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Nathan Goodyear

Late-Onset Hypogonadism and Mortality in Aging Men: The Journal of Clinical Endocrinolo... - 0 views

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    severe hypogonadism was associated with a 5 fold increase risk of cardiovascular mortality and all cause mortality in men ages 40-79 in European study.
Nathan Goodyear

Effects of Testosterone and Growth Hormone on the Structural and Mechanical Properties ... - 0 views

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    IN men with low Testosterone, Testosterone therapy improved trabecular bone, but not cortical bone.  Growth hormone provided no additional benefit.  This study looked at men with panhypopituitarism.
Nathan Goodyear

Fatigue and serum testosterone in obstructive ... [Clin Respir J. 2014] - PubMed - NCBI - 0 views

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    Severe sleep apnea associated with lower Testosterone levels and fatigue.  The low level of Testosterone was the only factor predictive of fatigue and reduced activity in sleep apnea.  This was only found in severe sleep apnea, not mild cases.
Nathan Goodyear

Impact of Low Testosterone on Response to Treatment ... [Urology. 2014] - Pub... - 0 views

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    Here is where science and particularly conclusions fail the public.  The authors conclusions are that tadalifl improves ED and sexual function irrespective of Testosterone levels.  However, the results say something different.  The group with normal Testosterone responded better versus the low Testosterone group.  This difference didn't reach statistical significance though.  This lack of statistical significance does not exclude the fact that there indeed was a difference.  The authors conlcusions take no part in reporting the whole truth, just that which supports their hypothesis. The diagnosis of low T in this study was < 300 ng/dl
Nathan Goodyear

Testosterone, thrombophilia, throm... [Blood Coagul Fibrinolysis. 2014] - PubMed - NCBI - 0 views

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    This study's conclusion is to evaluate clotting factor i.e. factor V leiden, Factor VIII, and prothrombin prior to giving Testosterone.  This small study found increased clotting in some men on Testosterone. The problem here is the dosing of Testosterone in these men was 50-160 mg.  Physiologic dosing is 5-10 mg.  The problem is doping.  One wonders if physiologic dosing was undertaken if any of the men in this study would develop clotting problems, even though they had undiagnosed hypercoagulabitliy.
Nathan Goodyear

Effect of different seasonal strength trai... [Hormones (Athens). 2014] - PubMed - NCBI - 0 views

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    Increased strength training associated with increased Total Testosterone and 3-alpha androstane idol  levels in trained athletes.  This was not found in free Testosterone levels.
Nathan Goodyear

Access : Prognostic and predictive value of plasma testosterone levels in patients rece... - 0 views

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    Higher base-line Testosterone levels associated with longer overall survival in men with prostate cancer.  The comparison was 32.7 months with higher T levels versus 22.4 months with lower T levels.  Anemia was also a poor prognostic variable.  Whether exogenous Testosterone therapy will change this is still unclear, but the authors suggest that this should play a role in whether to use salvage hormone therapy.
Nathan Goodyear

Testosterone, aging and s... [Curr Opin Endocrinol Diabetes Obes. 2014] - PubMed - NCBI - 0 views

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    Another review study.  Low Testosterone is associated with increased CVD in men.  However, some studies have suggested an increase in CVD with men using exogenous Testosterone therapy.  Is Testosterone the cause of CVD in men?  Likely, low T is a
Nathan Goodyear

Testosterone and cardiova... [Curr Opin Endocrinol Diabetes Obes. 2014] - PubMed - NCBI - 0 views

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    Review of recent articles suggest increased risk of cardiovascular disease in men. The issue at hand is the cause is not being treated and thus the Testosterone is fuel on the metabolic fire and the doping dose that most men receive.
Nathan Goodyear

Testosterone therapy affects Mexican American men differently - UNT Health Science Cent... - 0 views

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    This is the public announcement of a article yet to be published.  The study, yet unread, points to increase damage to brain health in those caucasian men with oxidative stress.  This was not found in mexican-Americans.  Until I read this study, that is all I will say here.  
Nathan Goodyear

Low testosterone is associated with disability in... [Mult Scler. 2014] - PubMed - NCBI - 0 views

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    low Testosterone associated with worse level of MS.
Nathan Goodyear

https://www.jstage.jst.go.jp/article/jmi/61/1.2/61_35/_pdf - 0 views

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    study looked at androgen deprivation therapy in non-metastatic prostate cancer.  This study found that the elimination of ADR post 5 years was associated with low recurrence.  Relapse of increased PSA was associated with increasing Testosterone off of ADR.  This study did not look at estrogens or androgen metabolites.  Too short sided in its design.
Nathan Goodyear

Present and future association between obesity and hypogonadism in Italian male | Boddi... - 0 views

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    Italian study projects an increase in the number of men with hypogonadism.  This will follow an increase in obesity, CVD and type II diabetes.
Nathan Goodyear

Low Testosterone at Time of Transplant Is Independent... [J Urol. 2014] - PubMed - NCBI - 0 views

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    More and more, low Testosterone is clearly a marker of poor health in men.  This study finds that low T at the time of renal transplant is associated with increase graft rejection/loss and patient death.  It appears to me that Testosterone levels should be a part of assessment for any man in poor health and/or headed for surgery.
Nathan Goodyear

Low testosterone elevates interleukin family cyto... [J Surg Res. 2014] - PubMed - NCBI - 0 views

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    low Testosterone associated with increased inflammatory cytokines in animal model.  The cytokines IL-2, IL-6, IL-10, Il-12, and IL-13 were specifically found to be elevated.  Translated, in animal model, low T equals increased inflammation.
Nathan Goodyear

Prevalence and Correlates of Late-Onset Hypogonadism Among Korean Men Aged 40 Years or ... - 0 views

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    Study of Korean men finds late onset of hypogonadism to be 16.8% in their study of 1,235 men older than 40.  This is a higher rate than other studies, but lower than others (38.7% in American men).  The test definition of low T was set at 3.2 ng/ml.  Abdominal obesity, metabolic syndrome, diabetes, and increasing age were associated with low T.

    Low T is clearly not a problem unique to America.  It definitely appears that a decreasing Testosterone level is a marker of poor health in men.  
Nathan Goodyear

Association of Preoperative Testosterone Levels with Biochemical Failure in Men Undergo... - 0 views

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    Study finds that low Testosterone preoperative is associated with increased positive surgical margins and worse staging post radical prostatectomy.  Also association with a non-statistical increase in biochemical failure.
Nathan Goodyear

Hypogonadism and Metabolic Syndrome in Nigerian Male Patients With Both Type 2 Diabetes... - 0 views

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    Asian study finds Testosterone is inversely associated with increased central obesity, increased dyslipidemia, and metabolic syndrome in me with new diagnosis of type II diabetes and hypertension.  Men with metabolic syndrome, type II diabetes, and CVD must have appropriate hormone evaluation.
Nathan Goodyear

Dehydroepiandrosterone supplementati... [J Clin Endocrinol Metab. 2013] - PubMed - NCBI - 0 views

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    meta-analysis finds reduction in fat mass from DHEA in elderly men.  The authors propose that it is due to the conversion to other hormones.  
Nathan Goodyear

Testosterone Supplementation and Sexual Function: ... [J Sex Med. 2014] - PubMed - NCBI - 0 views

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    Meta-analysis finds bias in industry studies versus independent studies.  No surprise there.   Testosterone in this meta-analysis was found to aid sexual dysfunction in men with hypogonadism.
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