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LeanBiome™ (Official) | Get Save UpTo $540 Today Only! - 0 views

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    LeanBiome™ (Official) | Get Save UpTo $540 Today Only! usleanbiome.com LeanBiome™ Hurry Up! Offer Expires in: 00 HOUR 29 MINUTE 59 SECOND LeanBiome Attention! Get Special 84% Discount Today Faster fat burning and weight loss Healthy cholesterol and sugar levels Higher energy levels Regular price: $129 Only for: 39$ What Is LeanBiome? LeanBiome Lean for Good is a weight loss dietary supplement derived from scientifically researched ingredients and comprehensively developed to help people achieve sustainable weight control. The formula comes in a capsule format that is easy to take and is made with natural ingredients from plants and other sources to achieve its goals. The main ingredient in LeanBiome is piperine, which has been found to affect the body's ability to absorb micronutrients and other compounds more effectively. LeanBiome is a dietary supplement that claims to help weight management. It contains 100% natural ingredients that support healthy weight loss. It does not interfere with any natural process making it safe for use. It ranks among the top weight loss supplements that claim to provide a permanent solution. LeanBiome is made by a company named Lean for Good. It is made with natural and research-backed ingredients that help you lose excess fat without hassles. It is sold in capsule form. The company assures the composition is GMO, gluten, and soy-free. As for manufacturing standards, you need not fret. The company makes the supplement in a facility certified by the FDA. How Does LeanBiome Work? The starting period of the LeanBiome program includes a detoxification process that effectively removes any accumulated ree radicals, toxins, fand oxidative stress. This cleansing enables improved blood circulation, setting the stage for the body to initiate its own fat-burning mechanisms. To enhance metabolic activity, introducing the lean bacteria contained in LeanBiome to your gut microbiome is a beneficial approach. This activation triggers r
Nathan Goodyear

Dietary Weight Loss and Exercise Effects on Serum Biomarkers of Angiogenesis in Overwei... - 0 views

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    only abstract available here.  Weight loss, through diet and exercise, decreased proteins important to tumor angiogenesis; thus weight loss associated with a reduction in VEGF, PEDF, and PAI-1 may reduce cancer risk, particularly in the overweight and obese. This is all the result of inflammation originating from obesity.
Nathan Goodyear

Lowered testosterone in male obesity: Mechanisms, morbidity and management Tang Fui MN,... - 0 views

  • The number of overweight people is expected to increase from 937 million in 2005 to 1.35 billion in 2030
  • Similarly the number of obese people is projected to increase from 396 million in 2005 to 573 million in 2030
  • By 2030, China alone is predicted to have more overweight men and women than the traditional market economies combined
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  • diacylglycerol O-acyltransferase 2 (DGAT2), mechanistically implicated in this differential storage, [10] is regulated by dihydrotestosterone, [11] suggesting a potential role for androgens to influence the genetic predisposition to either the MHO or MONW phenotype.
  • bariatric surgery achieves 10%-30% long-term weight loss in controlled studies
  • The fact that obese men have lower testosterone compared to lean men has been recognized for more than 30 years
  • Reductions in testosterone levels correlate with the severity of obesity and men
  • epidemiological data suggest that the single most powerful predictor of low testosterone is obesity, and that obesity is a major contributor of the age-associated decline in testosterone levels.
  • healthy ageing by itself is uncommonly associated with marked reductions in testosterone levels
  • obesity blunts this LH rise, obesity leads to hypothalamic-pituitary suppression irrespective of age which cannot be compensated for by physiological mechanisms
  • Reductions in total testosterone levels are largely a consequence of reductions in sex hormone binding globulin (SHBG) due to obesity-associated hyperinsulinemia
  • although controversial, measurement of free testosterone levels may provide a more accurate assessment of androgen status than the (usually preferred) measurement of total testosterone in situations where SHBG levels are outside the reference range
  • SHBG increases with age
  • marked obesity however is associated with an unequivocal reduction of free testosterone levels, where LH and follicle stimulating hormone (FSH) levels are usually low or inappropriately normal, suggesting that the dominant suppression occurs at the hypothalamic-pituitary level
  • adipose tissue, especially when in the inflamed, insulin-resistant state, expresses aromatase which converts testosterone to estradiol (E 2 ). Adipose E 2 in turn may feedback negatively to decrease pituitary gonadotropin secretion
  • diabetic obesity is associated with decreases in circulatory E 2
  • In addition to E 2 , increased visceral fat also releases increased amounts of pro-inflammatory cytokines, insulin and leptin; all of which may inhibit the activity of the HPT axis at multiple levels
  • In the prospective Massachusetts Male Aging Study (MMAS), moving from a non-obese to an obese state resulted in a decline of testosterone levels
  • weight loss, whether by diet or surgery, increases testosterone levels proportional to the amount of weight lost
  • fat is androgen-responsive
  • low testosterone may augment the effects of a hypercaloric diet
  • In human male ex vivo adipose tissue, testosterone decreased adipocyte differentiation by 50%.
  • Testosterone enhances catecholamine-induced lipolysis in vitro and reduces lipoprotein lipase activity and triglyceride uptake in human abdominal adipose tissue in vivo
  • in men with prostate cancer receiving 12 months of androgen deprivation therapy, fat mass increased by 3.4 kg and abdominal VAT by 22%, with the majority of these changes established within 6 months
  • severe sex steroid deficiency can increase fat mass rapidly
  • bidirectional relationship between testosterone and obesity
  • increasing body fat suppresses the HPT axis by multiple mechanisms [30] via increased secretion of pro-inflammatory cytokines, insulin resistance and diabetes; [19],[44] while on the other hand low testosterone promotes further accumulation of total and visceral fat mass, thereby exacerbating the gonadotropin inhibition
  • androgens may play a more significant role in VAT than SAT
  • men undergoing androgen depletion for prostate cancer show more marked increases in visceral compared to subcutaneous fat following treatment
    • Nathan Goodyear
       
      Interesting: low T increases VAT, yet T therapy does not reduce VAT, yet T therapy reduces SAT.
  • irisin, derived from muscle, induces brown fat-like properties in rodent white fat
  • androgens can act via the PPARg-pathway [37] which is implicated in the differentiation of precursor fat cells to the energy-consuming phenotype
  • low testosterone may compound the effect of increasing fat mass by making it more difficult for obese men to lose weight via exercise
  • pro-inflammatory cytokines released by adipose tissue may contribute to loss of muscle mass and function, leading to inactivity and further weight gain in a vicious cycle
  • Sarcopenic obesity, a phenotype recapitulated in men receiving ADT for prostate cancer, [55] may not only be associated with functional limitations, but also aggravate the metabolic risks of obesity;
  • observational evidence associating higher endogenous testosterone with reduced loss of muscle mass and crude measures of muscle function in men losing weight
  • genuine reactivation of the HPT axis in obese men requires more substantial weight-loss
  • A number of intervention studies have confirmed that both diet- and surgically-induced weight losses are associated with increased testosterone, with the rise in testosterone generally proportional to the amount of weight lost
  • men, regardless of obesity level, can benefit from the effect of weight loss.
  • inconsistent effect of testosterone on VAT
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    to be read
Nathan Goodyear

PLoS ONE: Metabolic and Behavioral Compensations in Response to Caloric Restriction: Im... - 0 views

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    exercise and muscle very important to maintaining weight loss long-term.  Calorie restriction results in muscle mass loss and this will impair the ability to maintain weight loss long term
Nathan Goodyear

Two-year changes in lipids and lipoproteins associa... [Obes Res. 1999] - PubMed - NCBI - 0 views

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    Weight loss improves lipid profile.  Total cholesterol, LDL, and triglycerides were reduced with weight loss of 5-10%.  However, weight loss exceeding 10% resulted in greater reduction and longer maintenance of the improved lipid panel results.
Nathan Goodyear

Obesity - Will All Americans Become Overweight or Obese? Estimating the Progression and... - 0 views

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    86% of Americans projected to be obese or overweight by the year 2030.
Nathan Goodyear

Obese Americans now outweigh the merely overweight | Reuters - 0 views

  • Numbers posted by the National Center for Health Statistics show that more than 34 percent of Americans are obese, compared to 32.7 percent who are overweight. It said just under 6 percent are "extremely" obese.
  • More than one-third of adults, or over 72 million people, were obese in 2005-2006, the NCHS said in its report
  • In May, the CDC reported that 32 percent of U.S. children fit the definition of being overweight, 16 percent were obese and 11 percent were extremely obese.
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    obesity in America
Nathan Goodyear

Benefits of Modest Weight Loss in Improving Cardiovascular Risk Factors in Overweight a... - 0 views

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    Weight loss of just 5% reduced cardiovascular disease risk.  Lifestyle interventions are still some of the best treatment options available for many chronic diseases of aging. 
Nathan Goodyear

The Effect of High-Intensity Intermittent Exercise on Body Composition of Overweight Yo... - 0 views

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    High intensity training results in effective fat loss.  This study followed individuals over a 12 week cycle.  They performed HIT at 20 mins 3 x weekly.  Fat loss was statistically significant when compared to control group.
Nathan Goodyear

The Effect of High-Intensity Intermittent Exercise on Body Composition of Overweight Yo... - 0 views

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    another study that shows that High intensity interval training (HIT) results in fat loss.  IN this study, training consisted of 20 minutes 3 x weekly for 12 weeks.  Fat loss in total, abdominal, trunk, and visceral was decreased.  This study only looked at men.
Nathan Goodyear

Effect of a High Protein Weight Loss Diet on Weight, High-Sensitivity C-Reactive Protei... - 0 views

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    This study concludes that a energy restricted, high protein diet is more effective at weight loss than just a high protein diet.  There were also positive impacts on blood pressure, glucose, cholesterol, and hsCRP.
Nathan Goodyear

Evaluation of the antiobesity effects of an amino ... [J Int Med Res. 2010 May-Jun] - P... - 0 views

  • four amino acids (lysine, proline, alanine and arginine)
  • with or without conjugated linoleic acid to healthy overweight humans before and after exercising
  • When compared with the placebo group, several indicators, such as waist and hip circumferences, were found to have significantly decreased in the test supplement groups compared with the placebo
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  • These results suggest that ingestion of these supplements might enhance the fat-burning effects of exercise.
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    certain amino acids pre and post exercise help to preserve muscle mass.  This has profound implications on fat loss and maintenance of fat loss long term
Nathan Goodyear

JAMA Network | JAMA Surgery | Long-term Metabolic Effects of Laparoscopic Sleeve Gastre... - 0 views

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    This study reveals what is wrong with a lot of the "standard practice" and literature in medicine today.  At 5 years, almost 50% of weight loss with gastric sleeve is regained--defined as excess weight loss (only 50% weight loss of excess weight).  That is a terrible 5 year outcome; not to mention the definition of success.  Even at 3 years, 31% had regained their "excess weight".  Add to that, the numbers of patients that followed up was terrible.  This poor follow up points to worse data outcomes than this study claims.
Nathan Goodyear

Concomitant changes in sleep duration and body weight and body composition during weigh... - 0 views

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    This study finds that losing weight, when overweight, improves sleep.
Nathan Goodyear

Effects of a Caloric Restriction Weight Loss Diet and Exercise on Inflammatory Biomarke... - 0 views

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    weight loss results in reduced IL-6, CRP, and other markers of inflammation.
Nathan Goodyear

Bariatric Surgery Results in Cortical Bone Loss - 0 views

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    no surprise here.  Bariatric surgery was found to result in bone loss.  Disruption of the GI tract and absorption is going to result in malnutrition states and bone loss will be one of the side effects.
Nathan Goodyear

Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet - NEJM - 0 views

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    Nice study, the DIRECT study, found a better weight loss and longer maintenance of weight loss in low carbohydrate diet compared to low fat diet and mediterranean diet.  
Nathan Goodyear

L-Arginine Potentiates Fat Loss ( May 2011) Townsend Letter for Doctors & Patients - 0 views

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    L-Arginine helps preserve muscle mass and increase fat loss.  This has enormous implications in maintaining weight loss long-term
Nathan Goodyear

Effects of catechin enriched green t... [Obesity (Silver Spring). 2010] - PubMed - NCBI - 0 views

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    green tea reduces body fat in overweight chinese adults
Nathan Goodyear

Conjugated Linoleic Acid Supplementation for 8 Weeks Does Not Affect Body Composition, ... - 0 views

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    CLA not shown to be beneficial in short-term weight loss
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