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Nathan Goodyear

Testosterone Levels and Sexual Function Disorders ... [J Sex Med. 2013] - PubMed - NCBI - 0 views

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    Interesting finding in this study. They looked at Total Testosterone and bioavailable Testosterone and found that antidepressant therapy increased both values post treatment.  This is counter to what has been readably seen in men--with a decline.  The abstract here does not point disclose the actual Testosterone numbers.  I wonder if the well known disruption of the CYP enzymes by antidepressants slowed clearance and increased Testosterone levels.  This study did not look at other hormones or inflammatory cytokines.  Very tunneled vision study.  Nothing can be drawn from this study.
Nathan Goodyear

Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy -... - 0 views

  • According to the published literature, it appeared that 94% of the trials conducted were positive. By contrast, the FDA analysis showed that 51% were positive
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    NEJM reanalyzed the results from 12 antidepressant studies involving over 12,000 patients and found that 40% of studies that found no benefit for antidepressants were omitted.  This seriously altered the statistics and is obvious manipulation of data.  This brings the current recommendations on antidepressants into serious question.
Nathan Goodyear

Active placebos versus antidepressants for depression - The Cochrane Library - Moncrief... - 0 views

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    cochrane review of 9 studies involving 751 patients, shows little difference between antidepressants and "active placebos".  The two groups both improved mood, but there was very little difference between the 2.  Take home: "...the effects of antidepressants my be generally overestimated..."
Nathan Goodyear

Are antidepressants as effective as claimed... [Can J Psychiatry. 2007] - PubMed - NCBI - 0 views

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    Editorial from Dr. Moncrieff.  The title of the editorial tells you everything you need to know.  
Nathan Goodyear

J Clin Psychiatry / Document Archive - 0 views

  • This trial of urban MDD patients failed to confirm that either active treatment was better than placebo
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    study reveals that antidepressants no better than placebo. This study was sponsored by the National Institute of Mental Health.  
Nathan Goodyear

Serotonin transporter occupancy of five selective ... [Am J Psychiatry. 2004] - PubMed ... - 0 views

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    SSRI's and serotonin transporter effect
Nathan Goodyear

Imaging the serotonin transporter during major depressive disorder and antidepressant t... - 0 views

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    serotonin transporters, SERT, major depression and antidepressant treatment
Nathan Goodyear

Depression and risk of sudden cardiac death and co... [J Am Coll Cardiol. 2009] - PubMe... - 0 views

  • Although antidepressant use might be a marker of worse depression, its specific association with SCD merits further study.

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    antidepressants increase sudden cardiac death and are marker for worse depression
Nathan Goodyear

Oral S-adenosylmethionine in depression: a randomi... [Am J Psychiatry. 1990] - PubMed ... - 0 views

  • The results suggest that oral S-adenosylmethionine is a safe, effective antidepressant with few side effects and a rapid onset of action
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     100 studies show SAMe is as effective/more effective than anti-depressants; just one such study
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