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Nathan Goodyear

http://download.springer.com/static/pdf/869/art%253A10.1007%252Fs12020-015-0650-6.pdf?o... - 0 views

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    Opinion publication recommends total Testosterone as primary means of evaluating Testosterone.  This recommendation relies on the use of immunoassay techniques which can lack specificity compared to newer LC/MS and GC/MS techniques.  The authors did recommend using salivary Testosterone when borderline and SHBG variables play in, which happens to be most clients I see.  The best approach is to use both simultaneously to give a more clear physiologic picture to start.
Nathan Goodyear

Seasonal variation of salivary testosterone in men, normally cycling women, and women u... - 0 views

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    study of 296 men with mean age at 22.7, have peak salivary Testosterone production in December and January. 
Nathan Goodyear

Exercise-Induced Responses in Salivary Testosterone, Cortisol, and ... - PubMed - NCBI - 0 views

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    Meta analysis of salivary Testosterone and cortisol finds mixed results.  The results are by no means uniform, but resistance training appears to trend to an increased salivary Testosterone and salivary Testosterone to salivary cortisol ratio.  Cardio trends the opposite.  This fits with prior literature on the types of exercise and hormone results.
Nathan Goodyear

Pattern recognition of estradiol, testosterone and dihydrotestosterone in children's sa... - 0 views

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    Sochastic sensors and pattern recognition proposed to improve levels of Estradiol, Testosterone, and DHT in salivary sampling in young children.  These levels are very low in pre-pubertal children and makes detection by ELIZA difficult.  This proposed mechanism improves hormone detection.
Nathan Goodyear

Salivary testosterone and immunoglobulin A were increased by resistance training in adu... - 0 views

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    short resistance training program increases SIgA and Salivary Testosterone levels in adults with Downs Syndrome.
Nathan Goodyear

A Critical evaluation of salivary testosterone as a... [Steroids. 2014] - PubMed - NCBI - 0 views

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    Since when did one medium of evaluation become the only standard.  Since serum T has been the historical standard, that is the only window of evaluation??  This study points to higher free Testosterone levels in saliva versus serum. Has anyone ever thought that we are merely looking through different windows of the same process.  Each window here, serum and saliva, are merely giving us different information on hormones.  That doesn't make one right or wrong, it just requires interpretation.  Science is about being objective!

    Saliva is the best means to evaluate intracellular hormone levels.  These levels should be different than serum.  Why should anyone think that the total levels would correlate with that delivered to a cell.  Think.
Nathan Goodyear

Salivary testosterone measurements in growing pi... [Res Vet Sci. 2014] - PubMed - NCBI - 0 views

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    validation of saliva testing in animals.  The point is saliva testing for Testosterone is valid.
Nathan Goodyear

Salivary estradiol and testosterone in filipin... [Am J Hum Biol. 2014] - PubMed - NCBI - 0 views

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    Study finds association between elevated Estradiol in young men and obesity.  No correlation was found with Testosterone.  This fits other research that points to early increased Estradiol production and late decrease in low T.  The men in this study were "young".  Testing was done in saliva.
Nathan Goodyear

Persistent intraprostatic androgen c... [J Clin Endocrinol Metab. 2006] - PubMed - NCBI - 0 views

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    Serum evaluation of hormones is useless from a functional perspective.  This study finds that post-castration, despite a 94% decline in serum androgens, intraprostatic androgens stay much higher.
Nathan Goodyear

Tissue and serum levels of principal androgens in benign prostatic hyperplasia and pros... - 0 views

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    Serum evaluation of Testosterone and DHT poorly correlates with intraprostatic hormone levels.  Must look to saliva to get better clinical picture.
Nathan Goodyear

Plasma and salivary steroid hormone resp... [J Strength Cond Res. 2011] - PubMed - NCBI - 0 views

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    plasma and salivary cortisol and Testosterone correlate in study of study assessing overreaching.
Nathan Goodyear

Salivary and plasma cortisol and testosterone r... [J Sports Sci. 2013] - PubMed - NCBI - 0 views

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    Plasma and salivary cortisol and Testosterone levels correlated in small study that looked at post-training hormones changes in athletes.  Cortisol and Testosterone peaked in all experimental groups. 
Nathan Goodyear

https://dl-web.dropbox.com/get/Public/Research/Salivary%20testosterone.pdf?w=AAA0jQi7Hq... - 0 views

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    salivary testosterone shown to be reliable measure of testosterone in men with suspected low T.
Nathan Goodyear

Diagnostic significance of salivary testosterone measurement revisited: using liquid ch... - 0 views

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    salivary testosterone, as measured by LC-MS and ELISA, showed strong correlation with serum free "calculated" testosterone.
Nathan Goodyear

Longitudinal Study of Hormonal and P... [J Clin Endocrinol Metab. 2013] - PubMed - NCBI - 1 views

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    salivary and urine testing used to assess sex hormone levels in young twins.  
Nathan Goodyear

Psychoendocrine and physical performan... [Aggress Behav. 2008 Nov-Dec] - PubMed - NCBI - 0 views

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    Rugby training resulted in a decrease in T:C salivary ratio through a decline in resting testosterone level.  In contrast, competition events increased the T:C ratio primarily through an increase in Cortisol production.
Nathan Goodyear

Simultaneous determination of salivary testosterone and dehydroepiandrosterone using LC... - 0 views

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    salivary testosterone and DHEA using LC-MS/MS accuracy exceeds 98.5%.  Compare that with historical 50% resolution of pain with a hysterectomy.  There is no perfect test, but if accuracy exceeds 98%, you have  reliable test.
Nathan Goodyear

Comparison of salivary versus serum testos... [Menopause. 2009 Jul-Aug] - PubMed - NCBI - 0 views

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    this study looked at salivary testosterone to serum testosterone and found poor correlation.  One major problem with this study is the significantly smaller amount (10 fold) of testosterone in women than men in healthy individuals.  This study took place in postmenopausal women, which would have significantly lower levels than healthy women.  They also don't discuss the pitfalls of equilibrium dialysis of serum free testosterone.  Another major flaw is the mere logic of looking at serum for tissue activity.   What is the correlation between serum levels and tissue activity.  There is tremendous assumptions being undertaken that serum levels of testosterone whether total or free translate to genomic or non-genomic signaling.  I also wonder if newer techniques using Mass Spec can better detect the typically pico levels of testosterone in women's saliva?  This study does nothing to dissuade the use of salivary testing.
Nathan Goodyear

Diagnostic significance of free salivary testosterone measurement using a direct lumine... - 0 views

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    salivary testosterone found to correlate will with blood free testosterone in men.
Nathan Goodyear

[Serum and salivary testosterone levels in erectil... [Orv Hetil. 1998] - PubMed - NCBI - 0 views

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    Small study looking at testosterone in men with ED.  They found "serum total testosterone level is not a sensitivity indicator for detection of hypogonadism".  Salivary free testosterone levels is the best way to evaluate androgen levels.
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