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Nathan Goodyear

International Journal of Obesity - Late-life obesity is associated with smaller global ... - 0 views

www.nature.com/...ijo201213a.html

obesity overweight brain CNS

shared by Nathan Goodyear on 29 Jan 13 - No Cached
  • Nathan Goodyear on 29 Jan 13
     
    Need your brain at its peak performance?  Better lose weight if you are overweight.  Studies show a reduced brain volume and decreased cognitive function in those that are overweight.
Nathan Goodyear

JAMA Network | JAMA | Association of All-Cause Mortality With Overweight and Obesity Us... - 0 views

jama.jamanetwork.com/article.aspx

obese obesity overweight mortality

shared by Nathan Goodyear on 02 Jan 13 - No Cached
  • Nathan Goodyear on 02 Jan 13
     
    Don't get to excited about this article.  It is just a meta-analysis.  Second, they looked at BMI and BMI is a notoriously bad estimater of muscle mass versus fat content.  I am the perfect example, my BMI has me as obese, yet my measured fat % is 16%.   My read on this, is most of the individuals that are "overweight" are actually at a health weight with a higher muscle mass percentage not picked up with the BMI measurement.
Nathan Goodyear

Altered Preconception Fatty Acid Intake Is Associated with Improved Pregnancy Rates in ... - 0 views

www.ncbi.nlm.nih.gov/...PMC4728624

obesity overweight infertility IVF nutrition pregnancy omega-6 omega-3 omega 3 omg

shared by Nathan Goodyear on 17 Oct 16 - No Cached
  • Nathan Goodyear on 17 Oct 16
     
    Health fat intake associated with improved fertility in overweight and obese women undergoing IVF.  Higher intake of polyunsaturated fats were associated with improved fertile rates: specifically omega 6 and Linoleum acid.  Only a trend was seen with omega 3's.
Nathan Goodyear

Dietary Weight Loss and Exercise Effects on Serum Biomarkers of Angiogenesis in Overwei... - 0 views

cancerres.aacrjournals.org/...4226

overweight obese inflammation exercise weight loss cancer diet nutrition VEGF PEDF PAI-1

shared by Nathan Goodyear on 19 Jul 16 - No Cached
  • Nathan Goodyear on 19 Jul 16
     
    only abstract available here.  Weight loss, through diet and exercise, decreased proteins important to tumor angiogenesis; thus weight loss associated with a reduction in VEGF, PEDF, and PAI-1 may reduce cancer risk, particularly in the overweight and obese. This is all the result of inflammation originating from obesity.
Nathan Goodyear

International Journal of Obesity - Abstract of article: Childhood overweight after esta... - 0 views

www.nature.com/...ijo201127a.html

overweight obesity antibiotics children pediatrics microbiota dysbiosis gut flora childhood weight

shared by Nathan Goodyear on 05 Apr 12 - No Cached
  • Nathan Goodyear on 05 Apr 12
     
    the usage of antibiotics during the first 6 months of a child's life appears to be associated with an increased risk of overweight in children.  There was a slight increased association with mode of delivery (C/S worse than vaginal), but this was not statistical.
Nathan Goodyear

Elevated C-Reactive Protein Levels in Overweight and Obese Adults - 0 views

jama.ama-assn.org/...2131.full.pdf

CRP overweight obese inflammation

shared by Nathan Goodyear on 15 Mar 12 - No Cached
  • Nathan Goodyear on 15 Mar 12
     
    Overweight and obese adults, irregardless of age, were associated with elevated CRP. This indicates inflammation and creates the link between adipose induced inflammation and a direct contribution to CVD and other associated disease of aging.
Nathan Goodyear

Obesity - Will All Americans Become Overweight or Obese? Estimating the Progression and... - 0 views

www.nature.com/...oby2008351a.html

obesity americans overweight weight-loss

shared by Nathan Goodyear on 25 Nov 11 - No Cached
  • Nathan Goodyear on 25 Nov 11
     
    86% of Americans projected to be obese or overweight by the year 2030.
Nathan Goodyear

Cereal Fiber Improves Whole-Body Insulin Sensitivity in Overweight and Obese Women - 0 views

care.diabetesjournals.org/...775.full

fiber insoluble insulin resistance obese women overweight obesity

shared by Nathan Goodyear on 22 Oct 13 - No Cached
  • Nathan Goodyear on 22 Oct 13
     
    insoluble fiber intake improves insulin sensitivity in obese and overweight women.
Nathan Goodyear

Duration of Breastfeeding and Risk of Overweight: A Meta-Analysis - 0 views

aje.oxfordjournals.org/...397.abstract

breast feeding obesity overweight pediatrics children GI bifidobacteria

shared by Nathan Goodyear on 25 Aug 11 - No Cached
  • Nathan Goodyear on 25 Aug 11
     
    the longer breast feeding occurs, the lower the risk of obesity/overweight in the child.  One role is the resultant GI colonization with bifidobacteria.
Nathan Goodyear

Obese Americans now outweigh the merely overweight | Reuters - 0 views

www.reuters.com/...sity-usa-idUSTRE50863H20090109

obese overweight americans statistics obesity weight loss

shared by Nathan Goodyear on 15 Apr 11 - No Cached
  • Numbers posted by the National Center for Health Statistics show that more than 34 percent of Americans are obese, compared to 32.7 percent who are overweight. It said just under 6 percent are "extremely" obese.
  • More than one-third of adults, or over 72 million people, were obese in 2005-2006, the NCHS said in its report
  • In May, the CDC reported that 32 percent of U.S. children fit the definition of being overweight, 16 percent were obese and 11 percent were extremely obese.
  • Nathan Goodyear on 15 Apr 11
     
    obesity in America
Nathan Goodyear

Concomitant changes in sleep duration and body weight and body composition during weigh... - 0 views

ajcn.nutrition.org/...25.abstract

sleep obesity overweight weight loss

shared by Nathan Goodyear on 26 Jun 13 - No Cached
  • Nathan Goodyear on 26 Jun 13
     
    This study finds that losing weight, when overweight, improves sleep.
Nathan Goodyear

Adiposity and cancer at major anatomical sites: umbrella review of the literature | The... - 0 views

www.bmj.com/bmj.j477

cancer obesity overweight

shared by Nathan Goodyear on 01 Mar 17 - No Cached
  • Nathan Goodyear on 01 Mar 17
     
    Strong evidence links overweight and obesity to cancer.
Nathan Goodyear

The polycystic ovary syndrome per se is not associated with increased chronic inflammation - 0 views

www.eje-online.org/...525.short

PCOS BMI fat overweight obese inflammation women CVD polycystic ovarian syndrome

shared by Nathan Goodyear on 10 May 12 - No Cached
  • Nathan Goodyear on 10 May 12
     
    This study finds no association between PCOS and inflammation, when matched with age/BMI controls.  However, inflammation was associated with increased BMI.  Not all women with PCOS are overweight.  But, the majority are and this would contribute to inflammation and thus CVD.
Nathan Goodyear

Effects of short-term chromium supplementatio... [J Nutr Biochem. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21216583

chromium overweight obesity insulin resistance

shared by Nathan Goodyear on 31 Aug 12 - No Cached
  • Nathan Goodyear on 31 Aug 12
     
    chromium supplementation shown to improve insulin sensitivity and reduce "body composition" in overweight children.
Nathan Goodyear

Effects of catechin enriched green t... [Obesity (Silver Spring). 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19680234

green tea EGCG overweight fat weight-loss obesity

shared by Nathan Goodyear on 22 Nov 11 - No Cached
  • Nathan Goodyear on 22 Nov 11
     
    green tea reduces body fat in overweight chinese adults
Nathan Goodyear

Excess Body Weight Associated With Increased Risk for Cancer Recurrence After Treatment... - 0 views

www.aacr.org/...aacr-in-the-news.aspx

prostate cancer obesity overweight men recurrence weight

shared by Nathan Goodyear on 16 May 12 - No Cached
  • Nathan Goodyear on 16 May 12
     
    overweight and obesity associated with higher risk of prostate cancer recurrence.  No surprise here.  Excess fat will increase inflammatory cytokines and aromatase conversion of Testosterone to Estradiol: also producing inflammation.
Nathan Goodyear

Lowered testosterone in male obesity: Mechanisms, morbidity and management Tang Fui MN,... - 0 views

www.ajandrology.com/article.asp

Testosterone male obesity overweight men hormone hormones low T Low T

shared by Nathan Goodyear on 15 Jan 14 - No Cached
  • The number of overweight people is expected to increase from 937 million in 2005 to 1.35 billion in 2030
  • Similarly the number of obese people is projected to increase from 396 million in 2005 to 573 million in 2030
  • By 2030, China alone is predicted to have more overweight men and women than the traditional market economies combined
  • ...37 more annotations...
  • diacylglycerol O-acyltransferase 2 (DGAT2), mechanistically implicated in this differential storage, [10] is regulated by dihydrotestosterone, [11] suggesting a potential role for androgens to influence the genetic predisposition to either the MHO or MONW phenotype.
  • bariatric surgery achieves 10%-30% long-term weight loss in controlled studies
  • The fact that obese men have lower testosterone compared to lean men has been recognized for more than 30 years
  • Reductions in testosterone levels correlate with the severity of obesity and men
  • epidemiological data suggest that the single most powerful predictor of low testosterone is obesity, and that obesity is a major contributor of the age-associated decline in testosterone levels.
  • healthy ageing by itself is uncommonly associated with marked reductions in testosterone levels
  • obesity blunts this LH rise, obesity leads to hypothalamic-pituitary suppression irrespective of age which cannot be compensated for by physiological mechanisms
  • Reductions in total testosterone levels are largely a consequence of reductions in sex hormone binding globulin (SHBG) due to obesity-associated hyperinsulinemia
  • although controversial, measurement of free testosterone levels may provide a more accurate assessment of androgen status than the (usually preferred) measurement of total testosterone in situations where SHBG levels are outside the reference range
  • SHBG increases with age
  • marked obesity however is associated with an unequivocal reduction of free testosterone levels, where LH and follicle stimulating hormone (FSH) levels are usually low or inappropriately normal, suggesting that the dominant suppression occurs at the hypothalamic-pituitary level
  • adipose tissue, especially when in the inflamed, insulin-resistant state, expresses aromatase which converts testosterone to estradiol (E 2 ). Adipose E 2 in turn may feedback negatively to decrease pituitary gonadotropin secretion
  • diabetic obesity is associated with decreases in circulatory E 2
  • In addition to E 2 , increased visceral fat also releases increased amounts of pro-inflammatory cytokines, insulin and leptin; all of which may inhibit the activity of the HPT axis at multiple levels
  • In the prospective Massachusetts Male Aging Study (MMAS), moving from a non-obese to an obese state resulted in a decline of testosterone levels
  • weight loss, whether by diet or surgery, increases testosterone levels proportional to the amount of weight lost
  • fat is androgen-responsive
  • low testosterone may augment the effects of a hypercaloric diet
  • In human male ex vivo adipose tissue, testosterone decreased adipocyte differentiation by 50%.
  • Testosterone enhances catecholamine-induced lipolysis in vitro and reduces lipoprotein lipase activity and triglyceride uptake in human abdominal adipose tissue in vivo
  • in men with prostate cancer receiving 12 months of androgen deprivation therapy, fat mass increased by 3.4 kg and abdominal VAT by 22%, with the majority of these changes established within 6 months
  • severe sex steroid deficiency can increase fat mass rapidly
  • bidirectional relationship between testosterone and obesity
  • increasing body fat suppresses the HPT axis by multiple mechanisms [30] via increased secretion of pro-inflammatory cytokines, insulin resistance and diabetes; [19],[44] while on the other hand low testosterone promotes further accumulation of total and visceral fat mass, thereby exacerbating the gonadotropin inhibition
  • androgens may play a more significant role in VAT than SAT
  • men undergoing androgen depletion for prostate cancer show more marked increases in visceral compared to subcutaneous fat following treatment
    • Nathan Goodyear
      Nathan Goodyear on 16 Jan 14
       
      Interesting: low T increases VAT, yet T therapy does not reduce VAT, yet T therapy reduces SAT.
  • irisin, derived from muscle, induces brown fat-like properties in rodent white fat
  • androgens can act via the PPARg-pathway [37] which is implicated in the differentiation of precursor fat cells to the energy-consuming phenotype
  • low testosterone may compound the effect of increasing fat mass by making it more difficult for obese men to lose weight via exercise
  • pro-inflammatory cytokines released by adipose tissue may contribute to loss of muscle mass and function, leading to inactivity and further weight gain in a vicious cycle
  • Sarcopenic obesity, a phenotype recapitulated in men receiving ADT for prostate cancer, [55] may not only be associated with functional limitations, but also aggravate the metabolic risks of obesity;
  • observational evidence associating higher endogenous testosterone with reduced loss of muscle mass and crude measures of muscle function in men losing weight
  • genuine reactivation of the HPT axis in obese men requires more substantial weight-loss
  • A number of intervention studies have confirmed that both diet- and surgically-induced weight losses are associated with increased testosterone, with the rise in testosterone generally proportional to the amount of weight lost
  • men, regardless of obesity level, can benefit from the effect of weight loss.
  • inconsistent effect of testosterone on VAT
  • Nathan Goodyear on 15 Jan 14
     
    to be read
Nathan Goodyear

Characteristics of Secondary, Primary, and Compensated Hypogonadism in Aging Men: Evide... - 0 views

press.endocrine.org/...jc.2009-1796

low T Testosterone obesity overweight men male hormone hormones

shared by Nathan Goodyear on 04 Feb 14 - No Cached
  • Older men were more likely to have primary [relative risk ratio (RRR) = 3.04; P < 0.001] and compensated (RRR = 2.41; P < 0.001) hypogonadism. Body mass index of 30 kg/m2 or higher was associated with secondary hypogonadism (RRR = 8.74; P < 0.001)
  • Nathan Goodyear on 04 Feb 14
     
    The prevalence of low T varies significantly between lean versus overweight men.  This suggests a significant contribution of obesity and its biologic effects as a cause of low T.  The difference is 30%.
Nathan Goodyear

[A meta-analysis on overweigh... [Zhonghua Yu Fang Yi Xue Za Zhi. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23928644

obesity overweight breast cancer

shared by Nathan Goodyear on 03 Dec 13 - No Cached
  • Nathan Goodyear on 03 Dec 13
     
    As the rates of obesity in women in China increases, the risk of breast cancer also rises.  This meta-analysis found a 7.7% increased risk of breast cancer among Chinese women that were overweight or obese.
Nathan Goodyear

PLOS ONE: Prediabetes Is Associated with an Increased Risk of Testosterone Deficiency, ... - 0 views

www.plosone.org/...10.1371%2Fjournal.pone.0074173

hormone hormones Testosterone low T metabolic syndrome obesity overweight MetS insulin resistance pre diabetes

shared by Nathan Goodyear on 20 Dec 13 - No Cached
  • Nathan Goodyear on 20 Dec 13
     
    This study found that low T was clearly associated with "pre diabetes" independent of weight and MetS.  All men that are overweight, obese, with metabolic syndrome, "pre diabetic" need evaluation of hormones, not just Testosterone.
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