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Nathan Goodyear

OASIS - 0 views

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    I look forward to the published results of this study as this abstract references the WHI as the "same entry" criteria.  I imagine the HRT would be the same too, but will wait to see.  There is a serious problem with proper reporting of synthetic estrogens as bioidentical estrogens and synthetic progestins as bioidentical progesterone;  Also, what is the dosage. Most individuals are massively overdosed.  This study was said to be a "landmark".  Could just be don't use synthetic hormones: which is what the WHI said.
Nathan Goodyear

The effects of compounded bioident... [Int J Pharm Compd. 2013 Jan-Feb] - PubMed - NCBI - 1 views

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    3 year study finds improvement in classic menopausal symptoms for women in perimenopause and menopause with improvement in other parameters: fasting glucose, cholesterol, MMP-9, CRP, fibrinogen and other clotting factors.  This study used bioidentical Bi-est, progesterone, and in some DHEA and Testosterone.
Nathan Goodyear

Study Finds Estrogen Therapy Improves Depression and Anxiety in Recently Menopausal Wom... - 0 views

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    Estrogen therapy in women recently postmenopausal, found to improve symptoms of depression and anxiety.  The mean age of women in this study was 52.7.  Average age of menopause is 51, so apprx 1 year postmenopausal in this study.  Both premarin and bioidentical estradiol was used in different arms of the study.  Bioidentical progesterone was used in all 3 arms.
Nathan Goodyear

Equine Estrogens Impair Nitric Oxide Production and Endothelial Nitric Oxide ... - 0 views

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    This is the perfect study to compare synthetic, unnatural hormones with bioidentical hormones.  Premarin was compared with bioidentical estradiol.  Premarin reduced the endothelial NO synthase transcription and activity by 30-50% compared to Estradiol.   Thus, premarin results in a lower NO production and thus greater endothelial dysfunction compared to Estradiol.
Nathan Goodyear

A randomized, controlled trial comparing the efficacy and safety of aqueous subcutaneou... - 0 views

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    Bioidentical progesterone used in IVF.  This is not new, the SQ administration is.  So, physicians cry against BHRT, yet bioidentical progesterone has been used for years in the treatment of infertility.
Nathan Goodyear

Physiologic progesterone reduces mitochondrial dysfunction and hippocampal cell loss af... - 0 views

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    Bioidentical progesterone shown to reduce post TBI mitochondrial dysfunction. This has significant implications on the ability of the damaged brain to heal and recover, thus limiting post-injury cognitive deficits.
Nathan Goodyear

Improved outcomes from the administrati - PubMed Mobile - 0 views

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    bioidentical progesterone shown to improve outcomes for up to 6 months in those with traumatic brain injuries (TBI).  That is decreased mortality and less cognitive deficits
Nathan Goodyear

JAMA Network | Archives of Internal Medicine | Combined Estrogen and Testosterone Use a... - 0 views

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    this study revealed increased breast cancer risk in women on "estrogen" and "testosterone" therapy.  Now, several problems here: first, are these synthetic hormone or bioidentical.  Second, the dosages appear, in what is written, to be supra physiologic.  Third, giving supra physiologic estradiol and testosterone will obviously create imbalances and growth potential.  Fourth, how were the women evaluated prior to starting hormone therapy and then were they remonitered (unlikely), fifth, were hormone metabolites evaluated (too, also unlikely).  This study has serious flaws and very little can be extrapolated other than: don't take supra physiologic hormone levels without appropriate evaluation.  Enough said
Nathan Goodyear

Comparison of the efficacy of micronized... [Arch Gynecol Obstet. 2014] - PubMed - NCBI - 0 views

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    Study compared bioidentical progesterone (micronized progesterone) to a synthetic progestin in the inhibition of endometrial hyperplasia progression.  The study found that the synthetic progestin worked best, but they both inhibited progression of the endometrial hyperplasia when followed out to 3 months therapy.
Nathan Goodyear

Bioidentical Hormones: An Evidence-Based Review for Primary Care Providers - 0 views

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    Bioidentical hormones (BHRT) preferred over HRT. 
Nathan Goodyear

Pregnancy, progesterone and progestins in relation... [J Steroid Biochem Mol Biol. 2005... - 0 views

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    Bioidentical Progesterone does not increase breast cancer risk
Nathan Goodyear

Transdermal progesterone cream as an alternative p... [Altern Ther Health Med. 2005 Nov... - 0 views

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    patients prefer bioidentical progesterone vs. provera.  Both shown to protect the endometrium
Nathan Goodyear

Hormone therapy and Alzheimer disease dementia: Ne... [Neurology. 2012] - PubMed - NCBI - 0 views

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    study finds that HRT given as women transition through menopause has benefiical effect in people with Alzheimer's.  However, when given years later, after menopause, no benefit is found.  In fact, rates increased.  Several flaws with this study.  First, they used synthetic hormones, particularily progestins.  Second, there seems to be no thought that the interpretation of the signal  has changed.  For example, we know that when men have low T, their estrogen receptor status changes from ER beta to ER alpha, which is more proinflammatory.  Third, use bioidentical hormones and compare these to synthetic hormones.
Nathan Goodyear

BMC Women's Health | Full text | Effectiveness of Compounded Bioidentical Hormone Repla... - 0 views

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    Cohort study of 6 compounding pharmacies find BHRT improves mood in those clients taking BHRT.
Nathan Goodyear

Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain i... - 0 views

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    Abstract on listed here: but bioidentical progesterone and allopregnanolone (product of progesterone metabolism) shown to reduce inflammation after TBI.  This inflammation is what results in much of the post-TBI complications.
Nathan Goodyear

JAMA Network | JAMA | Estrogen Plus Progestin and the Incidence of Dementia a... - 0 views

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    Estrogen with progestin worsens cognitive decline in women >65.  Little can be taken from this study other than, medroxyprogesterone acetate is a bad drug and should not be given to women for any purpose, especially in those >65.  One wonders if bioidentical, physiologic hormone replacement would have the same effect?  I doubt it.  The likely negative impact of hormones on the brain in women >65 is due to the negative effects of MPA, the change in inflammatory cytokines, and the change in receptors.
Nathan Goodyear

Medroxyprogesterone interferes with ovarian steroid ... [Nat Med. 1997] - PubMed - NCBI - 0 views

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    head to head study in rhesus monkeys finds that medroxyprogesterone acetate negates the positive vascular effects of estradiol.  This is in contrast to the bioidentical progesterone.
Nathan Goodyear

Breast cancer risk in relation to different types ... [Int J Cancer. 2005] - PubMed result - 0 views

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    bioidentical progesterone lowers breast cancer risk; synthetic progestins increase breast cancer risk
Nathan Goodyear

Comparison of regimens containing oral micronized ... [J Womens Health Gend Based Med. ... - 0 views

  • Approximately 80% of women reported overall satisfaction with the micronized progesterone-containing regimen. A micronized progesterone-containing HRT regimen offers the potential for improved QOL as measured by improvement of menopause-associated symptoms.
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    watch out!  bioidentical progesterone provides improved symptom control versus synthetic progestin MPA
Nathan Goodyear

Postmenopausal Hormone Therapy and Risk of Idiopathic Venous Thromboembolism: Results F... - 0 views

  • Transdermal estrogens alone or combined with progesterone might be safe with respect to thrombotic risk.
  • Oral but not transdermal estrogens were associated with an increased thrombotic risk
  • There was no significant association of venous thromboembolism with progesterone
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    bioidentical hormones do not increase stroke risk; also, route of delivery impacts stroke risk
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