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Nathan Goodyear

5B.06: ASSOCIATION OF PLASMA TESTOSTERONE WITH CENTRAL HAEMODYNAMICS IN HYPERTENSIVE ME... - 0 views

www.ncbi.nlm.nih.gov/...26102895

low T low Testosterone Testosterone blood pressure hypertension hormones

shared by Nathan Goodyear on 24 Jun 15 - No Cached
  • Nathan Goodyear on 24 Jun 15
     
    low total Testosterone is associated with increased central blood pressure elevation.  Less association was found with peripheral blood pressure.
Nathan Goodyear

Plasma Aldosterone Is Independently Associated With the Metabolic Syndrome -- Bochud et... - 0 views

hyper.ahajournals.org/...239

hypertension metabolic syndrome aldosterone cardiovascular disease

shared by Nathan Goodyear on 14 Jun 11 - No Cached
  • Nathan Goodyear on 14 Jun 11
     
    Aldosterone shown to increase cardiovascular disease associated with metabolic syndrome
Nathan Goodyear

Aged garlic extract lowers blood pressure in patie... [Maturitas. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20594781

aged garlic extract blood pressure high

shared by Nathan Goodyear on 20 Sep 11 - No Cached
  • Nathan Goodyear on 20 Sep 11
     
    significant improvement in hypertension with aged garlic extract
Nathan Goodyear

Vitamin D and cardiovascular risk. [Int Urol Nephrol. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20039126

D vitamin cardiovascular disease hypertension atherogenesis

shared by Nathan Goodyear on 06 Oct 11 - No Cached
  • vitamin D supplementation in adults may be regarded as simple means with few potential side effects to prevent atherogenesis or halt its progression and combat arterial hypertension
  • Nathan Goodyear on 06 Oct 11
     
    Vitamin D proves to be powerful benefit in those at risk for cardiovascular disease.
Nathan Goodyear

TBioMed | Full text | Arterial hypertension due to fructose ingestion: model based on i... - 0 views

www.tbiomed.com/27

fructose HCFS hypertension HTN. gastric bypass lap-band weight-loss surgery

shared by Nathan Goodyear on 25 Oct 11 - No Cached
  • Nathan Goodyear on 25 Oct 11
     
    fructose (HCFS) leads to increase in blood pressure.  Similar problem is also seen in post-gastric surgery for weight loss.
Nathan Goodyear

Coconut oil supplementation and physical exercise improves baroreflex sensitivity and o... - 0 views

www.nrcresearchpress.com/...apnm-2014-0351

coconut oil exercise oxidative stress hypertension nutrition blood pressure

shared by Nathan Goodyear on 17 Feb 15 - No Cached
  • Nathan Goodyear on 17 Feb 15
     
    Animal study finds the combination of coconut oil and exercise training reduced oxidative stress and lowered blood pressure.
Nathan Goodyear

Thiazide Diuretics Alone or with Beta-blockers Impair Glucose Metabolism in Hypertensiv... - 0 views

www.ncbi.nlm.nih.gov/...PMC2796286

hypertension HCTZ thiazide diuretics beta blockers

shared by Nathan Goodyear on 13 Sep 17 - No Cached
  • Nathan Goodyear on 13 Sep 17
     
    thiazide diuretics and beta blockers impair glucose metabolism; mechanism of action not exactly known.
Nathan Goodyear

Statin use and risk of diabetes mellitus - 0 views

www.ncbi.nlm.nih.gov/...PMC4360430

statin statin therapy diabetes insulin resistance GLUT4 HgbA1c

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • An increase in new onset diabetes, i.e., 3% in statin arm and 2.4% in placebo arm was reported. This was accompanied by increase in median value of glycated haemoglobin and was one of the earlier studies to report the increase in new onset diabetes in patients on statins
  • Even after adjustment for potential confounders, statin therapy was associated with an increased risk of new-onset diabetes mellitus
  • Authors suggest that statin-induced diabetes mellitus is a medication class effect
  • ...10 more annotations...
  • Another study also reported that as compared to placebo, statin group showed a higher risk of physician reported incident diabetes and it was also observed that risk was higher in women as compared to men
  • Meta-analysis of randomized controlled trials by Sattar et al[25] involving 91140 non-diabetic patients showed that statin therapy was associated with 9% increased risk of incident diabetes
  • A number of studies showed dose dependent association between statin administration and incident diabetes
  • intensive dose of statins was associated with high incidence of new - onset diabetes
  • Treatment with atorvastatin and simvastatin may be associated with an increased risk of new onset diabetes as compared to pravastatin
  • Increased incidence of diabetes was seen with atorvastatin in the Anglo-Scandinavian Cardiac Outcomes Trial
  • Increased insulin resistance secondary to statins was demonstrated in a prospective non randomised study in patients with coronary bypass surgery
  • downregulation of GLUT4
  • Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial
  • Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial
  • Nathan Goodyear on 04 Oct 17
     
    Great review article of the increased risk of worsening insulin resistance, glycated hemoglobin, and diabetes risk.  Atorvastatin appears to be the worst culprit.  Mechanism partially through a decrease in GLUT4.
fnfdoc

Stroke Genetics And Risk Factors | Your Health Our Priority - 0 views

www.fnfdoc.com/...stroke-genetics-risk-factors

Genetics Ischemic Stroke

shared by fnfdoc on 03 May 18 - No Cached
  • fnfdoc on 03 May 18
     
    Stroke is a cerebrovascular syndrome that involves the blockage and bursting of blood vessels in the brain. It shows a multifactorial pattern of inheritance. High cholesterol levels, high blood pressure, hypertension and obesity are the key causes of stroke besides inherited genes.
Nathan Goodyear

The anti‐hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ... - 0 views

embomolmed.embopress.org/...511

Glioblastoma glioblastoma multiforme hypertension prazosin cancer

shared by Nathan Goodyear on 14 May 18 - No Cached
  • glioblastoma‐initiating cells (GICs)
  • Nathan Goodyear on 14 May 18
     
    prazosin promotes apoptosis of gliobastoma-initiating cells in mouse model via Akt pathway.
Nathan Goodyear

Hypertension as a biomarker in patients with recurrent glioblastoma treated with antian... - 0 views

www.ncbi.nlm.nih.gov/...23075631

hypertension glioblastoma multiforme Glioblastoma

shared by Nathan Goodyear on 14 May 18 - No Cached
  • Nathan Goodyear on 14 May 18
     
    treatment with anti-angiogenesis meds often are associated with the SE of HTN; What is interesting about this is that this is associated with improved survival.
Nathan Goodyear

Ascorbic Acid-Induced Modulation of Venous Tone in Humans | Hypertension - 0 views

hyper.ahajournals.org/...949

vitamin C IV vitamin C hypertension blood pressure cardiovascular disease CVD

shared by Nathan Goodyear on 20 Dec 17 - No Cached
  • Nathan Goodyear on 20 Dec 17
     
    Acute vasodilation with IV vitamin C found to be independent of NO.
Nathan Goodyear

Changes in arterial distensibility and flow-mediated dilation after acute resistance vs... - 0 views

www.ncbi.nlm.nih.gov/...20885204

resistance training exercise hypertension blood pressure lifestyle intervention

shared by Nathan Goodyear on 17 May 16 - No Cached
  • Nathan Goodyear on 17 May 16
     
    resistance exercise found to lower blood pressure.  Another feather in the cap of lifestyle intervention.  The blood pressure lowering effects with resistance training outperformed aerobic exercise.
Nathan Goodyear

http://orthomolecular.org/library/jom/1992/pdf/1992-v07n01-p005.pdf - 0 views

orthomolecular.org/...1992-v07n01-p005.pdf

vitamin C CVD Pauling Linus Pauling Lp(a) cardiovascular disease hypertension

shared by Nathan Goodyear on 16 Jan 17 - No Cached
  • Nathan Goodyear on 16 Jan 17
     
    This is the unified paper theory of CVD and vitamin C as published by Pauling and Rath.  Vitamin C deficiency results in a decrease in the integrity and stability of the vascular wall.  Chronic deficiency results in in an increase in and accumulation of Lp(a) which leads to atherosclerotic plaques.
Nathan Goodyear

Plasma ascorbic acid concentrations relate inversely to blood pressure in human subject... - 0 views

www.ncbi.nlm.nih.gov/...8424391

blood pressure hypertension vitamin c

shared by Nathan Goodyear on 16 Jan 17 - No Cached
  • Nathan Goodyear on 16 Jan 17
     
    only abstract available here.  Serum vitamin C levels significantly inversely associated with systolic and diastolic blood pressure.  Also of note, this was a human study, not animal.
Nathan Goodyear

Vitamin C in plasma is inversely related to blood pressure and change in blood pressure... - 0 views

nutritionj.biomedcentral.com/...1475-2891-7-35

vitamin C blood pressure hypertension

shared by Nathan Goodyear on 16 Jan 17 - No Cached
  • Nathan Goodyear on 16 Jan 17
     
    serum vitamin C levels is found to be inversely associated with blood pressure in healthy you black and white women.
Nathan Goodyear

Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized c... - 0 views

ajcn.nutrition.org/...1079.long

blood pressure hypertension vitamin C

shared by Nathan Goodyear on 16 Jan 17 - No Cached
  • Nathan Goodyear on 16 Jan 17
     
    review article of 29 studies finds a reduction in blood pressure with vitamin C.  The average dosing of vitamin C was 500 mg, which is a woefully inadequate dose.  The average study follow up was 8 weeks.
Nathan Goodyear

Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle. - 0 views

www.ncbi.nlm.nih.gov/...PMC303514

cortisol mineralcorticoid low potassium hypokalemia hypertension 11-betaHSD

shared by Nathan Goodyear on 24 Apr 12 - No Cached
  • These results suggest that cortisol acts as a potent mineralocorticoid in 11 beta-OHSD deficiency
  • major site for the oxidation of cortisol to cortisone is the kidney
  • congenital deficiency of 11 beta-OHSD results in high intrarenal cortisol levels which then act on renal type I mineralocorticoid receptors
  • ...1 more annotation...
  • deficiency of 11 beta-OHSD results in high intrarenal cortisol concentrations that then bind to the type I receptor.
  • Nathan Goodyear on 24 Apr 12
     
    mechanism of how cortisol acts as a mineralcorticoid in those with dysfunctional 11-beta HSD activity.
Nathan Goodyear

Association of Hypertension and Hypokalemia with Cushing's Syndrome Caused by Ectopic A... - 0 views

onlinelibrary.wiley.com/...85BD06C2AC6C2355181DC95.d02t04

hypokalemia low potassium cortisol

shared by Nathan Goodyear on 24 Apr 12 - No Cached
  • cortisol may act as a mineralocorticoid when in excess, perhaps by saturating the 11β-hydroxysteroid-dehydrogenase (11β-HSD2 enzyme) that inactivates cortisol at the renal tubule
  • high cortisol levels may be the principal cause of hypokalemic alkalosis
  • Nathan Goodyear on 24 Apr 12
     
    high cortisol, whether exogenous or endogenous, can have a mineral corticoid effect and resultant low potassium.
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