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"Sixty years ago, Allied forces brought an end to Adolf Hitler's dream that Germany would rule Europe and dominate the world. The death of Nazi Germany gave birth to a charge that still haunts the scientific community--what might be called "the Nazi analogy." In ethical or policy disputes about science and medicine, no argument can bring debate to a more screeching halt then the invocation of the Nazi comparison. Whether the subject is stem cell research, end-of-life care, the conduct of clinical trials in poor nations, abortion, embryo research, animal experimentation, genetic testing, or human experimentation involving vulnerable populations, references to Nazi policies or practices tumble forth from critics. "If X is done, then we are on the road to Nazi Germany" has become a commonplace claim in contemporary bioethical debates. Sadly, too often those who draw an analogy between current behavior and what the Nazis did do not know what they are talking about. The Nazi analogy is equivalent to dropping a nuclear bomb in ethical battles about science and medicine. Because its misuse diminishes the horror done by Nazi scientists and doctors to their victims, it is ethically incumbent upon those who invoke the Nazi analogy to understand what they are claiming."

"As a fitness coach in Grand Rapids, Mich., Doreen Bolhuis has a passion for developing exercises for children. The younger, it seems, the better. "With the babies in our family," she said, "I start working them out in the hospital." Ms. Bolhuis turned her exercises into a company, Gymtrix, that offers a library of videos starting with training for babies as young as 6 months. There is no lying in the crib playing with toes. Infant athletes, accompanied by doting parents on the videos, do a lot of jumping, kicking and, in one exercise, something that looks like baseball batting practice. "We hear all the time from families that have been with us, 'Our kids are superstars when they're in middle school and they get into sports,' " Ms. Bolhuis said. Future Robinson Canos and Sidney Crosbys are getting their start in sports earlier than ever. Kindergartners play in soccer leagues and at an annual T-Ball World Series in Milton, Fla. But now children are being groomed as athletes before they can walk. The growing competition in marketing baby sports DVDs includes companies with names like athleticBaby and Baby Goes Pro. Even experts in youth sports seem startled that the age of entry has dipped so low. "That's really amazing. What's next?" said Dr. Lyle Micheli, an orthopedic surgeon and founder of the first pediatric sports medicine clinic in the United States at Children's Hospital in Boston. Dr. Micheli said he did not see any great advantages in exposing babies to sports. "I don't know of any evidence that training at this infancy stage accelerates coordination," he said. One of his concerns, he said, is "the potential for even younger ages of overuse injury." Bob Bigelow, a former National Basketball Association player and a critic of competitive sports for young children, is also skeptical. "This is Baby Mozart stuff; you play Mozart for the baby in utero and it comes out some sort of fine arts major," he said. �

"There's little doubt that the placebo effect's real, but it has always been argued that a person feels better because they think the pill is the real deal. But what if it works even when you know it's a fake? According to Ted Kaptchuk at Harvard Medical School and his colleagues at least one condition can be calmed by placebo, even when everyone knows it's just an inert pill. This raises a thorny question: should we start offering sugar pills for ailments without a treatment? In the latest study, Kaptchuk tested the effect of placebo versus no treatment in 80 people with irritable bowel syndrome. Twice a day, 37 people swallowed an inert pill could not be absorbed by the body. The researchers told participants that it could improve symptoms through the placebo effect. While 35 per cent of the patients who had not received any treatment reported an improvement, 59 per cent of the placebo group felt better. "The placebo was almost twice as effective as the control," says Kaptchuk. "That would be a great result if it was seen in a normal clinical trial of a drug." Edzard Ernst, professor of complementary medicine at the Peninsula Medical School in Exeter, UK, thinks that "the size of the benefit is too small to be clinically relevant". Kaptchuk agrees and wants to run some larger trials to get a better picture of the effect. If a dummy pill can improve IBS, shouldn't we be exploring its effect on other ailments? "It wouldn't work on a tumour or kill microbes, but it's likely to affect illnesses where self-appraisal is important, such as depression" says Kaptchuk. A 2008 study found that around a third of physicians had prescribed a dummy pill to unwitting patients. "Now we have shown that there are ethical ways of harnessing the placebo effect," says Kaptchuk. Surely now you can make a case for using a placebo when there are no other treatment options? Kaptchuk feels there is still an ethical dilemma here. "I'm against giving patients something unless it's been

"There has been much speculation that the lawyers for Jared Loughner, who has been charged in the Tucson shootings, may mount an insanity defense. Since John Hinckley Jr. was acquitted of trying to kill President Reagan, the use of the insanity defense has become very restricted in federal cases. Arizona, along with several other states, no longer allows a finding of not guilty by reason of insanity. In the three decades since the Hinckley case, brain research and brain scans have made many advances in diagnosing and categorizing mental illness. Yet this seems to have little bearing on how society deals with insanity and culpability in the legal arena. What has been learned in the decades since the Hinckley case? Should a better medical understanding of mental illness alter our legal definitions of insanity? Or is the insanity defense rooted in principles or traditions that actually don't have much to do with medicine?"

"A few months after the World Trade Center attacks, a strange message appeared on a U.S. Army computer: "Your security system is crap," it read. "I am Solo. I will continue to disrupt at the highest levels." Solo scanned thousands of U.S. government machines and discovered glaring security flaws in many of them. Between February 2001 and March 2002, Solo broke into almost a hundred PCs within the Army, Navy, Air Force, NASA, and the Department of Defense. He surfed around for months, copying files and passwords. At one point he brought down the U.S. Army's entire Washington, D.C., network, taking about 2000 computers out of service for three days. U.S. attorney Paul McNulty called his campaign "the biggest military computer hack of all time." But despite his expertise, Solo didn't cover his tracks. He was soon traced to a small apartment in London. In March 2002, the United Kingdom's National Hi-Tech Crime Unit arrested Gary McKinnon, a quiet 36-year-old Scot with elfin features and Spock-like upswept eyebrows. He'd been a systems administrator, but he didn't have a job at the time of his arrest; he spent his days indulging his obsession with UFOs. In fact, McKinnon claimed that UFOs were the reason for his hack. Convinced that the government was hiding alien antigravity devices and advanced energy technologies, he planned to find and release the information for the benefit of humanity. He said his intrusion was detected just as he was downloading a photo from NASA's Johnson Space Center of what he believed to be a UFO. Despite the outlandishness of his claims, McKinnon now faces extradition to the United States under a controversial treaty that could land him in prison for years-and possibly for the rest of his life. The case has transformed McKinnon into a cause célèbre. Supporters have rallied outside Parliament with picket signs. There are "Free Gary" websites, T-shirts, posters. Rock star David Gilmour, the former guitarist for Pink Floyd, even recorded

A physician's stubborn belief in the wrong diagnosis could prove fatal. The remedy; routine procedures and a dose of good luck.

Last week, the highly regarded medical journal, The Lancet, retracted a much debated 1998 study that had linked the measles, mumps and rubella vaccine to autism. The study was retracted after concerns about ethical breaches by one of the study authors. In addition, 10 of the 13 co-authors have disavowed the study's conclusions. "We fully retract this paper from the published record," The Lancet editors said in a statement. But the damage has been done. The paper has fueled fears about the risks of childhood vaccinations and autism, particularly the M.M.R. vaccine, despite numerous studies showing no link.

"Far fewer children would get a diagnosis of bipolar disorder. "Binge eating disorder" and "hypersexuality" might become part of the everyday language. And the way many mental disorders are diagnosed and treated would be sharply revised. "

"About this time every year, with the fall marathon season at its zenith, racers in training begin to hear the refrain, ''You are going to ruin your knees.''"

"Lies, Damned Lies, and Medical Science Much of what medical researchers conclude in their studies is misleading, exaggerated, or flat-out wrong. So why are doctors-to a striking extent-still drawing upon misinformation in their everyday practice? Dr. John Ioannidis has spent his career challenging his peers by exposing their bad science."

"RESEARCHERS say they have solved a conundrum about human perception that has stumped philosophers and scientists alike for three centuries. Irish politician William Molyneux first posed the question in a letter to the great British thinker John Locke written 323 years ago. Imagine, Molyneux wrote, that a man blind from birth who has learned to identify objects - a sphere and a cube, for example - only through his sense of touch is suddenly able to see. The puzzle, he continued, is: "Whether he Could, by his Sight, and before he touch them, know which is the Globe and which the Cube?" For philosophers of the time, answering "Molyneux's question", as it became known, would resolve a fundamental uncertainty about the human mind. Empiricists believed that we are born blank slates, and become the sum total of our accumulated experience. So-called "nativists" countered that our minds are, from the outset, pre-stocked with ideas waiting to be activated by sight, sound and touch. If a blind man who miraculously recovered his sight could instantly distinguish the cube from the globe it would mean the knowledge was somehow innate, they argued. More recently, this "nurture vs. nature" debate has found its counterpart in modern neuroscience."