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Nathan Goodyear

Acute and delayed effects of a single-dose inject... [Metabolism. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9781636

TSH thyroid TSH suppression IL-6 cytokine inflammation inflammatory

shared by Nathan Goodyear on 01 Feb 13 - No Cached
  • Nathan Goodyear on 01 Feb 13
     
    IL-6 is known to stimulate the HPA and increase cortisol production.  Both, IL-6 and cortisol can decrease TSH production.
Nathan Goodyear

Activation of the hypothalamo-pituitary-a... [Intensive Care Med. 1999] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10660848

TSH TSH suppression thyroid inflammation inflammatory cytokines IL-1Beta IL-6 TNF-alpha

shared by Nathan Goodyear on 01 Feb 13 - No Cached
  • Nathan Goodyear on 01 Feb 13
     
    Septic illnesses found to be associated with suppression of TSH centrally in the HPA axis. The cytokines found to be elevated were IL-1beta, TNF-alpha, and IL-6.
Nathan Goodyear

Biology of Cachexia - 0 views

jnci.oxfordjournals.org/...1763.full

cachexia cancer metabolism TNF-alpha IL-1 IL-6

shared by Nathan Goodyear on 03 Jul 13 - No Cached
  • Nathan Goodyear on 03 Jul 13
     
    Another good review on the metabolism of cancer.  But, this article touches on the cachexia effects from cancer.  Inflammatory cytokines TNF-alpha, IL-1, IL-6 play role in these decreased appetite and weight loss symptoms.
Nathan Goodyear

Obesity - Dietary Capsaicin Reduces Obesity-induced Insulin Resistance and Hepatic Stea... - 0 views

www.nature.com/...oby2009301a.html

obesity overweight capsaicin curcumin inflammation insuiln resistance IR cytokines adipocytokines IL-1B IL-6 TNF-alpha MCP-1

shared by Nathan Goodyear on 19 Mar 12 - No Cached
  • Nathan Goodyear on 19 Mar 12
     
    This study looks at the effects of capsaicin on inflammation and obesity.  Capsaicin decreases IL-1B, IL-6, TNF-alpha and MCP-1.  This reduces insulin and leptin levels, as well as increase adiponectin activity.  This article also briefly discusses curcumin, which has similar activity.
Nathan Goodyear

Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes - 0 views

diabetes.diabetesjournals.org/...812.full

inflammation inflammatory IL-1B IL-6 TNF-alpha diabetes Type II makers

shared by Nathan Goodyear on 20 Dec 11 - No Cached
  • Nathan Goodyear on 20 Dec 11
     
    elevated  inflammatory markers, IL-1B, IL-6, and TNF-alpha, found to be associated with the development of type II Diabetes.
Nathan Goodyear

Cordycepin Suppresses Expression of Diabetes Regulating Genes by Inhibition of Lipopoly... - 0 views

www.ncbi.nlm.nih.gov/...PMC2803303

cordyceps LPS inflammtion obesity DM Diabetes IL-1beta IL-6 TNF-alpha NF-KappaB

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • Nathan Goodyear on 19 Jan 12
     
    cordyceps shown to decrease LPS stimulated macrophage inflammation.  Specifically, IL-1Beta, IL-6, TNF-alpha were shown to be inhibited.  Also, NF-kappaB inhibition was found with cordyceps
Nathan Goodyear

IOS Press - Journal Article - 0 views

iospress.metapress.com/...vux3g01201610607

neuroinflammation excitotoxicity inflammation air pollution air pollution Alzheimer's disease IL-6 IL-1 TNF-alpha IFN-gamma

shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    neuroinflammaiton, also described as excitotoxicity, found in the brains of children/young adults that lived in high air pollution areas.  Neuroinflammation (IL-6, IL-1, TNF-alpha, IFN-gamma...) found in the brains of these children and young adults.  This is the same process found in Alzheimers and other excitotoxicity disease states.  Addtionally, it is also involved in most chronic diseases of aging.
Nathan Goodyear

Proinflammatory cytokines inhibit the expre... [Eur J Endocrinol. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11916626

inflammation cytokines cytokine IL-1beta IL-6 TNF-alpha thyroid hypothyroid hypothyroidism deiodinase

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    inflammatory cytokine IL-1beta reduced deiodinase transcription, thus reducing T4 to T3 conversion.  The inflammatory cytokines TNF-alpha and IL-6 did also but to a lesser degree.
Nathan Goodyear

Chronic Inflammation and Cytokines in the Tumor Microenvironment - 0 views

www.hindawi.com/...149185

inflammation cytokines tumor cancer inflammatory IL-6 IL-10 TNF-alpha

shared by Nathan Goodyear on 26 Jun 15 - No Cached
  • Nathan Goodyear on 26 Jun 15
     
    Acute inflammation is a response to an alteration induced by a pathogen or a physical or chemical insult, which functions to eliminate the source of the damage and restore homeostasis to the affected tissue. However, chronic inflammation triggers cellular events that can promote malignant transformation of cells and carcinogenesis. Several inflammatory mediators, such as TNF-α, IL-6, TGF-β, and IL-10, have been shown to participate in both the initiation and progression of cancer. In this review, we explore the role of these cytokines in important events of carcinogenesis, such as their capacity to generate reactive oxygen and nitrogen species, their potential mutagenic effect, and their involvement in mechanisms for epithelial mesenchymal transition, angiogenesis, and metastasis. Finally, we will provide an in-depth analysis of the participation of these cytokines in two types of cancer attributable to chronic inflammatory disease: colitis-associated colorectal cancer and cholangiocarcinoma.
Nathan Goodyear

Expression of proinflammatory genes during estrogen-induced inflammation of the rat pro... - 0 views

www.ncbi.nlm.nih.gov/...10861753

inflammation IL-1beta IL-6 MIP-2 cytokines prostate estrogen estradiol male hormones

shared by Nathan Goodyear on 15 Sep 15 - No Cached
  • Nathan Goodyear on 15 Sep 15
     
    Estrogen increased IL-1beta, IL-6, and MIP-2 in male rat prostate model.
Nathan Goodyear

Kolaviron and selenium reduce hydrogen peroxide-induced alterations of the inflammatory... - 0 views

www.ncbi.nlm.nih.gov/...PMC6353656

selenium TNF-alpha inflammation IL-1 IL-6

shared by Nathan Goodyear on 30 May 20 - No Cached
  • Nathan Goodyear on 30 May 20
     
    selenium reduces inflammatory signaling i.e. IL-1, IL-6...
Nathan Goodyear

Elevated serum interleukin-6 and decreased thyroid hormone levels in postoperative pati... - 0 views

pubmed.ncbi.nlm.nih.gov/9001195

thyroid hormones T3 IL-6

shared by Nathan Goodyear on 04 Feb 21 - No Cached
  • Nathan Goodyear on 04 Feb 21
     
    IL-6 decreases T3
Nathan Goodyear

Epigallocatechin-3-gallate ameliorates experimental autoimmune encephalomyelitis by alt... - 0 views

www.researchgate.net/...lance_among_CD4_T-cell_subsets

EGCG epigallocatechin-3-gallate autoimmune disease MS cytokine cytokines inflammation

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    EGCG found to reduce cytokine production in animal model of MS, experimental autoimmune encephalomyelitis.  Specifically, EGCG reduced interferon gamma, IL017, IL-6, IL-1beta, TNF-alpha and decreased Th1 and Th17 cells with an increase in Treg cells.
Nathan Goodyear

Testosterone: a metabolic hormone in health and disease - 0 views

joe.endocrinology-journals.org/...R25.full

male hormone hormones testosterone hypogonadal-obesity-adipocytokine hypothesis

shared by Nathan Goodyear on 08 May 13 - No Cached
  • E2 and the inflammatory adipocytokines tumour necrosis factor α (TNFα) and interleukin 6 (IL6) inhibit hypothalamic production of GNRH and subsequent release of LH and FSH from the pituitary
  • Leptin, an adipose-derived hormone with a well-known role in regulation of body weight and food intake, also induces LH release under normal conditions via stimulation of hypothalamic GNRH neurons
  • In human obesity, whereby adipocytes are producing elevated amounts of leptin, the hypothalamic–pituitary axis becomes leptin resistant
  • ...39 more annotations...
  • there is evidence from animal studies that leptin resistance, inflammation and oestrogens inhibit neuronal release of kisspeptin
  • Beyond hypothalamic action, leptin also directly inhibits the stimulatory action of gonadotrophins on the Leydig cells of the testis to decrease testosterone production; therefore, elevated leptin levels in obesity may further diminish androgen status
  • Prostate cancer patients with pre-existing T2DM show a further deterioration of insulin resistance and worsening of diabetic control following ADT
  • ADT for the treatment of prostatic carcinoma in some large epidemiological studies has been shown to be associated with an increased risk of developing MetS and T2DM
  • Non-diabetic men undergoing androgen ablation show increased occurrence of new-onset diabetes and demonstrate elevated insulin levels and worsening glycaemic control
  • increasing insulin resistance assessed by glucose tolerence test and hypoglycemic clamp was shown to be associated with a decrease in Leydig cell testosterone secretion in men
  • The response to testosterone replacement of insulin sensitivity is in part dependent on the androgen receptor (AR)
  • Low levels of testosterone have been associated with an atherogenic lipoprotein profile, characterised by high LDL and triglyceride levels
  • a positive correlation between serum testosterone and HDL has been reported in both healthy and diabetic men
  • up to 70% of the body's insulin sensitivity is accounted for by muscle
  • Testosterone deficiency is associated with a decrease in lean body mass
  • relative muscle mass is inversely associated with insulin resistance and pre-diabetes
  • GLUT4 and IRS1 were up-regulated in cultured adipocytes and skeletal muscle cells following testosterone treatment at low dose and short-time incubations
  • local conversion of testosterone to DHT and activation of AR may be important for glucose uptake
  • inverse correlation between testosterone levels and adverse mitochondrial function
  • orchidectomy of male Wistar rats and associated testosterone deficiency induced increased absorption of glucose from the intestine
  • (Kelley & Mandarino 2000). Frederiksen et al. (2012a) recently demonstrated that testosterone may influence components of metabolic flexibility as 6 months of transdermal testosterone treatment in aging men with low–normal bioavailable testosterone levels increased lipid oxidation and decreased glucose oxidation during the fasting state.
  • Decreased lipid oxidation coupled with diet-induced chronic FA elevation is linked to increased accumulation of myocellular lipid, in particular diacylglycerol and/or ceramide in myocytes
  • In the Chang human adult liver cell line, insulin receptor mRNA expression was significantly increased following exposure to testosterone
  • Testosterone deprivation via castration of male rats led to decreased expression of Glut4 in liver tissue, as well as adipose and muscle
  • oestrogen was found to increase the expression of insulin receptors in insulin-resistant HepG2 human liver cell line
  • FFA decrease hepatic insulin binding and extraction, increase hepatic gluconeogenesis and increase hepatic insulin resistance.
  • Only one, albeit large-scale, population-based cross-sectional study reports an association between low serum testosterone concentrations and hepatic steatosis in men (Völzke et al. 2010)
  • This suggests that testosterone may confer some of its beneficial effects on hepatic lipid metabolism via conversion to E2 and subsequent activation of ERα.
  • hypogonadal men exhibiting a reduced lean body mass and an increased fat mass, abdominal or central obesity
  • visceral adipose tissue was inversely correlated with bioavailable testosterone
  • there was no change in visceral fat mass in aged men with low testosterone levels following 6 months of transdermal TRT, yet subcutaneous fat mass was significantly reduced in both the thigh and the abdominal areas when analysed by MRI (Frederiksen et al. 2012b)
  • ADT of prostate cancer patients increased both visceral and subcutaneous abdominal fat in a 12-month prospective observational study (Hamilton et al. 2011)
  • Catecholamines are the major lipolysis regulating hormones in man and regulate adipocyte lipolysis through activation of adenylate cyclase to produce cAMP
  • deficiency of androgen action decreases lipolysis and is primarily responsible for the induction of obesity (Yanase et al. 2008)
  • may be some regional differences in the action of testosterone on subcutaneous and visceral adipose function
  • proinflammatory adipocytokines IL1, IL6 and TNFα are increased in obesity with a downstream effect that stimulates liver production of CRP
  • observational evidence suggests that IL1β, IL6, TNFα and CRP are inversely associated with serum testosterone levels in patients
  • TRT has been reported to significantly reduce these proinflammatory mediators
  • This suggests a role for AR in the metabolic actions of testosterone on fat accumulation and adipose tissue inflammatory response
  • testosterone treatment may have beneficial effects on preventing the pathogenesis of obesity by inhibiting adipogenesis, decreasing triglyceride uptake and storage, increasing lipolysis, influencing lipoprotein content and function and may directly reduce fat mass and increase muscle mass
  • Early interventional studies suggest that TRT in hypogonadal men with T2DM and/or MetS has beneficial effects on lipids, adiposity and parameters of insulin sensitivity and glucose control
  • Evidence that whole-body insulin sensitivity is reduced in testosterone deficiency and increases with testosterone replacement supports a key role of this hormone in glucose and lipid metabolism
  • Impaired insulin sensitivity in these three tissues is characterised by defects in insulin-stimulated glucose transport activity, in particular into skeletal muscle, impaired insulin-mediated inhibition of hepatic glucose production and stimulation of glycogen synthesis in liver, and a reduced ability of insulin to inhibit lipolysis in adipose tissue
  • Nathan Goodyear on 08 May 13
     
    Great review of the Hypogonadal-obesity-adipocytokine hypothesis.
Nathan Goodyear

Testosterone supplementation in aging men and women: possible impact on cardiovascular-... - 0 views

ajprenal.physiology.org/...F941.full

low T low testosterone kidney kidneys therapy testosterone hormone hormones

shared by Nathan Goodyear on 05 Mar 13 - No Cached
  • Nathan Goodyear on 05 Mar 13
     
    This study proposes that testosterone therapy aids in renal dysfunction in men.  However, they document that IL-6 and TNF-alpha and oxidative stress are a part of this process. What they fail to mention is that aromatase activity and conversion of T to E in men increases IL-6 and TNF-alpha.  Studies have also shown that T decreases TNF-alpha. Very likely, it is high aromatase activity causing the effects documented by this study.
Nathan Goodyear

IL-6 in autoimmune diseas... [Cytokine Growth Factor Rev. 2002 Aug-Oct] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12220549

IL-6 autoimmune disease inflammation

shared by Nathan Goodyear on 28 Apr 12 - No Cached
  • Nathan Goodyear on 28 Apr 12
     
    IL-6 over expression associated with autoimmune disease.
Nathan Goodyear

Low Cortisol, High DHEA, and High Levels of Stimulated TNFα, and IL-6 in Wome... - 0 views

www.ncbi.nlm.nih.gov/...PMC2829297

PTSD cortisol DHEA saliva salivary hormone testing evaluation TNF-alpha IL-6

shared by Nathan Goodyear on 03 Feb 12 - No Cached
  • Nathan Goodyear on 03 Feb 12
     
    low cortisol pattern with elevated DHEA found in women with PTSD.  Additionally, elevated levels of TNF-alpha and IL-6 were found. Hormone evaluation was tested through saliva.
Nathan Goodyear

IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while prom... - 0 views

europepmc.org/3083773

rT3 reverse T3 T3 thyroid deiodinase-3 inflammation IL-6 thyroid hormones T4

shared by Nathan Goodyear on 04 Feb 21 - No Cached
  • Nathan Goodyear on 04 Feb 21
     
    IL-6 decreases deiodinase type I and 2; but increases type 3. The result is an increase in rT3 and in cancer-growth.
Nathan Goodyear

Sodium selenite inhibits the expression of VEGF, TGFβ1 and IL-6 induced by LP... - 0 views

www.sciencedirect.com/...S1567576909003129

IL-6 NF-kappaB VEGF cancer selenium

shared by Nathan Goodyear on 30 May 20 - No Cached
  • Nathan Goodyear on 30 May 20
     
    selenium inhibits NF-kappaB and IL-6 amongs a few things. The implicates its efficacy in cancer treatment.
Nathan Goodyear

SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II ... - 0 views

journals.plos.org/...article

spike protein spike proteins IL-6 inflammation cytokine storm SARS-CoV-2

shared by Nathan Goodyear on 17 Dec 21 - No Cached
  • Nathan Goodyear on 17 Dec 21
     
    SARS-CoV-2 induces increase in IL-6; can anyone say cytokine storm which causes metastasis.
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