Inflammation is the most predominant feature during the early (relaping) phases of the disease and declines with aging of the patients and disease duration
Breast cancer risk in postmenopausal women using t... [Maturitas. 2008] - PubMed - NCBI - 0 views
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Review of the data of Testosterone therapy in women in surgical menopause finds no negative or positive influence on breast cancer risk.
High-dose testosterone is associated with atherosc... [Maturitas. 2007] - PubMed - NCBI - 0 views
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One of the rare long-term studies of Testosterone in women. This study was a respective study of high dose Testosterone. The authors found an increase in atherosclerosis in the aorta versus non-HRT.
Effects of androgen supplementation of hormone... [Fertil Steril. 2001] - PubMed - NCBI - 0 views
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Testosterone therapy in post menopausal women appears to have adverse cardiovascular effects in women. The negative effects were an increase in Pulsatility index and adverse change in lipid profiles. This seemed to counter the positive effects by estrogen. Others have proposed that combination E2 and T therapy hide the negative effects of testosterone on CV health in women.
Testosterone, SHBG and cardiovascular health in postmenopausal women - 0 views
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Master's thesis reviews Testosterone therapy in women. The evidence is poor. What is seen is that low SHBG and increasing Testosterone in the long term appears to be associated with adverse CV effects. Otherwise, the effects of Testosterone are negligible if negative at all. High dose studies did find increased CVD in women. The dosing here was at 40 mg.
Efficacy and safety of testosterone in the managem... [J Sex Med. 2012] - PubMed - NCBI - 0 views
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review of the literature finds that Testosterone therapy in women with low libido improves sexual activity without CVD and breast cancer risk in postmenopausal women. Post menopause is a time associated with an increased risk of CVD in women.
American College of Cardiology Foundation | Journal of the American College of Cardiolo... - 0 views
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Study finds that Testosterone therapy improves insulin sensitivity, muscle strength and function in women with advanced CHF. No levels were noted. If this is similar to men, I would expect a low Testosterone, which Testosterone replacement would then increase physiologic performance.
Androgens in relationship to cardiovascular risk factors in the menopausal transition, ... - 0 views
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Increasing androgens, male hormones, may be associated with the increased risk of CVD found in post menopausal women. Other variables also need to be included ie. fat, insulin resistance...
Association between hyperinsulinemia and endogeno... [Metabolism. 2002] - PubMed - NCBI - 0 views
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Increasing androgen levels associated with perimenopause/menopause transition. This is associated with increasing insulin resistance.
Glucose and Insulin Components of the Metabolic Syndrome Are Associated with Hyperandro... - 0 views
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Increasing Free androgen index is associated with worsening metabolic syndrome parameters in women. Paticularily increasing insulin and poor glucose control was found.
Access : Testosterone, SHBG and cardiovascular health in postmenopausal women : Interna... - 0 views
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Review finds that low SHBG and higher Testosterone levels are associated with increased CVD risk in post menopausal women. Exact relationship is undetermined.
Postmenopausal Women with a History of Irregular Menses and Elevated Androgen Measureme... - 0 views
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This study looked at post menopause women and found that those with PCOS had an increase in CAD and worse cardiovascular event survival. PCOS is a metabolic syndrome, in part, driven by elevated androgens in women.
Extremes of Endogenous Testosterone Are Associated with Increased Risk of Incident Coro... - 0 views
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Study finds that low and high Testosterone in women are associated with increased CVD risk.
The molecular basis of neurodegeneration in multiple sclerosis - 0 views
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anti-inflammatory or immunomodulatory treatments are effective in the relapsing stage, but the benefit is lost when the patients have entered the progressive phase
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in the process of oligodendrocyte destruction and demyelination in MS lesions iron is liberated from its intracellular ferritin bound stores into the extracellular space, where it is taken up by microglia and macrophages and again stored together with ferritin. When this happens in MS lesions in an environment, where free radicals are produced by oxidative burst, iron can be liberated from ferritin and transformed into reactive Fe++[114], which reacts with hydrogen peroxide to generate highly reactive hydroxyl radicals [36] and thus amplifies oxidative damage and associated cellular injury
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Very nice review of the neurodegenerative process in MS.
Estriol treatment ameliorates disease in male... [J Neuroimmunol. 2004] - PubMed - NCBI - 0 views
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Estriol found to be beneficial in experimental model of MS called EAE. The effect would be through E3's preferential binding to ERbeta. This study finds benefit in men and women.
Vitamin D in the healthy and inflamed central nervous system: access and function - 0 views
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Vitamin D3 helpful in treatment of an inflamed CNS, such as in TBI, MS...Vitamin D protects against the development of MS and the progression of MS.
Progesterone neuroprotection in trauma... [Front Neuroendocrinol. 2009] - PubMed - NCBI - 0 views
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Progesterone has a neuroprotective and promyelinating effects in the nervous system. Progesterone increases BDNF. Progesterone increases proliferation and differentiation of oligodendrocyte progenitor cells which will increase myelin production.
The Role of Progesterone in Traumatic Brain Injury : The Journal of Head Trauma Rehabil... - 0 views
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Progesterone useful in inflammation reduction in Traumatic Brain Injuries. This applies to both sexes.
Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxida... - 0 views
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This article proposes that increased antioxidant enzymatic activity is an adaption to the increased ROS found in MS. This increased ROS disrupts the blood-brain barrier.
Oxidative damage in multiple sclerosis lesions - 0 views
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Lesions in MS, found to have extensive oxidative damage of oligodendrocytes and neurons.
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