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Nathan Goodyear

Effect of testosterone treatment on cardiac biomarkers in a randomized controlled trial... - 0 views

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    40 week study finds that low Testosterone is associated with increased 10 risk of cardiac adverse events.  This was also associated with elevated BNP and hs-cardiac Troponin.  The study found that Testosterone therapy did decrease BNP, though not statistically significant; no effect on hs-cardiac troponin was found.
Nathan Goodyear

Hypogonadal men with psoriasis benefit from long-term testosterone replacement therapy ... - 0 views

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    only abstract available here, but Testosterone therapy in men with low T found to reduce CRP, weight and lipids in men with psoriasis.
Nathan Goodyear

Association of Free Testosterone With Hypogonadal Symptoms in Men With Near-normal Tota... - 0 views

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    only abstract available here, but the authors conclude that free Testosterone is no associated with low T symptoms with near normal serum TT.  Not so fast, the study did find that free Testosterone did prove significant in younger men and this is exactly when the TT and fT appear to have significant discrepencies.
Nathan Goodyear

Testosterone Deficiency Increases Hospital Readmission and Mortality Rates in Male Pati... - 0 views

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    Men with CHF and low Testosterone have higher readmission rates within 90 days compared to those men with CHF and normal Testosterone.
Nathan Goodyear

Normalization of testosterone level is associated with reduced incidence of myocardial ... - 0 views

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    Testosterone therapy in men with low T found to reduce all cause mortality, stroke and MI.
Nathan Goodyear

Low Testosterone Level and Risk of Alzheimer's Disease in the Elderly Men: a Systematic... - 0 views

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    Just abstract available here; low Testosterone in meta-analysis found to be associated with increased Alzheimer's disease risk in elderly men.
Nathan Goodyear

Effect of Opioids on Testosterone Levels: Cross-Sectional Study using NHANES. - PubMed ... - 0 views

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    opiate use increases odds of low Testosterone; however, this is just one piece. 
Nathan Goodyear

British Journal of Cancer - Androgen metabolism in prostate cancer: from molecular mech... - 0 views

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    androgen metabolites and prostate cancer promotion.
Nathan Goodyear

Association of metabolic syndrome with testosterone and inflammation in men. - PubMed -... - 0 views

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    only abstract available, but low Testosterone and elevated hs-CRP are found to predict metabolic syndrome in men.
Nathan Goodyear

Association between serum total testosterone and Body Mass Index in middle aged healthy... - 0 views

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    Study finds low total Testosterone significantly associated with increased BMI in university employees. The definition of low T in this study was 280 ng/dl.
Nathan Goodyear

5B.06: ASSOCIATION OF PLASMA TESTOSTERONE WITH CENTRAL HAEMODYNAMICS IN HYPERTENSIVE ME... - 0 views

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    low total Testosterone is associated with increased central blood pressure elevation.  Less association was found with peripheral blood pressure.
Nathan Goodyear

Low testosterone level is an independent risk factor for high-grade prostate cancer det... - 0 views

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    low Testosterone is associated with increased risk of high grade prostate cancer at time of biopsy compared to normal Testosterone.
Nathan Goodyear

Testosterone regulation of homocysteine metabolism modulates redox status in human pros... - 0 views

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    in disease prostate, Testosterone down regulates transulfuration pathway and glutathione production.
Nathan Goodyear

Salivary Testosterone and a Trinucleotide (CAG) Length Polymorphism in the Androgen Rec... - 0 views

  • Testosterone correlated inversely with participant age (r = −0.39, p = 0.012) and positively with number of CAG repeats
  • transactivation potential of the AR appears to decline in graded relation to an increasing number of CAG repeats, which are distributed over a normative range of 11–37 and, in Caucasian populations, commonly average 21–22 repeats
  • When activated by androgens, ARs translocate to the cell nucleus, where they exert transcriptional control of androgen-dependent genes by binding to androgen response elements within gene regulatory sequences
  • ...10 more annotations...
  • some evidence suggests a high number of CAG repeats may be associated with cognitive aging
  • androgens (like other steroid hormones) promote or repress the expression of genes specifying an array of cellular proteins
  • diurnal variation in testosterone levels
  • salivary testosterone correlated negatively with participant age and positively with CAG length variation in the AR gene
  • CAG repeat number varied inversely with reactivity of the ventral amygdala to facial expressions of negative affect
  • higher salivary testosterone was likewise associated with a greater number of AR CAG repeats
  • relative androgen insensitivity in ARs with a larger number of CAG repeats
  • Because circulating testosterone is regulated via negative feedback through the hypothalamic-pituitary-gonadal axis, diminished androgen sensitivity at higher CAG repeat lengths may reduce feedback suppression of luteinizing hormone (LH). LH would then be maintained at higher levels, in turn promoting higher testosterone production
  • Testosterone up-regulates AVP expression in the amygdala
  • Oxytocin exerts an inhibitory influence on AVP expression in the central amygdala, and the synthesis of oxytocin is mediated by estrogen and estrogen receptors
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    Study used saliva to measure Testosterone levels in men.  Testosterone levels were inversely associated with age, but positively associated with CAG repeat sequences in the AR.
Nathan Goodyear

Effects of endurance exercise on free testosterone concentration and the binding affini... - 0 views

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    exercise increases Testosterone production via catecholamine mechanism.  Free Testosterone increases independent from SHBG affinity.
Nathan Goodyear

Neuropsychopharmacology - Testosterone Suppression of CRH-Stimulated Cortisol in Men - 0 views

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    Testosterone inhibits CRH and thus cortisol.
Nathan Goodyear

Testosterone Suppression of CRH-stimulated Cortisol in Men - 0 views

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    Testosterone inhibits CRH and thus cortisol production in men.  This has implications in men with low T and low Cortisol.
Nathan Goodyear

PLOS ONE: Testosterone Induces Molecular Changes in Dopamine Signaling Pathway Molecule... - 0 views

  • The majority of the gene expression changes reported here are only induced by DHT and testosterone, and not by estradiol, indicating that in adolescent males androgen receptor, not ERα, activation is critical for these responses
  • It is less clear whether ERβ is involved or not as DHT, via conversion to 3β-diol has a high affinity for ERβ
  • the testosterone-induced, AR-driven modulation of molecular indices of dopamine responsivity of the nigrostriatal pathway may involve regulation of dopamine feedback inhibition in the somatodendritic field and post-synaptic dopamine action in the terminal field.
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    Testosterone increases dopamine signaling.  This study was done on male rats.  No effect was seen with Estradiol.
Nathan Goodyear

Age-related testosterone decline is due to waning of both testicular and hypothalamic-p... - 0 views

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    Only abstract available here, but low T is the result of primary (testicular failure) and/or secondary (HPA failure). 
Nathan Goodyear

Effects of Testosterone Level on Lower Urinary Tract Symptoms. - PubMed - NCBI - 0 views

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    no correlation between total Testosterone with LUTS and prostate size in men.
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