Skip to main content

Home/ Seasons Wellness/ Group items tagged disease CRP

Rss Feed Group items tagged

Nathan Goodyear

Garlic and Heart Disease - 0 views

  •  
    another positive study on Aged Garlic Extract in the treatment of hypertension, total cholesterol, and atherosclerosis.
Nathan Goodyear

C-Reactive Protein and All-Cause Mortality in a Large Hospital-Based Cohort - 0 views

  •  
    low sensitivity CRP associated with increased short-term and long-term mortality in hospitalized patients.  Also associated with a 28 fold increase in cancer mortality.
Nathan Goodyear

Clinical experience with intravenous administration of ascorbic acid: achievable levels... - 0 views

  • Patients with higher tumor markers are likely to have higher tumor burden, higher oxidative stress and, therefore, are more likely to have lower post IVC plasma levels.
  • Our data also showed that cancer patients with metastasis tend to have lower post-IVC vitamin C levels than those without metastasis
  • Lower peak plasma concentrations are obtained in cancer patients than in healthy subjects. Cancer patients who are deficient in vitamin C prior to therapy tend to achieve lower plasma levels post infusion.
  • ...23 more annotations...
  • Patients with higher inflammation or tumor burdens, as measured by CRP levels or tumor antigen levels, tend to show lower peak plasma ascorbate levels after IVC.
  • Patients with metastatic tumors tend to achieve lower post infusion plasma ascorbate levels than those with localized tumors.
  • The inflammatory microenvironment of cancer cells leads to increasing oxidative stress, which apparently depletes vitamin C, resulting in lower plasma ascorbate concentrations in blood samples post IVC infusion. Another explanation for this finding may be that cancers are themselves more metabolically active in their uptake of vitamin C, causing subjects to absorb more of the vitamin, and as a results show lower plasma ascorbate concentrations in blood post IVC infusion.
  • Most of the prostate cancer patients studied, 75 ± 19% (95% confidence), showed reductions in PSA levels during the course of their IVC therapy
  • Laboratory studies suggest that, at high concentrations, ascorbate does not interfere with chemotherapy or irradiation and may enhance efficacy in some situations
  • Cameron and Pauling observed fourfold survival times in terminal cancer patients treated with intravenous ascorbate infusions followed by oral supplementation
  • Meta-analyses of clinical studies involving cancer and vitamins also conclude that antioxidant supplementation does not interfere with the efficacy of chemotherapeutic regiments
  • patients with severely elevated CRP levels attain plasma ascorbate concentrations after IVC infusions that are only 65% of those attained for subjects with normal CRP levels
  • The finding of decreased plasma ascorbate levels in cancer patients may relate to the molecular structure of ascorbic acid; in particular, the similarity of its oxidized form, dihydroascorbic acid, to glucose
  • Since tumor have increased requirement for glucose [], transport of dehydroascorbate into the cancer cells via glucose transport molecules and ascorbate through sodium-dependent transporter may be elevated
  • Regarding inflammation, 73 ± 13% of subjects (95% confidence) showed a reduction in CRP levels during therapy. This was an even more dramatic 86 ± 13% (95% confidence) in subjects who started therapy with CRP levels above 10 mg/L
  • patients with advanced malignancies may have lower level of ascorbic acid in tissue, creating a higher demand for the vitamin C
  • IVC therapy appears to reduce CRP levels in cancer patients.
  • CRP concentrations directly correlate with disease activity in many cases and can contribute to disease progression through a range of pro-inflammatory properties.
  • Being an exquisitely sensitive marker of systemic inflammation and tissue damage, CRP is very useful in screening for organic disease and monitoring treatment responses
  • ncreases in CRP concentrations have been associated with poorer prognosis of survival in cancer patients, particularly with advance disease independent of tumor stage
  • Increased accumulation of ascorbic acid in the tumor site was supported by measurements of the level of ascorbic acid in tumors in animal experiments
  • patients treated by IVC with follow-up several year showed that suppression of inflammation in cancer patients by high-dose IVC is feasible and potentially beneficial
  • Inflammation is a marker of high cancer risk, and poor treatment outcome
  • The subjects with highly elevated CRP concentrations have a three-fold elevation “all-cause” mortality risk and a twenty-eight fold increase in cancer mortality risk
  • cancer patients may need higher doses to achieve a given plasma concentration.
  • patients with lower vitamin C levels may see more distribution of intravenously administered ascorbate into tissues and thus attain less in plasma.
  • When treating patients with IVC, the first treatment likely serves to replenish depleted tissue stores, if those subjects were vitamin C deficient at the beginning of the treatment. Then, in subsequent treatments, with increasing doses, higher plasma concentrations can be attained. On-going treatments serve to progressively reduce oxidative stress in cancer patients.
  •  
    Great review on the use of IV vitamin C in cancer and to reduce inflammation.  The article does a great job of discussing the mechanism of vitamin C therapy in cancer as well as the proposed reasons for low vitamin C in cancer patients.  The study also highlights the obstacles to rise in vitamin C levels post IV vitamin C in cancer patients.
Nathan Goodyear

Carotid artery intima-media thickness and erec... [Med Sci Monit. 2014] - PubMed - NCBI - 0 views

  •  
    The full pdf is available for free download.  ED should be used as a marker for cardiovascular disease.  This study, though small, of turkey men found low T to be a prominent feature of MetS.
Nathan Goodyear

Serum sex hormone-binding globulin and test... [Eur J Endocrinol. 2014] - PubMed - NCBI - 0 views

  •  
    SHBG positively associated with lower CVD risk profile, CRP, blood pressure, TC, triglycerides..., in young men.  This was found independent of Testosterone.  This is similar to a lot of the research on Metabolic Syndrome as well.
Nathan Goodyear

Preventing Chronic Disease | Plasma Vitamin D and Biomarkers of Cardiometabolic Disease... - 0 views

  •  
    Higher vitamin D levels associated with lower cardio biomarkers: insulin, insulin resistance, triglycerides, TC, LDL and TC:HDL.  Not found to be associated: glucose, apoliporotein A1 and B, CRP, fibrinogen, and homocysteine.
Nathan Goodyear

Weight Loss Reduces C-Reactive Protein Levels in Obese Postmenopausal Women - 0 views

  •  
    Weight loss in postmenopausal women reduces crp levels.  Translated: weight loss reduces fat induced inflammation and thus Cardiovascular disease.
Nathan Goodyear

Low vitamin C levels may raise heart failure patients' risk / American Heart Association - 0 views

  •  
    patients with heart failure and low vitamin C levels have higher inflammation as measured by hs-CRP and elevated risk of worse outcomes
Nathan Goodyear

Systemic inflammation, metabolic syndrome and progressive renal disease - 0 views

  •  
    metabolic syndrome = systemic inflammation
Nathan Goodyear

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease,... - 0 views

  •  
    Homocysteine elevation increases CAD risk
Nathan Goodyear

Low Testosterone and High C-Reactive Protein Concentrations Predict Low Hematocrit in T... - 0 views

  • In these patients, hematocrit is also inversely related to CRP concentration.
  •  
    low T associated with elevated CRP and thus increased cardiovascular risk
Nathan Goodyear

C-reactive protein, the metabolic syndrome, and pr... [Circulation. 2004] - PubMed result - 0 views

  • Elevated CRP levels are related to insulin resistance and the presence of the MetS, especially in women
  • both CRP and MetS are independent predictors of new CVD events.

  •  
    elevated CRP helps predict metabolic syndrome and cardiovascular disease
Nathan Goodyear

Serum C-reactive protein is an independent risk fa... [Metabolism. 2008] - PubMed result - 0 views

  •  
    CRP is an independent predictor of metabolic syndrome and  cardiovascular disease
Nathan Goodyear

Kidney International - Abstract of article: Inflammation enhances cardiovascular risk a... - 0 views

  •  
    Inflammation (point 5 of 5 points of wellness) increases CRP, which increases cardiovascular risk
Nathan Goodyear

C-Reactive Protein as a Cardiovascular Risk Factor : More Than an Epiphenomenon? -- Lag... - 0 views

  • CRP constitutes an independent cardiovascular risk factor
  •  
    CRP is an independent marker for future cardiovascular disease
1 - 15 of 15
Showing 20 items per page