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Nathan Goodyear

Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity - 0 views

lup.sagepub.com/...635.short

aromatase testosterone estrogen estradiol IL-6 TNF-alpha IL-1 autoimmune disease inflammation inflammatory cytokines men hormones immune system

shared by Nathan Goodyear on 29 Apr 12 - No Cached
  • Nathan Goodyear on 29 Apr 12
     
    high conversion of testosterone to estrogen conversion in men is from increased aromatase activity.  Inflammatory cytokines, such as IL-6, TNF-alpha, has been shown to increase aromatase activity and at the same time increase IL-6 and other inflammatory cytokines is the result of increased aromatase activity.
Nathan Goodyear

Full Text: Editorial - 0 views

jrheum.com/...419.html

aromatase activity testosterone estrogen autoimmune disease lupus RA inflammation inflammatory cytokines IL-6 TNF-alpha IL-1 men women hormones

shared by Nathan Goodyear on 29 Apr 12 - No Cached
  • Nathan Goodyear on 29 Apr 12
     
    high aromatase activity and conversion of testosterone to estrogen conversion plays a role in lupus and RA.  Inflammatory cytokines are shown to increase aromatase activity.
Nathan Goodyear

Therapeutic Testosterone Administration Preserves Excitatory Synaptic Transmission in t... - 0 views

www.jneurosci.org/...12312.long

Testosterone polyneuropathy MS multiple Sclerosis Estriol hormones autoimmune disease

shared by Nathan Goodyear on 17 Mar 15 - No Cached
  • direct androgen receptor activation is not a mutually exclusive requirement of testosterone-mediated neuroprotection.
  • Testosterone treatment after EAE induction restores synaptic transmission and corresponding synaptic protein levels within the hippocampus during EAE
  • A growing body of evidence suggests that testosterone enhances hippocampal synaptogenesis
  • ...7 more annotations...
  • This study demonstrates that testosterone treatment either before or after EAE disease induction partially restores deficits in synaptic transmission, preserves presynaptic and postsynaptic integrity, and prevents hippocampal pathology.
  • treatment with a pregnancy estrogen, estriol, can prevent deficits in excitatory synaptic transmission in the hippocampus during EAE
  • testosterone is important to the maintenance of normal synaptic spine density in the hippocampus
  • estriol treatment was also capable of preserving levels of synaptic proteins that are known to orchestrate functional synaptic transmission within the hippocampus.
  • Estriol is a therapeutic candidate in MS because it has widespread effects on the immune system and the CNS
  • MS patients have significantly decreased relapse rates during the third trimester of pregnancy, when estriol levels are most elevated, and relapse rates rebound during the postpartum period coinciding with an abrupt decline in serum estriol levels
  • In nonpregnant MS patients, estriol treatment has been shown to significantly reduce gadolinium-enhancing lesion number and volumes measured by MRI
  • Nathan Goodyear on 17 Mar 15
     
    Testosterone restores/preserves nerve synapsis within the hippocampus in autoimmune demyelinating disease.  Testosterone appears to have neuroprotection.  The authors conclude that the majority of the protective effect was through aromatase activity.
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