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Normally, when adenosine levels reach a certain point in your brain and spinal cord, your body will start nudging you toward sleep, or at least taking it easy. There are actually a few different adenosine receptors throughout the body, but the one caffeine seems to interact with most directly is the A1 receptor.

it functions as a supremely talented adenosine impersonator. It heads right for the adenosine receptors in your system and, because of its similarities to adenosine, it's accepted by your body as the real thing and gets into the receptors.

caffeine actually binds to those receptors in efficient fashion, but doesn't activate them—they're plugged up by caffeine's unique shape and chemical makeup. With those receptors blocked, the brain's own stimulants, dopamine and glutamate, can do their work more freely—"Like taking the chaperones out of a high school dance,"

caffeine very clearly doesn't press the "gas" on your brain, and that it only blocks a "primary" brake. There are other compounds and receptors that have an effect on what your energy levels feel like—GABA, for example—but caffeine is a crude way of preventing your brain from bringing things to a halt. "You can," Braun writes, "get wired only to the extent that your natural excitatory neurotransmitters support it." In other words, you can't use caffeine to completely wipe out an entire week's worth of very late nights of studying, but you can use it to make yourself feel less bogged down by sleepy feelings in the morning.

What's important to take away is that caffeine is not as simple in effect as a direct stimulant, such as amphet

amines or cocaine; its effect on your alertness is far more subtle.

The general consensus on caffeine studies shows that it can enhance work output, but mainly in certain types of work. For tired people who are doing work that's relatively straightforward, that doesn't require lots of subtle or abstract thinking, coffee has been shown to help increase output and quality. Caffeine has also been seen to improve memory creation and retention when it comes to "declarative memory," the kind students use to remember lists or answers to exam questions.

The effectiveness of caffeine varies significantly from person to person, due to genetics and other factors in play. The average half-life of caffeine—that is, how long it takes for half of an ingested dose to wear off—is about five to six hours in a human body. Women taking oral birth control require about twice as long to process caffeine. Women between the ovulation and beginning of menstruation see a similar, if less severe, extended half-life. For regular smokers, caffeine takes half as long to process—which, in some ways, explains why smokers often drink more coffee and feel more agitated and anxious, because they're unaware of how their bodies work without cigarettes.

regular caffeine use has also been shown to decrease receptors for norepinephrine, a hormone akin to adrenaline, along with serotonin, a mood enhancer. At the same time, your body can see a 65 percent increase in receptors for GABA, a compound that does many things, including regulate muscle tone and neuron firing. Some studies have also seen changes in different adenosine receptors when caffeine becomes a regular thing.

A 1995 study suggests that humans become tolerant to their daily dose of caffeine—whether a single soda or a serious espresso habit—somewhere between a week and 12 days. And that tolerance is pretty strong.

You start to feel caffeine withdrawal very quickly, anywhere from 12 to 24 hours after your last use. That's a big part of why that first cup or can in the morning is so important—it's staving off the early effects of withdrawal. The reasons for the withdrawal are the same as with any substance dependency: your brain was used to operating one way with caffeine, and now it's suddenly working under completely different circumstances, but all those receptor changes are still in place. Headaches are the nearly universal effect of cutting off caffeine, but depression, fatigue, lethargy, irritability, nausea, and vomiting can be part of your cut-off, too, along with more specific issues, like eye muscle spasms. Generally, though, you'll be over it in around 10 days—again, depending on your own physiology and other factors.

Beyond the equivalent of four cups of coffee in your system at once, caffeine isn't giving you much more boost—in fact, at around the ten-cup level, you're probably less alert than non-drinkers.

The Price of Inequality: How Today's Divided Society Endangers Our Future (2012) From the jacket: As those at the top continue to enjoy the best health care, education, and benefits of wealth, they often fail to realize that, as Joseph E. Stiglitz highlights, "their fate is bound up with how the other 99 percent live ... It does not have to be this way. In The Price of Inequality Stiglitz lays out a comprehensive agenda to create a more dynamic economy and fairer and more equal society"

Direct democracy (or pure democracy)[1] is a form of democracy in which people vote on policy initiatives directly, as opposed to a representative democracy in which people vote for representatives who then vote on policy initiatives.[2] Depending on the particular system in use, it might entail passing executive decisions, making laws, directly electing or dismissing officials and conducting trials. Two leading forms of direct democracy are participatory democracy and deliberative democracy.

Signaling Michael Spence originally proposed the idea of signaling. He proposed that in a situation with information asymmetry, it is possible for people to signal their type, thus believably transferring information to the other party and resolving the asymmetry.

This idea was originally studied in the context of looking for a job. An employer is interested in hiring a new employee who is "skilled in learning." Of course, all prospective employees will claim to be "skilled at learning", but only they know if they really are. This is an information asymmetry. Skill in learning is malleable, and depends upon many factors, including diet, exercise and money. Spence proposes, for example, that going to college can function as a credible signal of an ability to learn. Assuming that people who are skilled in learning can finish college more easily than people who are unskilled, then by finishing college the skilled people signal their skill to prospective employers. No matter how much or how little they may have learned in college, finishing functions as a signal of their capacity for learning. However, finishing college may merely function as a signal of their ability to pay for college, it may signal the willingness of individuals to adhere to orthodox views, or it may signal a willingness to comply with authority.

Screening Joseph E. Stiglitz pioneered the theory of screening. In this way the underinformed party can induce the other party to reveal their information. They can provide a menu of choices in such a way that the choice depends on the private information of the other party. Examples of situations where the seller usually has better information than the buyer are numerous but include used-car salespeople, mortgage brokers and loan originators, stockbrokers and real estate agents.

Examples of situations where the buyer usually has better information than the seller include estate sales as specified in a last will and testament, life insurance, or sales of old art pieces without prior professional assessment of their value.

Because of information asymmetry, unscrupulous sellers can "spoof" items (like replica goods such as watches) and defraud the buyer. As a result, many people not willing to risk getting ripped off will avoid certain types of purchases, or will not spend as much for a given item. It is even possible for the market to decay to the point of nonexistence.

The effect of Nineteen Eighty-Four on the English language is extensive; the concepts of Big Brother, Room 101, the Thought Police, thoughtcrime, unperson, memory hole (oblivion), doublethink (simultaneously holding and believing contradictory beliefs) and Newspeak (ideological language) have become common phrases for denoting totalitarian authority. Doublespeak and groupthink are both deliberate elaborations of doublethink, while the adjective "Orwellian" denotes "characteristic and reminiscent of George Orwell's writings" especially Nineteen Eighty-Four.

In September 2009, an album entitled The Resistance was released by English Alternative rock band Muse, which was based entirely on 1984[citation needed], including songs such as "Resistance", "Uprising" and "United States of Eurasia". The album resulted in Muse receiving a Grammy for Best Rock Album at the 53rd Grammys.

In November 2011, the United States government argued before the U.S. Supreme Court that it wants to continue utilizing GPS tracking of individuals without first seeking a warrant. In response, Justice Stephen Breyer questioned what this means for a democratic society by referencing Nineteen Eighty-Four. Justice Breyer asked, "If you win this case, then there is nothing to prevent the police or the government from monitoring 24 hours a day the public movement of every citizen of the United States. So if you win, you suddenly produce what sounds like 1984...."[65] In 1984, the book was made into a movie. In 2006, the movie V for Vendetta was released, which has many of the same running themes and principles.[66][67] In Nineteen Eighty-Four, John Hurt portrays Winston Smith, while in V for Vendetta he plays the Big Brother-like figure.[68][69]

Religion, although it is not the best method of determining moral norms, has often been very effective at promoting them. Religions often satisfy many of Daleiden's criteria for raising people to be conditioned egoists, especially by practicing the aforementioned elements of prosocial training. He suggests that this is what they are doing when they instill a sense of virtue and justice, right and wrong.

Aldous Huxley's novel Brave New World and George Orwell's 1984 imagine dystopian future societies that control the populace by advanced scientific techniques. Harris argues that moral scientists approaching truths does not imply an "Orwellian future" with "scientists at every door". Instead, Harris imagines data about normative moral issues being shared in the same way as other sciences (e.g. peer-reviewed journals on medicine).

Science of morality should identify basic components required for human flourishing, drawing heavily on findings from positive psychology. In a proto-scientific example, Abraham Maslow suggested a hierarchy of needs: basic physical survival, then social and self esteem needs, and lastly philosophical and self-actualization.

self-

Research looking for optimal ethical systems can draw on all the methods of science, especially those used by positive psychology. While this might include obvious methods like asking people to self-report what they think they need to flourish in life – psychology has shown that people are often surprisingly incorrect on these matters (particularly when it comes to making predictions and recollections). Some cases in point: having too many varieties of consumer goods actually creates consumer choice anxiety; when it comes to removing bandages, Dan Ariely's research suggests that "getting it over with as quickly as possible" may cause more negative memories than if one went slowly (with breaks) while being careful never to reach a 'peak' in pain; stress is not always harmful (such stress is called eustress). While very careful use of self-report can still be illuminating (e.g. bogus pipeline techniques), in the end, unconscious methods of inquiry seem to be more promising. Some unconscious methods of data collection include the Implicit Association Test and neuroimaging. In these ways, science can further our understanding of what humans need to flourish, and what ways of organizing society provide the greatest hope for flourishing.

Extensive study of cooperation has shed some light on the objective (and subjective) advantages of teamwork and empathy. The brain areas that are consistently involved when humans reason about moral issues have been investigated by a quantitative large-scale meta-analysis of the brain activity changes reported in the moral neuroscience literature.[76] In fact, the neural network underlying moral decisions overlapped with the network pertaining to representing others' intentions (i.e., theory of mind) and the network pertaining to representing others' (vicariously experienced) emotional states (i.e., empathy).

There is evidence to suggest that a risk factor for becoming victims of bullying is deficient moral development. Examples of deficient moral development may be something like neglecting an agent's intentions during an action, or blaming them for accidents. In other words, victims of bullying may be more likely to make less accurate moral assessments, for some reason. The researchers also found that, in contrast, bullies were just as morally developed as victim defenders. The difference is that bullies are more able to disengage themselves. That is, for whatever reason, bullies end up suppressing their feelings of compassion and conscience.[77]

aslow's Characteristics of Self-Actualizers A self-actualizer is a person who is living creatively and fully using his or her potentials. In his studies, Maslow found that self-actualizers share similarities. Whether famous or unknown, educated or not, rich or poor, self-actualizers tend to fit the following profile.[12] Efficient perceptions of reality. Self-actualizers are able to judge situations correctly and honestly. They are very sensitive to the fake and dishonest. Comfortable acceptance of self, others, nature. Self-actualizers accept their own human nature with all its flaws. The shortcomings of others and the contradictions of the human condition are accepted with humor and tolerance. Spontaneity. Maslow's subjects extended their creativity into everyday activities. Actualizers tend to be unusually alive, engaged, and spontaneous. Task centering. Most of Maslow's subjects had a mission to fulfill in life or some task or problem outside of themselves to pursue. Humanitarians such as Albert Schweitzer and Mother Teresa represent this quality. Autonomy. Self-actualizers are free from reliance on external authorities or other people. They tend to be resourceful and independent. Continued freshness of appreciation. The self-actualizer seems to constantly renew appreciation of life's basic goods. A sunset or a flower will be experienced as intensely time after time as it was at first. There is an "innocence of vision", like that of an artist or child. Fellowship with humanity. Maslow's subjects felt a deep identification with others and the human situation in general. Profound interpersonal relationships. The interpersonal relationships of self-actualizer

Fellowship with humanity. Maslow's subjects felt a deep identification with others and the human situation in general. Profound interpersonal relationships. The interpersonal relationships of self-actualizers are marked by deep loving bonds. Comfort with solitude. Despite their satisfying relationships with others, self-actualizing persons value solitude and are comfortable being alone. [13] Non-hostile sense of humor. This refers to the wonderful capacity to laugh at oneself. It also describes the kind of humor a man like Abraham Lincoln had. Lincoln probably never made a joke that hurt anybody. His wry comments were gentle proddings of human shortcomings. Peak experiences. All of Maslow's subjects reported the frequent occurrence of peak experiences (temporary moments of self-actualization). These occasions were marked by feelings of ecstasy, harmony, and deep meaning. Self-actualizers reported feeling at one with the universe, stronger and calmer than ever before, filled with light, beautiful and good, and so forth. In summary, self-actualizers feel safe, not anxious, accepted, loved, loving, and alive. Additionally, Schott discussed in connection with transpersonal business studies.

Broader criticism from within humanistic psychology of the concept of self-actualization includes the danger that 'emphasis on the actualizing tendency...can lead to a highly positive view of the human being but one which is strangely non-relational'.[20] According to Fritz Perls there is also the risk of confusing "self-actualizing and self-image actualizing...the curse of the ideal."[21] By conflating "the virtue of self-actualization and the reality of self-actualization,"[22] the latter becomes merely another measuring rod for the "topdog"

I have received a fair number of letters saying 'I am a self-actualized person'. Maslow said that he must have left something out. Fritz (Perls) put it in. He saw that most people actualized a self-concept. This is not self-actualizing."[24]

The pilot episode depicted a plane being flown into the New York World Trade Center; it originally aired six months before 9/11. Foreshadowing a number of conspiracy theories which would arise in the wake of the September 11, 2001 attacks, the plot of the March 4, 2001 episode depicts a secret faction within the US government plotting to hijack a Boeing 727 and fly it into the World Trade Center by remote control. The stated motive was to increase the military defense budget by blaming the attack on foreign interests. In the episode, the plot is foiled by the protagonists, who board the doomed plane and deactivate the malicious autopilot system just seconds before the plane would have reached the World Trade Center.