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"Sixty years ago, Allied forces brought an end to Adolf Hitler's dream that Germany would rule Europe and dominate the world. The death of Nazi Germany gave birth to a charge that still haunts the scientific community--what might be called "the Nazi analogy." In ethical or policy disputes about science and medicine, no argument can bring debate to a more screeching halt then the invocation of the Nazi comparison. Whether the subject is stem cell research, end-of-life care, the conduct of clinical trials in poor nations, abortion, embryo research, animal experimentation, genetic testing, or human experimentation involving vulnerable populations, references to Nazi policies or practices tumble forth from critics. "If X is done, then we are on the road to Nazi Germany" has become a commonplace claim in contemporary bioethical debates. Sadly, too often those who draw an analogy between current behavior and what the Nazis did do not know what they are talking about. The Nazi analogy is equivalent to dropping a nuclear bomb in ethical battles about science and medicine. Because its misuse diminishes the horror done by Nazi scientists and doctors to their victims, it is ethically incumbent upon those who invoke the Nazi analogy to understand what they are claiming."