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Nathan Goodyear

Systemic lupus erythematosus: sex hormones in male patients. - PubMed - NCBI - 0 views

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    more men with lupus have low Testosterone compared to controls in small study.
Nathan Goodyear

Profile of sex hormones in male patients with systemic lupus erythematosus. - PubMed - ... - 0 views

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    low Testosterone trends in some men with Lupus.  The authors conclude it may be causative in some men and not in others.
Nathan Goodyear

http://onlinelibrary.wiley.com/store/10.1002/art.11105/asset/11105_ftp.pdf;jsessionid=4... - 0 views

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    good review of sex hormones and LUPUS; whether it is causative or not, sex hormones trends exist in LUPUS i.e. low DHEA in both sexes, low progesterone in women, and low Testosterone in women>men.
Nathan Goodyear

Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secret... - 0 views

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    only abstract available here. Mouse model finds possible explanation for low Testosterone and diabetes link.  Actually, the link is between the metabolite DHT and the AR. The activity of AR from DHT binding induces beta cell insulin secretion in the presence of glucose.  This is dependent on glucagon-like peptide 1 receptor activation also, which AR activation by DHT does in fact do.
Nathan Goodyear

Subcutaneous administration of testosterone. A pilot study report. | Al-Futaisi | Saudi... - 0 views

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    subcutaneous Testosterone replacement therapy found to be effective and safe.
Nathan Goodyear

http://onlinelibrary.wiley.com/store/10.1002/sm2.80/asset/sm280.pdf;jsessionid=85D97ADB... - 0 views

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    sub cutaneous TEstosteorne therapy found to be equivalent to IM.  Interesting note: a lower dose seems to be required compared to IM Testosterone.
Nathan Goodyear

https://endo.confex.com/endo/2013endo/webprogram/Paper9064.html - 0 views

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    Sub cutaneous injection of Testosterone found to be effective in Testosterone replacement.
Nathan Goodyear

High estrogen in men after injectable testosterone therapy: the low T experience. - Pub... - 0 views

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    This is what amounts to science?  As if high estrogen production from overdosing Testosterone only results in gynecomastia.  This study is trying to validate doping utilizing testosterone by saying that no one listed gynecomastia as the reason for AI therapy?!?! No evaluation on PSA, TNF-alpha, CRP...was done.  This study is worthless.
Nathan Goodyear

Will testosterone replacement therapy become a new treatment of chronic heart failure? ... - 0 views

  • TRT could improve significantly the exercise capacity of patients, compared with placebo
  • it could be seen that the effect of TRT on SBP and DBP was controversial
  • in men with congestive heart failure, testosterone reduced the Q-Td, whereas placebo had no effects
  • ...5 more annotations...
  • The MVC and PTmax were significantly improved in TRT patients but remained unchanged in the placebo group
  • handgrip strength improved significantly with testosterone treatment
  • According to EF assessed by echocardiography, no differences were observed between the patients who were prescribed testosterone and those who received placebo
  • There were no differences between the groups in circulating levels of NT pro-BNP, and inflammatory markers were unchanged, except for a decrease in TNF-α from baseline in the placebo group
  • Testosterone supplementation therapy appeared to be safe, and the subjects who accepted testosterone treatment did not appear any obvious adverse reactions.
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    Testosterone therapy in men with CHF found to increase exercise capacity, reduced the Q-T interval in men, improved muscle strength in men, and was found to be safe in meta-analysis.
Nathan Goodyear

http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/Reprod... - 0 views

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    Testosterone has moved from therapy to recreational for many men.  The 50-25-21 rule.
Nathan Goodyear

Stable Intraprostatic Dihydrotestosterone in Healthy Medically Castrate Men Treated wit... - 0 views

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    Study finds that intraprostatic DHT levels correlate to Testosterone in TRT.  
Nathan Goodyear

Salivary cortisol and testosterone responses to resistance and plyometric exercise in 1... - 0 views

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    Study of 12-14 y/o boys found increased Testosterone after resistance training and plyometric exercise.  Cortisol did increase after plyometric, but not resistance exercise.
Nathan Goodyear

Methadone induces testosterone suppression in patients with opioid addiction : Scientif... - 0 views

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    Methadone suppresses Testosterone in men.
Nathan Goodyear

Increased estrogen formation and estrogen to androgen ratio in the synovial fluid of pa... - 0 views

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    high estrogen to Testosterone levels in synovial fluid in those with RA.  The authors here propose that DHEA can stimulate inflammation through aromatase activity.
Nathan Goodyear

Prevalence and prognosis of a low serum testosterone in men with type 2 diabetes: The F... - 0 views

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    when looking at men, Testosterone levels, diabetes, and death: this study found a U shaped pattern of risk; low and high-normal total Testosterone levels were associated with increased death.  No association was found with free Testosterone and SHBG.
Nathan Goodyear

Neutral associations of testosterone, dihydrotestosterone and estradiol with fatal and ... - 0 views

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    study of middle aged men (mean age--50) finds no correlation between Testosterone, DHT, and higher Estradiol levels in CVD outcomes, including mortality.  Men who died during the study had lower total Testosterone, free Testosterone, and DHT levels than those that survived during the study.
Nathan Goodyear

Effect of Lifestyle Intervention on the Hormonal Profile of Frail, Obese Older Men. - P... - 0 views

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    Nice study: 52 week study looked at lifestyle intervention to lose weight in men with low T and high estrogen levels.  The lifestyle intervention was successful in lower weight and estrogen levels, but not in raising Testosterone levels.
Nathan Goodyear

Anabolic androgenic steroids, an easily forgotten cause of polycythaemia and cerebral i... - 0 views

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    Only abstract available here.  Supra-physiologic Testosterone therapy needs to be included in potential causes of polycythemia and stroke in men.  Remember the 25-50-21 rule in that 25% of men on Testosterone therapy are never checked prior to initiation of Testosterone and 50% are not followed after initiation of Testosterone therapy.
Nathan Goodyear

Study finds testosterone supplementation reduces heart attack risk in men with heart di... - 0 views

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    This is simply a public release prior to publication.  Study found that Testosterone therapy in men with existing CAD did not increased adverse events; in fact, it appeared to decrease the adverse events when compared to that of the non-treatment group.  Study not yet available to read the specific design, stats, and results which would be required to better analyze the actually results.
Nathan Goodyear

Testosterone, SHBG and differential white blood cell count in middle-aged and older men... - 0 views

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    higher endogenous total Testosterone associated with decline in WBC.  Simply a cross sectional analysis.  No association with low free Testosterone.
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