Group items tagged

Increase in free Testosterone, DHEA, and Estradiol in postmenopause women associated with increase in insulin resistance.

A decrease in the SHBG in post menopause women is associated with increase in free Testosterone, which is associated with increase in MetS and CVD

Post menopause associated with lower SHBG, increase in free Testosterone and increase in metabolic syndrome.

Case study and review of potential side effects from the "doping" of Testosterone that is occuring today in physicians offices.

biomarker of low grade inflammation, CD163, associated with Klinefelter Syndrome.  Low T is common in Klinefelter syndrome.  However, Testosterone therapy did not decrease CD163.

This study found an association between increasing BMI and low T in men with BPH.

Study of Taiwanese men finds low free Testosterone and hs-CRP is predictive of ED in obese men.

Elevated estradiol, estrone, and Testosterone increases breast cancer risk by 50 to 200% depending on the hormone(s) elevated.

study suggests that vitamin D supplementation increases Testosterone production.  

HCG injections useful in raising intra-testicular testosterone levels and aiding sperm production in those with azoospermia.

study looked at androgen deprivation therapy in non-metastatic prostate cancer.  This study found that the elimination of ADR post 5 years was associated with low recurrence.  Relapse of increased PSA was associated with increasing Testosterone off of ADR.  This study did not look at estrogens or androgen metabolites.  Too short sided in its design.

Men with Metabolic Syndrome have lower Total Testosterone values.  Symptoms correlated with age: older men associated with increased symptoms.  This study only found lot T at 6.5%.  The authors in this study have come up with a new box--andropenia.  I don't know what the heck that is and how that helps clients.  If symptoms are present and if levels are on the decline, then symptomatic hypogonadism is present.  I know the logic seems simple, but it appears hard to follow in the science.  I don't see this any different then type II diabetes.  At 126 you have diabetes, but at 125, we don't know what to do with you but see us next year and you will have diabetes and we will know what to do because you are in the box of diabetes.

Study of Korean men finds late onset of hypogonadism to be 16.8% in their study of 1,235 men older than 40.  This is a higher rate than other studies, but lower than others (38.7% in American men).  The test definition of low T was set at 3.2 ng/ml.  Abdominal obesity, metabolic syndrome, diabetes, and increasing age were associated with low T. Low T is clearly not a problem unique to America.  It definitely appears that a decreasing Testosterone level is a marker of poor health in men.  

Asian study finds Testosterone is inversely associated with increased central obesity, increased dyslipidemia, and metabolic syndrome in me with new diagnosis of type II diabetes and hypertension.  Men with metabolic syndrome, type II diabetes, and CVD must have appropriate hormone evaluation.

Total prevalence of low Testosterone in this study was 12.3% per 1,000 person years.  With increasing age, comes decreasing Tesosteorne levels in men.

This study tried to see if questionnaires could replaced free Testosterone test to diagnosis hypogonadism.  The answer of course is no.  One needs both to properly assess a individual.

Again, Testosterone and here Estradiol are merely there for libido and sex.  What tunnel vision?!  What about hsCRP?  What about fibrinogen?  What about IL-1beta?  What about TNF-alpha?  These inflammatory cytokines have all been reported to elevate as a result of estrogen production in men.   And PSA?  No mention of it here.   This linear, tunnel vision thinking on hormones has got to stop! The study points out that all clients were using AIs and SERMs irregardless of whether they had elevated estrogens or not.  That is not a well designed study.  One group should have had AI's if elevated estrogens were present and another group should not--this would compare the effects of aromatase activity.  Second, this was simply a retrospective chart review.  Third, a 50% conversion of 34,000 + men is very high when you look at the literature.  Fourth, they point to gynecomastia as a means of negative?  The cardiovascular implications are more significant.  These studies just seem to focus on superficial things.  Fifth, did libido problems exist before?  What were the free levels?   This falls in the paucity of data (2 studies) that point to excessive lowering of estradiol effecting libido and sexual performance.

Review of low T, evaluation, and health benefits of physiologic Testosterone replacement.

Article looked at the anabolic effect of low-intensity resistance exercise.  This study found a decrease in cortisol post-exercise, but no increase in anabolic effects: GH and total Testosterone.  The exercise was in untrained men, which could explain some of the decrease in the anabolic effect with the men in this study.

Previous Testosterone therapy did not effect Gonadotropin therapy for azoospermia in men with hypogonadotropic hypogonadism.  Gonadotropin therapy was quite successful in generating spermatogenesis in this meta-analysis.