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Nathan Goodyear

CARDIOVASCULAR DISEASE IN TRANSSEXUAL PERSO... [Eur J Endocrinol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24616414

CVD cardiovascular disease estrogen estradiol men male hormone hormones

shared by Nathan Goodyear on 26 Mar 14 - No Cached
  • Nathan Goodyear on 26 Mar 14
     
    The point of this study post is not the focus on the sex change, but that estrogen dosing in men is associated with increased CVD. This is known from the other literature.
Nathan Goodyear

Longitudinal relationships of circul... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24628559

Testosterone low T free Estradiol Estrone muscle mass strength elderly men male hormone hormones men's health

shared by Nathan Goodyear on 24 Mar 14 - No Cached
  • Nathan Goodyear on 24 Mar 14
     
    Declining Testosterone, calculated free Testosterone, Estradiol, and Estrone levels appear to be associated with muscle mass/strength decline in elderly men.  This points to a global decrease in HPA function rather than an individual, specific hormone deficiency.
Nathan Goodyear

Oestradiol levels in diabetic men with and without a... [Q J Med. 1987] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...3671665

aromatase Estradiol E2 Testosterone men male Diabetes hormone hormones MI myocardial infarction

shared by Nathan Goodyear on 04 Mar 14 - No Cached
  • Nathan Goodyear on 04 Mar 14
     
    High Estradiol is reproducible finding in men with Diabetes.  Link to MI not able to be determined.
Nathan Goodyear

Salivary estradiol and testosterone in filipin... [Am J Hum Biol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24573919

saliva salivary hormone hormones male men Testosterone Estradiol E2 obesity aromatase

shared by Nathan Goodyear on 04 Mar 14 - No Cached
  • Nathan Goodyear on 04 Mar 14
     
    Study finds association between elevated Estradiol in young men and obesity.  No correlation was found with Testosterone.  This fits other research that points to early increased Estradiol production and late decrease in low T.  The men in this study were "young".  Testing was done in saliva.
Nathan Goodyear

Estrogen excess associated with novel gain-of-f... [N Engl J Med. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12736278

gynecomastia Man Boobs hypogonadotropic hypogonadism low T Testosterone aromatase estrogen estradiol men male hormone hormones

shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • Nathan Goodyear on 03 Mar 14
     
    Presentation of a familial incidence of male gynecomastia and hypogonadotropic hypogonadism via peripheral aromatase activity.
Nathan Goodyear

Coadministration of anastrozole sustains therapeut... [J Sex Med. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24119010

Testosterone aromatase aromatase activity estradiol anastrazole aromatase inhibitor aromatase inhibitors aromatase inhibition men male hormone hormones

shared by Nathan Goodyear on 19 Feb 14 - No Cached
  • Nathan Goodyear on 19 Feb 14
     
    First, Testosterone pellets are not the way to go.  Historically, these will go the way of all the implantable contraceptive devices.  However, the conclusion of this study is good and confirms the benefit of anastrazole to inhibit aromatase activity and help to maintain Testosterone levels.
Nathan Goodyear

Increased estradiol levels in venous... [Int J Impot Res. 2005 May-Jun] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15578040

estradiol estrogen ED erectile dysfunction men male hormone hormones NO VEGF

shared by Nathan Goodyear on 05 Feb 14 - No Cached
  • Nathan Goodyear on 05 Feb 14
     
    Study finds a link between Estradiol, venous insufficiency, and ED in men.  The signaling is through VEGF and NO.
Nathan Goodyear

Endocrine milieu and erectile dysfunction: is oestradiol-testosterone imbalance, a risk... - 0 views

www.ncbi.nlm.nih.gov/...PMC3739617

erectile dysfunction ED low T Testosterone T:E2 Estradiol men male hormone hormones

shared by Nathan Goodyear on 05 Feb 14 - No Cached
  • Nathan Goodyear on 05 Feb 14
     
    This article points to the impact of T:E2 on ED in men.  A declining T:E2 increases ED in older men.  
Nathan Goodyear

Roles of the gonadal steroid hormones in psychiatric depression in men and women - Rese... - 0 views

www.researchgate.net/...ic_depression_in_men_and_women

depression estradiol estrogen men Testosterone women hormones hormone

shared by Nathan Goodyear on 03 Feb 14 - No Cached
  • Nathan Goodyear on 03 Feb 14
     
    Fascinating difference in the sexes.  High estradiol is found to be associated with depression in men and high Testosterone is found to be associated with depression in women.  The exact mechanism or strength of association is unstated.
Nathan Goodyear

Sex Hormones and Age: A Cross-sectional Study of Testosterone and Estradiol and Their B... - 0 views

aje.oxfordjournals.org/...750.short

hormone hormones men male Estradiol Estrogen testosterone

shared by Nathan Goodyear on 03 Feb 14 - No Cached
  • Nathan Goodyear on 03 Feb 14
     
    Older men have Estradiol levels that are 3 x that of a post-menopausal women.  The bioavailable levels of Testosterone and Estradiol showed the greatest precipitous decline.
Nathan Goodyear

In older men an optimal plasma testo... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24257908

Testosterone DHT cardiovascular disease heart men estradiol E2 dihydrotestosterone male hormone hormones

shared by Nathan Goodyear on 03 Feb 14 - No Cached
  • Nathan Goodyear on 03 Feb 14
     
    Study finds that "midrange" Testosterone and DHT associated with a reduced ischemic heart disease and death rate.  No association was found with Estradiol.  One flaw of this study is in their use of serum.
Nathan Goodyear

http://eu-acme.org/europeanurology/upload_articles/Bonkhoff.pdf - 0 views

eu-acme.org/...Bonkhoff.pdf

estrogen estradiol ER receptors ER alpha ER beta prostate cancer male men hormone hormones

shared by Nathan Goodyear on 20 Jan 14 - No Cached
  • Nathan Goodyear on 20 Jan 14
     
    Estrogen plays a critical role in the initiation of carcinogenesis of prostate cancer through the ER alpha/beta expression.  As the authors state in their conclusion, "...ER alpha signaling potentiates the carcinogenic effects of androgens on the prostatic epithelium."
Nathan Goodyear

A potential paradox in prostate adenocarcinoma ... [Eur J Cancer. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18381236

estrogen estradiol prostate cancer men male hormone hormones

shared by Nathan Goodyear on 20 Jan 14 - No Cached
  • Nathan Goodyear on 20 Jan 14
     
    Estrogen is proposed to play an important role in the initiation of prostate cancer.  
Nathan Goodyear

The heritability of circulating testosterone, oestradiol, oestrone and sex hormone bind... - 0 views

www.medaus.com/2111

Testosterone Estradiol Estrogen genetics genetic hormone hormones men male

shared by Nathan Goodyear on 16 Jan 14 - No Cached
  • Nathan Goodyear on 16 Jan 14
     
    No surprise here as genetics and environment play in a role in all disease.  Here it is hormones.  
Nathan Goodyear

Circulating estradiol is an independ... [J Clin Endocrinol Metab. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16940451

Estradiol men male hormone hormones carotid intima-media thickness CVD atherosclerosis

shared by Nathan Goodyear on 16 Jan 14 - No Cached
  • Nathan Goodyear on 16 Jan 14
     
    increased Total and free Estradiol associated with progression of carotid intima-media thickness in men ie. increased atherosclerosis.
Nathan Goodyear

http://circ.ahajournals.org/content/109/17/2074.full.pdf - 0 views

circ.ahajournals.org/...2074.full.pdf

Testosterone Estradiol CVD atherosclerosis carotid intima-media thickness men male hormone hormones

shared by Nathan Goodyear on 16 Jan 14 - No Cached
  • Nathan Goodyear on 16 Jan 14
     
    lower Free Testosterone and increased Estradiol through aromatase activity is associated with increased atherosclerosis.  This was monitored with Carotid intima-media thickness.  This study found an increase associated with low free Testosterone and increased free estradiol levels independent of other CVD variables.
Nathan Goodyear

Sex steroids and cardiovascular disease Yeap BB - Asian J Androl - 0 views

www.ajandrology.com/article.asp

cardiovascular disease CVD sex estradiol carotid intima-media thickness hormones hormone men Testosterone estrogen

shared by Nathan Goodyear on 15 Jan 14 - No Cached
  • Levels of SHBG are higher in older men, therefore levels of free T decline more steeply than total T as men's age increases.
  • calculations based on mass action equations may not reflect precisely free T measured using a reference method
  • free T declines more steeply with age than total T in both cross-sectional [35] and longitudinal studies, [36] as does free E2 in comparison to total E2
  • ...22 more annotations...
  • T may slow development of or progression of atherosclerosis by modulating effects on insulin resistance, inflammation, endothelial function, preclinical atherosclerosis or the vasculature.
  • these cross-sectional and longitudinal studies support a relationship between low circulating T with CIMT and higher E2 with its progression
  • lower levels of T are biomarkers for aortic vascular disease
  • circulating free T was negatively associated with the presence of AAA
  • luteinizing hormone (LH) was positively associated.
  • low levels of total or bioavailable T were associated with aortic atherosclerosis manifested as calcified deposits detected by radiography
  • Men with total or free T in the lowest quartile had increased adjusted ORs for PAD defined as ABI <0.90, as did men with free E2 in the highest quartile of values
  • The apparent association of SHBG with intermittent claudication reflects the correlation of total T with SHBG, while the contribution of E2 to risk of PAD remains unclear
  • men with total T in the lowest quartile of values (<11.7 nmol l−1 ) experienced an increased incidence of stroke or transient ischemic attack
  • lower total T with increased incidence of CVD events
  • cohort studies in mostly older men have supported the association of lower androgen levels with higher mortality
  • lower total or free T levels were associated with mortality in older men, but with discordant results for cause-specific mortality and for associations of E2
  • several large studies identifying lower endogenous levels of total or free T as independent predictors of all-cause or CVD-related deaths in middle-aged and older men
  • T exhibits anti-inflammatory effects, enhances flow-mediated brachial artery reactivity, and reduces arterial stiffness
  • Short-term T therapy had a beneficial effect on exercise-induced myocardial ischemia in middle-aged men with coronary artery disease or chronic stable angina, [95],[96],[97] and reduced angina frequency in older men with diabetes and coronary artery disease
  • T therapy resulted in an increase in treadmill test duration and time to ST segment depression
  • there are interventional studies supporting a protective effect of exogenous T against myocardial ischemia in men with coronary artery disease
  • employ conservative doses
    • Nathan Goodyear
      Nathan Goodyear on 16 Jan 14
       
      This dosing is 100 fold higher then peak production of a  young man at 20-22.
  • Observational studies indicate that lower levels of endogenous T in older men are associated with the presence of carotid atherosclerosis, aortic and peripheral vascular disease, and incidence of CVD events and mortality
  • Interventional studies have shown beneficial effects of exogenous T on vascular function and on exercise-induced myocardial ischemia in men with coronary artery disease
    • Nathan Goodyear
      Nathan Goodyear on 16 Jan 14
       
      the therapies employed in these studies were massively overdosed.
  • Nathan Goodyear on 15 Jan 14
     
    Nice review of all the sex hormones and their relationship to CVD in men.  
Nathan Goodyear

The relationship between sex hormones and lipi... [Int J Cardiol. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15860391

aromatase estradiol men male hormone hormones lipids cholesterol Testosterone

shared by Nathan Goodyear on 08 Jan 14 - No Cached
  • Nathan Goodyear on 08 Jan 14
     
    High aromatase activity and estradiol production in men was found to be associated with elevated total cholesterol, LDL, TC:HDL, and triglycerides.  No association was found with Testosterone or SHBG.  The 111 men in this study had "stable CAD"
Nathan Goodyear

In Older Men an Optimal Plasma Testosterone Is Associated With Reduced All-Cause Mortal... - 0 views

jcem.endojournals.org/...jc.2013-3272.abstract

testosterone heart disease heart mortality DHT dihydrotestosterone estradiol male men hormone hormones

shared by Nathan Goodyear on 01 Dec 13 - No Cached
  • Nathan Goodyear on 01 Dec 13
     
    Older men, 70-89, Testosterone in the middle range of normal and higher DHT was associated with the lowest death rates.  Estradiol was not found to be associated.  This study only looked at Total levels, free bioavailable levels were not assessed.  This study also highlights the basic thought, that more is not always better as it pertains to Testosterone.  It also highlights the importance of DHT.  Testosterone is a pro hormone.
Nathan Goodyear

Circulating Estradiol Is an Independent Predictor of Progression of Carotid Artery Inti... - 0 views

jcem.endojournals.org/...4433.long

Estradiol inflammation carotid IMT men male hormone hormones CVD

shared by Nathan Goodyear on 15 Nov 13 - No Cached
  • Nathan Goodyear on 15 Nov 13
     
    Increasing Estradiol is associated with an increasing carotid IMT in men.
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