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Nathan Goodyear

Vitamin C Improves Endothelium-Dependent Vasodilation by Restoring Nitric Oxide Activit... - 0 views

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    IV Vitamin C improves endothelial vasodilation in essential hypertension.  The Vitamin C reduces the oxygen free radicals which allowed eNOS to increase NO production.  Two take homes: oxygen free radicals may be responsible for the endothelial dysfunction that leads to essential hypertension and vitamin C, particularly IV, can be used to counter this process.  Other studies have shown IV vitamin C to be anti-hypertensive in its action.
Nathan Goodyear

ENDOGENOUS SEX HORMONES, BLOOD PRESSURE CHANGE, AND RISK OF HYPERTENSION IN POSTMENOPAU... - 0 views

  • Among postmenopausal women, serum T was elevated in hypertensive participants [9, 11, 12], and total T, free T, and DHEA were positively correlated with SBP
  • T and DHEA were attenuated by adjustment for BMI, reflecting either a confounding or a mediating effect of obesity
  • SHBG concentration was inversely associated with risk of hypertension and longitudinal rise of BP over time
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  • SHBG has been postulated as a marker for insulin resistance
  • In vitro studies showed that insulin inhibits SHBG production from hepatoma cells
  • In intervention studies, successful weight loss and weight maintenance increased SHBG in men with obesity
  • E2 may also induce insulin resistance and thereafter tend to raise BP.
  • strong association between E2 and measures of insulin resistance in postmenopausal women, independent of adiposity
  • In postmenopausal women that received hormone replacement therapy, estrogen therapy increased mononuclear cell secretion of tumor necrosis factor alpha (TNF-α)
  • estrone levels were positively associated with inflammatory markers in postmenopausal women
  • higher baseline concentrations of endogenous E2, total and bioavailable T, and DHEA and lower concentration of SHBG were associated with a higher incidence of hypertension and a greater increase in BP during follow-up
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    Data from MESA study finds that increasing endogenous Estradiol, Total and free Testosterone, DHEA, and lower SHBG were associated with hypertension in postmenopausal women.
Nathan Goodyear

American Journal of Hypertension - Abstract of article: Superoxide Scavenging Effects o... - 0 views

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    IV vitamin C therapy shown to improved the response of blood pressure to acetylcholine and nitroprusside in those patients with essential hypertension.  This effect was not found in NAC.  Vitamin C acts as a superoxide scavenger and glutathione recycler.
Nathan Goodyear

PLOS ONE: Low Mercury Concentration Produces Vasoconstriction, Decreases Nitric Oxide B... - 0 views

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    Animal model found that low Hg decreased NO availability.  The result is vasoconstriction induced by ROS and hypertension. The hypertension is the result of an activation of the renin angiotensin system.  The importance here is that low Hg levels induced this change.
Nathan Goodyear

SpringerLink - Current Hypertension Reports, Volume 6, Number 4 - 0 views

  • Chronic, low-level lead exposure causes hypertension in both animals and humans
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    lead exposure causes hypertension
Nathan Goodyear

Lead-induced hypertension: role of oxidative stres... [Curr Hypertens Rep. 2004] - PubM... - 0 views

  • Chronic, low-level lead exposure causes hypertension in both animals and humans.
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    lead-induced hypertension
Nathan Goodyear

Pathogenesis of lead-induced hypertension: role of... [J Hypertens Suppl. 2002] - PubMe... - 0 views

  • Chronic exposure to low levels of lead causes hypertension in humans and experimental animals
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    Lead-induced hypertension
Nathan Goodyear

American Journal of Hypertension - Treatment of Hypertension: A Failing Report Card - 0 views

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    hypertension has different causes and needs to be treated based on the underlying pathophysiology, not a pin the tail on the donkey approach
Nathan Goodyear

American Journal of Hypertension - Abstract of article: Plasma Renin Test-Guided Drug T... - 0 views

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    renin test-guided therapeutic (RTGT) improves hypertension therapy
Nathan Goodyear

The thyroid hormone, parathyroid hormone and vitamin D associated hypertension - 0 views

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    Good review of the hypertension (different) found in those with thyroid problems, parathyroid problems, and low vitamin D.
Nathan Goodyear

Chronic antioxidant treatment improves arterial renovascular hypertension and oxidative... - 0 views

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    animal study finds vitamin C improves hypertension via renovascular source and oxidative stress.  The dosage was 150 mg/kg/day.  This would be equivalent to 10,800 grams daily for a 72 human.  But what about a 200 lb male or female?  That would be 13,650 grams of vitamin C daily.
Nathan Goodyear

Vitamin C Improves Endothelium-Dependent Vasodilation by Restoring Nitric Oxide Activit... - 0 views

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    vitamin C, in small study in patient with/without hypertension, found to increase endothelial vasodilation via increasing eNOS activity.
Nathan Goodyear

Hypertension - 0 views

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    low vitamin D levels have been shown to be associated with hypertension. 
Nathan Goodyear

ScienceDirect - Toxicology and Applied Pharmacology : Arsenic and diabetes and hyperten... - 0 views

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    long-term exposure to low levels of Arsenic associated with increased hypertension, elevated HgbA1C and many studies Diabetes.
Nathan Goodyear

Hypogonadism and Metabolic Syndrome in Nigerian Male Patients With Both Type 2 Diabetes... - 0 views

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    Asian study finds Testosterone is inversely associated with increased central obesity, increased dyslipidemia, and metabolic syndrome in me with new diagnosis of type II diabetes and hypertension.  Men with metabolic syndrome, type II diabetes, and CVD must have appropriate hormone evaluation.
Nathan Goodyear

Hypertension induced by methyl mercur... [Toxicol Appl Pharmacol. 1987] - PubMed - NCBI - 0 views

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    Hg induces hypertension in rat model.
Nathan Goodyear

The role of mercury and cadmi... [Altern Ther Health Med. 2007 Mar-Apr] - PubMed - NCBI - 0 views

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    Heavy metals play a role in the development of CVD.  Hg and Cd in particular play a role in hypertension.
Nathan Goodyear

Erectile dysfunction in high-risk hypertensive patients treated with beta-blockade agen... - 0 views

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    Beta blocker therapy appears to be associated with ED in patients with hypertension.
Nathan Goodyear

Journal of Clinical Investigation -- Pathophysiological role of leptin in obesity-relat... - 0 views

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    leptin-resistance as cause of obesity and contribution to hypertension
Nathan Goodyear

Journal of Clinical Investigation -- Oxidation of tetrahydrobiopterin leads to uncoupli... - 0 views

  • Tetrahydrobiopterin is a critical cofactor for the NO synthases
  • at hypertension produces a cascade involving production of ROSs from the NADPH oxidase leading to oxidation of tetrahydrobiopterin and uncoupling of endothelial NO synthase (eNOS). This decreases NO production and increases ROS production from eNOS
  • Tetrahydrobiopterin oxidation may represent an important abnormality in hypertension
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  • Treatment strategies that increase tetrahydrobiopterin or prevent its oxidation may prove useful in preventing vascular complications of this common disease.
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    tetrahydrobiopterin deficiency plays role in cardiovasular disease
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