Skip to main content

Home/ Seasons Wellness/ Group items tagged estradiol men

Rss Feed Group items tagged

Nathan Goodyear

CARDIOVASCULAR DISEASE IN TRANSSEXUAL PERSO... [Eur J Endocrinol. 2014] - PubMed - NCBI - 0 views

  •  
    The point of this study post is not the focus on the sex change, but that estrogen dosing in men is associated with increased CVD. This is known from the other literature.
Nathan Goodyear

Longitudinal relationships of circul... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

  •  
    Declining Testosterone, calculated free Testosterone, Estradiol, and Estrone levels appear to be associated with muscle mass/strength decline in elderly men.  This points to a global decrease in HPA function rather than an individual, specific hormone deficiency.
Nathan Goodyear

Oestradiol levels in diabetic men with and without a... [Q J Med. 1987] - PubMed - NCBI - 0 views

  •  
    High Estradiol is reproducible finding in men with Diabetes.  Link to MI not able to be determined.
Nathan Goodyear

Salivary estradiol and testosterone in filipin... [Am J Hum Biol. 2014] - PubMed - NCBI - 0 views

  •  
    Study finds association between elevated Estradiol in young men and obesity.  No correlation was found with Testosterone.  This fits other research that points to early increased Estradiol production and late decrease in low T.  The men in this study were "young".  Testing was done in saliva.
Nathan Goodyear

Estrogen excess associated with novel gain-of-f... [N Engl J Med. 2003] - PubMed - NCBI - 0 views

  •  
    Presentation of a familial incidence of male gynecomastia and hypogonadotropic hypogonadism via peripheral aromatase activity.
Nathan Goodyear

Coadministration of anastrozole sustains therapeut... [J Sex Med. 2014] - PubMed - NCBI - 0 views

  •  
    First, Testosterone pellets are not the way to go.  Historically, these will go the way of all the implantable contraceptive devices.  However, the conclusion of this study is good and confirms the benefit of anastrazole to inhibit aromatase activity and help to maintain Testosterone levels.
Nathan Goodyear

Increased estradiol levels in venous... [Int J Impot Res. 2005 May-Jun] - PubMed - NCBI - 0 views

  •  
    Study finds a link between Estradiol, venous insufficiency, and ED in men.  The signaling is through VEGF and NO.
Nathan Goodyear

Endocrine milieu and erectile dysfunction: is oestradiol-testosterone imbalance, a risk... - 0 views

  •  
    This article points to the impact of T:E2 on ED in men.  A declining T:E2 increases ED in older men.  
Nathan Goodyear

Roles of the gonadal steroid hormones in psychiatric depression in men and women - Rese... - 0 views

  •  
    Fascinating difference in the sexes.  High estradiol is found to be associated with depression in men and high Testosterone is found to be associated with depression in women.  The exact mechanism or strength of association is unstated.
Nathan Goodyear

Sex Hormones and Age: A Cross-sectional Study of Testosterone and Estradiol and Their B... - 0 views

  •  
    Older men have Estradiol levels that are 3 x that of a post-menopausal women.  The bioavailable levels of Testosterone and Estradiol showed the greatest precipitous decline.
Nathan Goodyear

In older men an optimal plasma testo... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

  •  
    Study finds that "midrange" Testosterone and DHT associated with a reduced ischemic heart disease and death rate.  No association was found with Estradiol.  One flaw of this study is in their use of serum.
Nathan Goodyear

http://eu-acme.org/europeanurology/upload_articles/Bonkhoff.pdf - 0 views

  •  
    Estrogen plays a critical role in the initiation of carcinogenesis of prostate cancer through the ER alpha/beta expression.  As the authors state in their conclusion, "...ER alpha signaling potentiates the carcinogenic effects of androgens on the prostatic epithelium."
Nathan Goodyear

A potential paradox in prostate adenocarcinoma ... [Eur J Cancer. 2008] - PubMed - NCBI - 0 views

  •  
    Estrogen is proposed to play an important role in the initiation of prostate cancer.  
Nathan Goodyear

The heritability of circulating testosterone, oestradiol, oestrone and sex hormone bind... - 0 views

  •  
    No surprise here as genetics and environment play in a role in all disease.  Here it is hormones.  
Nathan Goodyear

Circulating estradiol is an independ... [J Clin Endocrinol Metab. 2006] - PubMed - NCBI - 0 views

  •  
    increased Total and free Estradiol associated with progression of carotid intima-media thickness in men ie. increased atherosclerosis.
Nathan Goodyear

http://circ.ahajournals.org/content/109/17/2074.full.pdf - 0 views

  •  
    lower Free Testosterone and increased Estradiol through aromatase activity is associated with increased atherosclerosis.  This was monitored with Carotid intima-media thickness.  This study found an increase associated with low free Testosterone and increased free estradiol levels independent of other CVD variables.
Nathan Goodyear

Sex steroids and cardiovascular disease Yeap BB - Asian J Androl - 0 views

  • Levels of SHBG are higher in older men, therefore levels of free T decline more steeply than total T as men's age increases.
  • calculations based on mass action equations may not reflect precisely free T measured using a reference method
  • free T declines more steeply with age than total T in both cross-sectional [35] and longitudinal studies, [36] as does free E2 in comparison to total E2
  • ...22 more annotations...
  • T may slow development of or progression of atherosclerosis by modulating effects on insulin resistance, inflammation, endothelial function, preclinical atherosclerosis or the vasculature.
  • these cross-sectional and longitudinal studies support a relationship between low circulating T with CIMT and higher E2 with its progression
  • lower levels of T are biomarkers for aortic vascular disease
  • circulating free T was negatively associated with the presence of AAA
  • luteinizing hormone (LH) was positively associated.
  • low levels of total or bioavailable T were associated with aortic atherosclerosis manifested as calcified deposits detected by radiography
  • Men with total or free T in the lowest quartile had increased adjusted ORs for PAD defined as ABI <0.90, as did men with free E2 in the highest quartile of values
  • The apparent association of SHBG with intermittent claudication reflects the correlation of total T with SHBG, while the contribution of E2 to risk of PAD remains unclear
  • men with total T in the lowest quartile of values (<11.7 nmol l−1 ) experienced an increased incidence of stroke or transient ischemic attack
  • lower total T with increased incidence of CVD events
  • cohort studies in mostly older men have supported the association of lower androgen levels with higher mortality
  • lower total or free T levels were associated with mortality in older men, but with discordant results for cause-specific mortality and for associations of E2
  • several large studies identifying lower endogenous levels of total or free T as independent predictors of all-cause or CVD-related deaths in middle-aged and older men
  • T exhibits anti-inflammatory effects, enhances flow-mediated brachial artery reactivity, and reduces arterial stiffness
  • Short-term T therapy had a beneficial effect on exercise-induced myocardial ischemia in middle-aged men with coronary artery disease or chronic stable angina, [95],[96],[97] and reduced angina frequency in older men with diabetes and coronary artery disease
  • T therapy resulted in an increase in treadmill test duration and time to ST segment depression
  • there are interventional studies supporting a protective effect of exogenous T against myocardial ischemia in men with coronary artery disease
  • employ conservative doses
    • Nathan Goodyear
       
      This dosing is 100 fold higher then peak production of a  young man at 20-22.
  • Observational studies indicate that lower levels of endogenous T in older men are associated with the presence of carotid atherosclerosis, aortic and peripheral vascular disease, and incidence of CVD events and mortality
  • Interventional studies have shown beneficial effects of exogenous T on vascular function and on exercise-induced myocardial ischemia in men with coronary artery disease
    • Nathan Goodyear
       
      the therapies employed in these studies were massively overdosed.
  •  
    Nice review of all the sex hormones and their relationship to CVD in men.  
Nathan Goodyear

The relationship between sex hormones and lipi... [Int J Cardiol. 2005] - PubMed - NCBI - 0 views

  •  
    High aromatase activity and estradiol production in men was found to be associated with elevated total cholesterol, LDL, TC:HDL, and triglycerides.  No association was found with Testosterone or SHBG.  The 111 men in this study had "stable CAD"
Nathan Goodyear

In Older Men an Optimal Plasma Testosterone Is Associated With Reduced All-Cause Mortal... - 0 views

  •  
    Older men, 70-89, Testosterone in the middle range of normal and higher DHT was associated with the lowest death rates.  Estradiol was not found to be associated.  This study only looked at Total levels, free bioavailable levels were not assessed.  This study also highlights the basic thought, that more is not always better as it pertains to Testosterone.  It also highlights the importance of DHT.  Testosterone is a pro hormone.
Nathan Goodyear

Circulating Estradiol Is an Independent Predictor of Progression of Carotid Artery Inti... - 0 views

  •  
    Increasing Estradiol is associated with an increasing carotid IMT in men.
1 - 20 of 51 Next › Last »
Showing 20 items per page