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Nathan Goodyear

Comparison of Tripterygium wilfordii Hook F with methotrexate in the treatment of activ... - 0 views

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    Thunder god vine found to equal the effects of methotrexate in the treatment of rheumatoid arthritis joint pain.
Nathan Goodyear

Effect of high dose intravenous ascorbic acid on the level of inflammation in patients ... - 0 views

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    This study, small pilot, showed that they were able to lower inflammation in those suffering from RA, through high dose vitamin C IV therapy. This study stopped at 25 gms. The vitamin C is a scavenger of ROS and ROS stimulates inflammation through NF-kappaB. This is how vitamin C can reduce inflammation.
Nathan Goodyear

Endogenous Estrogen Regulation of Inflammatory Arthritis and Cytokine Express... - 0 views

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    this study looked at estrogen in rheumatoid arthritis in mice. They found an anti-inflammatory effect of estrogen in men through ER-alpha. This is in contrast to other studies. Maybe the immunomodulatory effects of estrogen is, in part, through which receptors are activated.
Nathan Goodyear

Inflammation and Sex Hormone Metabolism - SCHMIDT - 2006 - Annals of the New York Acade... - 0 views

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    Rheumatoid arthritis would benefit from non-aromatizable androgens (DHT) and from the use of aromatase inhibitors.  This suggests the role of estrogen in the inflammation in those with RA and the anti-inflammatory effect of DHT.
Nathan Goodyear

Intraarticular progesterone: effects of a local ... [J Rheumatol. 1988] - PubMed - NCBI - 0 views

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    progesterone injections shown to be effective as a local treatment in rheumatoid arthritis.
Nathan Goodyear

Study Finds High-dose Intravenous Vitamin C Reduces Pain and Inflammation in Those... -... - 0 views

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    High dose IV vitamin C shown to reduce both pain and inflammation in patients with RA.  This study looked at doses only up to 50 grams.  The specific inflammatory marker that this study looked at was CRP and it was reduced on average by 44%.
Nathan Goodyear

Adrenal and gonadal steroid hormone deficiency in the pathogenesis of rheumatoid arthri... - 0 views

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    Only abstract available here.  Low adrenal hormone output and low sex hormone production associated with increase RA.  Causation not proved here.
Nathan Goodyear

Hormonal alterations in rheumatoid arthritis, including the effects of pregnancy. - Pub... - 0 views

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    low adrenal hormone output and sex hormone output associated with RA; low adrenal output may pose a more direct effect.  This is likely why pregnancy is associated with a decrease with RA and the postpartum is associated with an increase.
Nathan Goodyear

Tumor necrosis factor inhibits conversion of dehydroepiandrosterone sulfate (DHEAS) to ... - 0 views

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    TNF-alpha inhibited activation of DHEA in RA.
Nathan Goodyear

Immune Modulation in Multiple Sclerosis Patients Treated with the Pregnancy Hormone Est... - 0 views

  • A beneficial effect of pregnancy on clinical symptoms has been observed in MS and other Th1-mediated autoimmune diseases, including rheumatoid arthritis (RA), psoriasis, uveitis, and thyroiditis
  • In general, Th1 lymphocytes secrete proinflammatory cytokines (e.g., IL-2, IL-12, IFN-γ, and TNF-α) that promote cellular immunity, while Th2 lymphocytes produce anti-inflammatory cytokines (e.g., IL-4, IL-5, IL-6, and IL-10) that promote humoral immunity
  • Th2 cytokines are associated with the down-regulation of Th1 cytokines and may confer protection from Th1-mediated autoimmune diseases
  • ...1 more annotation...
  • During pregnancy, there is a shift from Th1 to Th2 that occurs both locally, at the fetal maternal interface, (23, 24, 25), and systemically
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    MS is in part a Th1 autoimmune disease.  Estriol therapy induces a shift to Th2 through increase in Th10.  Estriol also decreases TNF-alpha cytokine production.
Nathan Goodyear

Increased estrogen formation and estrogen to androgen ratio in the synovial fluid of pa... - 0 views

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    high estrogen to Testosterone levels in synovial fluid in those with RA.  The authors here propose that DHEA can stimulate inflammation through aromatase activity.
Nathan Goodyear

New roles for estrogens in rheumatoid arthritis. - PubMed - NCBI - 0 views

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    Estradiol appears to be pro-inflammatory in the synovial fluids of men/women with RA.  This appears to be mediated through NF-KappaB.
Nathan Goodyear

Abnormal levels of serum dehydroepiandrosterone, estrone, and estradiol in men with rhe... - 0 views

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    elevated estradiol associated with increased inflammation symptoms in men with RA. Not found with estrone.
Nathan Goodyear

Abnormal levels of serum dehydroepiandrosterone, estrone, and estradiol in men with rhe... - 0 views

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    Estradiol positively associated with RF in men with RA.
Nathan Goodyear

Low free testosterone levels in rheumatoid arthritis. - 0 views

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    low Testosterone associated with increased RA in men in small study
Nathan Goodyear

Risk of major cardiovascular events in patients with psoriatic arthritis, psoriasis and... - 0 views

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    Abstract: Inflammatory diesease (psoriasis and RA in this study) associated with increased cardiovascular events.
Nathan Goodyear

Relationship between rheumatoid arthritis and Mycoplasma pneumoniae: a case-control stu... - 0 views

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    mycoplasma as a potential causative factor in RA.
laxmi2022

Best Rheumatologist Doctor in Pune | Dr. Laxmi Waprani - 0 views

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    Dr. Laxmi Waprani is a Rheumatologist in Pune. She specializes in the treatment of Rheumatoid arthritis. Provide best treatment for arthritis patients in pune.
Nathan Goodyear

Clinical Utility of Common Serum Rheumatologic Tests - American Family Physician - 0 views

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    older, but good review on autoimmune testing.
Nathan Goodyear

Regulatory effects of estriol on T cell migra... [J Neuroimmunol. 2002] - PubMed - NCBI - 0 views

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    Pregnancy is a immunosuppressive state.  Estriol therapy mimics that through decrease in T cell migration and activation.  Estriol moved the Tcells to a Th2 dominance and also was found to inhibit NF-kappaB.  Estriol decreased TNF-alpa through IL-10 production.
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