Skip to main content

Home/ Seasons Wellness/ Group items tagged estradiol men

Rss Feed Group items tagged

Nathan Goodyear

In Older Men an Optimal Plasma Testosterone Is Associated With Reduced All-Cause Mortal... - 0 views

  •  
    men with Testosterone levels in the middle quintiles had the lowest risk of death compared to low and high quintile levels.  
Nathan Goodyear

Testosterone and metabolic syndrome Cunningham GR - Asian J Androl - 0 views

  • The relationship of low testosterone to MetS often is considered to be bidirectional; however, the relationships probably are not direct
  • Many of the components of the MetS are recognized risk factors for the development of cardiovascular disease (CVD)
  • Multiple cross-sectional studies have found low TT and low sex hormone binding globulin (SHBG) levels in Caucasian and African-American men with the MetS, irrespective of age
  • ...20 more annotations...
  • Low TT and SHBG levels also are prevalent in Chinese [7],[8] and Korean [9] men with the MetS
  • Normally 40%-50% of TT is bound to SHBG, so reducing SHBG levels will decrease TT.
  • Hyperinsulinism suppresses SHBG synthesis and secretion by the liver
  • significant increase in SHBG levels occurred after acutely lowering insulin levels in obese men
  • Estradiol levels are increased in men with the MetS, and they are positively correlated with the number of abnormal components of the MetS.
  • Although it is known that estrogen will increase SHBG levels, apparently the hyperinsulinism associated with obesity has a greater effect on SHBG levels
  • Estradiol also can inhibit luteinizing hormone (LH) secretion
  • Inflammatory cytokines are thought to have a direct effect on the pituitary to reduce LH secretion [15] and also a direct effect on Leydig cell secretion of testosterone
  • Low TT Levels have been shown to predict development of the MetS in men with normal BMI
  • Men in the lowest quartiles of serum TT, calculated free testosterone (cFT) and SHBG at baseline had the highest odds ratios for developing the MetS or DM during the 11 years follow-up
  • More recently, investigators conducting population-based studies have reported that only SHBG is associated with future development of the MetS
  • Additional evidence that low TT increases the risk of MetS comes from androgen deprivation treatment of prostate cancer
  • Low TT and low bioavailable testosterone (bT) were each significantly associated with elevated 20 years risk of CVD mortality in an older population in which cause-specific mortality was age, adiposity, and lifestyle-adjusted.
  • combination of low bT and ATP III-defined MetS is associated with increased cardiovascular mortality in men aged 40 years and above
  • in elderly men, testosterone may weakly protect against CVD. Alternatively, low TT may indicate poor general health
  • Muraleedharan and Jones [27] concluded that there is convincing evidence that low T is a biomarker for disease severity and mortality.
  • The evidence that TRT improves insulin sensitivity and glucose control is conflicted
  • It is widely recognized that testosterone treatment can reduce fat mass and increase lean body mass; however, until recently most reports have not been associated with much weight loss
  • Changes in body composition and weight loss are considered potential mechanisms by which testosterone treatment improves insulin sensitivity and glucose control in patients with diabetes. Effects on inflammatory cytokines [38] and changes in oxidative metabolism [39] also have been reported to improve glucose metabolism.
  • Testosterone replacement therapy has been reported to improve some or all of the components of the MetS.
  •  
    To be read article on Testosterone and Metabolic Syndrome.
Nathan Goodyear

Higher serum testosterone and dihydrotestosterone, but not estradio... - PubMed - NCBI - 0 views

  •  
    Higher Testosterone and DHT levels in men was found to be positively associated with FEV1 and FVC; Estradiol was not.  The question here is cause or effect.  

    Also interesting is the fact that smokers had higher Testosterone levels compared to non-smokers.
Nathan Goodyear

Association Between Endogenous Sex Hormones and Liver Fat in a Mult... - PubMed - NCBI - 0 views

  •  
    Time that physicians start following the science.  Study using data from the Multi-ethnic Study of Atherosclerosis was used to assess hormones and fatty liver in men and women.  Increasing bioavailable Testosterone levels in women was found to be associated with increasing fatty liver in post-menopausal women.  The opposite was found to be true in men.  Higher Estradiol levels were found to be associated with increased fatty liver in both sexes.  However, the statistical significance was higher with men.  Higher SHBG was associated with lower fatty liver incidence in men.  
Nathan Goodyear

http://press.endocrine.org/doi/pdf/10.1210/jc.2014-3818 - 0 views

  •  
    Study finds that low free T and low Total T were associated with decline in desire, ED and activity versus none with Estradiol and SHBG in older men.  The difficult issue is the threshold of "low T".  The definition of "low T" is not uniform and varies with age.  Thus baseline evaluations and correlation with symptoms, metabolic dysfunction must be done.
Nathan Goodyear

Sex hormone levels in patients with sudden cardiac arrest - Heart Rhythm - 0 views

  •  
    Study finds increased risk of sudden MI in men with low Testosterone and elevated Estradiol.  In converse, increased risk is associated with elevated Estradiol in women.
Nathan Goodyear

Estrogen Mediates Metabolic Syndrome-Induced Erect... [J Sex Med. 2014] - PubMed - NCBI - 0 views

  •  
    animal model finds that high fat diet induces ED more through increased Estradiol production than low Testosterone.  Of course the authors focused on the drugs to block E2 once produced, rather then reducing the T to E2 aromatase activity.  This metabolic syndrome model implies that increased aromatase activity will be present.
Nathan Goodyear

Serum oestradiol levels in male partners of infer... [Andrologia. 2014] - PubMed - NCBI - 0 views

  •  
    Study points to association of low Estradiol and spermatogenesis in males in infertile couples.  The authors eluded to the association of low Estradiol with low Testosterone, and BMI which is the likely etiology.  Low BMI will result in low aromatase activity.  For men, the majority of Estradiol production occurs from Testosterone via aromatase activity.  Estradiol likely exists in a "U" shaped pattern of benefit: to low hinders optimal physiologic function and contributes to inflammation and disease in men.
Nathan Goodyear

Clomiphene citrate effects on testosterone/estroge... [J Sex Med. 2005] - PubMed - NCBI - 0 views

  •  
    small cohort with low serum Total Testosterone improved T:E2 ratio with clomid.  Clomid restores the HPA through inhibition of the negative feedback of Estradiol on the Hypothalamus and Pituitary in men.  This allows for an increase in gonadotropin production and thus increase in testosterone production.  Aromatase inhibition therapy would likely still prove beneficial in this situation.
Nathan Goodyear

https://endo.confex.com/endo/2014endo/webprogram/Paper11377.html - 0 views

  •  
    from CHAMP study: low serum Testosterone, free Testosterone, Estradiol and Estrone associated with functional decline in elderly men via muscle weakness.
Nathan Goodyear

High Estrogen in Men After Injectable Testo... [Am J Mens Health. 2014] - PubMed - NCBI - 0 views

  •  
    Again, Testosterone and here Estradiol are merely there for libido and sex.  What tunnel vision?!  What about hsCRP?  What about fibrinogen?  What about IL-1beta?  What about TNF-alpha?  These inflammatory cytokines have all been reported to elevate as a result of estrogen production in men.  

    And PSA?  No mention of it here.  

    This linear, tunnel vision thinking on hormones has got to stop!

    The study points out that all clients were using AIs and SERMs irregardless of whether they had elevated estrogens or not.  That is not a well designed study.  One group should have had AI's if elevated estrogens were present and another group should not--this would compare the effects of aromatase activity.  Second, this was simply a retrospective chart review.  Third, a 50% conversion of 34,000 + men is very high when you look at the literature.  Fourth, they point to gynecomastia as a means of negative?  The cardiovascular implications are more significant.  These studies just seem to focus on superficial things.  Fifth, did libido problems exist before?  What were the free levels?  

    This falls in the paucity of data (2 studies) that point to excessive lowering of estradiol effecting libido and sexual performance.

Nathan Goodyear

Circulating Estrone Levels Are Associated Prospectively With Diabetes Risk in Men of th... - 0 views

  •  
    A cross-sectional study of 1,458 men over a 13 years found an increase risk of diabetes incidence with elevated Estradiol and Estrone levels.  The greatest association was found with Estrone.  This should come as no surprise to anybody as type II diabetes is clearly associated with increasing weight and this is the source of 80% of estrogen production in men.
Nathan Goodyear

CARDIOVASCULAR DISEASE IN TRANSSEXUAL PERSO... [Eur J Endocrinol. 2014] - PubMed - NCBI - 0 views

  •  
    The point of this study post is not the focus on the sex change, but that estrogen dosing in men is associated with increased CVD. This is known from the other literature.
Nathan Goodyear

Longitudinal relationships of circul... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

  •  
    Declining Testosterone, calculated free Testosterone, Estradiol, and Estrone levels appear to be associated with muscle mass/strength decline in elderly men.  This points to a global decrease in HPA function rather than an individual, specific hormone deficiency.
Nathan Goodyear

Oestradiol levels in diabetic men with and without a... [Q J Med. 1987] - PubMed - NCBI - 0 views

  •  
    High Estradiol is reproducible finding in men with Diabetes.  Link to MI not able to be determined.
Nathan Goodyear

Salivary estradiol and testosterone in filipin... [Am J Hum Biol. 2014] - PubMed - NCBI - 0 views

  •  
    Study finds association between elevated Estradiol in young men and obesity.  No correlation was found with Testosterone.  This fits other research that points to early increased Estradiol production and late decrease in low T.  The men in this study were "young".  Testing was done in saliva.
Nathan Goodyear

Estrogen excess associated with novel gain-of-f... [N Engl J Med. 2003] - PubMed - NCBI - 0 views

  •  
    Presentation of a familial incidence of male gynecomastia and hypogonadotropic hypogonadism via peripheral aromatase activity.
Nathan Goodyear

Coadministration of anastrozole sustains therapeut... [J Sex Med. 2014] - PubMed - NCBI - 0 views

  •  
    First, Testosterone pellets are not the way to go.  Historically, these will go the way of all the implantable contraceptive devices.  However, the conclusion of this study is good and confirms the benefit of anastrazole to inhibit aromatase activity and help to maintain Testosterone levels.
Nathan Goodyear

Increased estradiol levels in venous... [Int J Impot Res. 2005 May-Jun] - PubMed - NCBI - 0 views

  •  
    Study finds a link between Estradiol, venous insufficiency, and ED in men.  The signaling is through VEGF and NO.
Nathan Goodyear

Endocrine milieu and erectile dysfunction: is oestradiol-testosterone imbalance, a risk... - 0 views

  •  
    This article points to the impact of T:E2 on ED in men.  A declining T:E2 increases ED in older men.  
1 - 20 of 63 Next › Last »
Showing 20 items per page