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Nathan Goodyear

The Aging Male Hypothalamic-Pituitary-Gonadal Axis: pulsatility and feedback - 0 views

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    good review of the male hypothalamic-pituitary-gonadal axis.  Of interest is a good discussion of the pulsatile LH activity.
Nathan Goodyear

Effect of low-fat diet on female sex hormone levels. - PubMed - NCBI - 0 views

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    low fat diet drops estrogen levels precipitously in women.  It also dropped Testosterone levels.
Nathan Goodyear

Variations in urine excretion of steroid hormones after an acute session and after a 4-... - 0 views

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    4 week resistance training program found to increase androgens in urine; this suggests increased androgen production as a result of the resistance program
Nathan Goodyear

http://jap.physiology.org/content/jap/82/1/49.full.pdf - 0 views

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    To much protein intake can be a bad thing.  This study found that high protein intake and high protein/carbohydrate intake lowered basal Testosterone levels.
Nathan Goodyear

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168024/ - 0 views

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    Good review of low Testosterone and treatment. The authors here recommend 400-700 ng/dl; I like 500-700 ng/dl
Nathan Goodyear

The effects of metformin and diet on plasma testosterone and leptin levels in obese men... - 0 views

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    metformin caused a decrease in total and free testosterone in men
Nathan Goodyear

Effects of weight loss on leptin, sex hormones, and measures of adiposity in obese chil... - 0 views

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    weight loss decreases leptin in boys and the result is an increase in Testosterone
Nathan Goodyear

Lowered testosterone in male obesity: mechanisms, morbidity and management - 0 views

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    nice review of the relationship between obesity and Testosterone in men.
Nathan Goodyear

Influence of dietary carbohydrate intake on the free testosterone: cortisol ratio respo... - 0 views

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    excessive carb restriction in athletes can lower Testosterone levels and negatively impact Testosterone to cortisol ratio. This will limit performance and hinder recovery.
Nathan Goodyear

Relationship between Testosterone and Erectile dysfunction - 1 views

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    Though Testosterone plays a role, it's role in the erectile process is overblown.
Nathan Goodyear

An update on the role of testosterone replacement therapy in the management of hypogona... - 0 views

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    very nice updated review on the evidence of TRT.
Nathan Goodyear

Testosterone replacement therapy for older men - 0 views

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    good review of Testosterone and Testosterone replacement in older men.
Nathan Goodyear

Reproductive toxicologic evaluations of Bulbine natalensis Baker stem extract in albino... - 0 views

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    Bulbine natalensis Baker stem extract found to increase LH and Testosterone in wistar rats in 7 days at doses of 25 to 50 mg/kg; this effect was not found at 100 mg/kg.  The result was an increase in testes size, rate of mating, libido, and fertility.
Nathan Goodyear

Anabolic and androgenic activities of Bulbine natalensis stem in male Wistar rats: Phar... - 0 views

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    Bulbine natalensis Baker stem found to increase Testosterone by up to 350% in animal studies in 2 weeks.  The dose with the optimum response was 25 and 50 mg/kg, with the most best effect at 50 mg/kg.  LH and FSH production was increase but exact mechanism not discussed.  Only abstract available here.
Nathan Goodyear

Treatment of Men for "Low Testosterone": A Systematic Review - 0 views

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    A systemic review of Testosterone benefit in men stirs the pot.  I can't say that I agree with the majority of their conclusions.  What I do agree with them on is that the majority of men on Testosterone therapy likely don't need it and are simply using Testosterone as a drug.
Nathan Goodyear

Vitamin D is associated with testosterone and hypogonadism in Chinese men: Results from... - 0 views

  • lower 25(OH)D level was significantly associated with lower total T, E2, SHBG, LH and FSH levels after adjusting for age, residence area, economic status and current smoker
  • association between 25(OH)D status and hypogonadism in Chinese men and confirms that this relationship is present in a large population
  • VDR knockout mutant mice showed gonadal insufficiencies
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  • High LH and FSH levels in the male mice indicated hypergonadotropic hypogonadism
  • Another mouse study reported a tendency towards low testosterone/LH ratio and Leydig cell hyperplasia in VDR null mice
  • The serum testosterone levels could increase to normal values in vitamin D-deficient rats replete with vitamin D
  • VDR knockout mice had decreased sperm count, reduced sperm motility, and histological abnormality of the testis
  • vitamin D supplementation increases testosterone levels in non-diabetic subjects
  • The data from the European Male Ageing Study [] indicated that 25(OH)D is positively associated with total T
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    Study of 713 Chinese men finds a correlation between low vitamin D and low total Testosterone.
Nathan Goodyear

Serum vitamin D and sex hormones levels in men and women: The Multi-Ethnic Study of Ath... - 0 views

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    cross sectional study finds low vitamin D associated with a decrease in SHBG and an increase in free Testosterone;  a decrease in estradiol and an increase in DHEA was seen in women.  No association with total Testosterone was found.  There are studies that show a direct decrease in testicular Testosterone production in men with low vitamin D and decrease in AR function.
Nathan Goodyear

Bioavailable Testosterone and Depressed Mood in Older Men: The Rancho Bernardo Study: T... - 0 views

  • bioavailable testosterone levels decrease much more with age than does total testosterone or estradiol levels
  • The decrease in bioavailable testosterone parallels the increase in sex hormone binding globulin with age, a change that accompanies increasing body fat independent of weight change
  • a graded stepwise decrease in bioavailable testosterone with increasing level of depressed mood
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  • This association was independent of age, weight change, and physical activity, the only three significant confounding covariates of the association between sex hormone levels and BDI scores
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    bioavailable Testosterone is inversely associated with increased depressive symptoms.
Nathan Goodyear

Testosterone Gel Supplementation for Men With Refractory Depression: A Randomized, Plac... - 0 views

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    study that looked at men with refractory depression symptoms on depression meds with low Testosterone finds Testosterone therapy improved depression symptoms.
Nathan Goodyear

Effect of Testosterone Replacement Therapy on Cognitive Performance and Depression in M... - 0 views

  • Azad et al [] used single photon emission computed tomography and showed that, after 3~5 weeks of TRT, cerebral perfusion was increased in the midbrain and the superior frontal gyrus in seven men with hypogonadism
  • After 12~14 weeks, increased perfusion was still observed in the midbrain as well as in the midcingulate gyrus
  • TDS patients who received TRT showed significant improvement in cognitive function only if mild cognitive impairment was present at baseline
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  • Cherrier et al [] evaluated a sample of 32 subjects, which included 17 men with mild cognitive impairment and 15 with Alzheimer's disease. At the 6-week follow-up, patients who received TRT showed significantly better scores regarding spatial memory, constructional abilities, and verbal memory compared to those noted in the placebo group. Taken together, these results suggest that TRT has a beneficial effect on cognitive function
  • TRT improved mood and well-being, and reduced fatigue and irritability in hypogonadal men
  • The study by Pope et al [] involved men with depression refractory to standard anti-depressants, and found that TRT lowered the Hamilton Depression score,
  • depression tends to increase as testosterone levels decrease [], it is highly likely that TRT improved symptoms of depression by increasing testosterone levels.
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    men with Testosterone <330 ng /><300 ng/dl with levels after 8 months of therapy achieving +680 ng/dl.
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