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Nathan Goodyear

Loss of lean body and muscle mass correlates with androgen levels in hypogonadal men wi... - 0 views

www.ncbi.nlm.nih.gov/...8923860

muscle loss Muscle mass Testosterone hormones AIDS AWS

shared by Nathan Goodyear on 15 Jun 15 - No Cached
  • Nathan Goodyear on 15 Jun 15
     
    Only abstract available here, but muscle loss associated with low Testosterone in men with AWS.
Nathan Goodyear

Salivary 8-OHdG: a useful biomarker for predicting severe ED and hypogonadism. - PubMed... - 0 views

www.ncbi.nlm.nih.gov/...18422497

oxidative stress 8-OHdG 8-hydroxy-2-deoxyguanosine hormones Testosterone phosphodiesterase 5 inhibitors

shared by Nathan Goodyear on 15 Jun 15 - No Cached
  • Nathan Goodyear on 15 Jun 15
     
    Study finds salivary 8-OHdG is associated with increased severity of ED in men.  The study found that phosphodiesterase 5 inhibitor therapy increased total and free Testosterone as well as decreased 8-OHdG.
Nathan Goodyear

Chronic Testosterone Replacement Exerts Cardioprotection against Cardiac Ischemia-Reper... - 0 views

www.ncbi.nlm.nih.gov/...PMC4379072

cardiovascular disease cardiovascular disease heart health Testosterone low T low Testosterone hormone hormones

shared by Nathan Goodyear on 04 Jun 15 - No Cached
  • In this study, the cardioprotective effects of testosterone in testosterone-deprived rats heart with I/R injury were demonstrated
  • Prior to I/R injury, testosterone replacement provided cardioprotective effects in testosterone-deprived rats as indicated by (1) improved cardiac functions by markedly preserved %EF and %FS, and (2) attenuated cardiac sympathovagal imbalance by a markedly decreased LF/HF ratio
  • Testosterone replacement exerts cardioprotective effects by improving left ventricular function and cardiac sympathovagal balance impaired by testosterone deprivation in ORX rats
  • ...3 more annotations...
  • During the I/R period, testosterone replacement in ORX rats exerted the beneficial effects as indicated by (1) improved left ventricular pressure; (2) markedly decreased infarct size; (3) reduced fatal cardiac arrhythmias by increased time to 1st VT/VF onset and reduced arrhythmia scores; and (4) attenuated cardiac mitochondrial dysfunction caused by I/R injury by reducing ROS production, cardiac mitochondrial swelling and mitochondria membrane depolarization.
  • Chronic testosterone replacement also ameliorates left ventricular dysfunction, and reduces the infarct size and cardiac arrhythmias impaired by I/R injury under testosterone-deprived conditions
  • The mechanisms responsible for these beneficial effects of testosterone could be due to its ability to attenuate cardiac mitochondrial dysfunction and cardiomyocyte apoptosis
  • Nathan Goodyear on 04 Jun 15
     
    animal study finds that Testosterone therapy is cardioprotective in a preventative mode and with myocardial injury.  Normalization of Testosterone in these animals with low T reduced infant injury size and improved heart function.  
Nathan Goodyear

Roles of Testosterone Replacement in Cardiac Ischemia-Reperfusion Injury. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...26015457

Testosterone cardiovascular disease cardiovascular disease heart health hormone hormones

shared by Nathan Goodyear on 04 Jun 15 - No Cached
  • Nathan Goodyear on 04 Jun 15
     
    Only abstract available here.  Authors of this review conclude, in a review of the current literature of Testosterone therapy and heart ischemia/reperfusion injury, that chronic, physiologic Testosterone therapy has positive cardiovascular protection whereas acute Testosterone has increased adverse events.  This is likely the difference between preventative and reactive medicine.
Nathan Goodyear

The association between hyperandrogenemia and the metabolic syndrome in morbidly obese ... - 0 views

www.ncbi.nlm.nih.gov/...PMC4443598

metabolic syndrome obesity Testosterone PCOS hormone hormones hyperandrogenemia

shared by Nathan Goodyear on 04 Jun 15 - No Cached
  • a significant inverse relationship between HA and HDL-cholesterol levels which is in accordance with previous studies of women with PCOS
  • HA was associated with 61 % increased adjusted odds of MetS, and that this association was mainly driven by increased odds of dysglycemia and dyslipidemia
  • the prevalences of MetS, PCOS and HA were high among morbidly obese women <50 years of age
  • ...3 more annotations...
  • Compared to women without HA, those with HA had significantly higher odds of having the MetS, which was mainly explained by the associations between HA and the lipid- and glucose components of the MetS
  • FTI-blood test might add value to the cardiovascular risk assessment of premenopausal women with morbid obesity
  • We calculated the free testosterone index (FTI) using the formula: FTI = 100 x serum testosterone (nmol/L) / sex hormone binding globulin (SHBG, nmol/L)
  • Nathan Goodyear on 04 Jun 15
     
    Another study that finds hyperandrogenism in women is associated with increased Metabolic Syndrome.  This study found obesity was associated with increased hyperandrogegism and Metabolic Syndrome irregardless of PCOS diagnosis or not.
Nathan Goodyear

Erectile dysfunction is a prognostic indicator of comorbidities in men with late onset ... - 1 views

www.ncbi.nlm.nih.gov/...26030350

erectile dysfunction ED low T men male hormone hormones Testosterone CVD hypogonadism low Testosterone LOH late onset hypogonadism metabolic syndrome

shared by Nathan Goodyear on 04 Jun 15 - No Cached
  • Nathan Goodyear on 04 Jun 15
     
    Study finds that increasing severity of ED is associated with increasing components of Metabolic Syndrome in men with late onset hypogonadism.   The link is really just an increased severity of CVD in men with severe ED and low T.  ED is CVD in men.
Nathan Goodyear

The effect of testosterone and fenofibrate, administered alone or in combination, on ca... - 0 views

www.ncbi.nlm.nih.gov/...26031507

Testosterone hormones cardiovascular disease hsCRP insulin insulin resistance insulin sensitivity

shared by Nathan Goodyear on 04 Jun 15 - No Cached
  • Nathan Goodyear on 04 Jun 15
     
    This study looked at oral Testosterone plus fenofibrate (tricor).  That is not the purpose of this post.  This study found that oral Testosterone decanoate reduced hsCRP and improved insulin sensitivity.  One caveat--Testosterone should not be given orally due to increased risk of hepatocellular cancer.
Nathan Goodyear

Is the degree of food processing and convenience linked with the nutritional quality of... - 0 views

ajcn.nutrition.org/...ajcn.114.100925.abstract

obesity nutrition diet

shared by Nathan Goodyear on 04 Jun 15 - No Cached
  • Nathan Goodyear on 04 Jun 15
     
    3/4 of calories from moderately/highly process foods in households in new study.  Obesity trend won't change if this one fact doesn't change.
Nathan Goodyear

Use of statins is associated with lower serum total and non-SHBG-bound testosterone lev... - 0 views

www.ncbi.nlm.nih.gov/...26034077

Statin statin therapy statins Testosterone low T low Testosterone free Testosterone HMG-CoQ reductase inhibitors

shared by Nathan Goodyear on 03 Jun 15 - No Cached
  • Nathan Goodyear on 03 Jun 15
     
    Statin use associated with lower total Testosterone and "non-SHBG bound Testosterone" (i.e. free testosterone) in men.  The higher the dose, the lower the trend in Testosterone.  The study found decreased testosterone could occur as soon as 1 month.
Nathan Goodyear

PLOS ONE: Metabolic Syndrome and Breast Cancer Risk: A Case-Cohort Study Nested in a Mu... - 0 views

journals.plos.org/...article

metabolic syndrome breast cancer cancer menopause women

shared by Nathan Goodyear on 03 Jun 15 - No Cached
  • Nathan Goodyear on 03 Jun 15
     
    new study finds increased post menopause breast cancer in women with Metabolic syndrome.
Nathan Goodyear

Herbal Medicine in the Treatment of Ulcerative Colitis - 0 views

www.ncbi.nlm.nih.gov/...PMC3271691

ulcerative colitis herbs natural gut health disease IBD inflammatory bowel disease

shared by Nathan Goodyear on 01 Jun 15 - No Cached
  • Nathan Goodyear on 01 Jun 15
     
    nice literature review of natural therapies for the treatment of UC.
Nathan Goodyear

Low testosterone in men predicts impaired arterial elasticity and microvascular functio... - 0 views

www.ncbi.nlm.nih.gov/...26022684

low T low Testosterone CVD cardiovascular disease Testosterone men male hormone hormones

shared by Nathan Goodyear on 01 Jun 15 - No Cached
  • Nathan Goodyear on 01 Jun 15
     
    study of 237 "healthy men" at 50+ found decreased arterial elasticity and microvascular dysfunction--both indicative of early CVD.
Nathan Goodyear

Testosterone therapy in men with Crohn's disease improves the clinical course of the di... - 0 views

www.ncbi.nlm.nih.gov/...26020563

low T low Testosterone Crohn's Crohn's disease Testosterone hypogonadism inflammation CRP men male hormone hormones

shared by Nathan Goodyear on 01 Jun 15 - No Cached
  • Nathan Goodyear on 01 Jun 15
     
    men with Crohn's disease and low Testosterone found to benefit from Testosterone therapy without side effects.  There was a decrease in disease as determined by the Crohn's disease activity index, a decrease in CRP, and a decrease in leukocyte count.
Nathan Goodyear

Differences in Hematopoietic Stem Cells Contribute to Sexually Dimorphic Inflammatory R... - 0 views

www.jbc.org/13250

obesity inflammation

shared by Nathan Goodyear on 01 Jun 15 - No Cached
  • Nathan Goodyear on 01 Jun 15
     
    Study of mice finds increased inflammatory response (increased macrophage response in adipose tissue) in male mice vs female mice.
Nathan Goodyear

Incidence of prostate cancer in hypogonadal men receiving testosterone therapy: observa... - 0 views

www.ncbi.nlm.nih.gov/...24980615

low T low Testosterone Testosterone men male hormone hormones prostate cancer

shared by Nathan Goodyear on 27 May 15 - No Cached
  • Nathan Goodyear on 27 May 15
     
    study finds Testosterone therapy in men with low T, as defined as < 350 ng/dl and symptoms, does not increase prostate cancer sick.   Follow up was median of 5 years and maximum of 17 years.
Nathan Goodyear

The relationship between lower urinary tract symptoms/benign prostatic hyperplasia and ... - 0 views

www.ncbi.nlm.nih.gov/...23850334

metabolic syndrome LUTS prostate BPH men male hormone hormones

shared by Nathan Goodyear on 27 May 15 - No Cached
  • Nathan Goodyear on 27 May 15
     
    Correlation found between increasing MetS components and LUTS/BPH incidence.  This points to more of a inflammatory, estrogen contribution, rather than an excess Testosterone issue as MetS is associated clearly with low T in men with MetS.
Nathan Goodyear

Testosterone Replacement Alone for Testosterone Deficiency Syndrome Improves Moderate L... - 0 views

www.ncbi.nlm.nih.gov/...PMC3640152

low T low testosterone LUTS prostate men male hormone hormones testosterone

shared by Nathan Goodyear on 27 May 15 - No Cached
  • Nathan Goodyear on 27 May 15
     
    Study finds that Testosterone therapy reduces LUTS in men with low T.  The definition of low T is a little wide in this study.  Another study that contradicts the belief that Testosterone contributes to LUTS through the prostate.
Nathan Goodyear

Lower urinary tract symptoms improve with testosterone replacement therapy in men with ... - 0 views

www.ncbi.nlm.nih.gov/...24135918

low T low Testosterone Testosterone prostate LUTS male hormone hormones men

shared by Nathan Goodyear on 27 May 15 - No Cached
  • Nathan Goodyear on 27 May 15
     
    Older men with low T found to have improved LUTS, based on prostate symptom score, with Testosterone therapy.  This flies in the face of concerns that Testosterone is a risk to the prostate.
Nathan Goodyear

Low Serum Testosterone Levels Are Associated with Elevated Urinary Mandelic Acid, and S... - 0 views

www.ncbi.nlm.nih.gov/...25996772

low T low Testosterone Testosterone mandolin acid strontium environmental chemicals toxins environmental toxins

shared by Nathan Goodyear on 27 May 15 - No Cached
  • Nathan Goodyear on 27 May 15
     
    analysis of 110 chemicals finds inverse association with Testosterone and elevated mandelic acid and strontium.
Nathan Goodyear

Neurobiological effects of the green tea constituent theanine and its potential role in... - 0 views

www.maneyonline.com/...1476830513Y.0000000079

green tea tea l-theanine anxiety brain mood BDNF

shared by Nathan Goodyear on 27 May 15 - No Cached
  • Nathan Goodyear on 27 May 15
     
    Only abstract available: l-Theanine appears to be a glutamate receptor antagonist.  The effects of l-Theanine have shown to be positive with mood disorders, psychiatric conditions, and neurodegenerative diseases.  L-Theanine increases BDNF.
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