Group items matching

in title, tags, annotations or url

Recently, a psychiatric study on first episodes of psychosis made front-page news. People seemed quite surprised by the finding: that lower doses of psychotropic drugs, when combined with individual psychotherapy, family education and a focus on social adaptation, resulted in decreased symptoms and increased wellness.

Recently, a psychiatric study on first episodes of psychosis made front-page news. People seemed quite surprised by the finding: that lower doses of psychotropic drugs, when combined with individual psychotherapy, family education and a focus on social adaptation, resulted in decreased symptoms and increased wellness. But the real surprise — and disappointment — was that this was considered so surprising.

But the real surprise — and disappointment — was that this was considered so surprising.

Knowledge, then, is less a canon than a consensus in a state of constant disruption. Part of the disruption has to do with error and its correction, but another part with simple newness—outright discoveries or new modes of classification and analysis, often enabled by technology.

ore commonly, however, changes in scientific facts reflect the way that science is done. Mr. Arbesman describes the "Decline Effect"—the tendency of an original scientific publication to present results that seem far more compelling than those of later studies. Such a tendency has been documented in the medical literature over the past decade by John Ioannidis, a researcher at Stanford, in areas as diverse as HIV therapy, angioplasty and stroke treatment. The cause of the decline may well be a potent combination of random chance (generating an excessively impressive result) and publication bias (leading positive results to get preferentially published). If shaky claims enter the realm of science too quickly, firmer ones often meet resistance. As Mr. Arbesman notes, scientists struggle to let go of long-held beliefs, something that Daniel Kahneman has described as "theory-induced blindness." Had the Austrian medical community in the 1840s accepted the controversial conclusions of Dr. Ignaz Semmelweis that physicians were responsible for the spread of childbed fever—and heeded his hand-washing recommendations—a devastating outbreak of the disease might have been averted.

It’s no secret that therapies that look promising in mice rarely work in people. But too often, experimental treatments that succeed in one mouse population do not even work in other mice, suggesting that many rodent studies may be flawed from the start.

Crohn’s disease affects as many as seven hundred thousand Americans, but, like other autoimmune disorders, it remains poorly understood and is considered incurable. (Autoimmune disorders are thought to arise when the immune system attacks healthy tissue, mistaking it for a threat.) The standard treatments for Crohn’s often don’t work, or work only temporarily, and many have serious side effects.