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Nathan Goodyear

[Pharmacological significance of alpha lipoic acid in up to date treatment of diabetic ... - 0 views

europepmc.org/...18543755

diabetic neuropathy ALA alpha lipoic acid diabetes

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  • Nathan Goodyear on 08 Sep 14
     
    alpha lipoic acid for diabetic neuropathy.
Nathan Goodyear

http://fulltext.calis.edu.cn/nature/nrc/11/5/nrc3038.pdf - 0 views

fulltext.calis.edu.cn/...nrc3038.pdf

cancer warburg Warburg effect

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  • Nathan Goodyear on 08 Sep 14
     
    Nice review of the Warburg effect.  Very nice diagrams.
Nathan Goodyear

http://biomedres.info/yahoo_site_admin/assets/docs/219-223-Gianfranco-Jan_14_2012.18155... - 0 views

biomedres.info/...ranco-Jan_14_2012.18155343.pdf

cancer alpha lipoic acid ALA hydroxycitrate

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  • Nathan Goodyear on 08 Sep 14
     
    Study finds combination of Alpha lipoic acid and hydroxycitrate beneficial as adjuvant with chemotherapy.  Side effects were minimal.
Nathan Goodyear

Low-dose naltrexone targets the opioid growth factor-opioid growth factor receptor path... - 0 views

ebm.sagepub.com/...1036.short

LDN low dose naltrexone opioid growth factor cancer

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  • Nathan Goodyear on 08 Sep 14
     
    LDN inhibits cell proliferation through increased opioid growth factor and receptor translation.
Nathan Goodyear

Metabolic Treatment of Cancer: Intermediate Results of a Prospective Case Series - 0 views

ar.iiarjournals.org/...973.abstract

IV intravenous alpha lipoic acid ALA cancer LDN low dose naltrexone

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  • Nathan Goodyear on 08 Sep 14
     
    advanced, end-stage cancer treated in few patients with IV alpha lipoic acid, oral LDN, and hydroxycitrate--case study presentation.  The therapies were well tolerated without toxicity.  The authors concluded that the therapy "enhances the efficacy" of the chemotherapy.
Nathan Goodyear

Revisiting the ALA/N (α-Lipoic Acid/Low-Dose Naltrexone) Protocol for People ... - 0 views

ict.sagepub.com/...416.short

alpha lipoic acid IV intravenous ALA pancreatic cancer cancer LDN low dose naltrexone

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  • Nathan Goodyear on 08 Sep 14
     
    Case study of 3 patients with Pancreatic cancer treated with IV alpha lipoic acid and LDN therapy.  This is a f/u to a patient treated and still living--case study published in '06.  Only, the abstract is currently available to the general public.  
Nathan Goodyear

Low free testosterone levels predict disease reclassification in men with prostate canc... - 0 views

onlinelibrary.wiley.com/...FD84CC276320B0418C0A839.f04t03

free Testosterone free Testosterone prostate cancer disease men male hormone hormones

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  • Nathan Goodyear on 08 Sep 14
     
    low free Testosterone was shown to be associated with higher reclassification rates in men with prostate Cancer.  Low free Testosterone has been associated with increased prostate cancer incidence via previous studies.
Nathan Goodyear

Effect of Vitamin C on Male Fertility in Rats Subjected to Forced Swimming Stress - 0 views

www.ncbi.nlm.nih.gov/...PMC4149087

vitamin C vitamin vitamins fertility stress

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  • Nathan Goodyear on 08 Sep 14
     
    Vitamin C improved stress response and thus fertility in stress rat mode.
Nathan Goodyear

Oral L-citrulline supplementation improves erection ... [Urology. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21195829

l-citrulline citrulline ED erection men male

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  • Nathan Goodyear on 08 Sep 14
     
    l-citrulline supplementation improves erectile strength in those with mild to moderate ED.  L-citrulline bypasses the systemic metabolism of arginine taken orally.
Nathan Goodyear

Sex Hormone Levels in Patients with Sudden Cardiac Arrest - Heart Rhythm - 0 views

www.heartrhythmjournal.com/...abstract

hormone hormones Testosterone Estrogen men women heart health cardiac arrest myocardial infarction cardiovascular disease

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  • Nathan Goodyear on 07 Sep 14
     
    Study looked at hormone levels via serum analysis at the time of sudden cardiac arrest in both men and women.  Low Testosterone and elevated Estrogen levels in  men were associated with increased odds (OR) versus women only had increased odds with elevated Estrogen.   ManBoob nation, my first book, discusses the mechanism behind this for men.  The finding in women really calls into question the Estrogen only model currently employed by physicians for post menopausal women.
Nathan Goodyear

Evaluation of atorvastatin efficacy and toxicity on spermatozoa, accessory glands and g... - 0 views

www.ncbi.nlm.nih.gov/...PMC4114109

statin statin therapy statins sperm men male fertility atorvastatin hormones

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  • Nathan Goodyear on 04 Sep 14
     
    I really don't understand the purpose of this study.  Why give "healthy" men with normal lipids atorvastatin???  The study found a reduction in TC and LDL, but also a reduction in sperm number, decreased sperm vitality, increased sperm morphology, decreased prostatic acid pho sphatases, epididymal neutral alpha-glucosidase and L-carnitine levels resulted.  
Nathan Goodyear

The kisspeptin-GnRH pathway in human reproductive health and disease - 0 views

humupd.oxfordjournals.org/...humupd.dmu009.full

kisspeptin kisspeptins hormones leptin hormone

shared by Nathan Goodyear on 04 Sep 14 - No Cached
  • Kisspeptin stimulates LH secretion in healthy men (filled squares) and women
  • This raises the possibility that diminished kisspeptin secretion is a potential mechanism for hypogonadotropic hypogonadism in patients with obesity and diabetes
  • The likely pathways for down-regulation of kisspeptin signalling include negative feedback by estrogen, which is markedly elevated in obesity (Schneider et al., 1979), resistance to leptin, also seen in human obesity (Finn et al., 1998), insulin resistance and hyperglycaemia (Castellano et al., 2006, 2009), and inflammation, which is up-regulated in hypogonadal men with diabetes (Dandona et al., 2008) and is associated with decreased kisspeptin expression in rats
  • Nathan Goodyear on 04 Sep 14
     
    Very nice, updated review of kisspeptins, hormone production and the negative/positive effects of kisspeptins.
Nathan Goodyear

http://joe.endocrinology-journals.org/content/208/2/97.full.pdf - 0 views

joe.endocrinology-journals.org/...97.full.pdf

kisspeptin kisspeptins hormones

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  • Nathan Goodyear on 04 Sep 14
     
    kisspeptins.
Nathan Goodyear

Obesity and testicular function. [Mol Cell Endocrinol. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19540307

obesity leydig cells Testosterone low T low Testosterone T SHBG LH leptin men male hormone hormones

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  • Nathan Goodyear on 04 Sep 14
     
    This article, here only abstract available, points to low Testosterone as the effect and not the cause.  The cause being obesity.  An interesting association between leptin and low T is found.  Leptin is a hormone produced from adipocytes, this study found leptin receptors in the leydig cells of testes.  Thus, increased leptin production from increased abdominal adiposity can result in a decrease in 17,20 lyase activity and thus a direct inhibition of leydig cell Testosterone production.
Nathan Goodyear

Resistance training increases SHBG in overweight/obese, young men - 0 views

www.ncbi.nlm.nih.gov/...PMC3845495

resistance training overweight obesity obese men male hormone hormones SHBG free Testosterone Testosterone free androgen index

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  • Nathan Goodyear on 03 Sep 14
     
    12 week study of obese  men in resistance training program finds increase in SHBG and resultant decrease in free Androgen index.  FAI is as a calculation of free Testosterone.  This is different in the studies in lean men which shows an increase in Testosterone. Here a different underlying metabolism is the result
Nathan Goodyear

Age-related hormonal adaptations, muscle circumference and strength development with 8w... - 0 views

www.biomedsearch.com/...23337018.html

resistance training resistance training exercise strength muscle Testosterone GH growth hormone ACTH cortisol hormone hormones men male

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  • Nathan Goodyear on 03 Sep 14
     
    Moderate resistance training program over 8 weeks associated with increased Testosterone production in young and middle age lean men.  Growth hormone was also increased in both groups.  ACTH and cortisol decreased in this lean men.  
Nathan Goodyear

GLUT4 expression at the plasma membrane is related to ... [APMIS. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12529013

GLUT4 exercise obesity diabetes

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  • Nathan Goodyear on 03 Sep 14
     
    Authors propose that exercise increases GLUT4 in those with obesity and type 2 diabetes.
Nathan Goodyear

Recovery after heavy resistance exercise... [J Strength Cond Res. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21311349

recovery resistance exercise training resistance training Testosterone Total free men male hormone hormones

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  • Nathan Goodyear on 03 Sep 14
     
    "Heavy resistance exercise" associated with acute increase in TT and fT in men.  No changes were see in basal T and fT in recovery or AR.  The recovery phase was estimated to take 6 days.
Nathan Goodyear

Hypothalamic-Pituitary-Testicular Axis Disruptions in Older Men Are Differentially Link... - 0 views

press.endocrine.org/...jc.2007-1972

low T low Testosterone low T Testosterone aging LH hormone hormones men male SHBG

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  • 0.4–2% annual decline
  • the age trend in free T was more substantial (−1.3% per annum)
  • The core hormonal pattern with increasing age is suggestive of incipient primary testicular dysfunction with maintained total T and progressively blunted free T associated with higher LH.
  • ...16 more annotations...
  • Obesity was associated with progressively lower total and free T independent of the simultaneous decrease in SHBG.
  • our data highlight the fact that LH was unchanged or even lower in older men in the face of lower T in obesity, suggesting that there may be a failure at the hypothalamic-pituitary level.
  • a change in BMI from nonobese to obese may be equivalent to a 15 yr fall in T.
  • This pattern supports the hypothesis that different underlying mechanisms influence the functions of the HPT axis: age predominantly affects testicular function, whereas obesity impairs hypothalamic/pituitary function.
  • the effects of aging on testicular function can be moderated by increased LH compensation for many decades
  • obesity impairs hypothalamic/pituitary function independent of age, arguably an adaptive response for which there should be no compensatory mechanism.
  • the concurrent but opposite (and separate) effects of obesity and age on SHBG
  • SHBG was negatively associated with increasing strata of obesity
  • Obesity is associated with insulin resistance (28), and the increased circulating insulin inhibits hepatic SHBG synthesis
  • the SHBG increase with age may be related to relative IGF-I deficiency (27), although this has not been directly proven.
  • Obesity is associated with peripheral and central insulin resistance (30) and proinflammatory cytokine production (TNFα and IL-6) from adipocytes (31) and central nervous system endocannibinoid release (32), all of which are potential candidates for abrogating hypothalamic endocrine and downstream reproductive axis functions.
    • Nathan Goodyear
      Nathan Goodyear on 03 Sep 14
       
      The HPA axis effect may be the result of inflammation.
  • The relationship between obesity and T can be bidirectional: low T may be the cause rather than consequence of obesity
  • chronic alcohol abuse is known to suppress LH (40), our data showed no significant association among the three hormones or SHBG and alcohol intake.
  • increase in total T in smokers occurs through a primary increase in SHBG with a compensatory rise in LH
  • the effects of obesity (BMI or waist circumference) was by far the most important determinant of variance in total T, whereas age per se was important for SHBG, LH, and free T with comorbidity and smoking being comparatively minor contributors
  • It is noteworthy that these predisposing lifestyle and health factors are modifiable. This implies that the apparent age-related decline in T may constitute a barometer of health and thus be potentially preventable and/or reversible.
  • Nathan Goodyear on 03 Sep 14
     
    Age induced decline in Testosterone is more associated with a decline in leydig cell function and thus elevated LH will be associated.  In contrast, obesity is more of a HPA axis disruption and thus LH may be normal to low.  The pulse amplitude is decrease.  No change in pulse frequency is noted.   With obesity, a decline in TT and fT was independent of SHBG. Aging is associated with a greater decrease in fT versus TT.
Nathan Goodyear

Effect of resistance exercise on muscle steroidogenesis | Journal of Applied Physiology - 0 views

jap.physiology.org/...1754

resistance resistance training training exercise Testosterone male female hormone hormones muscle

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  • skeletal muscle cell cultures incubated with DHEA produced testosterone in a DHEA dose-dependent manner
  • Muscle joins a growing list of tissues found to be capable of steroidogenesis
  • testosterone appears to have a role in the maintenance of muscle mass in women, although the importance of this role has not yet been fully established.
  • ...7 more annotations...
  • Circulating testosterone concentrations are generally elevated following a bout of resistance exercise in men (24, 31, 46, 52), whereas findings for the effect of resistance exercise on circulating testosterone in women are equivocal, with increases (10, 42) and no changes observed (22, 31)
  • swimming (51) and treadmill running (2) can significantly increase muscle testosterone concentrations in male and female rats
  • This upregulation of muscle testosterone in rats appears, at least in part, to be due to an increase in 3β-HSD and 17β-HSD type 1 expression
  • The primary finding in this study was that muscle steroidogenesis (i.e., testosterone production) in highly resistance-trained humans was not affected by an acute bout of heavy resistance exercise
  • A secondary finding was that the apparent molecular mass of 17β-HSD type 3 was increased following a single bout of heavy resistance exercise.
  • No differences were found for muscle testosterone or steroidogenic enzyme (17β-HSD type 3 and 3β-HSD types 1 and 2) concentrations between sexes or in response to resistance exercise
  • In conclusion, heavy resistance exercise did not induce changes in muscle steroidogenesis as measured by muscle concentrations of testosterone, 3β-HSD types 1 and 2, and 17β-HSD type 3 in highly resistance-trained young men and women.
  • Nathan Goodyear on 03 Sep 14
     
    Resistance exercise did not increase muscle concentrations of Testosterone in men or women.  The individuals in this study were actively training.  These were not sedentary individuals.
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