommended—who they had to see only once or twice for the green light. To make it more efficient for the therapists, we offered them a template for how to write a letter in support of transition. The next stop was a single visit to the endocrinologist for a testosterone prescription. 
  • When a female takes testosterone, the profound and permanent effects of the hormone can be seen in a matter of months. Voices drop, beards sprout, body fat is redistributed. Sexual interest explodes, aggression increases, and mood can be unpredictable. Our patients were told about some side effects, including sterility. But after working at the center, I came to believe that teenagers are simply not capable of fully grasping what it means to make the decision to become infertile while still a minor.
  • Many encounters with patients emphasized to me how little these young people understood the profound impacts changing gender would have on their bodies and minds. But the center downplayed the negative consequences, and emphasized the need for transition. As the center’s website said, “Left untreated, gender dysphoria has any number of consequences, from self-harm to suicide. But when you take away the gender dysphoria by allowing a child to be who he or she is, we’re noticing that goes away. The studies we have show these kids often wind up functioning psychosocially as well as or better than their peers.” 
  • Frequently, our patients declared they had disorders that no one believed they had. We had patients who said they had Tourette syndrome (but they didn’t); that they had tic disorders (but they didn’t); that they had multiple personalities (but they didn’t).
  • Here’s an example. On Friday, May 1, 2020, a colleague emailed me about a 15-year-old male patient: “Oh dear. I am concerned that [the patient] does not understand what Bicalutamide does.” I responded: “I don’t think that we start anything honestly right now.”
  • Bicalutamide is a medication used to treat metastatic prostate cancer, and one of its side effects is that it feminizes the bodies of men who take it, including the appearance of breasts. The center prescribed this cancer drug as a puberty blocker and feminizing agent for boys. As with most cancer drugs, bicalutamide has a long list of side effects, and this patient experienced one of them: liver toxicity. He was sent to another unit of the hospital for evaluation and immediately taken off the drug. Afterward, his mother sent an electronic message to the Transgender Center saying that we were lucky her family was not the type to sue.
  • How little patients understood what they were getting into was illustrated by a call we received at the center in 2020 from a 17-year-old biological female patient who was on testosterone. She said she was bleeding from the vagina. In less than an hour she had soaked through an extra heavy pad, her jeans, and a towel she had wrapped around her waist. The nurse at the center told her to go to the emergency room right away.
  • when there was a dispute between the parents, it seemed the center always took the side of the affirming parent.
  • Other girls were disturbed by the effects of testosterone on their clitoris, which enlarges and grows into what looks like a microphallus, or a tiny penis. I counseled one patient whose enlarged clitoris now extended below her vulva, and it chafed and rubbed painfully in her jeans. I advised her to get the kind of compression undergarments worn by biological men who dress to pass as female. At the end of the call I thought to myself, “Wow, we hurt this kid.”
  • There are rare conditions in which babies are born with atypical genitalia—cases that call for sophisticated care and compassion. But clinics like the one where I worked are creating a whole cohort of kids with atypical genitals—and most of these teens haven’t even had sex yet. They had no idea who they were going to be as adults. Yet all it took for them to permanently transform themselves was one or two short conversations with a therapist.
  • Being put on powerful doses of testosterone or estrogen—enough to try to trick your body into mimicking the opposite sex—-affects the rest of the body. I doubt that any parent who's ever consented to give their kid testosterone (a lifelong treatment) knows that they’re also possibly signing their kid up for blood pressure medication, cholesterol medication, and perhaps sleep apnea and diabetes. 
  • Besides teenage girls, another new group was referred to us: young people from the inpatient psychiatric unit, or the emergency department, of St. Louis Children’s Hospital. The mental health of these kids was deeply concerning—there were diagnoses like schizophrenia, PTSD, bipolar disorder, and more. Often they were already on a fistful of pharmaceuticals.
  • no matter how much suffering or pain a child had endured, or how little treatment and love they had received, our doctors viewed gender transition—even with all the expense and hardship it entailed—as the solution.
  • Another disturbing aspect of the center was its lack of regard for the rights of parents—and the extent to which doctors saw themselves as more informed decision-makers over the fate of these children.
  • We found out later this girl had had intercourse, and because testosterone thins the vaginal tissues, her vaginal canal had ripped open. She had to be sedated and given surgery to repair the damage. She wasn’t the only vaginal laceration case we heard about.
  • During the four years I worked at the clinic as a case manager—I was responsible for patient intake and oversight—around a thousand distressed young people came through our doors. The majority of them received hormone prescriptions that can have life-altering consequences—including sterility. 
  • I left the clinic in November of last year because I could no longer participate in what was happening there. By the time I departed, I was certain that the way the American medical system is treating these patients is the opposite of the promise we make to “do no harm.” Instead, we are permanently harming the vulnerable patients in our care.
  • Today I am speaking out. I am doing so knowing how toxic the public conversation is around this highly contentious issue—and the ways that my testimony might be misused. I am doing so knowing that I am putting myself at serious personal and professional risk.
  • Almost everyone in my life advised me to keep my head down. But I cannot in good conscience do so. Because what is happening to scores of children is far more important than my comfort. And what is happening to them is morally and medically appalling.
  • For almost four years, I worked at The Washington University School of Medicine Division of Infectious Diseases with teens and young adults who were HIV positive. Many of them were trans or otherwise gender nonconforming, and I could relate: Through childhood and adolescence, I did a lot of gender questioning myself. I’m now married to a transman, and together we are raising my two biological children from a previous marriage and three foster children we hope to adopt. 
  • The center’s working assumption was that the earlier you treat kids with gender dysphoria, the more anguish you can prevent later on. This premise was shared by the center’s doctors and therapists. Given their expertise, I assumed that abundant evidence backed this consensus. 
  • All that led me to a job in 2018 as a case manager at The Washington University Transgender Center at St. Louis Children's Hospital, which had been established a year earlier. 
Emily Horwitz

Studying the Effects of Playing Violent Video Games - NYTimes.com - 1 views

  •  
    This article talked about the connection for which psychologists are looking between violent video games and actual violence. Some studies have shown that exposure to a violent video game has short term effects, that drive people to act more rudely. However, other studies have shown that an increase in violent video game sales over a period of time have sometimes led to a decrease in crime. I'm interested to see if these psychologists can run some sort of brain scan as well, to see if there really is some sort of biological basis for a difference in behavior. Additionally, it would be great to see if the same phenomena occurred with violent or psychopathic movies or television shows.
Emily Horwitz

Long Prison Terms Eyed as Contributing to Poverty - NYTimes.com - 0 views

  •  
    A very eye-opening (albeit very long) article about the devastating effects that a stint in prison can have on a family. The article noted that many men who are sent to jail are often given sentences that are too long, so that, by the time they are released, they are way past the average age for committing crimes, and have missed out on valuable life experiences that could have aided them in getting a job. As a result, many of these men find it difficult to get a job, falling into a cycle of poverty, and perhaps, again, to crime. Additionally, for those who have spouses and/or children, time in prison can drastically harm the economic status of a man's family; without the extra income, these families may become homeless, as did the woman, Ms. Hamilton, in the article. Especially intriguing to me was the racial implications of the article; the author pointed out that African-American men are more likely to be incarcerated than they are to have a job, if they did not receive a high school diploma. In terms of TOK, this article showed that all the facets of the human sciences are related - from social problems to economic problems, times in prison can have a devastating effect on not only the jailed man, but his family as well.
Javier E

Science and gun violence: why is the research so weak? [Part 2] - Boing Boing - 1 views

  • Scientists are missing some important bits of data that would help them better understand the effects of gun policy and the causes of gun-related violence. But that’s not the only reason why we don’t have solid answers. Once you have the data, you still have to figure out what it means. This is where the research gets complicated, because the problem isn’t simply about what we do and don’t know right now. The problem, say some scientists, is that we —from the public, to politicians, to even scientists themselves—may be trying to force research to give a type of answer that we can’t reasonably expect it to offer. To understand what science can do for the gun debates, we might have to rethink what “evidence-based policy” means to us.
  • For the most part, there aren’t a lot of differences in the data that these studies are using. So how can they reach such drastically different conclusions? The issue is in the kind of data that exists, and what you have to do to understand it, says Charles Manski, professor of economics at Northwestern University. Manski studies the ways that other scientists do research and how that research translates into public policy.
  • Even if we did have those gaps filled in, Manski said, what we’d have would still just be observational data, not experimental data. “We don’t have randomized, controlled experiments, here,” he said. “The only way you could do that, you’d have to assign a gun to some people randomly at birth and follow them throughout their lives. Obviously, that’s not something that’s going to work.”
  • ...14 more annotations...
  • This means that, even under the best circumstances, scientists can’t directly test what the results of a given gun policy are. The best you can do is to compare what was happening in a state before and after a policy was enacted, or to compare two different states, one that has the policy and one that doesn’t. And that’s a pretty inexact way of working.
  • Add in enough assumptions, and you can eventually come up with an estimate. But is the estimate correct? Is it even close to reality? That’s a hard question to answer, because the assumptions you made—the correlations you drew between cause and effect, what you know and what you assume to be true because of that—might be totally wrong.
  • It’s hard to tease apart the effect of one specific change, compared to the effects of other things that could be happening at the same time.
  • This process of taking the observational data we do have and then running it through a filter of assumptions plays out in the real world in the form of statistical modeling. When the NAS report says that nobody yet knows whether more guns lead to more crime, or less crime, what they mean is that the models and the assumptions built into those models are all still proving to be pretty weak.
  • From either side of the debate, he said, scientists continue to produce wildly different conclusions using the same data. On either side, small shifts in the assumptions lead the models to produce different results. Both factions continue to choose sets of assumptions that aren’t terribly logical. It’s as if you decided that anybody with blue shoes probably had a belly-button piercing. There’s not really a good reason for making that correlation. And if you change the assumption—actually, belly-button piercings are more common in people who wear green shoes—you end up with completely different results.
  • The Intergovernmental Panel on Climate Change (IPCC) produces these big reports periodically, which analyze lots of individual papers. In essence, they’re looking at lots of trees and trying to paint you a picture of the forest. IPCC reports are available for free online, you can go and read them yourself. When you do, you’ll notice something interesting about the way that the reports present results. The IPCC never says, “Because we burned fossil fuels and emitted carbon dioxide into the atmosphere then the Earth will warm by x degrees.” Instead, those reports present a range of possible outcomes … for everything. Depending on the different models used, different scenarios presented, and the different assumptions made, the temperature of the Earth might increase by anywhere between 1.5 and 4.5 degrees Celsius.
  • What you’re left with is an environment where it’s really easy to prove that your colleague’s results are probably wrong, and it’s easy for him to prove that yours are probably wrong. But it’s not easy for either of you to make a compelling case for why you’re right.
  • Statistical modeling isn’t unique to gun research. It just happens to be particularly messy in this field. Scientists who study other topics have done a better job of using stronger assumptions and of building models that can’t be upended by changing one small, seemingly randomly chosen detail. It’s not that, in these other fields, there’s only one model being used, or even that all the different models produce the exact same results. But the models are stronger and, more importantly, the scientists do a better job of presenting the differences between models and drawing meaning from them.
  • “Climate change is one of the rare scientific literatures that has actually faced up to this,” Charles Manski said. What he means is that, when scientists model climate change, they don’t expect to produce exact, to-the-decimal-point answers.
  • “It’s been a complete waste of time, because we can’t validate one model versus another,” Pepper said. Most likely, he thinks that all of them are wrong. For instance, all the models he’s seen assume that a law will affect every state in the same way, and every person within that state in the same way. “But if you think about it, that’s just nonsensical,” he said.
  • On the one hand, that leaves politicians in a bit of a lurch. The response you might mount to counteract a 1.5 degree increase in global average temperature is pretty different from the response you’d have to 4.5 degrees. On the other hand, the range does tell us something valuable: the temperature is increasing.
  • The problem with this is that it flies in the face of what most of us expect science to do for public policy. Politics is inherently biased, right? The solutions that people come up with are driven by their ideologies. Science is supposed to cut that Gordian Knot. It’s supposed to lay the evidence down on the table and impartially determine who is right and who is wrong.
  • Manski and Pepper say that this is where we need to rethink what we expect science to do. Science, they say, isn’t here to stop all political debate in its tracks. In a situation like this, it simply can’t provide a detailed enough answer to do that—not unless you’re comfortable with detailed answers that are easily called into question and disproven by somebody else with a detailed answer.
  • Instead, science can reliably produce a range of possible outcomes, but it’s still up to the politicians (and, by extension, up to us) to hash out compromises between wildly differing values on controversial subjects. When it comes to complex social issues like gun ownership and gun violence, science doesn’t mean you get to blow off your political opponents and stake a claim on truth. Chances are, the closest we can get to the truth is a range that encompasses the beliefs of many different groups.
Javier E

Should we even go there? Historians on comparing fascism to Trumpism | US news | The Gu... - 0 views

  • “What are the necessary social and psychological conditions that allow populists of Hitler’s ilk to gain a mass following and attain power?”
  • “There are certain traits you can recognize that Hitler and Trump have in common,” Ullrich says. “I would say the egomania, the total egocentricity of both men, and the inclination to mix lies and truth – that was very characteristic of Hitler.”
  • Like Trump, “Hitler exploited peoples’ feelings of resentment towards the ruling elite.” He also said he would make Germany great again. Ullrich also notes both men’s talent at playing the media, making use of new technology and their propensity for stage effects.
  • ...26 more annotations...
  • “I think the differences are still greater than the similarities,” he says. “Hitler was not only more intelligent, but craftier. He was not just a powerful orator, but a talented actor who succeeded in winning over various social milieus. So not just the economically threatened lower middle classes which Trump targeted, but also the upper middle classes. Hitler had many supporters in the German aristocracy.”
  • Trump was also democratically elected, while Hitler never had a majority vote. “He was appointed by the president of the German Reich.” Then there’s the fact that Trump does not lead a party “which is unconditionally committed to him”.
  • “A further obvious difference is that Trump doesn’t have a private militia, as Hitler did with the SA, which he used in his first months after coming to power to settle scores with his opponents, like the Communists and Social Democrats. You can’t possibly imagine something similar with Trump – that he’ll be locking Democrats up into concentration camps
  • “Finally, the American constitution is based on a system of checks and balances. It remains to be seen how far Congress will really limit Trump or if, as is feared, he can override it. It was different with Hitler, who, as we know, managed to eliminate all resistance in the shortest space of time and effectively establish himself as an all-powerful dictator. Within a few months, there was effectively no longer any opposition.”
  • “Hitler profited from the fact that his opponents always underestimated him,” Ullrich explains. “His conservative allies in government assumed they could tame or ‘civilise’ him – that once he became chancellor he’d become vernünftig (meaning sensible, reasonable). Very quickly it became clear that was an illusion.”
  • “There were many situations where he could have been stopped. For example in 1923 after the failed Munich putsch – if he’d served his full prison sentence of several years, he wouldn’t have made a political comeback. Instead, he only spent a few months behind bars, [having been released after political pressure] and could rebuild his movement.”
  • The western powers made the same mistake with their appeasement politics, indecision and indulgence. “In the 1930s Hitler strengthened, rather than weakened, his aggressive intentions,” Ullrich says. “So you could learn from this that you have to react faster and much more vigorously than was the case at the time.”
  • llrich also contends that if Hindenburg, the president of the Reich, had allowed Chancellor Brüning, of the Centre party, to remain chancellor to the end of 1934, rather than responding to pressure from conservatives to dismiss him in 1932, “then the peak of the economic crisis would have passed and it would have been very questionable whether Hitler could still have come to power”.
  • At the same time, Hitler’s ascent was no mere fluke. “There were powerful forces in the big industries, but also in the landowning class and the armed forces, which approved of a fascist solution to the crisis.”
  • If fascism “now just means aggressive nationalism, racism, patriarchy and authoritarianism, then maybe it is back on the agenda,” Bosworth continues. But today’s context is fundamentally different
  • Today’s “alt-right” agitators “live in a neoliberal global order where the slogan, ‘all for the market, nothing outside the market, no one against the market’ is far more unquestionably accepted than the old fascist slogan of ‘all for the state, nothing outside the state, no one against the state’”.
  • “What is that if it’s not racially authoritarian?” asks Schama. “If you want to call it fascist, fine. I don’t really care if it’s called that or not. It’s authoritarian, you know, ferociously authoritarian.”
  • Schama also points to deeply worrying messaging, such as “the parallel universe of lies which are habitual, massive, cumulative”; the criminalization of political opponents; the threat to change the libel laws against the press and the demonization of different racial and ethnic groups, going as far as proposing a Muslim registry.
  • Schama is clear: Trump is obviously not Hitler. “But, you know, if you like, he’s an entertainment fascist, which may be less sinister but is actually in the end more dangerous. If you’re not looking for jackboots and swastikas – although swastikas are indeed appearing – there’s a kind of laundry list of things which are truly sinister and authoritarian and not business as usual.”
  • Don’t ignore what people vote fo
  • f you’re of German heritage, it’s hard to understand how so many people could have bought Mein Kampf and gone on to vote for Hitler. Maybe no one really read it, or got beyond the first few pages of bluster, or took antisemitism seriously, you tell yourself. “Or they liked what he said,
  • “I think one of the mistakes this time around would be not to think that the people who voted for Trump were serious. They may have been serious for different reasons, but it would be a big mistake not to try and figure out what their reasons were.
  • Hitler presented himself as a “messiah” offering the public “salvation”, Ullrich points out. With austerity and hostility to the EU and to immigrants riding high, there is fertile ground for European populists next year to seduce with equally simplistic, sweeping “solutions”.
  • The problem, in Mazower’s view, is that establishment politicians currently have no response
  • “The Gestapo was piddling compared with the size and reach of surveillance equipment and operations today,
  • “Very belatedly, everyone is waking up to the fact that there was a general assumption that no government in the west would fall into the wrong hands, that it was safe to acquiesce in this huge expansion of surveillance capabilities, and the debate wasn’t as vigorous as it could have been.”
  • “Now, there is a lot of discussion about allowing this kind of surveillance apparatus in the wrong hands,” he adds. “And we’ve woken up to this a bit late in the day.”
  • Ullrich calls crises, “the elixir of rightwing populists”, and urges that politicians “do everything they can to correct the inequalities and social injustice which have arisen in the course of extreme financial capitalism in western countries”
  • Jane Caplan, a history professor at Oxford University who has written about Trump and fascism, highlights the want of “dissenting voices against marketisation and neoliberalism
  • The failure to resist the incursion of the market as the only criterion for political utility, or economic utility, has been pretty comprehensive.
  • Paranoia, bullying and intimidation are a hallmark of authoritarian regimes. They are also alive and well in our culture today, where online trolls, violent thugs at rallies, threats of expensive libel action and of course terrorist acts are equally effective in getting individuals and the press to self-censor.
oliviaodon

Optimism Among Small-Business Owners Highest in Eight Years | Gallup - 0 views

  • Small-business owners' optimism improved to its highest level in eight years after the 2016 presidential election.
  •  
    I found this article interesting as Trump's political jargon appears to be making a significant impact on the morale of small business owners. This article outlines the effects of simple yet effective words and phrases coined by the president-elect without a clear display of action. Confirmation bias may play a role in this increase in optimism.
kushnerha

BBC - Future - Why does walking through doorways make us forget? - 0 views

  • We’ve all done it. Run upstairs to get your keys, but forget that it is them you’re looking for once you get to the bedroom. Open the fridge door and reach for the middle shelf only to realise that we can't remember why we opened the fridge in the first place. Or wait for a moment to interrupt a friend to find that the burning issue that made us want to interrupt has now vanished from our minds
  • It’s known as the “Doorway Effect”, and it reveals some important features of how our minds are organised. Understanding this might help us appreciate those temporary moments of forgetfulness as more than just an annoyance
  • “What are you doing today?” she asks the first. “I’m putting brick after sodding brick on top of another,” sighs the first. “What are you doing today?” she asks the second. “I’m building a wall,” is the simple reply. But the third builder swells with pride when asked, and replies: “I’m building a cathedral!”
  • ...7 more annotations...
  • Maybe you heard that story as encouragement to think of the big picture, but to the psychologist in you the important moral is that any action has to be thought of at multiple levels if you are going to carry it out successfully. The third builder might have the most inspiring view of their day-job, but nobody can build a cathedral without figuring out how to successfully put one brick on top of another like the first builder.
  • As we move through our days our attention shifts between these levels – from our goals and ambitions, to plans and strategies, and to the lowest levels, our concrete actions. When things are going well, often in familiar situations, we keep our attention on what we want and how we do it seems to take care of itself. If you’re a skilled driver then you manage the gears, indicators and wheel automatically, and your attention is probably caught up in the less routine business of navigating the traffic or talking to your passengers. When things are less routine we have to shift our attention to the details of what we’re doing, taking our minds off the bigger picture for a moment.
  • The way our attention moves up and down the hierarchy of action is what allows us to carry out complex behaviours, stitching together a coherent plan over multiple moments, in multiple places or requiring multiple actions.
  • The Doorway Effect occurs when our attention moves between levels, and it reflects the reliance of our memories – even memories for what we were about to do – on the environment we’re in.
  • Imagine that we’re going upstairs to get our keys and forget that it is the keys we came for as soon as we enter the bedroom. Psychologically, what has happened is that the plan (“Keys!”) has been forgotten even in the middle of implementing a necessary part of the strategy (“Go to bedroom!”). Probably the plan itself is part of a larger plan (“Get ready to leave the house!”), which is part of plans on a wider and wider scale (“Go to work!”, “Keep my job!”, “Be a productive and responsible citizen”, or whatever). Each scale requires attention at some point. Somewhere in navigating this complex hierarchy the need for keys popped into mind, and like a circus performer setting plates spinning on poles, your attention focussed on it long enough to construct a plan, but then moved on to the next plate
  • And sometimes spinning plates fall. Our memories, even for our goals, are embedded in webs of associations. That can be the physical environment in which we form them, which is why revisiting our childhood home can bring back a flood of previously forgotten memories, or it can be the mental environment – the set of things we were just thinking about when that thing popped into mind.
  • The Doorway Effect occurs because we change both the physical and mental environments, moving to a different room and thinking about different things. That hastily thought up goal, which was probably only one plate among the many we’re trying to spin, gets forgotten when the context changes.
sissij

How Inoculation Can Help Prevent Pseudoscience | Big Think - 2 views

  • It is easier to fool a person than it is to convince a person that they’ve been fooled. This is one of the great curses of humanity.
  • Given the incredible amount of information we process each day, it is difficult for any of us to critically analyze all of it.
  • The state of Minnesota is battling a measles outbreak caused by anti-vaccination propaganda. And Discussion over the effects of misinformation on recent elections in Austria, Germany, and the United States is still ongoing.
  • ...3 more annotations...
  • A recent set of experiments shows us that there is a way to help reduce the effects of misinformation on people: the authors amusingly call it the “inoculation.”
  • which even then were heavily influenced by their pre-existing worldviews.
  • teaching about misconceptions leads to greater learning overall then just telling somebody the truth.
  •  
    Fake news and alternative facts are things that mess up our perception a lot. As we learned in TOK, there are a lot of fallacies in human reasoning. People tend to stick with their pre-existing worldview or ideas. I found it very interesting that people reduce the effect of misinformation by having an "inoculation". I think our TOK class is like the "inoculation" in a way that it asks us question and challenge us with the idea that everything might not seem as definite or absolute as it seems. TOK class can definitely help us to be immune of the fake news. --Sissi (5/25/2017)
Javier E

Now Is the Time to Talk About the Power of Touch - The New York Times - 1 views

  • In 1945, the Austrian physician René Spitz investigated an orphanage that took extra care to make sure its infants were not infected with disease. The children received first-class nutrition and medical care, but they were barely touched, to minimize their contact with germs. The approach was a catastrophe. Thirty-seven percent of the babies died before reaching age 2.
  • It turns out that empathetic physical contact is essential for life. Intimate touch engages the emotions and wires the fibers of the brain together.
  • The famous Grant Study investigated a set of men who had gone to Harvard in the 1940s. The men who grew up in loving homes earned 50 percent more over the course of their careers than those from loveless ones. They suffered from far less chronic illness and much lower rates of dementia in old age. A loving home was the best predictor of life outcomes.
  • ...16 more annotations...
  • For this reason, cultures all around the world have treated emotional touching as something apart. The Greeks labeled the drive to touch with the word “eros,” and they meant something vaster and deeper than just sexual pleasure.
  • “Animals have sex and human beings have eros, and no accurate science is possible without making this distinction,” Allan Bloom observed.
  • The Abrahamic religions also treat sex as something sacred and beautiful when enveloped in loving and covenantal protections, and as something disordered and potentially peace-destroying when not.
  • Over the past 100 years or so, advanced thinkers across the West have worked to take the shame out of sex, surely a good thing. But they’ve also disenchanted it
  • “One of the principal outcomes of the sexual revolution was to establish that sex is just like any other social interaction — nothing taboo or sacred about it.” Sex is seen as a shallow physical and social thing, not a heart and soul altering thing.
  • One unintended effect of this disenchantment is that it becomes easy to underestimate the risks inherent in any encounter.
  • The woman who talked in an online article about her date with Aziz Ansari is being criticized because what happened to her was not like what happened to the victims of Harvey Weinstein and Louis C.K
  • The assumption seems to be that as long as there’s consent between adults, everything else is kosher.
  • Everything we know about touch suggests that even with full consent, the emotional quality of an encounter can have profound positive or negative effects. If Ansari did treat her coldly or neglectfully, it’s reasonable to think that the shame she felt right after was the surface effect of a deeper wound. Neglectful, dehumanizing sex is not harassment, but it’s some other form of serious harm.
  • Disenchanting emotional touch also causes people to underestimate the way past experiences shape current behavior.
  • Agency is learned, not bred. And one of the things that undermines agency most powerfully is past sexual harm.
  • The abuse of intimacy erodes all the building blocks of agency: self-worth, resiliency and self-efficacy (the belief that you can control a situation).
  • It is precisely someone who lives within a culture of supposedly zipless encounters who is most likely to be unable to take action when she feels uncomfortable.
  • I hate the way Babe, which published the story about the Ansari date, violated everybody’s privacy here. But it seems that the beginning of good sense is to take the power of touch seriously, as something that has profound good and bad effects.
  • It seems that the smarter we get about technology, the dumber we get about relationships. We live in a society in which loneliness, depression and suicide are on the rise.
  • The guiding moral principle here is not complicated: Try to treat other people as if they possessed precious hearts and infinite souls. Everything else will follow.
Javier E

Coronavirus Treatment: Hundreds of Scientists Scramble to Find One - The New York Times - 0 views

  • Working at a breakneck pace, a team of hundreds of scientists has identified 50 drugs that may be effective treatments for people infected with the coronavirus.
  • Many of the candidate drugs are already approved to treat diseases, such as cancer, that would seem to have nothing to do with Covid-19, the illness caused by the coronavirus.
  • If the research effort succeeds, it will be a significant scientific achievement: an antiviral identified in just months to treat a virus that no one knew existed until January.
  • ...12 more annotations...
  • Dr. Krogan and his colleagues set about finding proteins in our cells that the coronavirus uses to grow. Normally, such a project might take two years. But the working group, which includes 22 laboratories, completed it in a few weeks.
  • In 2011, Dr. Krogan and his colleagues developed a way to find all the human proteins that viruses use to manipulate our cells — a “map,” as Dr. Krogan calls it. They created their first map for H.I.V.
  • That virus has 18 genes, each of which encodes a protein. The scientists eventually found that H.I.V. interacts, in one way or another, with 435 proteins in a human cell.
  • In February, the research group synthesized genes from the coronavirus and injected them into cells. They uncovered over 400 human proteins that the virus seems to rely on.
  • The flulike symptoms observed in infected people are the result of the coronavirus attacking cells in the respiratory tract.
  • The new map shows that the virus’s proteins travel throughout the human cell, engaging even with proteins that do not seem to have anything to do with making new viruses.
  • Kevan Shokat, a chemist at U.C.S.F., is poring through 20,000 drugs approved by the Food and Drug Administration for signs that they may interact with the proteins on the map created by Dr. Krogan’s lab.
  • If promising drugs are found, investigators plan to try them in an animal infected with the coronavirus — perhaps ferrets, because they’re known to get SARS, an illness closely related to Covid-19.
  • Even if some of these drugs are effective treatments, scientists will still need to make sure they are safe for treating Covid-19. It may turn out, for example, that the dose needed to clear the virus from the body might also lead to dangerous side effects.
  • In past studies on animals, remdesivir blocked a number of viruses. The drug works by preventing viruses from building new genes.
  • In February, a team of researchers found that remdesivir could eliminate the coronavirus from infected cells. Since then, five clinical trials have begun to see if the drug will be safe and effective against Covid-19 in people.
  • Other researchers have taken startling new approaches. On Saturday, Stanford University researchers reported using the gene-editing technology Crispr to destroy coronavirus genes in infected cells.
sissij

Are You Lucky? How You Respond Affects Your Fate. | Big Think - 0 views

  • Humans are superstitious creatures. Our rituals are vast. We tie one shoelace before the other; if we tie one, we have to tie the other even if it’s not loose.
  • Luck is the ever-present elephant in the room, dwarfed in our vocabulary by destiny and blessings.
  • But a roll of seven has more to do with the flick of a wrist than fate. 
  • ...3 more annotations...
  • Considering yourself lucky is a good thing. Rather than having a negative worldview—“that’s just my luck”—thinking yourself to be lucky results in positive brain functioning and overall well-being.
  • To navigate this tricky terrain, Frank suggests asking someone about their luck rather than informing them of their luck.
  • As should we all. Luck is not a mystical ally.
  •  
    I think luck is very tricky thing in human social science. As study suggests, luck is not a real thing, it is just something that human invented to comfort themselves. However, the belief of luck does have an effect on people's performance. I remembered once I saw in a study that people who believe that they are very lucky would have a better chance of good performance. This does not necessarily means that there is some unknown force called luck. It just means that believing in oneself would have a positive effect. I think it is very interesting that people are so used to use the word luck when a thing that is low in possibility happened to them. I think the language itself is giving people suggestions that there is some force that helps people in their action. --Sissi (4/19/2017)
‹ Previous 21 - 40 of 922 Next › Last »
Showing 20 items per page