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Nathan Goodyear

A practical model of low-volume high-intensity interval training induces mitochondrial ... - 0 views

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    High-intensity interval training increase mitochondrial performance.
Nathan Goodyear

Improving the Vitamin D Status of Vitamin D Deficient Adults Is Associated With Improve... - 0 views

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    vitamin D improves mitochondrial function through improved oxidative phosporylation.
Nathan Goodyear

T3 increases mitochondrial ATP production in oxidative muscle despite increased express... - 0 views

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    T3 increases mitochondrial oxidative phosphorylation. This has huge impacts on which hypothyroidism is currently managed (only evaluate TSH and T4) and disease implication. We know that decoupling of oxidative phosporylation and a shift to glycolysis and glutaminolysis (substrate-level phosphorylation) results in genomic mutability and cancer, then a low T3 has implications in cancer prevention
Nathan Goodyear

Relationship Between Testosterone Levels, Insulin Sensitivity, and Mitochondrial Functi... - 0 views

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    Testosterone and insulin resistance.  Testosterone improves insulin sensitivity and mitochondrial function.
Nathan Goodyear

PLOS ONE: Overexpression of the Mitochondrial T3 Receptor p43 Induces a Shift in Skelet... - 0 views

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    T3 induces beneficial oxidative changes in muscles through its interaction with mitochondrial receptors.  PGC-1alpha and PPAR-gamma were involved in this process.  The important point here is that T3 is increasing oxidative function of muscle through interaction with mitochondria.
Nathan Goodyear

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communica... - 0 views

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    NAD found to slow mitochondrial decline associated with aging.  SIRT1 is involved; interesting of note is the inverse association with HIF-1alpha
Nathan Goodyear

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3 | ... - 0 views

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    NAD in the form of nicotinamide riboside found to be effective in treating mitochondrial myopathy in animal model.
Nathan Goodyear

Relationship Between Testosterone Levels, Insulin Sensitivity, and Mitochondrial Functi... - 0 views

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    Testosterone improves insulin resistance and mitochondrial function in those men with low Testosterone.
Nathan Goodyear

Physiologic progesterone reduces mitochondrial dysfunction and hippocampal cell loss af... - 0 views

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    Bioidentical progesterone shown to reduce post TBI mitochondrial dysfunction. This has significant implications on the ability of the damaged brain to heal and recover, thus limiting post-injury cognitive deficits.
Nathan Goodyear

Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity - Gash - 2007... - 0 views

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    TCE shown to mitochondrial toxic and risk factor for Parkinson's disease
Nathan Goodyear

IOS Press - Journal Article - 0 views

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    study links mitochondrial dysfunction to Parkinson's disease. 
Nathan Goodyear

Decreased Accumulation of Subcellular Amyloid-β with Improved Mitochondrial F... - 0 views

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    Huperzine A, a natural acetylcholinesterase inhibitor, provides neuroprotection through increase mitochondrial function and decrease in accumulated amyloid Beta protein.
Nathan Goodyear

Thyroid hormone action in mitochondria -- Wrutniak-Cabello et al. 26 (1): 67 -- Journal... - 0 views

  • Triiodothyronine (T3) is considered a major regulator of mitochondrial activity
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    T3 is major regulator of mitochondrial activity; not T4
Nathan Goodyear

Mitochondria: a therapeutic target in neurodegener... [Biochim Biophys Acta. 2010] - Pu... - 0 views

  • mitochondrial dysfunction has a central role in the pathogenesis of Alzheimer's, Parkinson's and Huntington's diseases and amyotrophic lateral sclerosis
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    mitochondrial dysfunction has a central role in the pathogenesis of Alzheimer's, Parkinson's and Huntington's diseases and amyotrophic lateral sclerosis
Nathan Goodyear

Lipid Replacement as an Adjunct to Therapy for Chronic Fatigue, Anti-Aging and Restorat... - 0 views

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    Omega-3 improves mitochondrial function and thus chronic fatigue
Nathan Goodyear

Chronic fatigue syndrome and mitochondrial dysfunction - 0 views

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    Discussion of the mitochondrial role in chronic fatigue syndrome.  As the authors conclude, there is dysfunction, but whether the cause is primary or secondary or likely varies from individual to individual is yet undetermined.
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    very helpful post!
Nathan Goodyear

The critical role of glutathione in maintenance of the mitochondrial genome. - Research... - 0 views

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    Only abstract available.  Loss of glutathione leads to loss in mitochondrial DNA.
Nathan Goodyear

Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC ... - 0 views

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    DCA works in synergy, augments, effects of anti-mitochondrial chemo agents cisplatin and topetecan
Nathan Goodyear

Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through... - 0 views

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    More recent study finds that ivermectin induces apoptosis in leukemia cell lines via oxidative stress and mitochondrial disruption.
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