Frontiers | Sarcopenia and Androgens: A Link between Pathology and Treatment | Endocrin... - 0 views
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sarcopenia induces a change in the proportion of skeletal muscle fibers, inducing a shift from type II (fast) to type I (slow) fibers as well as preferential loss of type II fibers
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testosterone stimulates protein synthesis by both a short-term mechanism-rapid activation of pre-existing components of the translational apparatus- and a long-term mechanism-increase in cell or tissue capacity at the protein synthesis level leading to increase in ribosome quantity
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testosterone induces an increase in cross-sectional area (CSA) in type I and II muscle fibers and in myonuclear quantity, indicating that testosterone exerts more of a hypertrophic than a hyperplasic effect on skeletal muscle