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Nathan Goodyear

Mendelian randomization suggests non-causal associations of testosterone with cardiomet... - 0 views

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    Study questions causal associations of testosterone and cardiometabolic risk.  In this analysis they used to SNPs, one on the SHBG gene rs12150660 and the other on the X chromosome rs59344505.
Nathan Goodyear

The rs5934505 single nucleotide polymorphism (SNP) is associated with low testosterone ... - 0 views

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    Four SNPs, rs12150660, rs727428, rs5934505, and rs10822184 associated with late-onset hypogonadism (low T) and obesity in men of European descent.  In Chinese populations, rs5934505 was associated with increased risk of low Total Testosterone and calculated free Testosterone.  OR was 2.01 for low TT and 2.14 for low calculated free Testosterone.
Nathan Goodyear

Genetic Determinants of Serum Testosterone Concentrations in Men - 0 views

  • mean serum testosterone concentrations were found to be lower in men with GG than in those with TT genotype for rs12150660
  • men with the CT genotype for rs6258 had lower serum testosterone concentrations than those with CC genotype.
  • The two autosomal SNPs identified by GWAS had a significant influence on the risk of having low serum testosterone (serum testosterone <300 ng/dl) in both the discovery and the replication cohorts with a combined odds ratio (OR) per minor allele of 0.72 (95% CI, 0.65 – 0.79) and 2.7 (95% CI, 2.1 – 3.5) for rs12150660 and rs6258, respectively
  • ...3 more annotations...
  • The risk of having low serum testosterone concentrations increased by the number of risk alleles with an OR of 1.62 (95% CI, 1.41 – 1.86) for each risk allele (Figure S4). Low serum testosterone concentrations were 6.5-times more prevalent in men with ≥3 risk alleles (30.1% prevalence of low serum testosterone) compared to men without any risk allele (4.6% prevalence of low serum testosterone;
  • SNP rs5934505 was associated with serum testosterone without SHBG-adjustment (combined p-value of 1.7×10−9) and with free testosterone (combined p-value of 6.7×10−15), but not with SHBG
  • The mean serum testosterone and calculated free testosterone but not SHBG concentrations were lower in men with T genotype than in those with C genotype for rs5934505
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    Genetic SNP rs5934505 associated with lower total Testosterone and lower calculated free Testosterone.  No effects on SHBG.
Nathan Goodyear

Age and BMI Adjusted Comparison of Reproductive Hormones in PCOS - 0 views

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    study of Saudi women with PCOS finds elevated LH/FSH ratio and elevated total Testosterone levels independent of age and weight; in addition, lower FSH, SHBG, and progesterone levels we found.
Nathan Goodyear

Genetic Determinants of Serum Testosterone Concentrations in Men - 0 views

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    SNP as significant contributor to low Testosterone in men via SHBG polymorphism and reduces the free Testosterone.
Nathan Goodyear

Effect of 1 Week of Sleep Restriction on Testosterone Levels in Young Healthy Men | End... - 0 views

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    Small study of young men, average age 24.5, found a 10-15% reduction in Testosterone levels with 1 week of sleep deprivation.  Sleep was reduced to 5 hours per night for just 1 week.
Nathan Goodyear

Four Thrombotic Events Over 5 Years, Two Pulmonary Emboli and Two Deep Venous Thrombosi... - 0 views

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    VTE in man as a result of supra-physiologic Testosterone and high aromatase activity prior to and on anticoagulant therapy.
Nathan Goodyear

Risk of Venous Thromboembolism in Men Receiving Testosterone Therapy - Mayo Clinic Proc... - 0 views

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    Venous thromboembolism found not be associated with prior Testosterone therapy in men.
Nathan Goodyear

Association Between Testosterone Replacement Therapy and the Incidence of DVT... - 0 views

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    Testosterone therapy in men with low Testosterone and mild/moderate clot risk found to not increase risk of clots
Nathan Goodyear

Randomized placebo-controlled trial of testosterone replacement in men with mild Leydig... - 0 views

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    The authors conclusion here is all wrong.  The men with low T had improvement in energy and LDL, but no improvement in mood and sexual function.
Nathan Goodyear

Increased serum C-reactive protein levels in normal weight women with polycystic ovary ... - 0 views

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    Study doesn't directly link causation, but increased Testosterone in women of normal weight with PCOS associated with increased CRP.
Nathan Goodyear

Testosterone therapy for reduced libido in women - 0 views

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    Testosterone and libido in women: the data is limited.  The data that links low T in women to low libido is not present.  That questions the whole low T, libido theory in women.
Nathan Goodyear

http://www.imperialendo.co.uk/mohr.pdf - 0 views

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    Massachusetts Male Aging Study (MMAS).
Nathan Goodyear

A Validated Age-Related Normative Model for Male Total Testosterone Shows Increasing Va... - 0 views

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    Interesting read: study finds peak Testosterone at age 19 in men; Testosterone decline was see up to age 40 at which decline was variable beyond age 40
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Nathan Goodyear

Hypogonadism in the Aging Male Diagnosis, Potential Benefits, and Risks of Testosterone... - 0 views

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    Review of the literature on Low T, causes of low T, and associated symptoms.
Nathan Goodyear

Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Me... - 0 views

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    great read on low T via BLSA
Nathan Goodyear

The association between androgen levels and premature coronary artery disease in men. -... - 0 views

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    low free Testosterone is found to be associated with a 3.3 fold increased risk of premature coronary artery disease.  The free Testosterone here is 17.3 pg/ml, but could be as high as 25 pg/ml.  
Nathan Goodyear

Effects of chronic celecoxib on testicular function in normal and lipopolysaccharide-tr... - 0 views

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    Animal study from '09 found that COX2 inhibitor blunted LPS decrease in testes weight, decrease in testicular interstitial fluid, and serum Testosterone.  The point here is that LPS, in this animal model, decreased gonadal weight and Testosterone production and the anti inflammatory, COX2, blunted that effect.
Nathan Goodyear

Bacterial Lipopolysaccharide-Induced Inflammation Compromises Testicular Function at Mu... - 0 views

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    animal study finds LPS, lipopolysaccharides, decreases Testosterone production at the level of the leydig cells in the testes.
Nathan Goodyear

Metabolic endotoxaemia related inflammation is associated with hypogonadism in overweig... - 0 views

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    Study finds that inflammation that is the result of obesity in men (IL-6) negatively effects the leading cell and Sertoli cells in men.  Testosterone levels in these men correlated significantly with lipopolysaccharide binding protein.  This points to a negative correlation b/t LPS metabolic endotoxemia and low Testosterone.  Could Testosterone merely be the result of an unhealthy diet and gut?
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