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Nathan Goodyear

Sex Hormones and Colorectal Cancer: What Have We Learned So Far? - 0 views

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    good synopsis of the knowledge of sex hormones and colon cancer.  The evidence suggests that low Testosterone increases risk.
Nathan Goodyear

Erratum to: Testosterone stimulates glucose uptake and GLUT4 translocation through LKB1... - 0 views

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    Testosterone increases glucose intake through increased GLUT4 translocation and activity.
Nathan Goodyear

The Effect of Simvastatin on Plasma Steroid Hormone Levels in Metformin-Treated Women w... - 0 views

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    Statins are known to reduce Testosterone in men; new study finds statins reduce all androgens in women.
Nathan Goodyear

https://www.jstage.jst.go.jp/article/jcbn/58/1/58_15-48/_pdf - 0 views

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    study finds that lifestyle interventions, aerobic exercise and calorie restriction, increased Testosterone levels in men that were overweight or obese.  The men included in this study did not meet most definitions of "low Testosterone".
Nathan Goodyear

Amount of Testosterone on Laundered Clothing After Use of Testosterone Topical 2% Solut... - 0 views

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    first study that I have seen that looked at the issue of Testosterone transmission through laundered clothing.  Only abstract available here, but 13% was transmitted to clothing through skin application and 3% remained following laundry of the clothing.
Nathan Goodyear

Association of vitamin D status with serum androgen levels in men. - PubMed - NCBI - 0 views

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    vitamin D correlates directly with Testosterone levels, Free Androgen Index, SHBG with a seasonal patter: highest in August and lowest in March.
Nathan Goodyear

An unusual cause of adult onset cerebellar ataxia with hypogonadism - 0 views

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    cases study of a middle age man with hypogonadotropic hypogonadism and celiac disease.
Nathan Goodyear

High Prevalence of Chronic Pituitary and Target-Organ Hormone Abnormalities after Blast... - 0 views

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    The prevalence of post traumatic hypopituitarism post TBI sits at around 35%.  
Nathan Goodyear

Sex Hormones and Ischemic Stroke: A Prospective Cohort Study and Meta-Analyses: The Jou... - 0 views

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    study finds Testosterone levels <10th percentile compared to men with Testosterone levels in the 11-90th percentile were associated with increased rate of ischemic stroke (34%).  The hazard ratio was overweight/obese, and hypertension in men.  no correlation was found in women.
Nathan Goodyear

Normalization of testosterone level is associated with reduced incidence of myocardial ... - 0 views

  • In this study of men with low TT levels and without prior MI or stroke, normalization of TT levels using TRT is associated with lower all-cause mortality, fewer MIs, and ischaemic strokes.
  • retrospective study
  • significant benefit is observed only if the dose is adequate to normalize the TT levels
  • ...9 more annotations...
  • the mechanisms for these effects remain speculative
  • It can be postulated that the beneficial effect of normal T levels on adipose tissue, insulin sensitivity, and lipid profiles or by its anti-inflammatory and anticoagulant properties, as reported by other investigators, might have contributed to our findings
  • off-label use of TRT remains a concern
  • Recent FDA analyses suggest that currently only half of the men on TRT had been diagnosed with hypogonadism
  • 25% of users did not have their T concentrations tested prior to initiating therapy
  • 21% of those prescribed TRT did not have their levels tested at any time during treatment
  • two very recent meta-analyses suggested a lack of convincing evidence posed by TRT.
  • men without a history of previous MI or stroke who have low TT levels, TRT might be associated with decreased risks of MI, ischaemic stroke, and all-cause mortality in long-term follow-up
  • TRT should aim for doses resulting in normalization of TT level as this was shown to be associated with reduction in adverse CV events
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    Testosterone therapy in men with low T to restore physiologic Testosterone levels found to reduce mortality, MI, and stroke risk.
Nathan Goodyear

Evidence of male hypogonadism at an early age as a familial risk of type 2 diabetes. - ... - 0 views

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    male children of parents with diabetes found to have significantly lower serum total Testosterone, free Testosterone, and bioavailable Testosterone compared to male children of parents without diabetes.
Nathan Goodyear

Serum androgens and prostate cancer risk: results from the placebo arm of the Prostate ... - 0 views

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    study finds no association between total Testosterone, free Testosterone, and 3alpha-andorstanediol glucuronide and prostate cancer.  Included: no association with SHBG and estrogen to Testosterone ratio.
Nathan Goodyear

Prospective longitudinal study of testosterone and incident depression in older men: Th... - 0 views

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    low Total Testosterone is associated with depression in oder men.
Nathan Goodyear

Androgen Deprivation Therapy and Future Alzheimer's Disease Risk - 0 views

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    new risk potential for Androgen Deprivation Therapy (ADT) for men with prostate cancer--increased Alzheimer's disease risk.
Nathan Goodyear

Effects of aromatase inhibition vs. testosterone in older men with low testosterone: ra... - 0 views

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    No surprise that Testosterone therapy improves Testosterone levels in men with low T, but aromatase inhibition (AI) did as well.  In this study, only lean mass increased compared to Testosterone therapy and placebo.  Strength increased in both Testosterone and AI.
Nathan Goodyear

EMAS position statement: Testosterone replacement therapy in the aging male 0f. - PubMe... - 0 views

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    we need to get away from expert opinion statements like this. Not that their conclusions are incorrect; but it promotes laziness among physicians.  We physicians need to take control over the data by which we practice medicine and the only way we can do that is to read it.
Nathan Goodyear

THERAPY OF ENDOCRINE DISEASE: Testosterone supplementation and body composition: result... - 0 views

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    new study finds Testosterone therapy in men with low T significantly reduces fat, increases lean muscle mass, and reduces fasting glucose and insulin levels.  Improvements in total cholesterol, triglycerides and HDL was also seen.  Only abstract available currently.
Nathan Goodyear

Effects of testosterone on neuronal nitric oxide synthase and tyrosine hydroxylase. - P... - 0 views

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    Testosterone proposed to increase NOS
Nathan Goodyear

Nitric oxide mediated erectile activity is a testosterone dependent event: a rat erecti... - 0 views

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    Only abstract available here, but rat model finds Testosterone increased NO synthase activity in corpora cavernous. 
Nathan Goodyear

Erectile dysfunction and testosterone deficiency. - PubMed - NCBI - 0 views

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    A high percentage of men that fail PDE5 therapy have low T and the addition of T therapy improves the effects of PDE5 therapy.  T provides a positive impact on NO synthase which increased NO, which PDE5 therapies must have to work.
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