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Nathan Goodyear

Effect of high dose intravenous ascorbic acid on the level of inflammation in patients ... - 0 views

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    This study, small pilot, showed that they were able to lower inflammation in those suffering from RA, through high dose vitamin C IV therapy. This study stopped at 25 gms. The vitamin C is a scavenger of ROS and ROS stimulates inflammation through NF-kappaB. This is how vitamin C can reduce inflammation.
Nathan Goodyear

Increased extracellular levels of ascorbate in the striatum after middle cerebral arter... - 0 views

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    vitamin C released in the brain with an ischemic stroke.  Question: is this a way to provide scavenger for free radicals following a stroke?
Nathan Goodyear

Effect of supplementation of vi... [J Nutr Sci Vitaminol (Tokyo). 2001] - PubMed - NCBI - 0 views

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    vitamin C inhibits acetylcholinesterase.  This will increase acetylcholine and thus can play a role in Alzheimer's disease.  People with Alzheimers disease have low levels of Vitamin C.  Vitamin C shown to improve memory in Alzheimer's mouse model.
Nathan Goodyear

Interaction Between Ascorbic Acid and Dopamine D2 Receptor in the Nucleus Accumbens She... - 0 views

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    vitamin C shown to interact with dopamine receptors and decrease food intake.
Nathan Goodyear

A radical approach to stroke therapy - 0 views

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    vitamin C shown to benefit stroke patients.  Vitamin C, ascorbic acid, is extremely prevalent in the brain.  Functions to scavenge free radicals
Nathan Goodyear

SYNTHESIS AND SOME MAJOR FUNCTIONS OF VITAMIN C IN ANIMALS* - Chatterjee - 2006 - Annal... - 0 views

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    major functions of vitamin C discussed
Nathan Goodyear

Septic impairment of capillary blood flow requires NADPH oxidase but not NOS and is rap... - 0 views

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    IV vitamin C and BH4 shown to resolve blood flow restriction in Sepsis rat model.  Again, revealing the benefits of not only vitamin C, but IV vitamin C.
Nathan Goodyear

Ascorbic Acid infusion in the resuscitation of burn patients - 0 views

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    review of the literature and scientific evidence finds high dose IV vitamin C to be beneficial in burn patients. Additionally, glucose testing (not serum) should be considered inaccurate for upto 36 hours following IV.
Nathan Goodyear

JTM | Full text | Intravenous ascorbic acid to prevent and treat cancer-associated sepsis? - 0 views

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    Cancer patients are depeleted of vitamin C.  IV vitamin C is suggested as a therapy to treat sepsis or SIRS in those individuals with cancer.
Nathan Goodyear

Alternative Medicine Review - A Journal of Clinical Therapeutics - 0 views

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    Study reveals decreased ant-tumor activity with IV vitamin C when Vitamin B's are added to IV solution.
Nathan Goodyear

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a p... - 0 views

  • Taken together, these data indicate that ascorbate at concentrations achieved only by i.v. administration may be a pro-drug for formation of H2O2, and that blood can be a delivery system of the pro-drug to tissues.
  • These findings give plausibility to i.v. ascorbic acid in cancer treatment, and have unexpected implications for treatment of infections where H2O2 may be beneficial
  • pharmacologic concentrations of ascorbate killed cancer but not normal cells, that cell death was dependent only on extracellular but not intracellular ascorbate, and that killing was dependent on extracellular hydrogen peroxide (H2O2) formation with ascorbate radical as an intermediate
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  • Our data show that ascorbic acid selectively killed cancer but not normal cells, using concentrations that could only be achieved by i.v. administration
  • Ascorbate-mediated cell death was due to protein-dependent extracellular H2O2 generation, via ascorbate radical formation from ascorbate as the electron donor. Like glucose, when ascorbate is infused i.v., the resulting pharmacologic concentrations should distribute rapidly in the extracellular water space (42). We showed that such pharmacologic ascorbate concentrations in media, as a surrogate for extracellular fluid, generated ascorbate radical and H2O2. In contrast, the same pharmacologic ascorbate concentrations in whole blood generated little detectable ascorbate radical and no detectable H2O2. These findings can be accounted for by efficient and redundant H2O2 catabolic pathways in whole blood (e.g., catalase and glutathione peroxidase) relative to those in media or extracellular fluid
  • ascorbic acid administered i.v. in pharmacologic concentrations may serve as a pro-drug for H2O2 delivery to the extracellular milieu
  • H2O2 generated in blood is normally removed by catalase and glutathione peroxidase within red blood cells, with internal glutathione providing reducing equivalents
  • The electron source for glutathione is NADPH from the pentose shunt, via glucose-6-phosphate dehydrogenase. If activity of this enzyme is diminished, the predicted outcome is impaired H2O2 removal causing intravascular hemolysis, the observed clinical finding.
  • Only recently has it been understood that the discordant clinical findings can be explained by previously unrecognized fundamental pharmacokinetics properties of ascorbate
  • Intracellular transport of ascorbate is tightly controlled in relation to extracellular concentration
  • Intravenous ascorbate infusion is expected to drastically change extracellular but not intracellular concentrations
  • For i.v. ascorbate to be clinically useful in killing cancer cells, pharmacologic but not physiologic extracellular concentrations should be effective, independent of intracellular ascorbate concentrations.
  • It is unknown why ascorbate, via H2O2, killed some cancer cells but not normal cells.
  • There was no correlation with ascorbate-induced cell death and glutathione, catalase activity, or glutathione peroxidase activity.
  • H2O2, as the product of pharmacologic ascorbate concentrations, has potential therapeutic uses in addition to cancer treatment, especially in infections
  • Neutrophils generate H2O2 from superoxide,
  • i.v. ascorbate is effective in some viral infections
  • H2O2 is toxic to hepatitis C
  • Use of ascorbate as an H2O2-delivery system against sensitive pathogens, viral or bacterial, has substantial clinical implications that deserve rapid exploration.
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    IV vitamin C benefits cancer patients
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