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Nathan Goodyear

An Overview of Melatonin and Breast Cancer | Natural Medicine Journal - 0 views

www.naturalmedicinejournal.com/...ew-melatonin-and-breast-cancer

melatonin cancer

shared by Nathan Goodyear on 31 May 18 - No Cached
  • Overall its effect on cancer cells is oncostatic at physiological levels, or cytotoxic at higher concentrations
  • direct antioxidant, antimitotic, antiestrogenic, prodifferentiating and antimetastatic effects have been well characterized
  • hypothalamic-pituitary axis (HPA) and immune system
  • ...2 more annotations...
  • On a cellular level, melatonin acts as a selective estrogen receptor modulator (SERM) through decreased expression of estrogen receptor alpha and reduction in the ability of estrogen-estrogen receptor alpha (ERα) complex to bind to the estrogen response element (ERE) on DNA
  • Melatonin also acts as a selective estrogen enzyme modulator (SEEM), reducing the activity of aromatase in cells
  • Nathan Goodyear on 31 May 18
     
    review of melatonins activity in cancer battle.
Nathan Goodyear

Sleep duration, melatonin and breast cancer among Chinese women in Singapore - 0 views

carcin.oxfordjournals.org/...1244

melatonin breast cancer risk sleep insomnia

shared by Nathan Goodyear on 23 Aug 11 - No Cached
  • Nathan Goodyear on 23 Aug 11
     
    sleep duration, melatonin and breast cancer risk.  Low melatonin and sleep < 6 hours increases breast cancer risk
Nathan Goodyear

Effects of Melatonin and Its Analogues on Pancreatic Inflammation, Enzyme Secretion, an... - 0 views

www.ncbi.nlm.nih.gov/...PMC5454927

kyneurinic cancer acid melatonin metabolism melatonin metabolites melatonin

shared by Nathan Goodyear on 04 Aug 20 - No Cached
  • Nathan Goodyear on 04 Aug 20
     
    Melatonin metabolites involved in the cancer process. The Indoleamine dioxygenase pathway is the mechanism.
Nathan Goodyear

-Absence of Melatonin and Insulin Resistance - 0 views

www.medaus.com/index.php

melatonin insulin resistance

shared by Nathan Goodyear on 06 Apr 11 - No Cached
  • Nathan Goodyear on 06 Apr 11
     
    insulin resistance associated with absence of melatonin
Nathan Goodyear

http://www.imedpub.com/articles/five-yearsurvival-with-highdose-melatonin-and--other-an... - 0 views

www.imedpub.com/...s-eligible-for-the-only-pa.pdf

Melatonin cancer immunotherapy

shared by Nathan Goodyear on 16 Nov 18 - No Cached
  • Nathan Goodyear on 16 Nov 18
     
    High dose melatonin in the immune treatment of cancer. A must read.
Nathan Goodyear

Prevention of interleukin-2-induced thrombocytopenia during the immunotherapy of cancer... - 0 views

www.ncbi.nlm.nih.gov/...7624582

cancer IL-2 melatonin platelets immunotherapy

shared by Nathan Goodyear on 01 Jun 18 - No Cached
  • Nathan Goodyear on 01 Jun 18
     
    Only abstract available here to general public.  Thrombocytopenia is associated with IL-2 therapy.  Melatonin found to block this effect when used in conjunction with IL-2 therapy.  Alone, melatonin did not increase platelet levels.  The proposed mechanism is an inhibition of macrophage mediated destruction of plateletes.
Nathan Goodyear

Amplification of eosinophilia by melatonin during the immunotherapy of cancer with inte... - 1 views

www.ncbi.nlm.nih.gov/...8346714

cancer melatonin IL-2 IL-5 eosinophils immunotherapy immune system

shared by Nathan Goodyear on 01 Jun 18 - No Cached
  • Nathan Goodyear on 01 Jun 18
     
    Melatonin concomitant with IL-2 found to increase eosinophils.  This occured with MLT and IL-2, not with IL-2 only.  The suggested mechanism is through IL-5 production from T helper cells.
Nathan Goodyear

Light at Night, Chronodisruption, Melatonin Suppression, and Cancer Risk: A Review - 0 views

www.researchgate.net/...n-and-Cancer-Risk-A-Review.pdf

Melatonin cancer

shared by Nathan Goodyear on 21 Feb 21 - No Cached
  • Nathan Goodyear on 21 Feb 21
     
    Great review and a must read. Melatonin with broad anti-cancer activity.
Nathan Goodyear

Boosting immune system against cancer by melatonin: A mechanistic T viewpoint - 0 views

www.researchgate.net/...in-A-mechanistic-viewpoint.pdf

immune system immunotherapy melatonin cancer

shared by Nathan Goodyear on 22 Feb 21 - No Cached
  • Nathan Goodyear on 22 Feb 21
     
    Another incredible read on the mechanism behind the action of melatonin. From the immune stimulating of NK, T lymphocytes...to the decrease int he Tregs and cancer associated fibroblasts in the TME.
Nathan Goodyear

Melatonin Reprograms Glucose Metabolism in Cancer Cell Mitochondria - 0 views

seriesscience.com/atonin-reprograms-mitochondria

Warburg effect Melatonin cancer

shared by Nathan Goodyear on 04 Aug 20 - No Cached
  • Nathan Goodyear on 04 Aug 20
     
    melatonin deficiency favors Warburg effect
Nathan Goodyear

Melatonin enhances hyperthermia-induced apoptotic cell death in human leukemia cells - ... - 0 views

scholars.uthscsa.edu/...uced-apoptotic-cell-death-in-h

hyperthermia melatonin apoptosis cancer leukemia

shared by Nathan Goodyear on 13 Oct 20 - No Cached
  • Nathan Goodyear on 13 Oct 20
     
    Melatonin and hyperthermia synergistic in stimulation of apoptosis.
Nathan Goodyear

Melatonin inhibits both ER alpha activation and... [J Pineal Res. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16635015

Cadmium CD estrogen receptor alpha estrogen receptor estrogen receptor melatonin hormones ER alpha

shared by Nathan Goodyear on 19 Jan 13 - No Cached
  • Nathan Goodyear on 19 Jan 13
     
    Several interesting points about this article.  Cadmium is a non-carcinogen.  Cadmium acts through estrogen receptors.  Cd acts as an estrogen.  Second, melatonin inhibits ER alpha, which promotes inflammation and growth signaling.
Nathan Goodyear

An Overview of Melatonin and Breast Cancer - Natural Medicine Journal: The Official Jou... - 0 views

www.naturalmedicinejournal.com/article_content.asp

cancer melatonin hormone hormones

shared by Nathan Goodyear on 19 Jan 13 - No Cached
  • Nathan Goodyear on 19 Jan 13
     
    Great review on the anti-cancer properties of melatonin.  Well referenced.
Nathan Goodyear

JAMA Network | JAMA | Melatonin Secretion and the Incidence of Type 2 DiabetesMelatonin... - 0 views

jama.jamanetwork.com/article.aspx

melatonin diabetes type II diabetes DM

shared by Nathan Goodyear on 09 Apr 13 - No Cached
  • Nathan Goodyear on 09 Apr 13
     
    lower melatonin secretion linked to increased diabetes risk
Nathan Goodyear

Melatonin and the Immune System in Aging - 0 views

content.karger.com/...produkte.asp

melatonin EPCs endothelial progenitor cells hormone hormones aging

shared by Nathan Goodyear on 11 Jul 12 - No Cached
  • Nathan Goodyear on 11 Jul 12
     
    melatonin stimulates increased production of EPCs
Nathan Goodyear

Effect of melatonin on normal and... [Clin Exp Rheumatol. 1996 Sep-Oct] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8913650

melatonin fibrosis scleroderma autoimmune disease

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    Melatonin inhibits fibrosis.
Nathan Goodyear

[Melatonin and metabolic syndrome: is there an asso... [Ter Arkh. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23227512

metabolic syndrome melatonin

shared by Nathan Goodyear on 01 Sep 13 - No Cached
  • Nathan Goodyear on 01 Sep 13
     
    Association between melatonin and metabolic syndrome
Nathan Goodyear

PLOS ONE: Effect of Melatonin on Tumor Growth and Angiogenesis in Xenograft Model of Br... - 0 views

www.plosone.org/...10.1371%2Fjournal.pone.0085311

breast cancer melatonin hormone hormones

shared by Nathan Goodyear on 31 Jan 14 - No Cached
  • Nathan Goodyear on 31 Jan 14
     
    In vivo study finds melatonin reduced tumor growth, proliferation, and inhibited angiogenesis in breast cancer model.
Nathan Goodyear

Beneficial effects of melatonin on obesity and lipid profile in young Zucker diabetic f... - 0 views

onlinelibrary.wiley.com/...abstract

obesity weight loss melatonin LDL HDL

shared by Nathan Goodyear on 27 May 11 - No Cached
  • Nathan Goodyear on 27 May 11
     
    melatonin appears to help in weight loss and improve LDL and HDL cholesterol levels
Nathan Goodyear

Beneficial effects of melatonin on obesity and lip... [J Pineal Res. 2011] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...21087312

obesity melatonin weight loss

shared by Nathan Goodyear on 05 May 11 - No Cached
  • Nathan Goodyear on 05 May 11
     
    Melatonin beneficial for weight loss in diabetic rat model 
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