Sensorica Knowledge

"Sovereign Accountable Commons"

"F.Lab's"

"As the open source development of additive manufacturing has led to low-cost desktop three-dimensional (3-D) printing, a number of scientists throughout the world have begun to share digital designs of free and open source scientific hardware. Open source scientific hardware enables custom experimentation, laboratory control, rapid upgrading, transparent maintenance, and lower costs in general. To aid in this trend, this study describes the development, design, assembly, and operation of a 3-D printable open source desktop nutating mixer, which provides a fixed 20° platform tilt angle for a gentle three-dimensional (gyrating) agitation of chemical or biological samples (e.g., DNA or blood samples) without foam formation. The custom components for the nutating mixer are designed using open source FreeCAD software to enable customization. All of the non-readily available components can be fabricated with a low-cost RepRap 3-D printer using an open source software tool chain from common thermoplastics. All of the designs are open sourced and can be configured to add more functionality to the equipment in the future. It is relatively easy to assemble and is accessible to both the science education of younger students as well as state-of-the-art research laboratories. Overall, the open source nutating mixer can be fabricated with US$37 in parts, which is 1/10th of the cost of proprietary nutating mixers with similar capabilities. The open source nature of the device allow it to be easily repaired or upgraded with digital files, as well as to accommodate custom sample sizes and mixing velocities with minimal additional costs."

"Centrifuges are commonly required devices in medical diagnostics facilities as well as scientific laboratories. Although there are commercial and open source centrifuges, the costs of the former and the required electricity to operate the latter limit accessibility in resource-constrained settings. There is a need for low-cost, human-powered, verified, and reliable lab-scale centrifuges. This study provides the designs for a low-cost 100% 3-D printed centrifuge, which can be fabricated on any low-cost RepRap-class (self-replicating rapid prototyper) fused filament fabrication (FFF)- or fused particle fabrication (FPF)-based 3-D printer. In addition, validation procedures are provided using a web camera and free and open source software. This paper provides the complete open source plans, including instructions for the fabrication and operation of a hand-powered centrifuge. This study successfully tested and validated the instrument, which can be operated anywhere in the world with no electricity inputs, obtaining a radial velocity of over 1750 rpm and over 50 N of relative centrifugal force. Using commercial filament, the instrument costs about U.S. $25, which is less than half of all commercially available systems. However, the costs can be dropped further using recycled plastics on open source systems for over 99% savings. The results are discussed in the context of resource-constrained medical and scientific facilities."