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Nathan Goodyear

Low Testosterone Level and Risk of Alzheimer's Disease in the Elderly Men: a Systematic... - 0 views

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    Just abstract available here; low Testosterone in meta-analysis found to be associated with increased Alzheimer's disease risk in elderly men.
Nathan Goodyear

Effect of Opioids on Testosterone Levels: Cross-Sectional Study using NHANES. - PubMed ... - 0 views

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    opiate use increases odds of low Testosterone; however, this is just one piece. 
Nathan Goodyear

British Journal of Cancer - Androgen metabolism in prostate cancer: from molecular mech... - 0 views

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    androgen metabolites and prostate cancer promotion.
Nathan Goodyear

Association of metabolic syndrome with testosterone and inflammation in men. - PubMed -... - 0 views

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    only abstract available, but low Testosterone and elevated hs-CRP are found to predict metabolic syndrome in men.
Nathan Goodyear

Association between serum total testosterone and Body Mass Index in middle aged healthy... - 0 views

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    Study finds low total Testosterone significantly associated with increased BMI in university employees. The definition of low T in this study was 280 ng/dl.
Nathan Goodyear

5B.06: ASSOCIATION OF PLASMA TESTOSTERONE WITH CENTRAL HAEMODYNAMICS IN HYPERTENSIVE ME... - 0 views

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    low total Testosterone is associated with increased central blood pressure elevation.  Less association was found with peripheral blood pressure.
Nathan Goodyear

Low testosterone level is an independent risk factor for high-grade prostate cancer det... - 0 views

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    low Testosterone is associated with increased risk of high grade prostate cancer at time of biopsy compared to normal Testosterone.
Nathan Goodyear

Testosterone regulation of homocysteine metabolism modulates redox status in human pros... - 0 views

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    in disease prostate, Testosterone down regulates transulfuration pathway and glutathione production.
Nathan Goodyear

Salivary Testosterone and a Trinucleotide (CAG) Length Polymorphism in the Androgen Rec... - 0 views

  • Testosterone correlated inversely with participant age (r = −0.39, p = 0.012) and positively with number of CAG repeats
  • transactivation potential of the AR appears to decline in graded relation to an increasing number of CAG repeats, which are distributed over a normative range of 11–37 and, in Caucasian populations, commonly average 21–22 repeats
  • When activated by androgens, ARs translocate to the cell nucleus, where they exert transcriptional control of androgen-dependent genes by binding to androgen response elements within gene regulatory sequences
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  • some evidence suggests a high number of CAG repeats may be associated with cognitive aging
  • androgens (like other steroid hormones) promote or repress the expression of genes specifying an array of cellular proteins
  • diurnal variation in testosterone levels
  • salivary testosterone correlated negatively with participant age and positively with CAG length variation in the AR gene
  • CAG repeat number varied inversely with reactivity of the ventral amygdala to facial expressions of negative affect
  • higher salivary testosterone was likewise associated with a greater number of AR CAG repeats
  • relative androgen insensitivity in ARs with a larger number of CAG repeats
  • Because circulating testosterone is regulated via negative feedback through the hypothalamic-pituitary-gonadal axis, diminished androgen sensitivity at higher CAG repeat lengths may reduce feedback suppression of luteinizing hormone (LH). LH would then be maintained at higher levels, in turn promoting higher testosterone production
  • Testosterone up-regulates AVP expression in the amygdala
  • Oxytocin exerts an inhibitory influence on AVP expression in the central amygdala, and the synthesis of oxytocin is mediated by estrogen and estrogen receptors
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    Study used saliva to measure Testosterone levels in men.  Testosterone levels were inversely associated with age, but positively associated with CAG repeat sequences in the AR.
Nathan Goodyear

Effects of endurance exercise on free testosterone concentration and the binding affini... - 0 views

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    exercise increases Testosterone production via catecholamine mechanism.  Free Testosterone increases independent from SHBG affinity.
Nathan Goodyear

Neuropsychopharmacology - Testosterone Suppression of CRH-Stimulated Cortisol in Men - 0 views

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    Testosterone inhibits CRH and thus cortisol.
Nathan Goodyear

Testosterone Suppression of CRH-stimulated Cortisol in Men - 0 views

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    Testosterone inhibits CRH and thus cortisol production in men.  This has implications in men with low T and low Cortisol.
Nathan Goodyear

PLOS ONE: Testosterone Induces Molecular Changes in Dopamine Signaling Pathway Molecule... - 0 views

  • The majority of the gene expression changes reported here are only induced by DHT and testosterone, and not by estradiol, indicating that in adolescent males androgen receptor, not ERα, activation is critical for these responses
  • It is less clear whether ERβ is involved or not as DHT, via conversion to 3β-diol has a high affinity for ERβ
  • the testosterone-induced, AR-driven modulation of molecular indices of dopamine responsivity of the nigrostriatal pathway may involve regulation of dopamine feedback inhibition in the somatodendritic field and post-synaptic dopamine action in the terminal field.
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    Testosterone increases dopamine signaling.  This study was done on male rats.  No effect was seen with Estradiol.
Nathan Goodyear

Age-related testosterone decline is due to waning of both testicular and hypothalamic-p... - 0 views

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    Only abstract available here, but low T is the result of primary (testicular failure) and/or secondary (HPA failure). 
Nathan Goodyear

Effects of Testosterone Level on Lower Urinary Tract Symptoms. - PubMed - NCBI - 0 views

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    no correlation between total Testosterone with LUTS and prostate size in men.
Nathan Goodyear

Effects of Resistance Training on Testosterone Metabolism in Younger and Older Men. - P... - 0 views

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    Resistance training increases Testosterone in younger and older men.  The effects in older men appears to involve more of a decreased metabolism.  
Nathan Goodyear

Leptin inhibits testosterone secretion from adult rat testis in vitro. - PubMed - NCBI - 0 views

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    high leptin levels found to inhibit pituitary LH/FSH release.  Of note, high leptin levels inhibited leydig cell production of Testosterone following hCG stimulation.  This is a rat in vitro study.
Nathan Goodyear

http://joe.endocrinology-journals.org/content/170/2/413.full.pdf - 0 views

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    Leptin shown to inhibit steroid hormone synthesis in the gonads via inhibition of 17beta-HSD.  This is in addition to other reports of inhibition of 17,20 lyase, adrenal cortisol inhibition, inhibition of CRF, and inhibition of LH/FSH.
Nathan Goodyear

Kisspeptin-10 Is a Potent Stimulator of LH and Increases Pulse Frequency in Men - 0 views

  • Kisspeptin, a hypothalamic neuropeptide
  • has recently emerged as a key central regulator of GnRH secretion
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    Kisspeptin increases LH pulse frequency and pluse amplititude; the result is an increase in Testosterone secretion.
Nathan Goodyear

The adipose tissue metabolism: role of testosterone and dehydroepiandrosterone. - PubMe... - 0 views

  • T inhibits lipid uptake and lipoprotein-lipase (LDL) activity in adipocytes, and stimulates lipolysis
  • T inhibits differentiation of adipocyte precursor cells
  • DHEA stimulates resting metabolic rate (RMR) and lipid oxidation, and enhances glucose disposal, by increasing the expression of GLUT-1 and GLUT-4 on fat cell plasma membrane
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  • The insulin-like effect of DHEA would be associated to a decrease of plasma insulin concentrations and, thus, to an increase of the molar ratio between lipolytic hormones and insulin
  • the fat-reducing effect of both T and DHEA seems to be more evident at the level of visceral adipose tissue
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    Testosterone inhibits lipid uptake into adipocytes.  Testosterone inhibits lipoprotein lipase.  Testosterone stimulated lipolysis.  Testosterone inhibits adipocyte differentiation of proginator cells.

    DHEAs effects are through different mechanisms.  

    Both have a preference for activity with visceral adipose tissue.
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