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Nathan Goodyear

Adipose Tissue Macrophages Are Innate to the Immunological Awareness of Adipose Tissue - 0 views

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    adipose tissue is a biological, inflammatory producing organ.
Nathan Goodyear

Dose-dependent effects of vitamin D on transdifferentiation of skeletal muscle cells to... - 0 views

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    Dose dependent vitamin D impact on fat.  Low vitamin D concentrations associated with fat adipogenesis.  Higher vitamin D concentrations inhibited adipogenesis.
Nathan Goodyear

Diabetology & Metabolic Syndrome | Full text | Visceral adiposity, insulin resistance a... - 0 views

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    adipose tissue and it's biological activity contribution to cancer risk.  Good review of our current understanding on how adipose tissue increases the favorably of cancer.
Nathan Goodyear

Pathways of adipose tissue androgen metabolism in women: depot differences and modulati... - 0 views

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    aromatase activity is concentrated in subcutaneous and visceral adipose tissue.
Nathan Goodyear

Low Grade Chronic Inflammation in Women with Polycystic Ovarian Syndrome - 0 views

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    Women with PCOS have associated increased inflammation.  This origin is primarily via adipose tissue and associate adipocytokines (TNF-alpha, and IL-6).  CRP elevation, as found in this study, is associated with increased CVD.
Nathan Goodyear

The Role of Adipose Tissue and Adipokines in Obesity-Related Inflammatory Diseases - 0 views

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    Great review of the current understanding on adipose tissue as a hormone, inflammatory producing organ.
Nathan Goodyear

Stimulation of aromatase activity in bre... [Mol Cell Endocrinol. 1994] - PubMed - NCBI - 0 views

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    inflammatory cytokine, TNF-alpha, increases aromatase activity.  This article discusses the increased production of estrone from androstenedione from aromatase activity in fat tissue in the breast.
Nathan Goodyear

Relationship of visceral adipose tissue and glucose disposal is independent of sex in b... - 0 views

  • an inverse nonlinear relationship existed between glucose disposal and visceral fat
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    Increase in visceral fat reduces glucose "disposal".  Translated: as visceral adiposity increases, associated insulin resistance increases glucose levels and all associated metabolic dysfunction.
Nathan Goodyear

JCI - Chronic inflammation in fat plays a crucial role in the development of obesity-re... - 0 views

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    how inflammation contributes to obesity.  Nice discussion of the inflammatory signaling that leads to obesity.  This occurs predominately in white adipose tissue WAT.  This leads to insulin resistance and type II DM.
Nathan Goodyear

Effect of DHEA-sulfate on adiponectin gene expression in adipose tissue from different ... - 0 views

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    DHEA-S shown to increase genetic expression of adiponectin in human adipose tissue.  This has enormous implications on the link between DHEA and insulin resistance induce obesity. This is a peripheral tissue problem, not a central problem.
Nathan Goodyear

Dehydroepiandrosterone reduces preadipocyte proliferation via androgen receptor - 0 views

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    DHEA reduces preadipocytes growth through the androgen receptor.
Nathan Goodyear

11beta-hydroxysteroid dehydrogenase type 1 an... [Front Horm Res. 2008] - PubMed - NCBI - 0 views

  • Adipose-selective 11beta -HSD1 transgenic mice exhibited elevated intra-adipose and portal, but not systemic corticosterone levels, abdominal obesity, hyperglycaemia, insulin resistance, dyslipidaemia and hypertension
  • transgenic overexpression of 11beta -HSD1 in liver yielded an attenuated metabolic syndrome with mild insulin resistance, dyslipidaemia, hypertension and fatty liver, but not obesity or glucose intolerance
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    11-betaHSD1 expression and effect is site specific.
Nathan Goodyear

Tissue-Specific Dysregulation of Cortisol Metabolism in Human Obesity - 0 views

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    dysregulated cortisol metabolism plays a role in obesity.  This study looked at obese men.  Decreased liver 11-betaHSD1 activity was found in the liver, with decreased cortisone to cortisol conversion.  Additionally, increase cortisol metabolites were found.  However, there was found to be an increase in 11-betaHSD1 activity in the adipose tissue increasing the cortisone to cortisol conversion indicating an increase in peripheral cortisol production.
Nathan Goodyear

Regulation of 11beta-HSD genes in human adipose tis... [Obes Res. 2004] - PubMed - NCBI - 0 views

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    adipocytes increase genetic expression of 11beta-HSD. This increases local cortisol production from cortisone.  This plays a pivotal role in obesity.  Question:  would this play a role in peripheral hypothyroid?  I think so.
Nathan Goodyear

Chronic inflammation in fat plays a crucial role in the development of obesity-related ... - 0 views

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    chronic low-grade inflammation plays role in development of insulin resistance and eventually obesity.  This occurs in White Adipose Tissue
Nathan Goodyear

Adipose Tissue Inflammation in Obesity and Metabolic Syndrome - - Satoshi Nishimura - D... - 0 views

  • Activation of inflammatory pathways in adipocytes impairs triglyceride storage and increases release of free fatty acids, an excess of which is known to induce insulin resistance in muscle and liver
  • recent studies have shown that large numbers of macrophages infiltrate obese adipose tissue,
  • It has been postulated that a paracrine loop involving free fatty acids and inflammatory cytokines establishes a vicious cycle between adipocytes and macrophages that propagates the inflammation
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  • not only does interrupting the accumulation of macrophages within obese adipose tissue suppresses adipose inflammation in various animal models, it also ameliorates systemic insulin resistance and metabolic abnormalities, suggesting macrophages are key effector cells involved in adipose inflammation
  • activation of the leukocyte adhesion cascade, a hallmark of inflammation
  • Thus, obese visceral adipose tissue is clearly a site of chronic inflammation
  • CD8+ T cells within obese adipose tissue induce activation and migration of monocytes/macrophages, and in cooperation with the adipose tissue, they also induce macrophage differentiation. At the same time, obese adipose tissue activates CD8+ T cells, creating a vicious cycle involving CD8+ T cells, macrophages, and obese adipose tissue that propagates local inflammation
  • In obese adipose tissue there is a shift to dominance of CD8+ and TH1 T cells, which appears to propagate inflammation
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    fascinating read how the immune system and resultant inflammation results in obesity.
Nathan Goodyear

Adipose Tissue as an Endocrine Organ - 0 views

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    You need to think of your fat differently.
Nathan Goodyear

Influence of high-carbohydrate mixed meals with different glycemic indexes on substrate... - 0 views

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    low-glycemic index diet aids in mobilization of adipose tissue in exercise.  In this study, exercise after a low-glycemic meal resulted in a greater mobilization of adipose tissue for energy production than a high glycemic meal.  This will help  in weight loss
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