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Nathan Goodyear

Low Testosterone Level and Risk of Alzheimer's Disease in the Elderly Men: a Systematic... - 0 views

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    Just abstract available here; low Testosterone in meta-analysis found to be associated with increased Alzheimer's disease risk in elderly men.
Nathan Goodyear

Effect of Opioids on Testosterone Levels: Cross-Sectional Study using NHANES. - PubMed ... - 0 views

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    opiate use increases odds of low Testosterone; however, this is just one piece. 
Nathan Goodyear

British Journal of Cancer - Androgen metabolism in prostate cancer: from molecular mech... - 0 views

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    androgen metabolites and prostate cancer promotion.
Nathan Goodyear

Estrogens and Their Genotoxic Metabolites Are Increased in Obese Prepubertal Girls: The... - 0 views

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    Obesity in young girls increases Estradiol production compared to thin young girls.  Obesity increased  the Estrogen metabolite 16lpha-OH-E1  and this positively correlated with IL-6. 
Nathan Goodyear

Salivary Testosterone and a Trinucleotide (CAG) Length Polymorphism in the Androgen Rec... - 0 views

  • Testosterone correlated inversely with participant age (r = −0.39, p = 0.012) and positively with number of CAG repeats
  • transactivation potential of the AR appears to decline in graded relation to an increasing number of CAG repeats, which are distributed over a normative range of 11–37 and, in Caucasian populations, commonly average 21–22 repeats
  • When activated by androgens, ARs translocate to the cell nucleus, where they exert transcriptional control of androgen-dependent genes by binding to androgen response elements within gene regulatory sequences
  • ...10 more annotations...
  • some evidence suggests a high number of CAG repeats may be associated with cognitive aging
  • androgens (like other steroid hormones) promote or repress the expression of genes specifying an array of cellular proteins
  • diurnal variation in testosterone levels
  • salivary testosterone correlated negatively with participant age and positively with CAG length variation in the AR gene
  • CAG repeat number varied inversely with reactivity of the ventral amygdala to facial expressions of negative affect
  • higher salivary testosterone was likewise associated with a greater number of AR CAG repeats
  • relative androgen insensitivity in ARs with a larger number of CAG repeats
  • Because circulating testosterone is regulated via negative feedback through the hypothalamic-pituitary-gonadal axis, diminished androgen sensitivity at higher CAG repeat lengths may reduce feedback suppression of luteinizing hormone (LH). LH would then be maintained at higher levels, in turn promoting higher testosterone production
  • Testosterone up-regulates AVP expression in the amygdala
  • Oxytocin exerts an inhibitory influence on AVP expression in the central amygdala, and the synthesis of oxytocin is mediated by estrogen and estrogen receptors
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    Study used saliva to measure Testosterone levels in men.  Testosterone levels were inversely associated with age, but positively associated with CAG repeat sequences in the AR.
Nathan Goodyear

Validation of Blood Spot Sampling for Gonadotropins and Ovarian Hormone Levels in Repro... - 0 views

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    blood spot Estradiol, Progesterone, LH, and FSH levels shown to be comparable to plasma levels.
Nathan Goodyear

Effects of endurance exercise on free testosterone concentration and the binding affini... - 0 views

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    exercise increases Testosterone production via catecholamine mechanism.  Free Testosterone increases independent from SHBG affinity.
Nathan Goodyear

Neuropsychopharmacology - Testosterone Suppression of CRH-Stimulated Cortisol in Men - 0 views

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    Testosterone inhibits CRH and thus cortisol.
Nathan Goodyear

Testosterone Suppression of CRH-stimulated Cortisol in Men - 0 views

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    Testosterone inhibits CRH and thus cortisol production in men.  This has implications in men with low T and low Cortisol.
Nathan Goodyear

Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regula... - 0 views

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    Leptin does have inhibitory activity at the level at the HPA; in addition to the inhibition at the gonadal level.

Nathan Goodyear

PLOS ONE: Testosterone Induces Molecular Changes in Dopamine Signaling Pathway Molecule... - 0 views

  • The majority of the gene expression changes reported here are only induced by DHT and testosterone, and not by estradiol, indicating that in adolescent males androgen receptor, not ERα, activation is critical for these responses
  • It is less clear whether ERβ is involved or not as DHT, via conversion to 3β-diol has a high affinity for ERβ
  • the testosterone-induced, AR-driven modulation of molecular indices of dopamine responsivity of the nigrostriatal pathway may involve regulation of dopamine feedback inhibition in the somatodendritic field and post-synaptic dopamine action in the terminal field.
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    Testosterone increases dopamine signaling.  This study was done on male rats.  No effect was seen with Estradiol.
Nathan Goodyear

Age-related testosterone decline is due to waning of both testicular and hypothalamic-p... - 0 views

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    Only abstract available here, but low T is the result of primary (testicular failure) and/or secondary (HPA failure). 
Nathan Goodyear

Effects of Testosterone Level on Lower Urinary Tract Symptoms. - PubMed - NCBI - 0 views

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    no correlation between total Testosterone with LUTS and prostate size in men.
Nathan Goodyear

Effects of Resistance Training on Testosterone Metabolism in Younger and Older Men. - P... - 0 views

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    Resistance training increases Testosterone in younger and older men.  The effects in older men appears to involve more of a decreased metabolism.  
Nathan Goodyear

http://joe.endocrinology-journals.org/content/170/2/413.full.pdf - 0 views

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    Leptin shown to inhibit steroid hormone synthesis in the gonads via inhibition of 17beta-HSD.  This is in addition to other reports of inhibition of 17,20 lyase, adrenal cortisol inhibition, inhibition of CRF, and inhibition of LH/FSH.
Nathan Goodyear

Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. - P... - 0 views

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    Leptin inhibits CRH, thus decreasing the HPA axis.
Nathan Goodyear

Leptin and the regulation of the hypothalamic-pituitary-adrenal axis. - PubMed - NCBI - 0 views

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    Leptin inhibits hormone production from the adrenal cortex, but increases catecholamine release from the adrenal medulla.
Nathan Goodyear

http://www.researchgate.net/profile/Costanzo_Moretti/publication/12777565_Leptin_and_an... - 0 views

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    Normal leptin levels are critical to puberty; but in obese men, increased leptin is associated with gonadal decrease in Testosterone.  It appears to occur through a decrease in 17-OH progesterone to Testosterone: suggesting an inhibitory activity in the conversion of 17-OH progesterone to Testosterone in obese men.
Nathan Goodyear

The kisspeptin-GnRH pathway in human reproductive health and disease - 0 views

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    good review of the current understanding of kisspeptin and gonadotropins.
Nathan Goodyear

http://download.springer.com/static/pdf/869/art%253A10.1007%252Fs12020-015-0650-6.pdf?o... - 0 views

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    Opinion publication recommends total Testosterone as primary means of evaluating Testosterone.  This recommendation relies on the use of immunoassay techniques which can lack specificity compared to newer LC/MS and GC/MS techniques.  The authors did recommend using salivary Testosterone when borderline and SHBG variables play in, which happens to be most clients I see.  The best approach is to use both simultaneously to give a more clear physiologic picture to start.
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