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Nathan Goodyear

Hypothalamo-Pituitary-Adrenal Axis Dysfunction in Chronic Fatigue Syndrome, and the Eff... - 0 views

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    This study reveals CFS to be low adrenal cortisol output problem. In this study, low dose cortisol (hydrocortisone) therapy improved symptoms of fatigue and improved the CRH adrenal stimulation of adrenal cortisol production.
Nathan Goodyear

Salivary cortisol response to awakening in chronic fatigue syndrome - 0 views

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    This study found suppressed am salivary cortisol in those with CFS.
Nathan Goodyear

Alterations in diurnal salivary cortisol rhyth... [Psychosom Med. 2008] - PubMed - NCBI - 0 views

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    Individuals with CFS found to have flattened salivary cortisol 4-point pattern and elevated IL-6.
Nathan Goodyear

Diurnal variation of adrenocortical activ... [Neuropsychobiology. 1998] - PubMed - NCBI - 0 views

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    adrenocortical dysfunction found to play a role in CFS
Nathan Goodyear

Low-Dose Hydrocortisone for Treatment of Chronic Fatigue Syndrome, September 23/30, 199... - 0 views

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    this study revealed symptom improvement with hydrocortisone treatment in those with CFS. Pre/post treatment was with serum cortisol and not salivary cortisol.  This is a weakness of the study.  The starting dosage of 25-30 mg hydrocortisone is high and with inadequate evaluation, this high dosage could have resulted in high dosage and adrenal suppression.  
Nathan Goodyear

Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial : The... - 0 views

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    low dose hydrocortisone therapy, 5-10 mg, shown to be effective short-term therapy in patients with chronic fatigue syndrome.  Additionally, and very important, this study found no adrenal function suppression at these doses.
Nathan Goodyear

Hypothalamo-Pituitary-Adrenal Axis Dysfunction in Chronic Fatigue Syndrome, and the Eff... - 0 views

  • We conclude that the improvement in fatigue seen in some patients with chronic fatigue syndrome during hydrocortisone treatment is accompanied by a reversal of the blunted cortisol responses to human CRH
  • These data further suggest that the hypocortisolism found in chronic fatigue syndrome may be secondary to reduced adrenal gland output.
  • 5-mg replacement dose of hydrocortisone, and the remainder 10 mg
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    low dose hydrocortisone therapy (defined as 5-10 mg), in this study, was used to treat CFS.  This study found an improvement in symptoms in these patients.  Additionally, low cortisol was found in these patients with CFS.  Their conclusion, was that low adrenal function is a component of CFS and low dose hydrocortisone therapy is an effective treatment.  

    Now, is the low cortisol as the result of increased metabolism as well?
Nathan Goodyear

Urinary Cortisol and Cortisol Metabolite Excretion in Chronic Fatigue Syndrome - 0 views

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    It has been suggested in the literature that low salivary cortisol is a common finding in those with chronic fatigue. This study found no difference in the cortisol metabolite excretion. This would suggest that an increase metabolization of cortisol exists in those with CFS.
Nathan Goodyear

Urinary Cortisol and Cortisol Metabolite Excretion in Chronic Fatigue Syndrome - 0 views

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    low cortisol is a frequent finding in chronic fatigue syndrome.  However, in the urine, the cortisol levels may be normal.  This is a reflection of increased metabolism of cortisol.  This is not a contradiction, but a metabolic effect.
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